Long Noncoding RNA LINC00460 Promotes Hepatocellular Carcinoma Progression via Regulation of miR-342-3p/AGR2 Axis.

abstract：BACKGROUND:Considerable interest is directed toward the enzyme aromatase (CYP19A1) and the development of cancer, due to CYP19A1's role in estrogen biosynthesis. Several cancers display excessive intra-tumor accumulation of estrogens, and aromatase inhibitors are used for treatment. The CYP19A1 gene exhibits polymorphi...

journal_title：OncoTargets and therapy

authors： Al-Mukaynizi FB,Alanazi M,Al-Daihan S,Parine NR,Almadi M,Aljebreen A,Azzam N,Alharbi O,Arafah M,Warsy A

更新日期：2017-09-14 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is often diagnosed at late incurable stage and lacks effective treatment strategy. Bufadienolides are cardiotonic steroids isolated from the skin and parotid venom glands of the toad Bufo bufo gargarizans Cantor with novel anticancer activity. However, there is little informat...

journal_title：OncoTargets and therapy

authors： Lv J,Lin S,Peng P,Cai C,Deng J,Wang M,Li X,Lin R,Lin Y,Fang A,Li Q

更新日期：2017-02-28 00:00:00

abstract：Background:Pancreatic cancer is one of the most lethal malignancies. Accumulating evidence supports for the critical contribution of long noncoding RNAs (lncRNAs) to the cancer development and progression. We tried to identify novel lncRNAs involved in the pancreatic carcinogenesis. Materials and Methods:Two independe...

journal_title：OncoTargets and therapy

authors： Chen G,Xu L,Ye G,Lin J,Meng Z,Shen Y

更新日期：2021-01-05 00:00:00

abstract：:Despite multimodal therapeutic treatments of osteosarcoma (OS), some patients develop resistance to currently available regimens and eventually end up with recurrent or metastatic outcomes. Many attempts have been made to discover effective drugs for improving outcome; however, due to the heterogeneity of the disease,...

journal_title：OncoTargets and therapy

authors： Chaiyawat P,Settakorn J,Sangsin A,Teeyakasem P,Klangjorhor J,Soongkhaw A,Pruksakorn D

更新日期：2017-02-01 00:00:00

abstract：Purpose:Intraoperative identification of rectal cancer (RC) can be challenging, especially because of fibrosis after treatment with preoperative chemo- and radiotherapy (CRT). Tumor-targeted fluorescence imaging can enhance the contrast between tumor and normal tissue during surgery. Promising targets for RC imaging ar...

journal_title：OncoTargets and therapy

authors： Boogerd LS,van der Valk MJ,Boonstra MC,Prevoo HA,Hilling DE,van de Velde CJ,Sier CF,Fariña Sarasqueta A,Vahrmeijer AL

更新日期：2018-03-23 00:00:00

abstract：Background:Leukemia related protein 16 (LRP16), one of the genes belonging to the macro domain family, has been found up-regulated in various tumors including testicles, ovaries and mucosa of colon and is associated with poor clinical outcomes. Purpose:The objective of this study was to investigate expression pattern ...

journal_title：OncoTargets and therapy

authors： Mo Z,Hu M,Yu F,Shao L,Fan K,Jiao S

更新日期：2018-03-05 00:00:00

abstract：:Piwi-interacting RNAs (piRNAs) are a newly discovered class of small non-coding RNAs involved in silencing of transposable elements and in sequence-specific chromatin modifications. PIWI proteins (PIWIL), which belong to the family of Argonaute genes/proteins, bind to piRNAs and function mainly in germ line cells, but...

journal_title：OncoTargets and therapy

authors： Iliev R,Stanik M,Fedorko M,Poprach A,Vychytilova-Faltejskova P,Slaba K,Svoboda M,Fabian P,Pacik D,Dolezel J,Slaby O

更新日期：2016-01-08 00:00:00

abstract：BACKGROUND:Laminin gamma2 (Ln-γ2) chain, a distinctive subunit of heterotrimeric laminin-332, is frequently upregulated in carcinomas and is of great importance in cell migration and invasion. Despite this, the status of circulating Ln-γ2 in lung cancer patients is still uncertain. PATIENTS AND METHODS:In this retrosp...

journal_title：OncoTargets and therapy

authors： Teng Y,Wang Z,Ma L,Zhang L,Guo Y,Gu M,Wang Z,Wang Y,Yue W

更新日期：2016-07-07 00:00:00

abstract：:Over the last decades, a better understanding of breast cancer heterogeneity provided tools for a biologically based personalization of anticancer treatments. In particular, the overexpression of the human epidermal growth factor receptor 2 (HER2) by tumor cells provided a specific target in these HER2-positive tumors...

journal_title：OncoTargets and therapy

authors： Kourie HR,El Rassy E,Clatot F,de Azambuja E,Lambertini M

更新日期：2017-07-10 00:00:00

abstract：:Despite the prominent effects of BCR-ABL tyrosine kinase inhibitors (TKI) therapy in patients with chronic phase-chronic myeloid leukemia (CP-CML) and thus low incidence of blastic transformation, blast phase (BP)-CML remains a major therapeutic challenge in the TKI era. The "gatekeeper" mutation T315I in BCR-ABL1 kin...

