Abstract:
Background:The aberrant expression of circular RNAs (circRNAs) has been identified as a novel trait of cancers. However, the role of circRNAs in colorectal cancer (CRC) remains to be elucidated. Methods:Informatic analysis was performed to identify circRNAs in CRC tissues and adjacent tissues. Gain- and loss-of-function experiments were constructed to analyze hsa_circ_001806 roles in CRC cell stemness by sphere-formation, ALDH activity, stemness marker expression and tumor-initiating ability assays. CCK8 cell viability was carried out to evaluate hsa_circ_0001806 roles in CRC cell viability. Luciferase reporter and pull-down assays were used to reveal the underlying mechanisms. Results:Hsa_circ_0001806 was significantly upregulated in CRC tissues and correlated with TNM stage, depth of invasion, lymphatic metastasis and distant metastasis. Hsa_circ_0001806 promoted the stemness of CRC cells, as evident by increasing sphere-formation ability, ALDH1 activity and stemness marker expression while had no effect on cell viability. Mechanistically, the same miR-193-5p-binding sites are shared between hsa_circ_0001806 and COL1A1. Hsa_circ_0001806 upregulates COL1A1 expression in a miR-193-5p-dependent manner, which is essential for hsa_circ_0001806-mediated regulation on CRC cell stemness. Conclusion:CircRNA hsa_circ_0001806 may act as a promising therapeutic target by facilitating the stemness of CRC cells via activating the hsa_circ_0001806/miR-193a-5p/COL1A1 axis.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Sun J,Liu J,Zhu Q,Xu F,Kang L,Shi Xdoi
10.2147/OTT.S255485subject
Has Abstractpub_date
2020-06-30 00:00:00pages
6315-6327issn
1178-6930pii
255485journal_volume
13pub_type
杂志文章abstract:Background:Esophageal cancer (EC) is one of the aggressive gastrointestinal malignancies. It has been reported that microRNAs (miRNAs) play key roles during the tumorigenesis of EC. To identify novel potential targets for EC, differential expressed miRNAs (DEG) between EC and adjacent normal tissues were analyzed with ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S251508
更新日期:2020-09-24 00:00:00
abstract:Introduction:The purpose of present study was to investigate the effect of limonin on tumor glycolysis and the underlying mechanisms in hepatocellular carcinoma (HCC). Methods:Cell proliferation and colony formation assays were performed to evaluate the potency of limonin against HCC cells in vitro. The glucose consum...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S165220
更新日期:2018-07-03 00:00:00
abstract::Medullary thyroid carcinoma (MTC) is a rare malignancy originating from calcitonin-producing parafollicular C cells of the thyroid. Neither radiotherapy nor chemotherapy has demonstrated durable objective responses in patients with advanced MTC. Vandetanib and cabozantinib are the 2 tyrosine kinase inhibitors recently...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S142598
更新日期:2018-01-19 00:00:00
abstract:BACKGROUND:Breast cancer is one of the most frequently occurring cancers in women. In recent years, Dendrobium candidum has played a part in antihyperthyroidism and anticancer drugs. This study aims to examine the antitumor effect of D. candidum on breast cancer. METHODS:Human breast cancer cell line MCF-7 and normal ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S93305
更新日期:2015-12-21 00:00:00
abstract:Background:Renal cell cancer (RCC) is one of the most lethal malignancies of the kidney in adults. mTOR (mammalian target of rapamycin) signaling pathway plays a pivotal role in RCC tumorigenesis and progression and inhibitors targeting the mTOR pathway have been widely used in advanced RCC treatment. Therefore, it is ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S266095
更新日期:2020-10-15 00:00:00
abstract:BACKGROUND:Due to the hypervascular nature of glioblastoma (GBM), antiangiogenic treatments, such as vatalanib, have been added as an adjuvant to control angiogenesis and tumor growth. However, evidence of progressive tumor growth and resistance to antiangiogenic treatment has been observed. To counter the unwanted eff...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S93790
更新日期:2016-03-09 00:00:00
abstract::Purpose: Lung adenocarcinoma (LUAD) is a main subtype of lung cancer, which is the leading cause of cancer-related deaths. The five-year survival rates of lung cancer patients are still comparatively low. Therefore, potential therapeutic targets are urgently needed to improve the survival of lung cancer patients. In t...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S190934
更新日期:2019-04-17 00:00:00
