Comparison of neoadjuvant therapy and upfront surgery in resectable pancreatic cancer: a meta-analysis and systematic review.

abstract：:Prostate cancer is the leading malignancy and the second most common cause of cancer-related death in men. Despite high cure rates with surgery and/or radiation, 30%-40% of patients eventually develop advanced cancer. Docetaxel is one of the most effective and well established chemotherapeutic agents for prostate canc...

journal_title：OncoTargets and therapy

authors： Zhou F,Chen X,Fan S,Tai S,Jiang C,Zhang Y,Hao Z,Zhou J,Shi H,Zhang L,Liang C

更新日期：2015-04-10 00:00:00

abstract：:During the past decade, immunotherapy targeting immune checkpoints has become an important component of the treatment paradigm for numerous malignancies, especially PD-1/PD-L1 blockade which was demonstrated to rejuvenate disabled T cells in cancer patients to achieve long-term remissions. However, the clinical outcom...

journal_title：OncoTargets and therapy

authors： Cai J,Wang D,Zhang G,Guo X

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:Pancreatic cancer is one of the most aggressive and intractable malignant tumors, and most deaths from pancreatic cancer are related to metastases. It has been demonstrated in vitro that overexpression of programmed death-ligand 1 (PD-L1) correlates with a lack of phosphatase and tensin homologue (PTEN) expr...

journal_title：OncoTargets and therapy

authors： Zhao L,Li C,Liu F,Zhao Y,Liu J,Hua Y,Liu J,Huang J,Ge C

更新日期：2017-04-12 00:00:00

abstract：OBJECTIVES:This study aimed to analyze incidence and mortality trends in breast cancer (BC), corpus uteri cancer (CUC), and ovarian cancer (OC) in Poland in the context of sociodemographic changes. MATERIALS AND METHODS:Incidence and mortality data (1980-2013) were retrieved from the Polish National Cancer Registry, w...

journal_title：OncoTargets and therapy

authors： Banas T,Juszczyk G,Pitynski K,Nieweglowska D,Ludwin A,Czerw A

更新日期：2016-09-07 00:00:00

abstract：:Human testis development-related gene 1 (TDRG1) is a recently identified gene that is expressed exclusively in the testes and promotes the development of testicular germ cell tumors. In this study, the role of TDRG1 in the development of testicular seminoma, which is the most common testicular germ cell tumor, was fur...

journal_title：OncoTargets and therapy

authors： Wang Y,Gan Y,Tan Z,Zhou J,Kitazawa R,Jiang X,Tang Y,Yang J

更新日期：2016-01-20 00:00:00

abstract：Background:Several trials evaluated the role of intensive regimens, made of triplet chemotherapies plus bevacizumab, as first-line treatment for patients with metastatic colorectal cancer (mCRC). We previously reported, in a Phase II prospective study, the efficacy and the tolerability of FIrB/FOx regimen, reporting in...

journal_title：OncoTargets and therapy

authors： Cortellini A,Cannita K,Parisi A,Lanfiuti Baldi P,Venditti O,D'Orazio C,Dal Mas A,Calvisi G,Giordano AV,Vicentini V,Vicentini R,Felicioni L,Marchetti A,Buttitta F,Russo A,Ficorella C

更新日期：2019-03-25 00:00:00

abstract：:The view that B lymphocytes are pathogenic in diverse pathological settings is supported by the efficacy of B-cell-ablative therapy in lymphoproliferative disorders, autoimmune diseases and graft rejection. Anti-B-cell antibodies (Abs) directed against CD20 have therefore been generated, and of these, rituximab was th...

journal_title：OncoTargets and therapy

authors： Hammadi M,Pers JO,Berthou C,Youinou P,Bordron A

更新日期：2010-06-24 00:00:00

abstract：:Gastric cancer (GC) is one of the leading causes of tumor-related mortality. In addition to surgery and endoscopic resection, systemic therapy remains the main treatment option for GC, especially for advanced-stage disease and for cases not suitable for surgical therapy. Hence, improving the efficacy of systemic thera...

journal_title：OncoTargets and therapy

authors： Zhao X,Hu GF,Shi YF,Xu W

更新日期：2019-12-24 00:00:00

abstract：Background:Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Long non-coding RNA taurine-upregulated gene 1 (lncRNA TUG1) has been discovered to participate in multiple cancers including AML. However, the detailed mechanism of TUG1 in AML remains obscure. Materials and methods:AML cell ...

journal_title：OncoTargets and therapy

authors： Li G,Zheng P,Wang H,Ai Y,Mao X

更新日期：2019-11-29 00:00:00

abstract：Background:Recent evidence showed cancerous inhibitor of protein phosphatase 2A (CIP2A) plays carcinogenesis roles in several types of human cancer. However, the expression and function of CIP2A in gliomas are unknown. Methods:qRT-PCR, IHC and Western blot were used to evaluate CIP2A expression in glioma tissues and ...

