Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells.

abstract：Objective:The objective of this study was to investigate the safety of robotic stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC) patients and its related factors. Methods:A total of 74 HCC patients with Child-Turcotte-Pugh (CTP) Class A were included in a multi-institutional, single-arm Pha...

journal_title：OncoTargets and therapy

authors： Liu X,Song Y,Liang P,Su T,Zhang H,Zhao X,Yuan Z,Wang P

更新日期：2017-11-06 00:00:00

abstract：:Pancreatic cancer is a formidable malignancy with poor outcomes. The majority of patients are unable to undergo resection, which remains the only potentially curative treatment option. The management of locally advanced (unresectable) pancreatic cancer is controversial; however, treatment with either chemotherapy or c...

journal_title：OncoTargets and therapy

authors： Hong JC,Czito BG,Willett CG,Palta M

更新日期：2016-10-31 00:00:00

abstract：Introduction:Dynamin 3 (DNM3) is a large GTPase that possesses mechanochemical properties and has been shown to be involved in malignancies. However, most studies about DNM3 are observational, and knowledge of the precise molecular mechanism of DNM3 remains limited. Materials and methods:We constructed a PCDH-CMV-MCS-...

journal_title：OncoTargets and therapy

authors： Jiang L,Liang QL,Liang WM,Zhang HJ,Huang J,Yuan GL,Peng XX,Cheng SA,Huang ZG,Zhang XN

更新日期：2018-10-09 00:00:00

abstract：Background:Abnormal miR-27a-3p expression has been frequently reported in several types of human cancer and contributes to tumor progression. However, the role and potential molecular mechanism of miR-27a-3p in the progression of pancreatic carcinoma have not been clarified. Materials and methods:The expression of miR...

journal_title：OncoTargets and therapy

authors： Rao X,Wan L,Jie Z,Zhu X,Yin J,Cao H

更新日期：2019-12-19 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) have transformed the therapeutic strategy and prognosis of advanced non-small cell lung cancer (NSCLC) patients. Nowadays, ICIs as monotherapy or in combination with chemotherapy are the standard of care treatment in advanced NSCLC, and in stage III, durvalumab (a programmed death l...

journal_title：OncoTargets and therapy

authors： Gullapalli S,Remon J,Hendriks LEL,Lopes G

更新日期：2020-07-14 00:00:00

abstract：:Purpose: Several microRNAs (miRNAs) that are aberrantly expressed in glioblastoma multiforme (GBM) play a significant role in GBM formation and progression. The expression profile and functions of miR-559 in GBM remain unclear. Here, we quantified the expression and investigated the involvement of miR-559 in the oncog...

journal_title：OncoTargets and therapy

authors： Yang F,Zhang C,Xu C,Fu F,Han D,Li H

更新日期：2019-06-05 00:00:00

abstract：Purpose:Primary squamous cell carcinoma is a rare malignancy in the thyroid gland (SCCTh). The overall prognosis of this carcinoma is poor. This study aimed to explore the application of Raman spectroscopy in investigating the expression of CK5/6 and P63 in SCCTh. Patients and Methods:Tissues of the SCCTh and adjacent...

journal_title：OncoTargets and therapy

authors： Wang SS,Ye DX,Wang B,Xie C

更新日期：2020-01-20 00:00:00

abstract：Objective:Cumulative data from clinical trials suggest that Lin28 may contribute to poor survival in breast cancer patients. The purpose of this study was to investigate the relationship between Lin28 expression and breast cancer patients' clinicopathological parameters. Methods:Data from a total of 291 breast cancer ...

journal_title：OncoTargets and therapy

authors： Xu C,Jin S,Huang L

更新日期：2019-02-08 00:00:00

abstract：BACKGROUND/AIM:To elucidate the mechanism responsible for developing acute kidney injury in patients with diabetes mellitus, we also evaluated the issue of whether advanced glycation endproducts (AGEs) influence the expressions of multi antimicrobial extrusion protein (MATE1/SLC47A1) in tubular cells. MATERIALS AND ME...

journal_title：OncoTargets and therapy

authors： Mizuno T,Sato W,Ishikawa K,Terao Y,Takahashi K,Noda Y,Yuzawa Y,Nagamatsu T

更新日期：2015-07-10 00:00:00

abstract：:Background/Aims: MiR-145 and Smad2 have been widely reported in the development and progression of human malignancies. In the present study, we investigated the correlation between miR-145 and Smad2 in human glioblastoma multiforme (GBM). Methods: The epithelial-mesenchymal transition (EMT) biomarkers and Smad2 were a...

journal_title：OncoTargets and therapy

authors： Chen W,Huang B,Wang E,Wang X

更新日期：2019-04-23 00:00:00

abstract：:Metastatic colorectal cancer (mCRC) is a highly heterogeneous disease. Its treatment outcome has been significantly improved over the last decade with the incorporation of biological targeted therapies, including anti-EGFR antibodies, cetuximab and panitumumab, and VEGF inhibitors, bevacizumab, ramucirumab, and aflibe...

