Abstract:
Background:Erdheim-Chester Disease (ECD) is a clonal non-Langerhans histiocytosis, classified as a macrophage-dendritic cell neoplasm in the 2016 WHO classification. The exact cell of origin of ECD is unknown, although some limited evidence suggests that it arises from myeloid progenitors. Case Presentation:A 43-year-old patient, diagnosed with BRAFV600E mutated ECD, developed NPM1+/FLT3+ acute myeloid leukemia (AML) with wild-type BRAF, 15 months after the initial ECD diagnosis. The patient received intensive chemotherapy plus midostaurin, followed by midostaurin maintenance. Six months into maintenance, the patient remains in complete remission with low-level measurable residual disease, whereas ECD shows a sustained partial metabolic response. Molecular karyotype at several distinct timepoints, namely ECD diagnosis, AML diagnosis, and following treatment of AML, highlighted a molecular signature, indicative of a persistent, underlying clonal hematopoiesis. Conclusion:This case report suggests that ECD and AML might represent an expansion of two distinct clones in a background of clonal hematopoiesis, indicating their shared origin. Moreover, molecular karyotype might serve as a strong, inexpensive tool for revealing clonal hematopoiesis in cases of negative targeted next-generation sequencing. Finally, the moderate response of ECD to midostaurin suggests that kinase inhibition might have a potential role in ECD treatment.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Papageorgiou SG,Divane A,Roumelioti M,Kottaridi C,Bouchla A,Georgakopoulos A,Ieremiadou F,Daraki A,Bazani E,Thomopoulos TP,Chatziioannou S,Mavrogenis A,Panayiotidis P,Panayiotides IG,Pappa V,Foukas PGdoi
10.2147/OTT.S276497subject
Has Abstractpub_date
2020-11-16 00:00:00pages
11689-11695issn
1178-6930pii
276497journal_volume
13pub_type
abstract:PURPOSE:The prognostic significance of circulating tumor cells (CTCs) in esophageal carcinoma (EC) is controversial. We aim to assess its association with clinicopathological and prognostic relevance in EC by using a meta-analysis. METHODS:We searched PubMed, Cochrane Database, Embase databases, and the references in ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S100005
更新日期:2016-03-31 00:00:00
abstract::Dichloroacetate (DCA), a small molecule mitochondria-targeting agent, can penetrate the blood-brain barrier, showing potential therapeutic effects on brain tumors. Considering the effects of DCA on tumor cellular metabolism, penetrating across the blood-brain barrier, as well as having potential antitumor activity on ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S40992
更新日期:2013-01-01 00:00:00
abstract:Background:Malignant glioma is the second leading cause of cancer-related death worldwide, and is known to exhibit a high degree of heterogeneity in its deregulation of different oncogenic pathways. The molecular subclasses of human glioma are not well known. Thus, it is crucial to identify vital oncogenic pathways in ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S139243
更新日期:2017-11-15 00:00:00
abstract:AIM:To investigate the significance of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER)2, and HER3 expression on survival outcomes in Chinese gastric cancer patients. MATERIALS AND METHODS:Formalin-fixed, paraffin-embedded specimens from 121 patients who underwent gastrectomy at Sh...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S70922
更新日期:2014-12-16 00:00:00
abstract:Purpose:As a novel type of non-coding RNAs, circRNAs were found to play important roles in cancer progression. In this study, we aim to investigate genome-wide circRNAs expression and potential functions in glioma to find new therapeutic targets for glioma treatment. Patients and Methods:A total of 92 pairs of glioma ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S241347
更新日期:2020-04-01 00:00:00
abstract::ALK rearrangements account for ~5% of non-small-cell lung cancer (NSCLC). Numerous rearrangement partners have been discovered. Here, we describe a 53-year-old nonsmoker with NSCLC, in whom we identified four novel rearrangements. The patient was diagnosed as adenocarcinoma in the right middle lobe of lung, with metas...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S258067
更新日期:2020-08-20 00:00:00
abstract:INTRODUCTION:The introduction of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) has improved the outlook for patients with advanced non-small-cell lung cancer (NSCLC) with EGFR+ mutations. However, most patients develop resistance, with the result that median progression-free survival (PFS) iŝ1...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S134382
更新日期:2017-05-05 00:00:00
abstract::[This corrects the article DOI: 10.2147/OTT.S196910.]. ...
