Abstract:
Purpose:X-Ray Repair Cross Complementing 1 (XRCC1) functioning in the base excision repair pathway plays an important role in the repair of DNA single-strand breaks caused by ionizing radiation. The relationship between XRCC1 polymorphisms and the risk of radiation-induced side effects on normal tissues remains controversial. Therefore, we performed a comprehensive meta-analysis to elucidate these associations. Materials and methods:A systematic literature search was carried out in PubMed, Medline (Ovid), Embase, Web of Science, Cochrane database, and the references of relevant studies. The pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were calculated to evaluate the strength of the association. Results:A total of 40 studies including 6,682 patients were eventually identified in this meta-analysis. Pooled results suggested that rs25487 Arg399Gln polymorphism significantly increased the risk of acute radiation-induced side effects (OR=1.29, 95% CI: 1.10-1.52, P=0.002), especially acute mucositis (OR=1.91, 95% CI: 1.17-3.11, P=0.01) and acute gastrointestinal and genitourinary toxicity (OR=1.49, 95% CI: 1.04-2.11, P=0.03). Furthermore, patients who received head and neck irradiation with rs25487 Arg399Gln polymorphism were more likely to experience radiotherapy (RT)-induced side effects (OR=1.46, 95% CI: 1.12-1.90, P=0.005). However, no statistically significant correlations were identified between rs25487 polymorphism and any late side effects and other irradiation areas. Likewise, no significant associations were detected between rs25489, rs1799782, or rs3213245 polymorphism and RT-induced toxicity. Conclusion:Our meta-analysis demonstrated that XRCC1 rs25487 Arg399Gln polymorphism had a significant predictive value and might predict a risk of severely acute RT-induced adverse effects, especially in acute mucositis and acute gastrointestinal and genitourinary toxicity, or in patients with head and neck irradiation. However, large-scale and well-designed studies are required to further evaluate the predictive value of XRCC1 variations on radiation-induced side effects in order to identify radiosensitive patients and predict radiotoxicity.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Zhao J,Zhi Z,Zhang M,Li Q,Li J,Wang X,Ma Cdoi
10.2147/OTT.S156175subject
Has Abstractpub_date
2018-07-06 00:00:00pages
3901-3918issn
1178-6930pii
ott-11-3901journal_volume
11pub_type
杂志文章abstract:BACKGROUND:Breast cancer is one of the most frequently occurring cancers in women. In recent years, Dendrobium candidum has played a part in antihyperthyroidism and anticancer drugs. This study aims to examine the antitumor effect of D. candidum on breast cancer. METHODS:Human breast cancer cell line MCF-7 and normal ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S93305
更新日期:2015-12-21 00:00:00
abstract:Background and aims:Studies show that the long non-coding RNA, SBF2-AS1, plays a critical role in cancer progression, but the role of SBF2-AS1 in gastric cancer has not been reported. Therefore, this study aimed to elucidate the mechanism of SBF2-AS1 in gastric cancer (GC). Methods:A meta-analysis, based on the gene e...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,收录出版
doi:10.2147/OTT.S210697
更新日期:2019-10-30 00:00:00
abstract::Introduction: In recent years, an increasing amount of literature has demonstrated the functional role of long non-coding RNA (lncRNA) in human diseases. LINC00515 is a newly defined lncRNA and is reported to act as an oncogene in multiple myeloma. However, the function of LINC00515 in glioma is still uncertain. Mater...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S198087
更新日期:2019-04-08 00:00:00
abstract:AIMS:Metastasis-associated gene 2 (MTA2) is reported to play an important role in tumor progression, but little is known about the role of MTA2 in nasopharyngeal carcinoma (NPC). The aim of the study was to explore the expression and function of MTA2 in NPC. METHODS:Expression of MTA2 in NPC tissues and cell lines was...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S96518
更新日期:2016-03-18 00:00:00
abstract::Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. Since the discovery that the KIT and PDGFRA receptor tyrosine kinases are the primary oncogenic drivers in the vast majority of GISTs, targeted therapy with tyrosine kinase inhibitors has been the mainstay ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S180763
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:Bevacizumab plus taxane chemotherapy improves progression-free survival (PFS) versus taxane monotherapy in the first-line treatment of HER2-negative metastatic breast cancer (MBC) and appears promising in the second-line setting. This retrospective analysis evaluated the efficacy and safety of this combinati...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S70654
更新日期:2014-11-27 00:00:00
abstract:Purpose:The clinical studies carried out in the last few decades unequivocally introduced activated androgen receptor (AR) as a pathogenic feature of human malignancies which not only endows cancer cells with survival advantage, but also may be exploited for anticancer interventions. Patients and Methods:In this study...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S265364
