Abstract:
:Dichloroacetate (DCA), a small molecule mitochondria-targeting agent, can penetrate the blood-brain barrier, showing potential therapeutic effects on brain tumors. Considering the effects of DCA on tumor cellular metabolism, penetrating across the blood-brain barrier, as well as having potential antitumor activity on brain tumors, the purpose of this study is to investigate the antitumor activity of DCA on C6 glioma cells in vitro and in vivo. DCA inhibited C6 glioma cell proliferation, induced C6 cell apoptosis, and arrested C6 cells in S phase. DCA can inhibit the expression of heat shock proteins 70 (Hsp70) in a dose-dependent and time-dependent manner (P < 0.01). Our in vivo antitumor effect results indicated that DCA markedly inhibited the growth of C6 glioma tumors in both C6 brain tumor-bearing rats and C6 tumor-bearing nude mice (P < 0.01). DCA significantly induced the ROS production and decreased the mitochondrial membrane potential in tumor tissues. Our in vivo antitumor effect results also indicated that DCA has potential antiangiogenic effects. In conclusion, DCA may be a viable therapeutic agent in the treatment of gliomas.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Duan Y,Zhao X,Ren W,Wang X,Yu KF,Li D,Zhang X,Zhang Qdoi
10.2147/OTT.S40992subject
Has Abstractpub_date
2013-01-01 00:00:00pages
189-98issn
1178-6930pii
ott-6-189journal_volume
6pub_type
杂志文章abstract:BACKGROUND:Studies on the association between two single nucleotide polymorphisms (SNPs) in estrogen receptor α (ERα), PvuII (rs2234693 T>C) and XbaI (rs9340799 A>G), and the prostate cancer risk are inconsistent. Therefore, we performed a meta-analysis to derive a more accurate estimation of this relationship. METHOD...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S132419
更新日期:2017-06-29 00:00:00
abstract::Aberrant promoter methylation of RUNX3 has been reported in several tumors including human breast cancer (BC). However, the association between RUNX3 hypermethylation and incidence of BC remains elusive. In this study, a detailed literature search was performed in Medline and Google Scholar for related research public...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S77828
更新日期:2016-08-26 00:00:00
abstract::Ovarian cancer (OC) is the most lethal cancer of all gynecological malignancies, while endometrial cancer (EC) is the most common one. Current strategies for OC/EC diagnosis consist of the extraction of a solid tissue from the affected area. This sample enables the study of specific biomarkers and the genetic nature o...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S227156
更新日期:2019-12-27 00:00:00
abstract:BACKGROUND:MicroRNA (miR)-126, acting as a tumor suppressor, has been reported to inhibit the invasion of gastric cancer cells in part by targeting v-crk sarcoma virus CT10 oncogene homologue (CRK). The aim of this study was to investigate the clinical significance of miR-126/CRK axis in gastric cancer. METHODS:miR-12...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S87778
更新日期:2016-10-11 00:00:00
abstract::The incidence of lung neuroendocrine carcinomas, which originate from lung neuroendocrine cells, is 1.35/100,000, among which mixed neuroendocrine carcinomas are very rare. Because of the heterogeneity and significant differences in sensitivity to treatments, there is no effective treatment, and the prognosis is poor....