journal_title:OncoTargets and therapy
pub_type: 已发布勘误
doi:10.2147/OTT.S229714
更新日期:2019-09-19 00:00:00
abstract:OBJECTIVE:Although our previous studies have confirmed that 1, 3, 8-trihydroxy-6-methylant hraquinone (emodin) inhibits migration and invasion in epithelial ovarian cancer (EOC) cells, the underlying molecular mechanism remains unknown. Here, the aim was to investigate the effects of emodin on EOC cells and to study fu...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S138217
更新日期:2017-07-19 00:00:00
abstract::Lymphangioleiomyomatosis (LAM) is a rare disease that generally affects young women and involves the abnormal proliferation of smooth muscle-like cells (LAM cells) in the lungs (pulmonary LAM) and extrapulmonary sites (extrapulmonary LAM). This disease is rare in males. It is hard to distinguish between lung cancer an...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S161360
更新日期:2018-08-31 00:00:00
abstract:BACKGROUND:Progression-free survival (PFS) and time to progression (TTP) are frequently used to establish the clinical efficacy of anti-cancer drugs. However, the surrogacy of PFS/TTP for overall survival (OS) remains a matter of uncertainty in metastatic breast cancer (mBC). This study assessed the relationship betwee...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S63302
更新日期:2014-06-18 00:00:00
abstract:Purpose:Gastric cancer has a high mortality rate worldwide. Although treatments, such as molecular-targeted therapy, have been introduced, the resulting long-term survival and prognosis remain unsatisfactory. Downregulation of the target genes using lentivirus-mediated short hairpin RNA (shRNA) can be an effective ther...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S234344
更新日期:2020-02-13 00:00:00
abstract:Background:LncRNA cancer susceptibility candidate 15 (CASC15) has been demonstrated to act as an oncogene in different cancers; however, its role in ovarian cancer remains elusive. Methods:Quantitative real-time PCR (qRT-PCR) was performed to examine the expression of lncRNA CASC15. Kaplan-Meier survival analysis was ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S219900
更新日期:2019-10-23 00:00:00
abstract:Purpose:To evaluate the association between tertiary Gleason pattern 5 (TGP5) and biochemical recurrence (BCR) in patients with prostate cancer (PCa) with a Gleason score (GS) of 7 after radical prostatectomy (RP). Patients and methods:This retrospective study identified 350 patients who received RP and were graded as...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S218001
更新日期:2019-09-02 00:00:00
abstract::Intrahepatic cholangiocarcinomas (IHCCs) are morphologically and biologically similar to pancreatic ductal adenocarcinomas (PDACs), so newly identified PDAC-associated genes or proteins could provide clues for screening novel biomarkers for IHCC. In this study, the expression of three novel PDAC tumor markers (T-box t...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S39646
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Primary angiosarcoma of breast (PAOB) is a rare and highly aggressive malignancy. There is no general agreement on optimal treatments or prognostic factors for this orphan disease. The objective of this study was to investigate the clinicopathologic features and management experiences of PAOB. METHODS:We pe...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S92769
更新日期:2015-11-04 00:00:00
abstract:Background:Galangin (GLN), a pure natural flavonoid compound found in plants, has been shown to exert anti-cancer effects against multiple cancer types, including glioma. However, its underlying molecular mechanism remains unclear. Epithelial-to-mesenchymal transition (EMT) performs an important function in the genesis...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S264209
更新日期:2020-09-17 00:00:00
abstract::Neuroendocrine tumors are a rare and heterogeneous group of tumors with a variety of primary origins and variable aggressiveness. Platinum-based chemotherapy has been the cornerstone of treatment for the poorly differentiated tumors. However, well-differentiated neuroendocrine tumors are quite chemoresistant and thera...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S72155
更新日期:2016-02-09 00:00:00
abstract:Background:Exosomes are nano-sized biological vesicles released by many kinds of cells, which play an important role in tumor metastasis through transporting cytokines, RNAs and proteins. However, the molecular mechanisms of exosomes in hepatocellular carcinoma (HCC) metastasis are not completely understood. Materials...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S209413