journal_title：OncoTargets and therapy

authors： Yan Y,Grothey A

更新日期：2015-10-15 00:00:00

abstract：Background:Lupeol, a triterpene isolated from various herbal plants, possesses an anti-inflammatory function and has been proposed as a candidate for anticancer agents. The purpose of this research was to investigate the effect of lupeol on the viability, apoptosis, cell-cycle distribution, and migration of colorectal ...

journal_title：OncoTargets and therapy

authors： Wang Y,Hong D,Qian Y,Tu X,Wang K,Yang X,Shao S,Kong X,Lou Z,Jin L

更新日期：2018-11-09 00:00:00

abstract：Purpose:The microRNA (miRNA) profile changes in the tumor-associated macrophages. However, the role of miR-106b-5p in the glioblastoma-associated macrophages is poorly understood. Materials and Methods:In our study, miR-106b-5p and M2 macrophage markers were detected by qRT-PCR and Western blotting in THP1 cells, with...

journal_title：OncoTargets and therapy

authors： Shi Y,Zhang B,Zhu J,Huang W,Han B,Wang Q,Qi C,Wang M,Liu F

更新日期：2020-07-30 00:00:00

abstract：:Orbital metastasis as the initial presentation of lung adenocarcinoma is very rare, and so the lack of knowledge about this phenomenon can easily result in misdiagnosis, either as a orbital primary tumor or benign lesion. Here, we report a rare case in which the orbital symptom appeared first without any pulmonary man...

journal_title：OncoTargets and therapy

authors： Sun L,Qi Y,Sun X,Yu J,Meng X

更新日期：2016-05-09 00:00:00

abstract：Purpose:Pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) is associated with favourable outcomes of patients with triple-negative breast cancer (TNBC). However, a proportion of TNBC patients with the residual disease do not relapse and achieve long-term survival. The aim of this study was to ident...

journal_title：OncoTargets and therapy

authors： Wei LY,Zhang XJ,Wang L,Hu LN,Zhang XD,Li L,Gao JN

更新日期：2020-07-03 00:00:00

abstract：Background:It has been reported that ribophorin II (RPN2) expression is increased in many cancers, but the role of RPN2 in nasopharyngeal carcinoma (NPC) remains unclear. Patients and methods:This study found that the expression of RPN2 is increased dramatically in NPC tissues of patients compared with that in the adj...

journal_title：OncoTargets and therapy

authors： Hong F,Li Y,Ni H,Li J

更新日期：2018-06-15 00:00:00

abstract：:Erastin was initially discovered as a small molecule compound that selectively kills tumor cells expressing ST and RASV12 and was later widely investigated as an inducer of ferroptosis. Ferroptosis is a recently discovered form of cell death caused by peroxidation induced by the accumulation of intracellular lipid rea...

journal_title：OncoTargets and therapy

authors： Zhao Y,Li Y,Zhang R,Wang F,Wang T,Jiao Y

更新日期：2020-06-11 00:00:00

abstract：Background and aim:Despite several studies being conducted to examine the associations between the NUDT15 R139C polymorphism and thiopurine-induced leukopenia in the Asian population, the results remain inconsistent. This meta-analysis determined the risk of thiopurine-induced leukopenia conferred by the NUDT15 R139C p...

journal_title：OncoTargets and therapy

authors： Liu Y,Meng Y,Wang L,Liu Z,Li J,Dong W

更新日期：2018-11-23 00:00:00

abstract：Purpose:FAM110B is a member of the FAM110 family (family with sequence similarity 110), which is a component of the centrosome associated proteins. Previous studies have shown that FAM110B may be involved in the process of cell cycle and may play a role in carcinogenesis and tumor progression. Using an online database,...

journal_title：OncoTargets and therapy

authors： Xie M,Cai L,Li J,Zhao J,Guo Y,Hou Z,Zhang X,Tian H,Li A,Miao Y

更新日期：2020-05-19 00:00:00

abstract：Purpose:Traditional Chinese medicine (TCM) has gained increasing attention for the treatment of multiple chronic diseases, such as cancer. Here we aim to identify the antitumor activity of Sichong formula, a novel TCM, in human gastric cancer cells and investigate the underlying mechanisms. Methods:The AGS and MKN45 g...

journal_title：OncoTargets and therapy

authors： Wang M,Tian Z,Zhu Y,Ding J,Li C,Zhou Y,Zhang Y

更新日期：2019-07-16 00:00:00

abstract：Background:Erdheim-Chester Disease (ECD) is a clonal non-Langerhans histiocytosis, classified as a macrophage-dendritic cell neoplasm in the 2016 WHO classification. The exact cell of origin of ECD is unknown, although some limited evidence suggests that it arises from myeloid progenitors. Case Presentation:A 43-year-...

