MicroRNA-148a suppresses proliferation and invasion potential of non-small cell lung carcinomas via regulation of STAT3.

abstract：Purpose:X-Ray Repair Cross Complementing 1 (XRCC1) functioning in the base excision repair pathway plays an important role in the repair of DNA single-strand breaks caused by ionizing radiation. The relationship between XRCC1 polymorphisms and the risk of radiation-induced side effects on normal tissues remains controv...

journal_title：OncoTargets and therapy

authors： Zhao J,Zhi Z,Zhang M,Li Q,Li J,Wang X,Ma C

更新日期：2018-07-06 00:00:00

abstract：Objective:To clarify the role and mechanism of GABPB1-AS1 in renal cell carcinoma. Methods:We collected 48 pairs of tumor and adjacent normal tissues from patients with clear cell renal cell carcinoma (ccRCC). Both 786-o and caki-1 ccRCC cell lines were transfected with GA-binding protein transcription factor subunit ...

journal_title：OncoTargets and therapy

authors： Gao S,Zhang F,Sun H,Yang X

更新日期：2020-07-12 00:00:00

abstract：Background:Few data have been published on the clinical and histopathological characteristics of advanced non-small-cell lung cancer (NSCLC) patients with high PD-L1 expression versus intermediate or none and the prognostic value of PD-L1 expression for patients treated with chemotherapy is unknown. This study was unde...

journal_title：OncoTargets and therapy

authors： Auliac JB,Guisier F,Bizieux A,Assouline P,Bernardini M,Lamy R,Justeau G,François G,Damotte D,Chouaïd C

更新日期：2020-12-30 00:00:00

abstract：Background:Nasopharyngeal carcinoma (NPC) is a common malignant cancer that is distributed particularly in Southeastern Asia. Previous studies have manifested that long noncoding RNA urothelial carcinoma associated 1 (UCA1) was involved in NPC tumorigenesis and metastasis. However, the biological mechanism of UCA1 for ...

journal_title：OncoTargets and therapy

authors： Liu C,Zhang H,Liu H

更新日期：2019-10-11 00:00:00

abstract：Background:Although there have been great advances in mechanisms and therapeutic methods of prostate cancer, the mortality rate of prostate cancer remains high. The castration-resistant prostate cancer (CRPC), which develops from hormone-sensitive prostate cancer, foreshadows a more dismal outcome. Concomitant with the...

journal_title：OncoTargets and therapy

authors： Wang K,Ruan H,Xu T,Liu L,Liu D,Yang H,Zhang X,Chen K

更新日期：2018-05-28 00:00:00

abstract：Background:Biologics have gained traction for use in oncology, but have demonstrate clinical variability for efficacy and safety. Therapeutic drug monitoring (TDM) can benefit patients' outcomes from a biologic therapy when the latter has a defined therapeutic window. A clinically relevant therapeutic window may exist ...

journal_title：OncoTargets and therapy

authors： Fleisher B,Ait-Oudhia S

更新日期：2017-12-27 00:00:00

abstract：:Intracranial myeloid sarcoma is a very rare disease with poor prognosis. We report a case of a 28-year-old male patient who was admitted with intense headache, vision disturbance and severe vomiting in June 2017. He had a history of neurosurgical tumor resection operation in April 2017, and the pathological diagnosis ...

journal_title：OncoTargets and therapy

authors： Zhou L,Zhang X,Feng S,Zhao N,Hu X,Huang L,Zheng C

更新日期：2020-01-09 00:00:00

abstract：:Aberrant promoter methylation of RUNX3 has been reported in several tumors including human breast cancer (BC). However, the association between RUNX3 hypermethylation and incidence of BC remains elusive. In this study, a detailed literature search was performed in Medline and Google Scholar for related research public...

journal_title：OncoTargets and therapy

authors： Song XY,Li BY,Zhou EX,Wu FX

更新日期：2016-08-26 00:00:00

abstract：:Patients diagnosed as lung adenocarcinoma with brain metastasis usually result in poor prognosis with limited survival time. Palliative systematic therapy has emerged as the primary choice for non-small cell lung cancer patients with brain metastasis harboring wild-type drive genes. However, the objective response rat...

journal_title：OncoTargets and therapy

authors： Chen J,Wang J,Zheng Q,Weng M,Wu X

更新日期：2019-11-11 00:00:00

abstract：Background:A biosynthetic ginsenoside, 3-O-β-D-glucopyranosyl-12-O-β-D-glucopyranosyl-dammar-24-ene-3β, 12β, 20S-triol (C3C12PPD), showed antitumor activity against many tumor cells in vitro, especially had better anti-lung cancer activity than Rg3 in vitro and in vivo. However, the effects and molecular mechanisms of ...