abstract:Purpose:Tumor drug resistance limits the response to chemotherapy. Interestingly, sequential combination therapy enhances the anticancer efficacy of drugs like cisplatin (CDDP) via synergistic effects. We assayed the synergistic effects of combined photodynamic therapy programmed death receptor-ligand 1 (PDT) and chemo...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S198422
更新日期:2019-07-10 00:00:00
abstract:Background:Many studies have explored the prognostic value of T-cell lymphoma invasion and metastasis inducing factor 1 (Tiam1) and its association with lymphatic metastasis in malignant solid tumors, but the conclusions remain controversial. Therefore, we performed a meta-analysis to systematically assess the prognost...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S191571
更新日期:2019-07-25 00:00:00
abstract:Background:Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide. LINC00460, a novel long non-coding RNA (lncRNA), was recently confirmed as an oncogene in various cancers. However, the biological function and underlying mechanism of LINC00460 in HCC is largely obscure. Methods:Fifty pa...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S239258
更新日期:2020-03-06 00:00:00
abstract::Major advances in the understanding of the pathophysiology of melanoma have led to a new era of melanoma treatment with targeted therapy and immunotherapies. Since 2011, four new classes of medications with unique mechanisms of action have been approved, which allow melanoma to be treated at many different stages in i...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S171693
更新日期:2018-12-14 00:00:00
abstract::Cancers of the stomach and gastro-esophageal junction represent a significant challenge in oncology. Despite some recent advances in genetic categorization and the development of novel agents, outcomes remain poor. The vascular endothelial growth factor receptor 2 monoclonal antibody ramucirumab is the first targeted ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S84153
更新日期:2016-07-25 00:00:00
abstract:Background:Lung cancer is one of the most common malignancies in the world and is at the forefront of causes of all cancer deaths. Identification of new prognostic predictors or therapeutic targets might improve a patient's survival rate. Purpose:The Homeodomain interacting protein kinases (HIPKs) function as modulato...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S166878
更新日期:2018-10-25 00:00:00
abstract:Background:Abnormal miR-27a-3p expression has been frequently reported in several types of human cancer and contributes to tumor progression. However, the role and potential molecular mechanism of miR-27a-3p in the progression of pancreatic carcinoma have not been clarified. Materials and methods:The expression of miR...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S220621
更新日期:2019-12-19 00:00:00
abstract:Purpose:Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer and its incidence continues to rise yearly. Photodynamic therapy (PDT) is a non-invasive form of cancer therapy, which utilizes the combined action of a photosensitizer, light, and oxygen molecules to selectively cause cellul...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S228792
更新日期:2019-12-31 00:00:00
abstract::Malignant pericardial effusion (MPCE) is a common complication of advanced malignant tumors, and interferes severely with patient prognosis and quality of life. The standard treatment for this complication is intracavitary perfusion of chemotherapeutic drugs, which is limited by unsatisfactory therapeutic effects and ...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S90145
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Activating transcription factor 5 (ATF5) is a member of the activating transcription/cAMP response element-binding protein family of basic leucine zipper proteins that plays an important role in cell survival, differentiation, proliferation, and apoptosis. The ATF5 gene generates two transcripts: ATF5 isofor...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S113194
更新日期:2016-10-11 00:00:00
abstract::The antidiabetic drug metformin has been shown to possess antitumor functions in many types of cancers. Although studies have revealed its beneficial effects on the prognosis of hepatocellular carcinoma (HCC), the detailed molecular mechanism underlying this event remains largely unknown. In this work, we showed that ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S99770
更新日期:2016-05-12 00:00:00
abstract:BACKGROUND:We aimed to investigate the patterns of failure (locoregional and distant metastasis), associated factors, and treatment outcomes in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy (IMRT) combined with chemotherapy. PATIENTS AND METHODS:From April 2006 to December 2011, ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S95457