journal_title：OncoTargets and therapy

authors： Zhang S,Wang K

更新日期：2020-05-12 00:00:00

abstract：:Quercetin, a flavone, is multifaceted, having anti-oxidative, anti-inflammatory, and anticancer properties. In the present study, we explored the effects of quercetin on the epithelial-mesenchymal transition (EMT) and invasion of pancreatic cancer cells and the underlying mechanisms. We noted that quercetin exerted pr...

journal_title：OncoTargets and therapy

authors： Yu D,Ye T,Xiang Y,Shi Z,Zhang J,Lou B,Zhang F,Chen B,Zhou M

更新日期：2017-09-25 00:00:00

abstract：:Angiogenesis plays an essential role in the development of most solid tumors by delivering nutrients and oxygen to the tumor. Therefore, anti-angiogenic therapy, particularly anti-VEGF and anti-VEGF receptor (VEGFR) therapy, has been a popular strategy to treat cancer. However, anti-angiogenic therapy does not signifi...

journal_title：OncoTargets and therapy

authors： Tian W,Cao C,Shu L,Wu F

更新日期：2020-11-24 00:00:00

abstract：BACKGROUND:Breast cancer is one of the most frequently occurring cancers in women. In recent years, Dendrobium candidum has played a part in antihyperthyroidism and anticancer drugs. This study aims to examine the antitumor effect of D. candidum on breast cancer. METHODS:Human breast cancer cell line MCF-7 and normal ...

journal_title：OncoTargets and therapy

authors： Sun J,Guo Y,Fu X,Wang Y,Liu Y,Huo B,Sheng J,Hu X

更新日期：2015-12-21 00:00:00

abstract：Purpose:Pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) is associated with favourable outcomes of patients with triple-negative breast cancer (TNBC). However, a proportion of TNBC patients with the residual disease do not relapse and achieve long-term survival. The aim of this study was to ident...

journal_title：OncoTargets and therapy

authors： Wei LY,Zhang XJ,Wang L,Hu LN,Zhang XD,Li L,Gao JN

更新日期：2020-07-03 00:00:00

abstract：:Circulating tumor DNA (ctDNA) can be identified in the peripheral blood of patients and harbors the genomic alterations found in tumor tissues, which provides a noninvasive approach for detection of gene mutations. We conducted this meta-analysis to investigate whether ctDNA can be used for monitoring KRAS gene mutati...

journal_title：OncoTargets and therapy

authors： Hao YX,Fu Q,Guo YY,Ye M,Zhao HX,Wang Q,Peng XM,Li QW,Wang RL,Xiao WH

更新日期：2017-02-16 00:00:00

abstract：Background:Immunosenescence, the age-related decline of immunity, affects the immune responses of melanoma patients. Through immune responses, immune checkpoint inhibitors (ICIs) exert their antitumor robustness. In different ages of melanoma patients, especially the older patients, the effectiveness of ICIs remains un...

journal_title：OncoTargets and therapy

authors： Li P,Yang X,Feng Y,Wu L,Ma W,Ding G,Wei Y,Sun L

更新日期：2018-10-26 00:00:00

abstract：Background:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors and exhibit a high frequency of oncogenic KIT or PDGFRA mutations. Tyrosine kinase inhibitors (TKIs) have been mainly used in the treatment of GISTs bearing KIT/PDGFRA mutations. However, other mutation profiles have been found to...

journal_title：OncoTargets and therapy

authors： Chen Q,Li R,Zhang ZG,Deng QT,Li K,Wang H,Yang XX,Wu YS

更新日期：2018-04-20 00:00:00

abstract：Background:Nasopharyngeal carcinoma (NPC) is a common malignant cancer that is distributed particularly in Southeastern Asia. Previous studies have manifested that long noncoding RNA urothelial carcinoma associated 1 (UCA1) was involved in NPC tumorigenesis and metastasis. However, the biological mechanism of UCA1 for ...

journal_title：OncoTargets and therapy

authors： Liu C,Zhang H,Liu H

更新日期：2019-10-11 00:00:00

abstract：BACKGROUND:Computed tomography-guided transthoracic needle aspiration (TTNA) and biopsy (TTNB) is a well established, safe, and rapid method of reaching a definitive diagnosis for most thoracic lesions. The present study aimed to determine the roles of TTNA and TTNB in the diagnosis of pulmonary diseases and to compare...

journal_title：OncoTargets and therapy

authors： Tuna T,Ozkaya S,Dirican A,Findik S,Atici AG,Erkan L

更新日期：2013-11-05 00:00:00

abstract：Purpose:Traditional Chinese medicine (TCM) has gained increasing attention for the treatment of multiple chronic diseases, such as cancer. Here we aim to identify the antitumor activity of Sichong formula, a novel TCM, in human gastric cancer cells and investigate the underlying mechanisms. Methods:The AGS and MKN45 g...

