Erratum: Upregulated LINC00565 Accelerates Ovarian Cancer Progression by Targeting GAS6 [Corrigendum].

abstract：:This study aimed to identify the genes and pathways associated with smoking-related lung adenocarcinoma. Three lung adenocarcinoma associated datasets (GSE43458, GSE10072, and GSE50081), the subjects of which included smokers and nonsmokers, were downloaded to screen the differentially expressed feature genes between ...

journal_title：OncoTargets and therapy

authors： Liu Y,Ni R,Zhang H,Miao L,Wang J,Jia W,Wang Y

更新日期：2016-12-07 00:00:00

abstract：:Ovarian cancer (OC) is the most lethal cancer of all gynecological malignancies, while endometrial cancer (EC) is the most common one. Current strategies for OC/EC diagnosis consist of the extraction of a solid tissue from the affected area. This sample enables the study of specific biomarkers and the genetic nature o...

journal_title：OncoTargets and therapy

authors： Chen Q,Zhang ZH,Wang S,Lang JH

更新日期：2019-12-27 00:00:00

abstract：Background and Objectives:Non-small cell lung cancer (NSCLC) patients with an epidermal growth factor receptor (EGFR) mutation demonstrate only a median progression-free survival (PFS) of 8 to 10 months and undergo EGFR tyrosine kinase inhibitors (EGFR-TKIs) therapy. For decades, bilirubin has been reported to be assoc...

journal_title：OncoTargets and therapy

authors： Geng Y,Mei Y,Xi Y,Yu J,Meng K,Zhang T,Ma W

更新日期：2020-10-29 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. Since the discovery that the KIT and PDGFRA receptor tyrosine kinases are the primary oncogenic drivers in the vast majority of GISTs, targeted therapy with tyrosine kinase inhibitors has been the mainstay ...

journal_title：OncoTargets and therapy

authors： Li GZ,Raut CP

更新日期：2019-07-01 00:00:00

abstract：:Huaier (Trametes robiniophila Murr), a Chinese traditional herb of medicine, has demonstrated promising curative effects in clinical treatment for various tumors. There are documented experiments showing the biological functions of Huaier with its antineoplastic molecular mechanisms: restraining proliferation and meta...

journal_title：OncoTargets and therapy

authors： Qi T,Dong Y,Gao Z,Xu J

更新日期：2020-12-08 00:00:00

abstract：:Targeted radioimmunotherapy in non-Hodgkin's B-cell lymphoma (NHL) offers an efficacious therapy and minimal toxicity compared to conventional chemotherapy. Iodine 131 tositumomab ((131)I-TST) is a murine monoclonal antibody against the CD20 cell surface protein and is directly covalently conjugated to (131)I, a radio...

journal_title：OncoTargets and therapy

authors： Burdick MJ,Macklis RM

更新日期：2009-02-18 00:00:00

abstract：PURPOSE:E3 ubiquitin ligase ZNRF3 is linked to the pathogenesis of diseases and tumorigenesis. The present study aims to explore the expression of ZNRF3 and its association with prognostic survival of human colorectal carcinoma. METHODS:A follow-up survey of 168 patients with colorectal carcinoma was performed, and sp...

journal_title：OncoTargets and therapy

authors： Yu N,Zhu H,Tao Y,Huang Y,Song X,Zhou Y,Li Y,Pei Q,Tan Q,Pei H

更新日期：2016-10-28 00:00:00

abstract：Background:Lung cancer is one of the most common malignancies in the world and is at the forefront of causes of all cancer deaths. Identification of new prognostic predictors or therapeutic targets might improve a patient's survival rate. Purpose:The Homeodomain interacting protein kinases (HIPKs) function as modulato...

journal_title：OncoTargets and therapy

authors： Liu Y,Qian L,Yang J,Huang H,Feng J,Li X,Bian T,Ke H,Liu J,Zhang J

更新日期：2018-10-25 00:00:00

abstract：:Lung cancer has the highest morbidity and mortality in the world, and non-small cell lung carcinomas (NSCLC) account for 80% of cases of lung cancer. The mechanism of NSCLC is still largely unknown, and finding novel targets is of great importance for the treatment of NSCLC. The current study was designed to evaluate ...

journal_title：OncoTargets and therapy

authors： He M,Xue Y

更新日期：2017-03-02 00:00:00

abstract：:The development of deep-sequencing methods is now unveiling a new landscape of previously undetected gene fusion across different tumor types. Chromosomal translocation involving the NTRK gene family occur across a wide range of cancers in both children and adults. Preclinical studies have demonstrated that chimeric p...