更新日期:2019-08-23 00:00:00
abstract:Introduction:Because only a small portion of NSCLC (non-small-cell lung cancer) patients benefit from molecular targeted therapy or immunotherapy and do not develop therapeutic resistance, continued research on new targets is warranted. Serotonin has recently emerged as a growth factor for tumor cells, and its receptor...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S244339
更新日期:2020-03-09 00:00:00
abstract::The prevalence of cancer remains high. With the improvement of diagnosis and treatment level and the increase of cancer survivors after treatment, multiple primary tumors are more common than before. The diagnosis and treatment of synchronous multiple primary tumors is more complicated than that of single or metachron...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S200625
更新日期:2019-04-02 00:00:00
abstract:Background:Hepatocellular carcinoma (HCC) is prevalent throughout the world. The aim of this study is to explore new long non-coding RNAs (lncRNAs) associated with hepatocellular carcinoma and detect their expression levels in hepatocellular carcinoma cell lines and tissues. These results will provide new clues on furt...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S251231
更新日期:2020-10-14 00:00:00
abstract:BACKGROUND:Stereotactic body radiotherapy (SBRT) or stereotactic ablative radiotherapy (SABR) has been reported to be a comparable alternative therapy to surgery for patients with T1-3N0M0 non-small cell lung cancer (NSCLC). However, it has not been clarified whether SBRT/SABR is as effective as surgery. We conducted t...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S138701
更新日期:2017-06-07 00:00:00
abstract:BACKGROUND:We investigated the functional roles of microRNA-125a-5p in regulating human prostate carcinoma. METHODS:Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was conducted to evaluate the gene expression levels of miR-125a-5p in eight prostate cancer cell lines and nine biopsy specimens fr...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S92314
更新日期:2015-12-17 00:00:00
abstract:Background and objective:RNF6, an E3 ligase, has been reported to play an important role in the tumorigenesis in several tissues, but its role in gastric cancer is still unknown. In this study, we aimed to investigate the biological function and molecular mechanisms of RNF6 in gastric cancer. Materials and methods:The...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S174846
更新日期:2018-10-05 00:00:00
abstract:Background:Patients with BRAF (v-Raf murine sarcoma viral oncogene homolog B) V600E-mutated metastatic colorectal cancer (mCRC) have a poor prognosis. The Southwest Oncology Group (SWOG) 1406 study evaluated the efficacy of vemurafenib in combination with irinotecan and cetuximab for simultaneous inhibition of epiderma...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S180845
更新日期:2019-01-08 00:00:00
abstract:Background:Several intracellular signaling pathways that are deregulated during hepatocarcinogenesis might constitute potential targets for hepatocellular carcinoma (HCC) therapy. The aim of this study was to test the potential synergic antitumor effect of salirasib and sorafenib in a diethylnitrosamine (DEN)-induced H...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S176903
更新日期:2018-10-17 00:00:00
abstract::Understanding of molecular mechanisms of tumor growth has an increasing impact on the development of diagnostics and targeted therapy of human neoplasia. In this review, we summarize the current knowledge on molecular mechanisms and their clinical implications in von Hippel-Lindau (VHL) disease. This autosomal dominan...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S190753
更新日期:2020-06-16 00:00:00
abstract:Background:Anti-programmed cell death-1/programmed cell death ligand-1 monoclonal antibodies have been widely used in non-small-cell lung cancer (NSCLC), but not every patient can get benefits from them. Whether other molecular markers can predict the results of programmed cell death-1/programmed cell death ligand-1 in...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S164178
更新日期:2018-08-13 00:00:00
abstract:BACKGROUND:Tumor cells before and after epidermal growth-factor receptor (EGFR) tyrosine-kinase inhibitor (TKI) therapy might display different characteristics. The aim of this study was to evaluate the influence of prior EGFR TKI therapy on the efficacy of subsequent pemetrexed plus platinum (PP) in advanced chemonaïv...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S62639
更新日期:2014-05-23 00:00:00