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S210699
更新日期:2019-11-14 00:00:00
abstract:Background:The oncogenic potential of special AT-rich binding protein 1 (SATB1) has been reported in various types of cancer, but its function in cervical cancer remains not fully investigated. This study aimed to investigate the effect of SATB1 mRNA expression on tumor progression and outcomes in the cervical cancer p...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S191414
更新日期:2019-01-30 00:00:00
abstract:Purpose:Primary squamous cell carcinoma is a rare malignancy in the thyroid gland (SCCTh). The overall prognosis of this carcinoma is poor. This study aimed to explore the application of Raman spectroscopy in investigating the expression of CK5/6 and P63 in SCCTh. Patients and Methods:Tissues of the SCCTh and adjacent...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S229436
更新日期:2020-01-20 00:00:00
abstract:Background:Melatonin (MLT), a kind of neuroendocrine active substance, has been reported to function in the treatment of tumors. However, there remain controversies about the curative effect of MLT in tumors in clinical studies. This study investigates the efficacy of MLT on tumor therapeutic strategies by meta-analysi...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S174100
更新日期:2018-11-08 00:00:00
abstract::CD47 belongs to immunoglobulin superfamily and is widely expressed on the surface of cell membrane, while another transmembrane protein SIRPα is restricted to the surface of macrophages, dendritic cells, and nerve cells. As a cell surface receptor and ligand, respectively, CD47 and SIRPα interact to regulate cell migr...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S249822
更新日期:2020-09-22 00:00:00
abstract:Purpose:Strategies to increase radiosensitivity are urgently needed. Combining radiosensitizing reagents with radiotherapy could improve the outcome of cancer treatment. Some preclinical studies showed that sepantronium bromide (YM155) could sensitize cancer cells to radiation by inhibiting the survivin protein. In thi...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S166798
更新日期:2018-05-24 00:00:00
abstract:PURPOSE:In asymptomatic patients with Stage IV colorectal cancer, the debate continues over the efficacy of primary resection compared to chemotherapy alone. The aim of this study was to define the optimal management for asymptomatic patients with colorectal cancer and unresectable liver metastases. PATIENTS AND METHO...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S39448
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:This study aims to investigate the potential benefit of combination therapy with magnetic nanoparticles of Fe3O4 (Fe3O4-MNP) and gambogic acid (GA) on SMMC-7721 cells. METHODS:The inhibition of proliferation of SMMC-7721 cells was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assa...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S86494
更新日期:2015-08-26 00:00:00
abstract:Objective:To compare cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and CHOP plus etoposide (CHOPE) with regard to outcomes including efficacy and safety for patients with peripheral T-cell lymphoma (PTCL). Methods:Relevant literature was searched using PubMed, Embase, Wanfang, and CNKI for eligible...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S189825
更新日期:2019-03-28 00:00:00
abstract::Aberrant methylation of CpG dinucleotides is a commonly observed epigenetic modification in human cancer. Thus, detection of aberrant gene promoter methylation as a tool for diagnosis of tumors or as a prognostic marker has been widely described for many types of cancers, including nonsmall cell lung cancer (NSCLC). E...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S67355
更新日期:2014-10-31 00:00:00
abstract:Purpose:Programmed death ligand 1 (PD-L1) is widely used for predicting immune checkpoint inhibitors but has a limited effect on predicting clinical response. The aim of this study was to examine the prognostic value and PD-1 inhibitor therapeutic efficiency of SNX20 in lung adenocarcinoma. Methods:We evaluated the mR...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S262909
更新日期:2020-10-09 00:00:00
abstract:Background:Previous studies have reported that nuclear receptor subfamily 5, group A, member 2 (NR5A2) polymorphisms (rs3790843 G>A, rs3790844 T>C, rs12029406 C>T) are associated with the risk of pancreatic cancer. However, the results of epidemiological investigations are still controversial. In order to explore its p...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S157759
更新日期:2018-05-09 00:00:00
abstract:Background:Although several long non-coding RNAs (lncRNAs) have been found to be involved in gastric cancer tumorigenesis, the more comprehensive contributions of lncRNAs to gastric cancer require further investigation. Here, we identify a cytoplasmic lncRNA, LINC01485, which promotes tumor growth and migration in gast...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S257151
更新日期:2020-08-21 00:00:00