journal_title：OncoTargets and therapy

authors： Huang LL,Tang M,Du QQ,Liu CX,Yan C,Yang JL,Li Y

更新日期：2019-09-09 00:00:00

abstract：:Quercetin, a flavone, is multifaceted, having anti-oxidative, anti-inflammatory, and anticancer properties. In the present study, we explored the effects of quercetin on the epithelial-mesenchymal transition (EMT) and invasion of pancreatic cancer cells and the underlying mechanisms. We noted that quercetin exerted pr...

journal_title：OncoTargets and therapy

authors： Yu D,Ye T,Xiang Y,Shi Z,Zhang J,Lou B,Zhang F,Chen B,Zhou M

更新日期：2017-09-25 00:00:00

abstract：:Orbital metastasis as the initial presentation of lung adenocarcinoma is very rare, and so the lack of knowledge about this phenomenon can easily result in misdiagnosis, either as a orbital primary tumor or benign lesion. Here, we report a rare case in which the orbital symptom appeared first without any pulmonary man...

journal_title：OncoTargets and therapy

authors： Sun L,Qi Y,Sun X,Yu J,Meng X

更新日期：2016-05-09 00:00:00

abstract：BACKGROUND:Associations between Arg399Gln single-nucleotide polymorphism (SNP) in the XRCC1 gene and leukemia susceptibility have been studied extensively, however, the results are inconsistent. The aim of this study was to determine these associations using meta-analytical methods. METHODS:A meta-analysis was perform...

journal_title：OncoTargets and therapy

authors： Wang F,Zhao Q,He HR,Zhai YJ,Lu J,Hu HB,Zhou JS,Yang YH,Li YJ

更新日期：2015-11-06 00:00:00

abstract：Purpose:Both obesity and gender are important etiological factors in renal cell carcinoma (RCC) development, suggesting a pivotal role of sex hormone signaling pathway and insulin-like growth factor (IGF) family in RCC carcinogenesis. Here, we aimed to investigate the effect of estrogen on RCC growth and the possible i...

journal_title：OncoTargets and therapy

authors： Sun L,Gao Z,Luo L,Tan H,Zhang G

更新日期：2018-09-17 00:00:00

abstract：BACKGROUND:Mast cells (MCs) can stimulate angiogenesis, releasing several proangiogenic cytokines stored in their cytoplasm. In particular MCs can release tryptase, a potent in vivo and in vitro proangiogenic factor via proteinase-activated receptor-2 (PAR-2) activation and mitogen-activated protein kinase phosphorylat...

journal_title：OncoTargets and therapy

authors： Ammendola M,Sacco R,Sammarco G,Piardi T,Zuccalà V,Patruno R,Zullo A,Zizzo N,Nardo B,Marech I,Crovace A,Gadaleta CD,Pessaux P,Ranieri G

更新日期：2016-07-21 00:00:00

abstract：Background:Malignant glioma is the second leading cause of cancer-related death worldwide, and is known to exhibit a high degree of heterogeneity in its deregulation of different oncogenic pathways. The molecular subclasses of human glioma are not well known. Thus, it is crucial to identify vital oncogenic pathways in ...

journal_title：OncoTargets and therapy

authors： Hu T,Xi J

更新日期：2017-11-15 00:00:00

abstract：Background:Deleted in breast cancer 1 (DBC1) is believed to be involved in human cancers. However, it is still uncertain whether DBC1 expression can be regarded as a prognostic factor in patients with various cancers. This meta-analysis aimed to evaluate the relationship between high levels of DBC1 and prognosis in tum...

journal_title：OncoTargets and therapy

authors： Liu G,Wu Q,Wang Y,Xiong Q,Fu F

更新日期：2019-02-22 00:00:00

abstract：BACKGROUND:"Gefitinib" is a first-generation epidermal growth factor receptor tyrosine-kinase inhibitor. More than half of patients receiving gefitinib develop acne-like eruption. Evozac(®) Calming Skin Spray (Evaux Laboratoires, Évaux-les-Bains, France) is made of Évaux thermal spring water and commonly used for the t...

journal_title：OncoTargets and therapy

authors： Wang Y,Yang Y,Xu J,Yu J,Liu X,Gao R,Zhang L

更新日期：2014-07-10 00:00:00

abstract：BACKGROUND:The purpose of this research was to investigate the relationship between epidermal growth factor receptor (EGFR) mutations and the response to first-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). METHODS:A total of 266 patients with stage IIIB or IV NSCLC who received platin...

journal_title：OncoTargets and therapy

authors： Fang S,Wang Z,Guo J,Liu J,Li C,Liu L,Shi H,Liu L,Li H,Xie C,Zhang X,Sun W,Li M

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:SASH1 is a member of the SH3/SAM adapter molecules family and has been identified as a new tumor suppressor and critical protein in signal transduction. An ectopic expression of SASH1 is associated with decreased cell viability of breast cancer. The aim of this study was to explore the association between SAS...