更新日期:2020-10-02 00:00:00
abstract:Purpose:As a novel type of non-coding RNAs, circRNAs were found to play important roles in cancer progression. In this study, we aim to investigate genome-wide circRNAs expression and potential functions in glioma to find new therapeutic targets for glioma treatment. Patients and Methods:A total of 92 pairs of glioma ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S241347
更新日期:2020-04-01 00:00:00
abstract:Introduction:Because only a small portion of NSCLC (non-small-cell lung cancer) patients benefit from molecular targeted therapy or immunotherapy and do not develop therapeutic resistance, continued research on new targets is warranted. Serotonin has recently emerged as a growth factor for tumor cells, and its receptor...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S244339
更新日期:2020-03-09 00:00:00
abstract:BACKGROUND:The purpose of this study was to investigate the prognosis of ipsilateral supraclavicular lymph node metastasis (ISLM) without evidence of distant metastases at diagnosis in Chinese women with breast cancer and to elucidate the clinical value of adjuvant radiotherapy. METHODS:We performed a retrospective an...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S56596
更新日期:2014-02-15 00:00:00
abstract::High-mobility group AT-hook 2 (HMGA2) is involved in a wide spectrum of biological processes and is upregulated in several tumors, but its role in renal carcinoma remains unclear. The aim of this study was to examine the expression of HMGA2 and its relationship to the overall survival (OS) of patients with non-metasta...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S116953
更新日期:2016-11-22 00:00:00
abstract:Purpose:Strategies to increase radiosensitivity are urgently needed. Combining radiosensitizing reagents with radiotherapy could improve the outcome of cancer treatment. Some preclinical studies showed that sepantronium bromide (YM155) could sensitize cancer cells to radiation by inhibiting the survivin protein. In thi...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S166798
更新日期:2018-05-24 00:00:00
abstract:Objectives:We aimed to demonstrate the clinical characteristics and risk factors associated with recurrence of adult granulosa cell tumor (AGCT), as well as the pregnancy and long-term outcomes among patients in a single institution in China. Patients and methods:We reviewed 141 patients with AGCT in Peking Union Medi...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S155473
更新日期:2018-03-07 00:00:00
abstract:Background:Patients with BRAF (v-Raf murine sarcoma viral oncogene homolog B) V600E-mutated metastatic colorectal cancer (mCRC) have a poor prognosis. The Southwest Oncology Group (SWOG) 1406 study evaluated the efficacy of vemurafenib in combination with irinotecan and cetuximab for simultaneous inhibition of epiderma...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S180845
更新日期:2019-01-08 00:00:00
abstract::Giant-cell carcinoma of the lung (GCCL) is a rare histological form of poorly differentiated non-small-cell lung cancer, which is classified as a subtype of pulmonary sarcomatoid carcinomas. In this case report, we describe the case of a 50-year-old Chinese male who presented with a pulmonary nodule in the right upper...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S150124
更新日期:2018-02-09 00:00:00
abstract:Background and objective:Transcriptional coactivator with PDZ-binding motif (TAZ) has been found to be associated with tumor progression. Mitochondrial homeostasis regulates cancer cell viability and metastasis. However, the roles of TAZ and mitochondrial homeostasis in liver cancer viability have not been explored. Th...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S196142
更新日期:2019-03-01 00:00:00
abstract:Purpose:Traditional Chinese medicine (TCM) has gained increasing attention for the treatment of multiple chronic diseases, such as cancer. Here we aim to identify the antitumor activity of Sichong formula, a novel TCM, in human gastric cancer cells and investigate the underlying mechanisms. Methods:The AGS and MKN45 g...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S199605
更新日期:2019-07-16 00:00:00
abstract:OBJECTIVES:MicroRNA (miRNA)-related single-nucleotide polymorphisms (SNPs) in miRNA processing machinery genes can affect cancer risk, treatment efficacy, and patient prognosis. A miR-SNP of rs11077 located in the 3' untranslated region (3' UTR) of the miRNA processing machinery gene XPO5 was examined in 112 advanced n...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S48284
更新日期:2013-07-11 00:00:00
abstract::HES1 is the target of Notch signaling which is reported to affect cell differentiation and maintain the cells in G0 phase in various tissues including the hematopoietic tissue. HES1 expression appears to be an independent prognostic factor for survival in a heterogeneous group of acute myeloid leukemia (AML) patients....
