Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury.

abstract：Purpose:The aim was to investigate resveratrol effects on A549 cells proliferation. Methods:A total of 104 lung adenocarcinoma tissues and nontumor tissues were collected. BEAS-2B cells were cultured in RPMI 1640 medium (group A). A549 cells were treated with RPMI 1640 medium containing different resveratrol concentra...

journal_title：OncoTargets and therapy

authors： Li X,Li F,Wang F,Li J,Lin C,Du J

更新日期：2018-05-22 00:00:00

abstract：Background:Despite the breadth of understanding the noncoding RNAs' function in molecular biology, their functional roles in hepatocellular carcinoma (HCC) is poorly understood. In this study, we investigated the effect of hepatitis C virus (HCV) core upon the expression of noncoding RNAs. Methods:The lncRNAs, mRNAs, ...

journal_title：OncoTargets and therapy

authors： Wang X,Peng J,Wang J,Li M,Wu D,Wu S,Liao J,Dou J

更新日期：2018-03-02 00:00:00

abstract：:Quercetin is proven to have anticancer effects for many cancers. However, the role of tumor suppressor p53 on quercetin's radiosensitization and regulation of endoplasmic reticulum (ER) stress response in this process remains obscure. Here, quercetin exposure resulted in ER stress, prolonged DNA repair, and the expres...

journal_title：OncoTargets and therapy

authors： Gong C,Yang Z,Zhang L,Wang Y,Gong W,Liu Y

更新日期：2017-12-21 00:00:00

abstract：:Androgen deprivation therapy (ADT) is well established as a backbone therapy for metastatic prostate cancer (mPCa), and both European and American guidelines emphasize the importance of maintaining ADT after progression to metastatic castration-resistant prostate cancer (CRPC). However, the use of ADT varies widely in...

journal_title：OncoTargets and therapy

authors： Merseburger AS,Alcaraz A,von Klot CA

更新日期：2016-11-29 00:00:00

abstract：Background:Lupeol, a triterpene isolated from various herbal plants, possesses an anti-inflammatory function and has been proposed as a candidate for anticancer agents. The purpose of this research was to investigate the effect of lupeol on the viability, apoptosis, cell-cycle distribution, and migration of colorectal ...

journal_title：OncoTargets and therapy

authors： Wang Y,Hong D,Qian Y,Tu X,Wang K,Yang X,Shao S,Kong X,Lou Z,Jin L

更新日期：2018-11-09 00:00:00

abstract：:Mesothelin (MSLN) is considered a promising target for cancer therapy. Originally extracted in 1992 after the immunization of mice with a human ovarian cancer (OC) cell line and cloned in 1996, MSLN seems to be involved in cell adhesion and metastasis. MSLN is prevalent in mesothelia tissues but is expressed in severa...

journal_title：OncoTargets and therapy

authors： Baldo P,Cecco S

更新日期：2017-11-08 00:00:00

abstract：Background:The immune environment of lung cancer is complex, and the critical immune factors that promote lung cancer progression need to be explored. Granulocytic myeloid-derived suppressor cells (G-MDSCs) are regarded as immune suppressing cells. However, they also promote tumor progression through other ways, which ...

journal_title：OncoTargets and therapy

authors： Zhou JH,Yao ZX,Zheng Z,Yang J,Wang R,Fu SJ,Pan XF,Liu ZH,Wu K

更新日期：2020-09-30 00:00:00

abstract：BACKGROUND:Studies on the association between two single nucleotide polymorphisms (SNPs) in estrogen receptor α (ERα), PvuII (rs2234693 T>C) and XbaI (rs9340799 A>G), and the prostate cancer risk are inconsistent. Therefore, we performed a meta-analysis to derive a more accurate estimation of this relationship. METHOD...

journal_title：OncoTargets and therapy

authors： Zhao Y,Zheng X,Zhang L,Hu Q,Guo Y,Jiang H,Shi S,Zhang X

更新日期：2017-06-29 00:00:00

abstract：Purpose:Sorafenib has revolutionized treatment of hepatocellular carcinoma (HCC), but its efficacy is limited by drug resistance. Autophagy is the process by which cellular components are transported to lysosomes for degradation, which promotes energy production and production of macromolecular precursors. Studies have...

journal_title：OncoTargets and therapy

authors： Yang S,Wang M,Yang L,Li Y,Ma Y,Peng X,Li X,Li B,Jin H,Li H

更新日期：2020-04-28 00:00:00

abstract：:Tumor development is closely related to angiogenesis, and VEGFR2 plays an important role in tumor angiogenesis. It is broadly expressed in the blood vessels, especially in the microvessels of tumor tissues. Furthermore, VEGFR2 is detected on the surface of the cell membrane in various immune cells, such as dendritic c...