journal_title：OncoTargets and therapy

authors： Gong X,Wu J,Wu J,Liu J,Gu H,Shen H

更新日期：2017-01-10 00:00:00

abstract：Objective:Long non-coding RNAs (lncRNAs) have been identified as important players in tumorigenesis. LncRNA highly upregulated in liver cancer (HULC) has been identified as a key regulator in the progression of various cancers. However, the functional role and the mechanisms of HULC in regulating cervical cancer cell b...

journal_title：OncoTargets and therapy

authors： Lu W,Wan X,Tao L,Wan J

更新日期：2020-02-05 00:00:00

abstract：Purpose:The clinical studies carried out in the last few decades unequivocally introduced activated androgen receptor (AR) as a pathogenic feature of human malignancies which not only endows cancer cells with survival advantage, but also may be exploited for anticancer interventions. Patients and Methods:In this study...

journal_title：OncoTargets and therapy

authors： Soleymani Fard S,Yazdanbod M,Sotoudeh M,Bashash D,Mahmoodzadeh H,Saliminejad K,Mousavi SA,Ghaffari SH,Alimoghaddam K

更新日期：2020-10-02 00:00:00

abstract：Background and objective:HSF1 is reported to be overexpressed in various solid tumors and play a pivotal role in cancer progression. A meta-analysis was conducted to assess the potential prognostic role of HSF1 in patients with solid tumors. Methods:An extensive electronic search of three databases was performed for r...

journal_title：OncoTargets and therapy

authors： Wan T,Shao J,Hu B,Liu G,Luo P,Zhou Y

更新日期：2018-01-17 00:00:00

abstract：Background:Abnormal miR-27a-3p expression has been frequently reported in several types of human cancer and contributes to tumor progression. However, the role and potential molecular mechanism of miR-27a-3p in the progression of pancreatic carcinoma have not been clarified. Materials and methods:The expression of miR...

journal_title：OncoTargets and therapy

authors： Rao X,Wan L,Jie Z,Zhu X,Yin J,Cao H

更新日期：2019-12-19 00:00:00

abstract：:Despite multimodal therapeutic treatments of osteosarcoma (OS), some patients develop resistance to currently available regimens and eventually end up with recurrent or metastatic outcomes. Many attempts have been made to discover effective drugs for improving outcome; however, due to the heterogeneity of the disease,...

journal_title：OncoTargets and therapy

authors： Chaiyawat P,Settakorn J,Sangsin A,Teeyakasem P,Klangjorhor J,Soongkhaw A,Pruksakorn D

更新日期：2017-02-01 00:00:00

abstract：:This retrospective study was conducted to evaluate the prognostic significance of the preoperative plasma D-dimer levels and platelet counts in patients with pancreatic adenocarcinoma. A total of 168 consecutive locally advanced pancreatic adenocarcinoma patients who underwent intensity modulated radiation therapy wit...

journal_title：OncoTargets and therapy

authors： Liu P,Zhu Y,Liu L

更新日期：2015-06-04 00:00:00

abstract：:Background: Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer morbidity and mortality worldwide. In the present study, we identified novel biomarkers associated with the pathogenesis of NSCLC aiming to provide new diagnostic and therapeutic approaches for NSCLC. Methods: The microarray datasets of...

journal_title：OncoTargets and therapy

authors： Wu Q,Zhang B,Sun Y,Xu R,Hu X,Ren S,Ma Q,Chen C,Shu J,Qi F,He T,Wang W,Wang Z

更新日期：2019-05-13 00:00:00

abstract：BACKGROUND:The prognostic value of inflammatory index in esophageal cancer (EC) has not been established. In the present study, therefore, we initially evaluated a novel prognostic system, named the COCC (COmbination of C-reactive protein [CRP] and carcinoembryonic antigen [CEA]), for making a prognosis in patients wit...

journal_title：OncoTargets and therapy

authors： Huang Y,Liu JS,Feng JF

更新日期：2015-04-10 00:00:00

abstract：Background:The aberrant expression of microRNA-139-3p (miR-139-3p) has been recently involved in the development of multiple tumor types, but its function in ovarian cancer remains not well investigated. In this study, we mainly investigated the function of miR-139-3p in the progression of ovarian cancer. Methods:The ...

journal_title：OncoTargets and therapy

authors： Xue F,Li QR,Xu YH,Zhou HB

更新日期：2019-11-05 00:00:00

abstract：Purpose:The proportion of central pulmonary adenocarcinoma (ADC) in central-type lung cancer has been gradually increasing due to the overall increasing incidence of pulmonary ADC. But the clinical and radiological characteristics of central ADCs remain unclear. In this study, we compared the clinical and radiological ...

journal_title：OncoTargets and therapy

authors： Wang Z,Li M,Huang Y,Ma L,Zhu H,Kong L,Yu J

更新日期：2018-05-04 00:00:00