miR-383 Down-Regulates the Oncogene CIP2A to Influence Glioma Proliferation and Invasion.

abstract：BACKGROUND:The purpose of this study was to investigate the prognosis of ipsilateral supraclavicular lymph node metastasis (ISLM) without evidence of distant metastases at diagnosis in Chinese women with breast cancer and to elucidate the clinical value of adjuvant radiotherapy. METHODS:We performed a retrospective an...

journal_title：OncoTargets and therapy

authors： Wu SG,Sun JY,Zhou J,Li FY,Lin Q,Lin HX,He ZY

更新日期：2014-02-15 00:00:00

abstract：BACKGROUND:Lapatinib is a dual epidermal growth factor receptor (EGFR) and HER2 inhibitor. Overexpression of these receptors is frequently observed in head and neck squamous cell carcinoma (HNSCC). As growing proportion of HNSCC is characterized by human papillomavirus (HPV) infection, we aimed at evaluating the effica...

journal_title：OncoTargets and therapy

authors： Fumagalli I,Dugue D,Bibault JE,Clémenson C,Vozenin MC,Mondini M,Deutsch E

更新日期：2015-02-02 00:00:00

abstract：Purpose:Programmed death ligand 1 (PD-L1) is widely used for predicting immune checkpoint inhibitors but has a limited effect on predicting clinical response. The aim of this study was to examine the prognostic value and PD-1 inhibitor therapeutic efficiency of SNX20 in lung adenocarcinoma. Methods:We evaluated the mR...

journal_title：OncoTargets and therapy

authors： Fan L,Li L,Huang C,Huang S,Deng J,Xiong J

更新日期：2020-10-09 00:00:00

abstract：:Drug delivery system based on nanobiotechnology can improve the pharmacokinetics and therapeutic index of chemotherapeutic agents, which has revolutionized tumor therapy. Onivyde, also known as MM-398 or PEP02, is a nanoliposomal formulation of irinotecan which has demonstrated encouraging anticancer activity across a...

journal_title：OncoTargets and therapy

authors： Zhang H

更新日期：2016-05-20 00:00:00

abstract：:Background and aims: HOXD antisense growth-associated long noncoding RNA (HOXD-AS1) was reported to be upregulated in various cancers, such as gastric cancer, hepatocellular carcinoma, colorectal cancer, and glioma. Here, we conducted a meta-analysis and The Cancer Genome Atlas data review to investigate the clinicopa...

journal_title：OncoTargets and therapy

authors： Zhang F,Chen X,Xi K,Qiu Z,Wang Y,Gui Y,Hou Y,Chen K,Zhang X

更新日期：2018-11-05 00:00:00

abstract：Background:Abnormal miR-27a-3p expression has been frequently reported in several types of human cancer and contributes to tumor progression. However, the role and potential molecular mechanism of miR-27a-3p in the progression of pancreatic carcinoma have not been clarified. Materials and methods:The expression of miR...

journal_title：OncoTargets and therapy

authors： Rao X,Wan L,Jie Z,Zhu X,Yin J,Cao H

更新日期：2019-12-19 00:00:00

abstract：Introduction:Odd-skipped related transcription factor 1 (OSR1) is a newly identified tumor suppressor in many tumor types. However, the role and mechanism of OSR1 in colon adenocarcinoma (COAD) remain unknown. Methods:OSR1 expression was detected in COAD tissues and cells. COAD cells with OSR1 overexpression or knockd...

journal_title：OncoTargets and therapy

authors： Zhang F,Jiang Z

更新日期：2020-04-24 00:00:00

abstract：:Pancreatic cancer is a formidable malignancy with poor outcomes. The majority of patients are unable to undergo resection, which remains the only potentially curative treatment option. The management of locally advanced (unresectable) pancreatic cancer is controversial; however, treatment with either chemotherapy or c...

