Abstract:
:The incidence of lung neuroendocrine carcinomas, which originate from lung neuroendocrine cells, is 1.35/100,000, among which mixed neuroendocrine carcinomas are very rare. Because of the heterogeneity and significant differences in sensitivity to treatments, there is no effective treatment, and the prognosis is poor. In this article, we report the diagnosis and treatment of a case of mixed neuroendocrine carcinoma of the lung in our hospital. During the treatment, the patients had significant myelosuppression after initial chemotherapy, but benefited from oral chemotherapy consisting of a combination of capecitabine and temozolomide (CAPTEM). The report was approved by the affiliated Cancer Hospital of Shandong University.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Zhang B,Wang D,Zhang X,Cui X,Kong L,Li M,Yu Jdoi
10.2147/OTT.S210699subject
Has Abstractpub_date
2019-11-14 00:00:00pages
9663-9668issn
1178-6930pii
210699journal_volume
12pub_type
abstract::Hepatocellular carcinoma (HCC) with inferior vena cava (IVC) tumor thrombus rarely occurs, its prognosis is extremely poor. A 49-year-old locally advanced HCC male with tumor thrombus extension into the IVC and the right atrium was successfully treated with stereotactic body radiotherapy (SBRT). A radiation dose of 40...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S208560
更新日期:2019-07-04 00:00:00
abstract:Background:PD-1 checkpoint inhibitors have shown a robust tumor response in the treatment of various cancers. Pembrolizumab is an anti-PD-1 checkpoint antibody approved for the treatment of unresectable or metastatic melanoma in more than 40 countries. Although autoimmune pneumonitis is considered a common immune-relat...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S178246
更新日期:2018-10-24 00:00:00
abstract:Purpose:Anaplastic thyroid cancer (ATC) is a kind of rare thyroid cancer with very poor prognosis. Doxorubicin has been approved in ATC treatment as a single agent, but monotherapy still shows no improvement of the total survival in advanced ATC. Lenvatinib was investigated with encouraging results in treating patients...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S278349
更新日期:2020-11-02 00:00:00
abstract::Gastrointestinal stromal tumor (GIST) is an uncommon mesenchymal tumor, and has been shown to be associated with synchronous or metachronous second malignancies. Rare cases of coincident GIST and non-Hodgkin lymphomas (NHL) have been reported previously. Here, we report two cases of GIST and coincident primary breast ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S159843
更新日期:2018-12-10 00:00:00
abstract:Background:Galangin (GLN), a pure natural flavonoid compound found in plants, has been shown to exert anti-cancer effects against multiple cancer types, including glioma. However, its underlying molecular mechanism remains unclear. Epithelial-to-mesenchymal transition (EMT) performs an important function in the genesis...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S264209
更新日期:2020-09-17 00:00:00
abstract:OBJECTIVES:This study aimed to analyze incidence and mortality trends in breast cancer (BC), corpus uteri cancer (CUC), and ovarian cancer (OC) in Poland in the context of sociodemographic changes. MATERIALS AND METHODS:Incidence and mortality data (1980-2013) were retrieved from the Polish National Cancer Registry, w...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S112187
更新日期:2016-09-07 00:00:00
abstract:Background:Long non-coding RNAs (lncRNAs) have been verified to have a vital role in the progression of glioblastoma multiforme (GBM). Our research was about to identify the potential lncRNAs which was closely associated with the pathogenesis and prognosis of glioblastoma multiforme. Methods:All RNA sequence profiling...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S235951
更新日期:2020-02-04 00:00:00
abstract:INTRODUCTION:The prognostic impact of smoking and drinking on esophageal squamous cell carcinoma (ESCC) was scarcely discussed. We investigated the prognostic value of smoking and drinking and their relationships with clinicopathological characteristics in a large cohort of patients with locoregional ESCC. PATIENTS AN...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S104182
更新日期:2016-07-13 00:00:00
abstract:OBJECTIVE:Even though the primary mediastinal extragonadal germ cell tumors (EGCTs) are rare, they are noteworthy in the differential diagnosis of mediastinal masses. In this study, we aimed to identify the clinical features of mediastinal malignant GCTs and compare the results of hematopoietic stem cell transplantatio...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S107899
更新日期:2016-12-09 00:00:00
abstract:PURPOSE:In asymptomatic patients with Stage IV colorectal cancer, the debate continues over the efficacy of primary resection compared to chemotherapy alone. The aim of this study was to define the optimal management for asymptomatic patients with colorectal cancer and unresectable liver metastases. PATIENTS AND METHO...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S39448
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:The prognostic significance of circulating tumor cells (CTCs) in esophageal carcinoma (EC) is controversial. We aim to assess its association with clinicopathological and prognostic relevance in EC by using a meta-analysis. METHODS:We searched PubMed, Cochrane Database, Embase databases, and the references in ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S100005
更新日期:2016-03-31 00:00:00
abstract:Introduction:The consolidation of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. In this study, a multifunctional platform by WS2 quantum dots (WQDs)-coated doxorubicin (DOX)-loaded periodic mesoporous organosilicas (PMOs-DOX@WQDs) nanoparticles were fabricated f...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S160748
更新日期:2018-04-05 00:00:00
abstract::Immune cells are essential for defending the body's balance and have increasingly been implicated in controlling tumor growth. In cervical cancer (CC), the immune landscape is extensively connected with human papillomavirus (HPV) status. Recent insights from studies have revealed that as a result of infection with HPV...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S264312
更新日期:2020-08-12 00:00:00
abstract::Programmed cell death-1 (PD-1) immune checkpoint inhibitors have exhibited promising efficacy in various types of tumors. Here, we report an unresectable locally advanced gastric cancer (GC) with programmed cell death ligand-1 (PD-L1) positive and microsatellite instability (MSI), which exhibiting an unexpected effica...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S243298