journal_title：OncoTargets and therapy

authors： Zhu P,Hu C,Hui K,Jiang X

更新日期：2017-09-01 00:00:00

abstract：BACKGROUND:The grading of pancreatic neuroendocrine neoplasms (PanNENs) is associated with the choice of treatment strategy. The aim of this study is to identify the magnetic resonance imaging (MRI) features in differentiating pancreatic neuroendocrine tumors (PanNETs) grade 1/2 (G1/G2) and pancreatic neuroendocrine ca...

journal_title：OncoTargets and therapy

authors： Guo C,Chen X,Xiao W,Wang Q,Sun K,Wang Z

更新日期：2017-03-07 00:00:00

abstract：:[This corrects the article DOI: 10.2147/OTT.S227758.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2020-01-29 00:00:00

abstract：Purpose:The aim of this study was to investigate the antitumor effect of chidamide in combination with bortezomib on gastric cancer cell lines. Materials and Methods:First, the sensitivity and IC50 values of chidamide and bortezomib in several gastric cancer cell lines (MGC-803, BGC-823, SGC-7901, and MKN45) were meas...

journal_title：OncoTargets and therapy

authors： Zhang W,Niu J,Ma Y,Yang X,Cao H,Guo H,Bao F,Haw A,Chen Y,Sun K

更新日期：2020-05-06 00:00:00

abstract：Background:Many studies have explored the prognostic value of T-cell lymphoma invasion and metastasis inducing factor 1 (Tiam1) and its association with lymphatic metastasis in malignant solid tumors, but the conclusions remain controversial. Therefore, we performed a meta-analysis to systematically assess the prognost...

journal_title：OncoTargets and therapy

authors： Yang C,Ma C,Li Y,Mo P,Yang Y

更新日期：2019-07-25 00:00:00

abstract：Background:Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide. LINC00460, a novel long non-coding RNA (lncRNA), was recently confirmed as an oncogene in various cancers. However, the biological function and underlying mechanism of LINC00460 in HCC is largely obscure. Methods:Fifty pa...

journal_title：OncoTargets and therapy

authors： Yang J,Li K,Chen J,Hu X,Wang H,Zhu X

更新日期：2020-03-06 00:00:00

abstract：:Angiogenesis (the growth of new blood vessels) is essential in most of the body's physiological processes, such as in the normal functioning of the endometrium during and after the menstrual cycle. Vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP) are the mostly expressed angiogenic factors,...

journal_title：OncoTargets and therapy

authors： Mahecha AM,Wang H

更新日期：2017-09-19 00:00:00

abstract：Background:Emerging researches have demonstrated that aberrantly expressed long non-coding RNAs (lncRNAs) have great significance in non-small cell lung cancer (NSCLC) progression. The aim of this study was to explore the role of lncRNA AZIN1 antisense RNA 1 (AZIN1-AS1) in NSCLC and the related mechanism. Methods:Expr...

journal_title：OncoTargets and therapy

authors： Cai Y,Wu Q,Liu Y,Wang J

更新日期：2020-10-09 00:00:00

abstract：BACKGROUND:We investigated the functional roles of microRNA-125a-5p in regulating human prostate carcinoma. METHODS:Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was conducted to evaluate the gene expression levels of miR-125a-5p in eight prostate cancer cell lines and nine biopsy specimens fr...

journal_title：OncoTargets and therapy

authors： Fu Y,Cao F

更新日期：2015-12-17 00:00:00

abstract：BACKGROUND:To evaluate the benefit of second-line chemotherapy with platinum-based treatment in patients with recurrent small cell lung cancer (SCLC). PATIENTS AND METHODS:A total of 535 patients continued with follow-up or best supportive care if needed, and 229 patients who progressed after the completion of first-l...

journal_title：OncoTargets and therapy

authors： Zarogoulidis K,Boutsikou E,Zarogoulidis P,Darwiche K,Freitag L,Porpodis K,Latsios D,Kontakiotis T,Huang H,Li Q,Hohenforst-Schmidt W,Kipourou M,Turner JF,Spyratos D

更新日期：2013-10-22 00:00:00

abstract：:Despite remarkable progress in cancer-drug discovery, the delivery of novel, safe, and sustainably effective products to the clinic has stalled. Using Src as a model, we examine key steps in drug development. The preclinical evidence on the relationship between Src and solid cancer is in sharp contrast with the modest...

journal_title：OncoTargets and therapy

authors： Rösel D,Brábek J,Veselý P,Fernandes M

更新日期：2013-06-26 00:00:00

abstract：:We report the case of a man with an advanced nonkeratinizing squamous cell thymic carcinoma harboring c-KIT exon 13 missense mutation K642E. This aberration is rare and has never been described previously in patients with thymic cancers. It has been found in a small number of cases of gastrointestinal stromal tumor an...