journal_title：OncoTargets and therapy

authors： Zhou L,Shi H,Shi W,Yang L,Zhang Y,Xu M,Chen X,Zhu Y,Mu H,Wan X,Yang Z,Zeng Y,Liu H

更新日期：2019-12-13 00:00:00

abstract：Purpose:It is widely known that some specific microRNAs can regulate the expressions of genes in gastric cancer cells at the post-transcriptional level. Previous studies have identified that miRNA-4766-5p was involved in tumor cell proliferation and can be an independent prognostic indicator for malignant pleural mesot...

journal_title：OncoTargets and therapy

authors： Wei Y,Wang Y,Zang A,Wang Z,Fang G,Hong D

更新日期：2019-10-16 00:00:00

abstract：:Background: Seminoma accounts for the most part of cases of testicular germ cell tumor, which is the most common malignancy among males between ages 15 and 44 years. Understanding the molecular mechanism of tumorigenesis is important for better clinical diagnosis and treatment. Purpose: We performed bioinformatics ana...

journal_title：OncoTargets and therapy

authors： Chen YH,Lin TT,Wu YP,Li XD,Chen SH,Xue XY,Wei Y,Zheng QS,Huang JB,Xu N

更新日期：2019-05-14 00:00:00

abstract：Background:Cordycepin, the main active ingredient of a traditional Chinese herbal remedy - extracted from Cordyceps sinensis - has been demonstrated as a very effective anti-inflammatory and antitumor drug. The present study investigated its antitumor effect on pancreatic cancer, a highly aggressive cancer with extreme...

journal_title：OncoTargets and therapy

authors： Zhang Y,Zhang XX,Yuan RY,Ren T,Shao ZY,Wang HF,Cai WL,Chen LT,Wang XA,Wang P

更新日期：2018-08-01 00:00:00

abstract：:Malignant gliomas are invasive tumors with the potential to progress through current available therapies. These tumors are characterized by a number of abnormalities in molecular signaling that play roles in tumorigenesis, spread, and survival. These pathways are being actively investigated in both the pre-clinical an...

journal_title：OncoTargets and therapy

authors： Lukas RV,Boire A,Nicholas MK

更新日期：2009-02-18 00:00:00

abstract：Purpose:Several studies have proved that single nucleotide polymorphisms (SNPs) of mismatch repair system genes are closely related to the development of colorectal cancer (CRC) by causing microsatellite instability, while effects of the SNPs of MMR system-related genes on the clinical outcomes of cytotoxic chemotherap...

journal_title：OncoTargets and therapy

authors： Wang D,Zhang X,Zhang Y,Wu Y,Guan X,Zhu W,Wang M,Qi C,Shen B

更新日期：2018-11-13 00:00:00

abstract：BACKGROUND:Progression-free survival (PFS) and time to progression (TTP) are frequently used to establish the clinical efficacy of anti-cancer drugs. However, the surrogacy of PFS/TTP for overall survival (OS) remains a matter of uncertainty in metastatic breast cancer (mBC). This study assessed the relationship betwee...

journal_title：OncoTargets and therapy

authors： Beauchemin C,Cooper D,Lapierre MÈ,Yelle L,Lachaine J

更新日期：2014-06-18 00:00:00

abstract：BACKGROUND AND PURPOSE:Vandetanib is a promising anticancer targeted agent for treating advanced carcinomas, such as non-small-cell lung cancer, small-cell lung cancer, breast cancer, malignant glioma, hepatocellular cancer, and unresectable, locally advanced, or metastatic medullary thyroid cancer. However, diarrhea i...

journal_title：OncoTargets and therapy

authors： Huo Z,Yu S,Hong S,Cao X,Xiu L,Liao Z,Li Y,Xiao H

更新日期：2016-06-20 00:00:00

abstract：Introduction:Ribosome binding protein 1 (RRBP1) is reported to be correlated with tumor formation and progression. However, the role of RRBP1 in bladder cancer is unclear. In this study, we aimed to investigate the expression of RRBP1 and its influence on cell proliferation in bladder cancer. Methods:Quantification re...

journal_title：OncoTargets and therapy

authors： Lv SW,Shi ZG,Wang XH,Zheng PY,Li HB,Han QJ,Li ZJ

更新日期：2020-07-07 00:00:00

abstract：:Iliac vein-ureteral fistula is a rare cause of hematuria. The diagnosis of an iliac vein-ureteral fistula can be elusive even with the use of multiple methods. With regards to the treatment, there appears to be a shift in management from primarily open surgical to primarily angiographic management. We present a unique...

journal_title：OncoTargets and therapy

authors： Luo JD,Liu B,Wang P,Zhou F,Xu XL,Li SQ,Cai SL,Wang YM

更新日期：2014-07-23 00:00:00

abstract：:HES1 is the target of Notch signaling which is reported to affect cell differentiation and maintain the cells in G0 phase in various tissues including the hematopoietic tissue. HES1 expression appears to be an independent prognostic factor for survival in a heterogeneous group of acute myeloid leukemia (AML) patients....