journal_title：OncoTargets and therapy

authors： Papageorgiou SG,Divane A,Roumelioti M,Kottaridi C,Bouchla A,Georgakopoulos A,Ieremiadou F,Daraki A,Bazani E,Thomopoulos TP,Chatziioannou S,Mavrogenis A,Panayiotidis P,Panayiotides IG,Pappa V,Foukas PG

更新日期：2020-11-16 00:00:00

abstract：BACKGROUND:Fibroblast growth factor receptor 4 (FGFR4) has been proved to be correlated with progression and prognosis in many cancers. However, the significance of FGFR4 in non-small-cell lung cancer (NSCLC) is still not well elucidated. METHODS:In our experiment, we detected FGFR4 expression in 237 samples of NSCLC ...

journal_title：OncoTargets and therapy

authors： Huang HP,Feng H,Qiao HB,Ren ZX,Zhu GD

更新日期：2015-05-22 00:00:00

abstract：INTRODUCTION:To investigate the clinical features, diagnosis, treatment, and prognosis of ductal adenocarcinoma of the prostate. METHODS:The clinicopathological and immunohistochemical data of seven patients with ductal adenocarcinoma of the prostate were retrospectively analyzed. All patients underwent physical exami...

journal_title：OncoTargets and therapy

authors： Sha J,Bo J,Pan J,Zhang L,Xuan H,Chen W,Li D,Wang Z,Liu D,Huang Y

更新日期：2013-10-24 00:00:00

abstract：Background:Cellular senescence-inhibited gene (CSIG) strongly prolongs the progression of replicative senescence. However, roles and mechanisms of CSIG in tumor progression have not been studied widely. Methods:Roles of CSIG in migration and proliferation of SMMC7721 and Huh7 cells were analyzed by transwell or cell v...

journal_title：OncoTargets and therapy

authors： Cheng Q,Tong TJ,Li Z,Hu SH,Chen DB,Wang SQ,Zhu JY

更新日期：2019-03-15 00:00:00

abstract：:Two decades ago, lymphatic mapping of sentinel lymph nodes (SLN) was introduced into surgical cancer management and was termed sentinel node navigated surgery. Although this technique is now routinely performed in the management of breast cancer and malignant melanoma, it is still under investigation for use in other ...

journal_title：OncoTargets and therapy

authors： Tausch C,Baege A,Rageth C

更新日期：2014-06-24 00:00:00

abstract：:HES1 is the target of Notch signaling which is reported to affect cell differentiation and maintain the cells in G0 phase in various tissues including the hematopoietic tissue. HES1 expression appears to be an independent prognostic factor for survival in a heterogeneous group of acute myeloid leukemia (AML) patients....

journal_title：OncoTargets and therapy

authors： Tian C,Tang Y,Wang T,Yu Y,Wang X,Wang Y,Zhang Y

更新日期：2015-04-22 00:00:00

abstract：:Bladder cancer (BC) is the most common urinary system malignancy and is a serious threat to human health. Circular RNAs (circRNAs) are members of a newly defined class of noncoding RNAs (ncRNAs) that can regulate gene expression at the transcriptional or posttranscriptional level. Studies have shown that circRNAs are ...

journal_title：OncoTargets and therapy

authors： Cai Z,Li H

更新日期：2020-09-29 00:00:00

abstract：:This study tested the potential of circulating RNA-based signals as predictive biomarkers for docetaxel response in patients with metastatic castration-resistant prostate cancer (CRPC). RNA was analyzed in blood from six CRPC patients by whole-transcriptome sequencing (total RNA-sequencing) before and after docetaxel ...

journal_title：OncoTargets and therapy

authors： Kohli M,Young CY,Tindall DJ,Nandy D,McKenzie KM,Bevan GH,Donkena KV

更新日期：2015-07-30 00:00:00

abstract：:Hodgkin lymphoma (HL) and anaplastic large-cell lymphoma (ALCL) account for ~10% and 2%-3% of all cases of lymphoid neoplasms, respectively. Up to 30% of patients with HL are refractory or relapse after first-line therapy, and elderly patients with HL represent a subgroup of patients with suboptimal responses to the c...

journal_title：OncoTargets and therapy

authors： Donato EM,Fernández-Zarzoso M,Hueso JA,de la Rubia J

更新日期：2018-08-06 00:00:00

abstract：:Circulating tumor DNA (ctDNA) can be identified in the peripheral blood of patients and harbors the genomic alterations found in tumor tissues, which provides a noninvasive approach for detection of gene mutations. We conducted this meta-analysis to investigate whether ctDNA can be used for monitoring KRAS gene mutati...

journal_title：OncoTargets and therapy

authors： Hao YX,Fu Q,Guo YY,Ye M,Zhao HX,Wang Q,Peng XM,Li QW,Wang RL,Xiao WH

更新日期：2017-02-16 00:00:00