journal_title：OncoTargets and therapy

authors： Catania C,Conforti F,Spitaleri G,Barberis M,Preda L,Noberasco C,Lazzari C,Toffalorio F,de Marinis F,Manzotti M,De Pas TM

更新日期：2014-05-08 00:00:00

abstract：OBJECTIVE:To analyze the management and prognosis of primary choriocarcinoma (PCC) in male patients. METHODS:The clinical records of males with PCC who were treated at Peking Union Medical College Hospital between 1990 and 2012 were analyzed retrospectively. The literature regarding this clinical condition was also re...

journal_title：OncoTargets and therapy

authors： Jiang F,Xiang Y,Feng FZ,Ren T,Cui ZM,Wan XR

更新日期：2014-06-20 00:00:00

abstract：:Cutaneous metastasis from primary visceral malignancy is a relatively uncommon clinical entity, with a reported incidence ranging from 0.22% to 12% of all malignancies. Here we report a 64-year-old asymptomatic female patient with Peutz-Jeghers syndrome presenting with multiple scalp metastases as the initial manifest...

journal_title：OncoTargets and therapy

authors： Yu Q,Subedi S,Tong Y,Wei Q,Xu H,Wang Y,Gong Y,Shi Y

更新日期：2018-09-21 00:00:00

abstract：Background:Immunosenescence, the age-related decline of immunity, affects the immune responses of melanoma patients. Through immune responses, immune checkpoint inhibitors (ICIs) exert their antitumor robustness. In different ages of melanoma patients, especially the older patients, the effectiveness of ICIs remains un...

journal_title：OncoTargets and therapy

authors： Li P,Yang X,Feng Y,Wu L,Ma W,Ding G,Wei Y,Sun L

更新日期：2018-10-26 00:00:00

abstract：:The aim of this study was to evaluate the efficacy and toxicity of stereotactic body radiation therapy (SBRT) in the treatment of patients with liver metastases. Between August 2006 and July 2011, patients with 1-4 liver metastases were enrolled and treated with SBRT using the CyberKnife(®) system at Tianjin Medical U...

journal_title：OncoTargets and therapy

authors： Yuan ZY,Meng MB,Liu CL,Wang HH,Jiang C,Song YC,Zhuang HQ,Yang D,Wang JS,Wei W,Li FT,Zhao LJ,Wang P

更新日期：2014-06-12 00:00:00

abstract：Purpose:miR-497-5p can inhibit cervical cancer cell proliferation. However, the underlying mechanism remains to be elucidated. Methods:Bioinformatics was used to analyze the target genes of miR-497-5p. qRT-PCR and Western blot were used to analyze mRNA and protein expression, respectively. Dual-luciferase reporter ass...

journal_title：OncoTargets and therapy

authors： Chen Y,Du J,Wang Y,Shi H,Jiang Q,Wang Y,Zhang H,Wei Y,Xue W,Pu Z,Gao Y,Li D,Feng Y,Yan J,Zhang J

更新日期：2019-12-02 00:00:00

abstract：BACKGROUNDS:Sitting time and physical activity are associated with cancer risk; however, their roles in the development of esophageal squamous cell carcinoma (ESCC) are inconclusive. This study aimed to investigate the effects of total sitting time, occupational activity time (OAT), and recreational activity time (RAT)...

journal_title：OncoTargets and therapy

authors： Chen P,Song Q,Han J,Xu H,Chen T,Xu J,Cheng Y

更新日期：2017-09-27 00:00:00

abstract：OBJECTIVE:This study aims to investigate the potential benefit of combination therapy with magnetic nanoparticles of Fe3O4 (Fe3O4-MNP) and gambogic acid (GA) on SMMC-7721 cells. METHODS:The inhibition of proliferation of SMMC-7721 cells was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assa...

journal_title：OncoTargets and therapy

authors： Tian L,Chen BA,Cheng J,Guo QL

更新日期：2015-08-26 00:00:00

abstract：PURPOSE:Liver metastasis is one of the leading causes of death in colorectal cancer (CRC) patients. The present study aimed to evaluate the value of eIF4E as a prognostic marker of colorectal liver metastasis (CLM) and identify the functional role of eIF4E in CRC metastasis. PATIENTS AND METHODS:The expression level o...

journal_title：OncoTargets and therapy

authors： Xu T,Zong Y,Peng L,Kong S,Zhou M,Zou J,Liu J,Miao R,Sun X,Li L

更新日期：2016-02-19 00:00:00

abstract：:Targeted radioimmunotherapy in non-Hodgkin's B-cell lymphoma (NHL) offers an efficacious therapy and minimal toxicity compared to conventional chemotherapy. Iodine 131 tositumomab ((131)I-TST) is a murine monoclonal antibody against the CD20 cell surface protein and is directly covalently conjugated to (131)I, a radio...

journal_title：OncoTargets and therapy

authors： Burdick MJ,Macklis RM

更新日期：2009-02-18 00:00:00