journal_title：OncoTargets and therapy

authors： Hong JC,Czito BG,Willett CG,Palta M

更新日期：2016-10-31 00:00:00

abstract：BACKGROUND:Recurrent laryngeal nerve (RLN) invasion in papillary thyroid carcinoma (PTC) is one of the main predictors of poor prognosis. The present study investigated the risk factors for RLN invasion in PTC patients. METHODS:A total of 3,236 patients who received thyroidectomy due to PTC in Thyroid and Parathyroid ...

journal_title：OncoTargets and therapy

authors： Chen W,Lei J,You J,Lei Y,Li Z,Gong R,Tang H,Zhu J

更新日期：2017-09-11 00:00:00

abstract：:Despite the prominent effects of BCR-ABL tyrosine kinase inhibitors (TKI) therapy in patients with chronic phase-chronic myeloid leukemia (CP-CML) and thus low incidence of blastic transformation, blast phase (BP)-CML remains a major therapeutic challenge in the TKI era. The "gatekeeper" mutation T315I in BCR-ABL1 kin...

journal_title：OncoTargets and therapy

authors： Zhou L,Shi H,Shi W,Yang L,Zhang Y,Xu M,Chen X,Zhu Y,Mu H,Wan X,Yang Z,Zeng Y,Liu H

更新日期：2019-12-13 00:00:00

abstract：Background:Deleted in breast cancer 1 (DBC1) is believed to be involved in human cancers. However, it is still uncertain whether DBC1 expression can be regarded as a prognostic factor in patients with various cancers. This meta-analysis aimed to evaluate the relationship between high levels of DBC1 and prognosis in tum...

journal_title：OncoTargets and therapy

authors： Liu G,Wu Q,Wang Y,Xiong Q,Fu F

更新日期：2019-02-22 00:00:00

abstract：:Lung cancer remains the leading cause of death in cancer patients. Severe treatment side effects and late stage of disease at diagnosis continue to be an issue. We investigated whether local treatment using 2-diethylaminoethyl-dextran methyl methacrylate copolymer with p53 (DDMC-p53) with or without cisplatin and/or m...

journal_title：OncoTargets and therapy

authors： Hohenforst-Schmidt W,Zarogoulidis P,Stopek J,Vogl T,Hübner F,Turner JF,Browning R,Zarogoulidis K,Drevelegas A,Drevelegas K,Darwiche K,Freitag L,Rittger H

更新日期：2015-05-20 00:00:00

abstract：:The fusion of echinoderm microtubule-associated protein-like 4 with anaplastic lymphoma kinase (ALK) was identified as a transforming gene for lung cancer in 2007. This genetic rearrangement accounts for 2%-5% of non-small-cell lung cancer (NSCLC) cases, occurring predominantly in younger individuals with adenocarcino...

journal_title：OncoTargets and therapy

authors： Iwama E,Okamoto I,Harada T,Takayama K,Nakanishi Y

更新日期：2014-03-05 00:00:00

abstract：PURPOSE:In asymptomatic patients with Stage IV colorectal cancer, the debate continues over the efficacy of primary resection compared to chemotherapy alone. The aim of this study was to define the optimal management for asymptomatic patients with colorectal cancer and unresectable liver metastases. PATIENTS AND METHO...

journal_title：OncoTargets and therapy

authors： Boselli C,Renzi C,Gemini A,Castellani E,Trastulli S,Desiderio J,Corsi A,Barberini F,Cirocchi R,Santoro A,Parisi A,Redler A,Noya G

更新日期：2013-01-01 00:00:00

abstract：Introduction:Cyclophosphamide, which is widely used to treat malignant disease, causes ovarian follicular atresia, which leads to premature ovarian insufficiency. The present study evaluated the protective effect of testosterone in preventing the decline in the ovarian reserve during cyclophosphamide treatment. Method...

journal_title：OncoTargets and therapy

authors： Yoo M,Tanaka T,Konishi H,Tanabe A,Taniguchi K,Komura K,Hayashi M,Ohmichi M