更新日期:2020-02-26 00:00:00
abstract::Non-small cell lung cancer (NSCLC) patients with anaplastic lymphoma kinase (ALK) rearrangement benefit from treatment with ALK inhibitors. Therefore, the identification of druggable ALK fusions is necessary for NSCLC treatment. More than 90 fusion partners of ALK have been reported in NSCLC patients, but the striatin...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S282933
更新日期:2020-12-04 00:00:00
abstract::Background: Circ-SHPRH is a novel circular RNA which was down-regulated in various cancer tissues. Several recent studies hinted that circ-SHPRH might function as a diagnostic and prognostic biomarker for solid cancers. This meta-analysis was performed to determine the diagnostic and prognostic roles of circ-SHPRH for...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S200755
更新日期:2019-05-31 00:00:00
abstract::Immune checkpoint inhibitors (ICIs) have transformed the therapeutic strategy and prognosis of advanced non-small cell lung cancer (NSCLC) patients. Nowadays, ICIs as monotherapy or in combination with chemotherapy are the standard of care treatment in advanced NSCLC, and in stage III, durvalumab (a programmed death l...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S259308
更新日期:2020-07-14 00:00:00
abstract:Objective:The objective of this study was to investigate the safety of robotic stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC) patients and its related factors. Methods:A total of 74 HCC patients with Child-Turcotte-Pugh (CTP) Class A were included in a multi-institutional, single-arm Pha...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S142025
更新日期:2017-11-06 00:00:00
abstract::The antidiabetic drug metformin has been shown to possess antitumor functions in many types of cancers. Although studies have revealed its beneficial effects on the prognosis of hepatocellular carcinoma (HCC), the detailed molecular mechanism underlying this event remains largely unknown. In this work, we showed that ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S99770
更新日期:2016-05-12 00:00:00
abstract:Background:Long non-coding RNAs (lncRNAs) can affect tumorigenesis. Data from The Cancer Genome Atlas (TCAG) suggest that LINC02783 is highly expressed in renal cell carcinoma (RCC) and is expected to be a potential biological target. We conducted this study to verify this. Patients and Methods:We conducted this study...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S262046
更新日期:2020-10-09 00:00:00
abstract:Background:Minichromosome maintenance protein 2 (MCM2), which is a member of MCM family, has been found to be a relevant marker for progression and prognosis in a variety of human cancers. Due to lack of effective therapeutic target in lung squamous cell carcinoma (LUSC) patients, the aim of our study was to screen and...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S169002
更新日期:2018-08-20 00:00:00
abstract:BACKGROUNDS:Sitting time and physical activity are associated with cancer risk; however, their roles in the development of esophageal squamous cell carcinoma (ESCC) are inconclusive. This study aimed to investigate the effects of total sitting time, occupational activity time (OAT), and recreational activity time (RAT)...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S147711
更新日期:2017-09-27 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) patients with fever as the initial presentation are extremely rare. Our aim was to investigate the clinical characteristics and prognosis of patients with this disease. PATIENTS AND METHODS:The clinical features were analyzed in a retrospective study of 63 HCC patients with fe...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S109023
更新日期:2016-10-13 00:00:00
abstract:Background:The immune environment of lung cancer is complex, and the critical immune factors that promote lung cancer progression need to be explored. Granulocytic myeloid-derived suppressor cells (G-MDSCs) are regarded as immune suppressing cells. However, they also promote tumor progression through other ways, which ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S256378
更新日期:2020-09-30 00:00:00
abstract:BACKGROUND:This meta-analysis aimed to assess available evidence on possible associations of interleukin-28B polymorphisms rs8099917 and rs12979860 with development of hepatitis virus-related hepatocellular carcinoma (HCC). METHODS:PubMed, EMBASE, Google Scholar, and the Chinese National Knowledge Infrastructure datab...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S104904
更新日期:2016-05-30 00:00:00
abstract:Purpose:Pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) is associated with favourable outcomes of patients with triple-negative breast cancer (TNBC). However, a proportion of TNBC patients with the residual disease do not relapse and achieve long-term survival. The aim of this study was to ident...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S256818
更新日期:2020-07-03 00:00:00
abstract:Objective:The role of neoadjuvant therapy (NAT) in resectable pancreatic cancer (RPC) remains controversial. Therefore, this meta-analysis was performed to compare the clinical differences between NAT and upfront surgery in RPC. Materials and methods:A systematic literature search was performed in PubMed, Embase, Web ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S190810
更新日期:2019-01-22 00:00:00
abstract:Objective:Multidrug resistance-associated protein 2 (MRP2), encoded by ABCC2 gene, is involved in the efflux of certain anticancer drugs. Here we observed whether the ABCC2 (G1249A) polymorphism impacts the transport abilities of MRP2-dependent paclitaxel, docetaxel, and doxorubicin in recombinant LLC-PK1 cell lines. ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S207613
更新日期:2020-02-17 00:00:00
abstract:Background:This study was designed to research the potential function of lncRNA ANRIL in osteosarcoma (OS). Materials and methods:Quantitative real-time PCR, cell counting kit-8, wound healing assay, Transwell assay, flow cytometric analysis, caspase activity analysis, and Western blot were carried out. Results:ANRIL...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S170293
更新日期:2018-08-14 00:00:00
abstract::Hormone-receptor-positive breast cancer is the most common subtype of breast cancer among patients with both early-stage and metastatic disease. Recent advances in the understanding of its pathophysiology have led to the discovery and utilization of targeted inhibitors to cyclin-dependent kinases 4 and 6 (CDK4/6). The...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S149245
更新日期:2018-08-29 00:00:00