abstract:Background:Chemotherapy remains a major clinical option for the successful treatment of cancer by eliminating fast-growing populations of cancer cells. However, drug resistance causes the failure of antitumor treatment. Increasing evidence suggests that a small subpopulation of cancer cells will enter a "persister stat...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S212465
更新日期:2019-07-08 00:00:00
abstract:Background:Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide. LINC00460, a novel long non-coding RNA (lncRNA), was recently confirmed as an oncogene in various cancers. However, the biological function and underlying mechanism of LINC00460 in HCC is largely obscure. Methods:Fifty pa...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S239258
更新日期:2020-03-06 00:00:00
abstract:Background:It was previously reported that downregulation of miR-218 promoted thyroid cancer cell invasion, migration, and proliferation. However, the biological functions of miR-218 and its possible regulatory mechanisms in papillary thyroid cancer (PTC) cells are still elusive. Materials and methods:The expression l...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S172152
更新日期:2018-09-28 00:00:00
abstract::Background: Altered expression of the BCL-2 family member MCL-1 has been linked to the progression and outcome of various malignancies. Recently, MCL-1 inhibitor S63845 was reported to kill MCL-1-dependent cancer cells and has potential value in clinical application. Purpose: Herein, we reported MCL-1 expression patte...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S194549
更新日期:2019-05-01 00:00:00
abstract::Primary urethral non-Hodgkin's lymphoma (NHL) is uncommon. This case study reports the case of a 52-year-old woman with a light red mass at the urethral orifice. Her clinical manifestations included frequent urination, urgency, dysuria, and occasionally blood in urine. The tumor was surgically removed, and the patholo...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S283704
更新日期:2020-12-21 00:00:00
abstract:PURPOSE:The prognostic significance of circulating tumor cells (CTCs) in esophageal carcinoma (EC) is controversial. We aim to assess its association with clinicopathological and prognostic relevance in EC by using a meta-analysis. METHODS:We searched PubMed, Cochrane Database, Embase databases, and the references in ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S100005
更新日期:2016-03-31 00:00:00
abstract:Purpose:MicroRNA-939 (miR-939) has crucial roles in several types of human cancer. However, the expression profile and precise functions of miR-939 in prostate cancer (PCa) are still unclear. This study aimed to determine miR-939 expression in PCa and explore its roles in PCa tumorigenesis. Methods:miR-939 expression ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S250101
更新日期:2020-05-18 00:00:00
abstract::Ewing's sarcoma is a rare and highly aggressive cancer most frequently arising in people under 20 years of age. We report an uncommon case of primary paraesophageal Ewing's sarcoma in a 25-year-old male harboring the infrequent EWSR1/ERG fusion transcript with multiple splice variants coexisting in the same tumor. The...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S80879
更新日期:2015-05-14 00:00:00
abstract:BACKGROUND:In patients with gastric cancer (GC), survival is poor, given the late diagnosis. Risk-stratifying these patients earlier could help improve care. We determined whether combining preoperative albumin concentration and the neutrophil lymphocyte ratio (COA-NLR) could predict overall survival (OS) better than o...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S108631
更新日期:2016-07-27 00:00:00
abstract:OBJECTIVE:To analyze the management and prognosis of primary choriocarcinoma (PCC) in male patients. METHODS:The clinical records of males with PCC who were treated at Peking Union Medical College Hospital between 1990 and 2012 were analyzed retrospectively. The literature regarding this clinical condition was also re...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S62561
更新日期:2014-06-20 00:00:00
abstract::The mitogen-activated protein kinase (MAPK) pathway is a critical oncogenic driver signal in a number of malignancies. The discovery of activating mutations in the MAPK pathway has led to the development of MAPK pathway inhibitors. Selumetinib is a potent and selective inhibitor of MEK1 and MEK2, which are essential d...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S51596
更新日期:2014-09-19 00:00:00
abstract::Purpose: Several microRNAs (miRNAs) that are aberrantly expressed in glioblastoma multiforme (GBM) play a significant role in GBM formation and progression. The expression profile and functions of miR-559 in GBM remain unclear. Here, we quantified the expression and investigated the involvement of miR-559 in the oncog...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S202309
更新日期:2019-06-05 00:00:00
abstract:Introduction:Dynamin 3 (DNM3) is a large GTPase that possesses mechanochemical properties and has been shown to be involved in malignancies. However, most studies about DNM3 are observational, and knowledge of the precise molecular mechanism of DNM3 remains limited. Materials and methods:We constructed a PCDH-CMV-MCS-...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S176388
更新日期:2018-10-09 00:00:00