journal_title：OncoTargets and therapy

authors： Ricciuti B,Genova C,Crinò L,Libra M,Leonardi GC

更新日期：2019-04-30 00:00:00

abstract：:Lung cancer is the leading cause of cancer-related mortality in both sexes, accounting for over one quarter of cancer deaths. Non-small-cell lung cancer (NSCLC) comprises 85%-90% of lung cancer diagnoses and despite advances in multimodality therapies, 5-year survival rates remain dismal with a median survival for pat...

journal_title：OncoTargets and therapy

authors： Kanaan Z,Kloecker GH,Paintal A,Perez CA

更新日期：2015-04-20 00:00:00

abstract：:Advances in therapies have led to the approval of six therapeutic agents since 2004, each demonstrating overall survival benefit in randomized studies, and these have significantly improved the outlook for men facing metastatic castration-resistant prostate cancer (CRPC). More recently, efforts have been directed at t...

journal_title：OncoTargets and therapy

authors： Chong JT,Oh WK,Liaw BC

更新日期：2018-04-12 00:00:00

abstract：:Intracranial myeloid sarcoma is a very rare disease with poor prognosis. We report a case of a 28-year-old male patient who was admitted with intense headache, vision disturbance and severe vomiting in June 2017. He had a history of neurosurgical tumor resection operation in April 2017, and the pathological diagnosis ...

journal_title：OncoTargets and therapy

authors： Zhou L,Zhang X,Feng S,Zhao N,Hu X,Huang L,Zheng C

更新日期：2020-01-09 00:00:00

abstract：:Background: CD19-directed chimeric antigen receptor (CAR) T cells have substantial benefit in the treatment of patients with B-cell malignancies. However, despite encouraging therapeutic efficiency, there is limited overall response rate when anti-CD19 CAR-T cells are used to treat patients with relapsed and refractor...

journal_title：OncoTargets and therapy

authors： Li S,Xue L,Wang M,Qiang P,Xu H,Zhang X,Kang W,You F,Xu H,Wang Y,Liu X,Yang L,Wang X

更新日期：2019-07-12 00:00:00

abstract：:Understanding of molecular mechanisms of tumor growth has an increasing impact on the development of diagnostics and targeted therapy of human neoplasia. In this review, we summarize the current knowledge on molecular mechanisms and their clinical implications in von Hippel-Lindau (VHL) disease. This autosomal dominan...

journal_title：OncoTargets and therapy

authors： Gläsker S,Vergauwen E,Koch CA,Kutikov A,Vortmeyer AO

更新日期：2020-06-16 00:00:00

abstract：PURPOSE:Although numerous studies have demonstrated associations between the preoperative neutrophil-to-lymphocyte ratio (NLR) and long-term outcomes in patients with non-small cell lung cancer (NSCLC), the prognostic significance of postoperative NLR and change in NLR (ΔNLR) is unknown for patients who underwent compl...

journal_title：OncoTargets and therapy

authors： Jin F,Han A,Shi F,Kong L,Yu J

更新日期：2016-10-21 00:00:00

abstract：Aim:This systematic review was designed to evaluate the efficacy of neoadjuvant chemotherapy with radical surgery vs radical surgery alone for cervical cancer. Methods:A computerized search was done for trials from PubMed, EMBASE, CENTRAL, and Cochrane Database of Systematic Reviews. The trials included neoadjuvant ch...

journal_title：OncoTargets and therapy

authors： Zhao H,He Y,Yang SL,Zhao Q,Wu YM

更新日期：2019-03-07 00:00:00

abstract：BACKGROUND:MDS1 and EVI1 complex locus protein EVI1 (MECOM) is an oncogenic transcription factor in several kinds of cancers. However, the clinical significance of MECOM in glioblastoma multiforme (GBM) has not been well elucidated. PATIENTS AND METHODS:Our study enrolled 86 resected samples of GBM in three medical ce...

journal_title：OncoTargets and therapy

authors： Hou A,Zhao L,Zhao F,Wang W,Niu J,Li B,Zhou Z,Zhu D

更新日期：2016-01-13 00:00:00

abstract：Purpose:Several studies have proved that single nucleotide polymorphisms (SNPs) of mismatch repair system genes are closely related to the development of colorectal cancer (CRC) by causing microsatellite instability, while effects of the SNPs of MMR system-related genes on the clinical outcomes of cytotoxic chemotherap...

journal_title：OncoTargets and therapy

authors： Wang D,Zhang X,Zhang Y,Wu Y,Guan X,Zhu W,Wang M,Qi C,Shen B

更新日期：2018-11-13 00:00:00

abstract：Background:Breast cancer (BC) has been the commonest malignant tumor with a low survival rate among woman. Long non-coding RNA hypoxia-inducible factor-1 alpha antisense RNA-2 (HIF1A-AS2) was correlated with various cancers. Purpose:The study aimed to investigate the roles and related underlying molecular mechanisms o...