更新日期:2016-10-25 00:00:00
abstract::Armillaria mellea is a honey mushroom often used in the traditional Chinese medicine "Tianma". Currently, this medicinal mushroom is also used as a dietary supplement in numerous Western and Eastern countries. Armillarikin was isolated from A. mellea, and we previously discovered that it induced cytotoxicity in human ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S103940
更新日期:2016-08-01 00:00:00
abstract::Bladder cancer (BC) is a common urinary system tumor with high aggressiveness, and it results in relatively high mortality due to a lack of precise and suitable biomarkers. In this study, we applied the weighted gene coexpression network analysis method to miRNA expression data from BC patients, and screened for netwo...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S146479
更新日期:2017-11-22 00:00:00
abstract:Background:Sesquiterpene lactones are plant-derived, natural, bioactive molecules often used against inflammatory diseases in traditional Chinese medicines. Recently, sesquiterpene lactones have been reported to exhibit potent anticancer activity. In the present study, we have investigated the anticancer activity of Br...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S179730
更新日期:2018-10-16 00:00:00
abstract::Patients diagnosed as lung adenocarcinoma with brain metastasis usually result in poor prognosis with limited survival time. Palliative systematic therapy has emerged as the primary choice for non-small cell lung cancer patients with brain metastasis harboring wild-type drive genes. However, the objective response rat...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S226735
更新日期:2019-11-11 00:00:00
abstract:BACKGROUND:The authors conducted this prospective study to analyze the amount of interfractional prostate bed motion (PBM) and quantify its components with the use of an endorectal balloon (ERB). METHODS:A total of 1,348 cone beam computed tomography images from 46 patients who underwent postprostatectomy radiotherapy...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S98112
更新日期:2016-05-24 00:00:00
abstract:PURPOSE:To investigate the biological effect of gyromagnetic fields (GMFs) on cell proliferation and apoptosis of human prostatic adenocarcinoma cells and explore the underlying mechanisms. METHODS:PC-3 cells were grouped into normal control (NC) and GMF treatment groups. Cell proliferation was analyzed with kit-8 and...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S95306
更新日期:2015-11-24 00:00:00
abstract::Hormone-receptor-positive breast cancer is the most common subtype of breast cancer among patients with both early-stage and metastatic disease. Recent advances in the understanding of its pathophysiology have led to the discovery and utilization of targeted inhibitors to cyclin-dependent kinases 4 and 6 (CDK4/6). The...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S149245
更新日期:2018-08-29 00:00:00
abstract:BACKGROUND:Breast cancer stem cells with a CD44(+)CD24(-) phenotype are the origin of breast tumors. Strong CD44 expression in this population indicates its important role in maintaining the stem cell phenotype. Previous studies show that CD44 down-regulation causes CD44(+)CD24(-) breast cancer stem cells to differenti...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S30609
更新日期:2012-01-01 00:00:00
abstract:Introduction:Multiple myeloma (MM) remains an incurable disease, and patient survival requires a better understanding of this malignancy's molecular aspects. Heparanase (HPSE) is highly expressed in aggressive MM cells and related to tumor growth, metastasis, and bortezomib (BTZ) resistance. Thus, targeting HPSE seems ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S286751
更新日期:2021-01-15 00:00:00
abstract::Despite remarkable progress in cancer-drug discovery, the delivery of novel, safe, and sustainably effective products to the clinic has stalled. Using Src as a model, we examine key steps in drug development. The preclinical evidence on the relationship between Src and solid cancer is in sharp contrast with the modest...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S45177
更新日期:2013-06-26 00:00:00
abstract:Purpose:It is widely known that some specific microRNAs can regulate the expressions of genes in gastric cancer cells at the post-transcriptional level. Previous studies have identified that miRNA-4766-5p was involved in tumor cell proliferation and can be an independent prognostic indicator for malignant pleural mesot...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S220234
更新日期:2019-10-16 00:00:00