更新日期：2020-04-08 00:00:00

abstract：Background and objective:RNF6, an E3 ligase, has been reported to play an important role in the tumorigenesis in several tissues, but its role in gastric cancer is still unknown. In this study, we aimed to investigate the biological function and molecular mechanisms of RNF6 in gastric cancer. Materials and methods:The...

journal_title：OncoTargets and therapy

authors： Huang Z,Cai Y,Yang C,Chen Z,Sun H,Xu Y,Chen W,Xu D,Tian W,Wang H

更新日期：2018-10-05 00:00:00

abstract：OBJECTIVE:Resveratrol is a phytoestrogen with various antiproliferative and proapoptotic effects. This in vitro study aimed to analyze the effect of resveratrol on the viability and expression of modulators of apoptosis in GH3 pituitary adenoma cells of the rat. METHODS:GH3 cells were incubated with resveratrol concen...

journal_title：OncoTargets and therapy

authors： Voellger B,Kirches E,Wilisch-Neumann A,Weise A,Tapia-Perez JH,Rupa R,Mawrin C,Firsching R

更新日期：2013-09-16 00:00:00

abstract：:Quercetin is proven to have anticancer effects for many cancers. However, the role of tumor suppressor p53 on quercetin's radiosensitization and regulation of endoplasmic reticulum (ER) stress response in this process remains obscure. Here, quercetin exposure resulted in ER stress, prolonged DNA repair, and the expres...

journal_title：OncoTargets and therapy

authors： Gong C,Yang Z,Zhang L,Wang Y,Gong W,Liu Y

更新日期：2017-12-21 00:00:00

abstract：Introduction:The purpose of present study was to investigate the effect of limonin on tumor glycolysis and the underlying mechanisms in hepatocellular carcinoma (HCC). Methods:Cell proliferation and colony formation assays were performed to evaluate the potency of limonin against HCC cells in vitro. The glucose consum...

journal_title：OncoTargets and therapy

authors： Yao J,Liu J,Zhao W

更新日期：2018-07-03 00:00:00

abstract：OBJECTIVE:Malignant chest wall tumors are rare neoplasms. Resection with wide-free margins is an important prognostic factor, and massive chest wall resection and reconstruction are often necessary. A recent case series of 20 consecutive patients is reported in order to find any possible correlation between tumor histo...

journal_title：OncoTargets and therapy

authors： Foroulis CN,Kleontas AD,Tagarakis G,Nana C,Alexiou I,Grosomanidis V,Tossios P,Papadaki E,Kioumis I,Baka S,Zarogoulidis P,Anastasiadis K

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:The purpose of this research was to investigate the relationship between epidermal growth factor receptor (EGFR) mutations and the response to first-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). METHODS:A total of 266 patients with stage IIIB or IV NSCLC who received platin...

journal_title：OncoTargets and therapy

authors： Fang S,Wang Z,Guo J,Liu J,Li C,Liu L,Shi H,Liu L,Li H,Xie C,Zhang X,Sun W,Li M

更新日期：2014-07-01 00:00:00

abstract：Background:Cellular senescence-inhibited gene (CSIG) strongly prolongs the progression of replicative senescence. However, roles and mechanisms of CSIG in tumor progression have not been studied widely. Methods:Roles of CSIG in migration and proliferation of SMMC7721 and Huh7 cells were analyzed by transwell or cell v...

journal_title：OncoTargets and therapy

authors： Cheng Q,Tong TJ,Li Z,Hu SH,Chen DB,Wang SQ,Zhu JY

更新日期：2019-03-15 00:00:00

abstract：Background:The diagnosis rate of early stage esophageal squamous cell carcinoma (ESCC) is low due to the lack of specific tumor markers. Seeking for these markers is beneficial to improve the early diagnosis rate and the prognosis of patients. This study profiles the differentially expressed proteins of early stage ESC...