journal_title：OncoTargets and therapy

authors： Wang M,Tian Z,Zhu Y,Ding J,Li C,Zhou Y,Zhang Y

更新日期：2019-07-16 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare myeloid malignancy, for which conventional chemotherapy has poor outcomes. CD123, the α-subunit of interleukin (IL)-3 receptor, is constantly overexpressed at the surface of tumoral cells. Tagraxofusp (or SL-401) is a recombinant cytotoxin which consists o...

journal_title：OncoTargets and therapy

authors： Beziat G,Ysebaert L

更新日期：2020-06-09 00:00:00

abstract：Objective:As an epidermal growth factor, receptor-tyrosine kinase inhibitor (EGFR-TKI), gefitinib demonstrates a good therapeutic effect in patients with EGFR-mutant non-small-cell lung cancer (NSCLC). However, an overwhelming majority of these patients inevitably develop resistance against gefitinib. Unfortunately, th...

journal_title：OncoTargets and therapy

authors： Zhang D,Han LL,Du F,Liu XM,Li J,Wang HH,Song MH,Li Z,Li GY

更新日期：2019-11-18 00:00:00

abstract：:The clinicopathological and prognostic significance of telomerase reverse transcriptase (TERT) promoter mutations have been widely investigated in thyroid cancer; however, the results are still discrepant. Systematic searches were performed in PubMed, Web of Science, Scopus, Ovid, and the Cochran Library databases for...

journal_title：OncoTargets and therapy

authors： Su X,Jiang X,Wang W,Wang H,Xu X,Lin A,Teng X,Wu H,Teng L

更新日期：2016-11-11 00:00:00

abstract：Background:Gastric cancer (GC) is one of the most common malignant tumors and the second most frequent cause of cancer death worldwide. Crocin is a kind of bioactive constituent found in the stigmas of saffron, which has shown various pharmacological activities. Methods:In this study, we investigated the inhibitory ef...

journal_title：OncoTargets and therapy

authors： Luo Y,Yu P,Zhao J,Guo Q,Fan B,Diao Y,Jin Y,Wu J,Zhang C

更新日期：2021-01-07 00:00:00

abstract：AIM:This study was designed to investigate the predictive and prognostic values of serum vascular endothelial growth factor (VEGF) level in non-small cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy. METHODS:Patients' peripheral blood samples were collected prior to chemotherapy and after 1 w...

journal_title：OncoTargets and therapy

authors： Zang J,Hu Y,Xu X,Ni J,Yan D,Liu S,He J,Xue J,Wu J,Feng J

更新日期：2017-01-18 00:00:00

abstract：:Defects in the innate immune system, particularly in Toll-like receptors (TLRs), have been reported in several cigarette smoke-promoted diseases. The aim of this study was to examine the impact of tobacco smoke on allelic frequencies of TLR4 single-nucleotide polymorphisms (SNPs) and to compare the genotypic distribut...

journal_title：OncoTargets and therapy

authors： Kohailan M,Alanazi M,Rouabhia M,Al Amri A,Parine NR,Semlali A

更新日期：2017-02-09 00:00:00

abstract：Background:Bladder cancer is a serious threat to human health. It is meaningful to study the pathogenesis of bladder cancer. Long non-coding RNAs (lncRNAs) are reported to promote or inhibit bladder cancer development. However, the role of lncRNA BCAR4 in the regulation of bladder cancer remains unclear. Purpose:This ...

journal_title：OncoTargets and therapy

authors： Wang X,He H,Rui W,Xie X,Wang D,Zhu Y

更新日期：2020-03-24 00:00:00

abstract：:Orbital metastasis as the initial presentation of lung adenocarcinoma is very rare, and so the lack of knowledge about this phenomenon can easily result in misdiagnosis, either as a orbital primary tumor or benign lesion. Here, we report a rare case in which the orbital symptom appeared first without any pulmonary man...

journal_title：OncoTargets and therapy

authors： Sun L,Qi Y,Sun X,Yu J,Meng X

更新日期：2016-05-09 00:00:00

abstract：Background:Bromodomain and extra-terminal domain inhibitors like JQ1 have proved to be promising epigenetic agents for the treatment of malignant ovarian carcinoma. However, the resistance of ovarian cancer cells to BET inhibitors has not been elucidated. In this study, we investigated the potential mechanisms underlyi...

journal_title：OncoTargets and therapy

authors： Luan W,Pang Y,Li R,Wei X,Jiao X,Shi J,Yu J,Mao H,Liu P

更新日期：2019-10-03 00:00:00

abstract：Aim:We aimed to assess the role of 21-gene recurrence score (RS) in the decision-making for surgical treatment in early stage breast cancer and compared the outcomes between breast-conserving surgery (BCS) and mastectomy (MAST) among various 21-gene RS groups. Methods:We included patients with stage T1-2M0M0 and estro...

journal_title：OncoTargets and therapy

authors： Wu SG,Zhang WW,Wang J,Dong Y,Chen YX,He ZY

更新日期：2019-03-19 00:00:00