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S83511
更新日期:2015-04-22 00:00:00
abstract:Background:Osteosarcoma (OSA), the most common primary bone malignancy, is characterized by a wide spectrum of complicated pathologies and frequent distal metastasis and causes death in adolescents and young adults worldwide. Antitumor drug treatment strategies include various cytotoxic chemotherapy drugs, while molecu...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S215145
更新日期:2019-08-21 00:00:00
abstract:Purpose:Although cisplatin-based adjuvant chemotherapy improves the survival of patients with resected non-small-cell lung cancer, not all patients show a survival benefit, and some patients experience severe toxicity. Therefore, identifying biomarkers is important for selecting subgroups of patients who may show impro...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S145072
更新日期:2017-11-02 00:00:00
abstract::Tbx2 is a cancer-related protein that was found to be overexpressed in several human malignancies. The present study aims to investigate the clinical significance and biological role of Tbx2 in human astrocytoma. We examined its protein expression in 102 cases of astrocytoma tissues using immunohistochemical staining....
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S124012
更新日期:2017-02-20 00:00:00
abstract:BACKGROUND:Activating transcription factor 5 (ATF5) is a member of the activating transcription/cAMP response element-binding protein family of basic leucine zipper proteins that plays an important role in cell survival, differentiation, proliferation, and apoptosis. The ATF5 gene generates two transcripts: ATF5 isofor...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S113194
更新日期:2016-10-11 00:00:00
abstract::Basal cell carcinoma (BCC) is a common malignant tumor throughout the world. One of the known risk factors of BCC is intense exposure to ultraviolet radiation. More than 50% of BCCs of the eyelid initially occur on the lower lid. The gold standard of diagnosis of BCC is histopathology. Treatment options for BCC consis...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S130371
更新日期:2017-05-08 00:00:00
abstract::[This retracts the article DOI: 10.2147/OTT.S215674.]. ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,撤回出版物
doi:10.2147/OTT.S273162
更新日期:2020-07-28 00:00:00
abstract:Background:Lupeol, a triterpene isolated from various herbal plants, possesses an anti-inflammatory function and has been proposed as a candidate for anticancer agents. The purpose of this research was to investigate the effect of lupeol on the viability, apoptosis, cell-cycle distribution, and migration of colorectal ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,收录出版
doi:10.2147/OTT.S183925
更新日期:2018-11-09 00:00:00
abstract:Background:The aberrant expression of circular RNAs (circRNAs) has been identified as a novel trait of cancers. However, the role of circRNAs in colorectal cancer (CRC) remains to be elucidated. Methods:Informatic analysis was performed to identify circRNAs in CRC tissues and adjacent tissues. Gain- and loss-of-functi...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S255485
更新日期:2020-06-30 00:00:00
abstract:OBJECTIVE:SASH1 is a member of the SH3/SAM adapter molecules family and has been identified as a new tumor suppressor and critical protein in signal transduction. An ectopic expression of SASH1 is associated with decreased cell viability of breast cancer. The aim of this study was to explore the association between SAS...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S119244
更新日期:2017-01-10 00:00:00
abstract:Purpose:Numerous metabolomics studies have been conducted to detect the metabolic mechanisms and biomarkers related to gastric cancer and colorectal cancer. Because of the common metabolic features between gastric cancer and colorectal cancer, a differential diagnosis is difficult. Here, we performed a systematic revie...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S247393
更新日期:2020-06-25 00:00:00
abstract:BACKGROUND:Stereotactic body radiotherapy (SBRT) or stereotactic ablative radiotherapy (SABR) has been reported to be a comparable alternative therapy to surgery for patients with T1-3N0M0 non-small cell lung cancer (NSCLC). However, it has not been clarified whether SBRT/SABR is as effective as surgery. We conducted t...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S138701
更新日期:2017-06-07 00:00:00