journal_title：OncoTargets and therapy

authors： Tong Q,Wang XL,Li SB,Yang GL,Jin S,Gao ZY,Liu XB

更新日期：2018-09-12 00:00:00

abstract：Objective:This study aimed to evaluate the safety and efficacy of intensity-modulated radiotherapy (IMRT) plus nimotuzumab with or without concurrent chemotherapy (CCT) for patients with locally advanced nasopharyngeal carcinoma (LA-NPC). Patients and methods:A total of 50 newly diagnosed patients with LA-NPC treated ...

journal_title：OncoTargets and therapy

authors： Huang J,Zou Q,Qian D,Zhou L,Yang B,Chu J,Pang Q,Wang K,Zhang F

更新日期：2017-12-08 00:00:00

abstract：INTRODUCTION:The prognostic impact of smoking and drinking on esophageal squamous cell carcinoma (ESCC) was scarcely discussed. We investigated the prognostic value of smoking and drinking and their relationships with clinicopathological characteristics in a large cohort of patients with locoregional ESCC. PATIENTS AN...

journal_title：OncoTargets and therapy

authors： Sun P,Chen C,Zhang F,Yang H,Bi XW,An X,Wang FH,Jiang WQ

更新日期：2016-07-13 00:00:00

abstract：Background:Celastrol is a major active component of the thunder god vine (Tripterygium wilfordii) used in traditional Chinese medicine to treat chronic inflammatory and autoimmune diseases. Celastrol inhibits PI3K-Akt-mTOR signaling, which is frequently dysregulated in tumors and critical for tumor-cell proliferation a...

journal_title：OncoTargets and therapy

authors： Li X,Zhu G,Yao X,Wang N,Hu R,Kong Q,Zhou D,Long L,Cai J,Zhou W

更新日期：2018-12-11 00:00:00

abstract：:Hodgkin lymphoma (HL) and anaplastic large-cell lymphoma (ALCL) account for ~10% and 2%-3% of all cases of lymphoid neoplasms, respectively. Up to 30% of patients with HL are refractory or relapse after first-line therapy, and elderly patients with HL represent a subgroup of patients with suboptimal responses to the c...

journal_title：OncoTargets and therapy

authors： Donato EM,Fernández-Zarzoso M,Hueso JA,de la Rubia J

更新日期：2018-08-06 00:00:00

abstract：Purpose:The proportion of central pulmonary adenocarcinoma (ADC) in central-type lung cancer has been gradually increasing due to the overall increasing incidence of pulmonary ADC. But the clinical and radiological characteristics of central ADCs remain unclear. In this study, we compared the clinical and radiological ...

journal_title：OncoTargets and therapy

authors： Wang Z,Li M,Huang Y,Ma L,Zhu H,Kong L,Yu J

更新日期：2018-05-04 00:00:00

abstract：Background:Patients with BRAF (v-Raf murine sarcoma viral oncogene homolog B) V600E-mutated metastatic colorectal cancer (mCRC) have a poor prognosis. The Southwest Oncology Group (SWOG) 1406 study evaluated the efficacy of vemurafenib in combination with irinotecan and cetuximab for simultaneous inhibition of epiderma...

journal_title：OncoTargets and therapy

authors： Wang Z,Dai WP,Zang YS

更新日期：2019-01-08 00:00:00

abstract：OBJECTIVE:To study microRNA (miR)-20a expression in hepatocellular carcinoma (HCC) and its effects on the proliferation, migration, and invasion of HepG2. METHODS:The real-time polymerase chain reaction was used to detect the expression of miR-20a in HCC tissue and normal tissue, as well as in HCC cell lines and norma...

journal_title：OncoTargets and therapy

authors： Chen GS,Zhou N,Li JQ,Li T,Zhang ZQ,Si ZZ

更新日期：2016-05-27 00:00:00