journal_title：OncoTargets and therapy

authors： Tian C,Tang Y,Wang T,Yu Y,Wang X,Wang Y,Zhang Y

更新日期：2015-04-22 00:00:00

abstract：Background:Insulin-like growth factor binding protein-2 (IGFBP2) levels are significantly increased in the plasma of hepatocellular carcinoma (HCC) patients. However, the correlation between IGFBP2 levels and clinical parameters and the exact role of IGFBP2 in HCC are unclear. In this study, we identified the role and ...

journal_title：OncoTargets and therapy

authors： Ma Y,Cui D,Zhang Y,Han CC,Wei W

更新日期：2020-06-08 00:00:00

abstract：:Soft tissue sarcomas (STS) represent a variety of tumors of mesenchymal origin, accounting for about 1% of all adult cancers. This group of tumors comprises over 60 different histotypes with different biology showing different sensitivity to therapeutic agents. For decades, the standard first-line systemic treatment o...

journal_title：OncoTargets and therapy

authors： Recine F,Bongiovanni A,Riva N,Fausti V,De Vita A,Mercatali L,Liverani C,Miserocchi G,Amadori D,Ibrahim T

更新日期：2017-02-23 00:00:00

abstract：:Androgen deprivation therapy (ADT) is well established as a backbone therapy for metastatic prostate cancer (mPCa), and both European and American guidelines emphasize the importance of maintaining ADT after progression to metastatic castration-resistant prostate cancer (CRPC). However, the use of ADT varies widely in...

journal_title：OncoTargets and therapy

authors： Merseburger AS,Alcaraz A,von Klot CA

更新日期：2016-11-29 00:00:00

abstract：Purpose:The aim of this study was to investigate the antitumor effect of chidamide in combination with bortezomib on gastric cancer cell lines. Materials and Methods:First, the sensitivity and IC50 values of chidamide and bortezomib in several gastric cancer cell lines (MGC-803, BGC-823, SGC-7901, and MKN45) were meas...

journal_title：OncoTargets and therapy

authors： Zhang W,Niu J,Ma Y,Yang X,Cao H,Guo H,Bao F,Haw A,Chen Y,Sun K

更新日期：2020-05-06 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) patients with fever as the initial presentation are extremely rare. Our aim was to investigate the clinical characteristics and prognosis of patients with this disease. PATIENTS AND METHODS:The clinical features were analyzed in a retrospective study of 63 HCC patients with fe...

journal_title：OncoTargets and therapy

authors： Gong ZJ,Guo W,Sun YF,Zhang X,Qiu SJ,Zhou J,Fan J,Yang XR

更新日期：2016-10-13 00:00:00

abstract：:Background: During the past decades, great efforts have been built to develop lung cancer vaccines. Whole tumor cell lysate (TCL) are ideal sources of antigens for cancer vaccine design, which however have limited efficacy due to insufficient immunogenicity. Recently, radiotherapy has been closely related to immunothe...

journal_title：OncoTargets and therapy

authors： Luo L,Lv M,Zhuang X,Zhang Q,Qiao T

更新日期：2019-05-16 00:00:00

abstract：:Anterior gradient protein (AGR) 3 is a highly related homologue of pro-oncogenic AGR2 and belongs to the family of protein disulfide isomerases. Although AGR3 was found in breast, ovary, prostate, and liver cancer, it remains of yet poorly defined function in tumorigenesis. This study aimed to determine AGR3 expressio...

journal_title：OncoTargets and therapy

authors： Obacz J,Brychtova V,Podhorec J,Fabian P,Dobes P,Vojtesek B,Hrstka R

更新日期：2015-06-24 00:00:00

abstract：Background:As a component of the EIF3 complex, EIF3C is essential for several steps in protein synthesis initiation. Recently, it has been addressed that EIF3C is overexpressed in several human cancers and plays a pivotal role in cell proliferation and tumorigenesis. Materials and methods:Immunohistochemistry, quantit...

journal_title：OncoTargets and therapy

authors： Gao W,Hu Y,Zhang Z,Du G,Yin L,Yin Z

更新日期：2019-02-14 00:00:00

abstract：BACKGROUND:Gallbladder carcinoma is a highly malignant tumor and a public health problem in some parts of the world. It is characterized by a poor prognosis and its resistance to radio and chemotherapy. There is an urgent need to develop novel therapeutic alternatives for the treatment of gallbladder carcinoma. The mam...

journal_title：OncoTargets and therapy

authors： Leal P,Garcia P,Sandoval A,Buchegger K,Weber H,Tapia O,Roa JC

更新日期：2013-10-03 00:00:00

abstract：:ISL1 plays a key role in several cancers, including pheochromocytoma, gastrointestinal, pancreatic, and lung tumors and bile duct carcinoma. In order to elucidate the role of ISL1 in breast cancer, we performed quantitative real-time polymerase chain reaction and Western blotting analysis, and we found that ISL1 was u...

journal_title：OncoTargets and therapy

authors： Li L,Sun F,Chen X,Zhang M

更新日期：2018-02-14 00:00:00