journal_title：OncoTargets and therapy

authors： Guo X,Lee S,Cao P

更新日期：2019-01-24 00:00:00

abstract：:Purpose: NSD3 (WHSC1L1) is a protein lysine methyltransferase that is recurrently amplified (8p11.23) in several cancer types, and its upregulation is involved in tumor cell proliferation, metastasis, and epithelial-mesenchymal transition (EMT). We aimed to evaluate its potential function as an oncogenic force in colo...

journal_title：OncoTargets and therapy

authors： Yi L,Yi L,Liu Q,Li C

更新日期：2019-05-21 00:00:00

abstract：Background:Malignant glioma is the second leading cause of cancer-related death worldwide, and is known to exhibit a high degree of heterogeneity in its deregulation of different oncogenic pathways. The molecular subclasses of human glioma are not well known. Thus, it is crucial to identify vital oncogenic pathways in ...

journal_title：OncoTargets and therapy

authors： Hu T,Xi J

更新日期：2017-11-15 00:00:00

abstract：Aim:Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer worldwide. Despite the decrease in mortality of CRC patients, further investigation of the molecular pathogenesis of CRC could unveil new therapeutic targets and offer better prognosis predictions, which might direct attention to epigenetic regu...

journal_title：OncoTargets and therapy

authors： Liu X,Hou X,Zhou Y,Li Q,Kong F,Yan S,Lei S,Xiong L,He J

更新日期：2019-11-26 00:00:00

abstract：:The use of additional radiotherapy for resected stage IIIA N2 non-small-cell lung cancer in the setting of standard adjuvant chemotherapy remains controversial. A comprehensive search (last search updated in March 2015) for relevant studies comparing patients with stage IIIA N2 non-small-cell lung cancer undergoing re...

journal_title：OncoTargets and therapy

authors： Lei T,Xu XL,Chen W,Xu YP,Mao WM

更新日期：2016-02-24 00:00:00

abstract：:Historically, patients with locally advanced or metastatic melanoma have an extremely poor prognosis. In recent years, major breakthroughs in cutaneous melanoma treatment have led to remarkable improvements in patient outcomes. However, there are limited published data on the efficacy of these novel therapies in the t...

journal_title：OncoTargets and therapy

authors： Yu Z,Quiroz E,Shen Y,Jaiyesimi IA

更新日期：2018-12-04 00:00:00

abstract：Background:Esophageal cancer (EC) is one of the aggressive gastrointestinal malignancies. It has been reported that microRNAs (miRNAs) play key roles during the tumorigenesis of EC. To identify novel potential targets for EC, differential expressed miRNAs (DEG) between EC and adjacent normal tissues were analyzed with ...

journal_title：OncoTargets and therapy

authors： Shi W,Song J,Gao Z,Liu X,Wang W

更新日期：2020-09-24 00:00:00

abstract：Background:Our previous study demonstrated that Id-1 may promote the tumorigenicity of esophageal squamous cell carcinoma (ESCC). Id-4 is another member of Id family, which is rare to be studied in ESCC. In this study, we investigated the expression of Id-4 in human ESCC specimens and determined whether Id-4 expression...

journal_title：OncoTargets and therapy

authors： Wang X,Lu Q,Fei X,Zhao Y,Shi B,Li C,Chen H

更新日期：2020-02-12 00:00:00

abstract：BACKGROUND:Sunitinib is widely used as first-line treatment for metastatic clear cell renal cancer (MCRC). No reports are known of treatment after sunitinib failure. As irinotecan, cisplatin, and mitomycin-C (IPM) chemotherapy has been reported to influence MCRC after progression on cytokine therapy, we report on the o...

journal_title：OncoTargets and therapy

authors： Powles T,McFaul S,Stebbing J,Wilson P,Oliver T,Tranter N,Shamash J

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) patients with fever as the initial presentation are extremely rare. Our aim was to investigate the clinical characteristics and prognosis of patients with this disease. PATIENTS AND METHODS:The clinical features were analyzed in a retrospective study of 63 HCC patients with fe...

journal_title：OncoTargets and therapy

authors： Gong ZJ,Guo W,Sun YF,Zhang X,Qiu SJ,Zhou J,Fan J,Yang XR

更新日期：2016-10-13 00:00:00

abstract：AIM:The aim of this study was to assess if the expression of Notch 1 receptor is associated with tumor aggressiveness in papillary thyroid carcinomas (PTCs). PATIENTS AND METHODS:By searching the electronic medical record system of Xin Hua Hospital, all cases of PTC patients who underwent thyroidectomy in the hospital...

journal_title：OncoTargets and therapy

authors： Fu H,Ma C,Guan W,Cheng W,Feng F,Wang H

更新日期：2016-03-15 00:00:00