Predictive factors and prognosis for recurrent laryngeal nerve invasion in papillary thyroid carcinoma.

abstract：:EGFR pathway is an important therapeutic target in human tumors, including metastatic colorectal cancer (mCRC). The advent of EGFR-targeted monoclonal antibodies panitumumab and cetuximab has generated promise for the treatment of mCRC and has largely improved patients' progression-free survival (PFS) and overall surv...

journal_title：OncoTargets and therapy

authors： Liu J,Hu J,Cheng L,Ren W,Yang M,Liu B,Xie L,Qian X

更新日期：2016-01-27 00:00:00

abstract：BACKGROUND:Increasing evidence suggests that the dysregulation of certain microRNAs plays an important role in tumorigenesis and metastasis. MiR-200c exhibits a disordered expression in many tumors and presents dual roles in bladder cancer (BC). Therefore, the definite role of miR-200c in BC needs to be investigated fu...

journal_title：OncoTargets and therapy

authors： Cheng Y,Zhang X,Li P,Yang C,Tang J,Deng X,Yang X,Tao J,Lu Q,Li P

更新日期：2016-08-16 00:00:00

abstract：BACKGROUND:Breast cancer stem cells with a CD44(+)CD24(-) phenotype are the origin of breast tumors. Strong CD44 expression in this population indicates its important role in maintaining the stem cell phenotype. Previous studies show that CD44 down-regulation causes CD44(+)CD24(-) breast cancer stem cells to differenti...

journal_title：OncoTargets and therapy

authors： Van Pham P,Vu NB,Duong TT,Nguyen TT,Truong NH,Phan NL,Vuong TG,Pham VQ,Nguyen HM,Nguyen KT,Nguyen NT,Nguyen KG,Khat LT,Van Le D,Truong KD,Phan NK

更新日期：2012-01-01 00:00:00

abstract：Background:Recent evidence showed cancerous inhibitor of protein phosphatase 2A (CIP2A) plays carcinogenesis roles in several types of human cancer. However, the expression and function of CIP2A in gliomas are unknown. Methods:qRT-PCR, IHC and Western blot were used to evaluate CIP2A expression in glioma tissues and ...

journal_title：OncoTargets and therapy

authors： Zhang S,Wang K

更新日期：2020-05-12 00:00:00

abstract：Backgrounds:microRNA-493-3p (miR-493) has been reported to be critically downregulated in multiple types of human cancer. However, the expression level, biological roles and underlying mechanism of miR‑493 in tongue squamous cell carcinoma (TSCC) remain to be elucidated. Methods:RT-qPCR was utilized for the determinat...

journal_title：OncoTargets and therapy

authors： Jiao D,Liu Y,Tian Z

更新日期：2019-08-28 00:00:00

abstract：:Programmed cell death-1 (PD-1) immune checkpoint inhibitors have exhibited promising efficacy in various types of tumors. Here, we report an unresectable locally advanced gastric cancer (GC) with programmed cell death ligand-1 (PD-L1) positive and microsatellite instability (MSI), which exhibiting an unexpected effica...

journal_title：OncoTargets and therapy

authors： Jin H,Li P,Mao C,Zhu K,Chen H,Gao Y,Yu J

更新日期：2020-02-26 00:00:00

abstract：BACKGROUND:MicroRNA (miR)-126, acting as a tumor suppressor, has been reported to inhibit the invasion of gastric cancer cells in part by targeting v-crk sarcoma virus CT10 oncogene homologue (CRK). The aim of this study was to investigate the clinical significance of miR-126/CRK axis in gastric cancer. METHODS:miR-12...

journal_title：OncoTargets and therapy

authors： Yue S,Shi H,Han J,Zhang T,Zhu W,Zhang D

更新日期：2016-10-11 00:00:00

abstract：Background:It was previously reported that downregulation of miR-218 promoted thyroid cancer cell invasion, migration, and proliferation. However, the biological functions of miR-218 and its possible regulatory mechanisms in papillary thyroid cancer (PTC) cells are still elusive. Materials and methods:The expression l...

journal_title：OncoTargets and therapy

authors： Han M,Chen L,Wang Y

更新日期：2018-09-28 00:00:00

abstract：Purpose:Here, we investigated the involvement of the miR-188-5p/inhibitor of the DNA binding 4 (ID4) axis in retinoblastoma (Rb). Patients and methods:We included 35 Rb tissues and the corresponding adjacent normal tissues. RT-qPCR, Western blot, lentivirus transfection, measurement of cell migration in vitro, and chi...

journal_title：OncoTargets and therapy

authors： Yang M,Li Y,Wei W

更新日期：2019-11-27 00:00:00

abstract：Purpose:Both obesity and gender are important etiological factors in renal cell carcinoma (RCC) development, suggesting a pivotal role of sex hormone signaling pathway and insulin-like growth factor (IGF) family in RCC carcinogenesis. Here, we aimed to investigate the effect of estrogen on RCC growth and the possible i...

journal_title：OncoTargets and therapy

authors： Sun L,Gao Z,Luo L,Tan H,Zhang G

更新日期：2018-09-17 00:00:00

abstract：Background:The oncogenic potential of special AT-rich binding protein 1 (SATB1) has been reported in various types of cancer, but its function in cervical cancer remains not fully investigated. This study aimed to investigate the effect of SATB1 mRNA expression on tumor progression and outcomes in the cervical cancer p...

journal_title：OncoTargets and therapy

authors： Zhao L,Zheng Y,Ji Y,Zhang X

更新日期：2019-01-30 00:00:00

abstract：:Lung cancer has the highest morbidity and mortality in the world, and non-small cell lung carcinomas (NSCLC) account for 80% of cases of lung cancer. The mechanism of NSCLC is still largely unknown, and finding novel targets is of great importance for the treatment of NSCLC. The current study was designed to evaluate ...

journal_title：OncoTargets and therapy

authors： He M,Xue Y

更新日期：2017-03-02 00:00:00

abstract：Background:Pancreatic cancer (PC) is one of the fatal cancers globally. CircDEAD-box helicase 42 (circDDX42) has been reported to play an oncogenic role in many cancers. The purpose of our study was to explore the relationship between circDDX42 and PC development and the potential mechanism by which circDDX42 modulatin...

journal_title：OncoTargets and therapy

authors： Yan Z,Yin H,Lin G

更新日期：2020-10-28 00:00:00

abstract：Background:Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Long non-coding RNA taurine-upregulated gene 1 (lncRNA TUG1) has been discovered to participate in multiple cancers including AML. However, the detailed mechanism of TUG1 in AML remains obscure. Materials and methods:AML cell ...

journal_title：OncoTargets and therapy

authors： Li G,Zheng P,Wang H,Ai Y,Mao X

更新日期：2019-11-29 00:00:00

abstract：Background:Patients with BRAF (v-Raf murine sarcoma viral oncogene homolog B) V600E-mutated metastatic colorectal cancer (mCRC) have a poor prognosis. The Southwest Oncology Group (SWOG) 1406 study evaluated the efficacy of vemurafenib in combination with irinotecan and cetuximab for simultaneous inhibition of epiderma...

journal_title：OncoTargets and therapy

authors： Wang Z,Dai WP,Zang YS

更新日期：2019-01-08 00:00:00

abstract：PURPOSE:This study aimed to spare hematopoietical bone marrow (BM) identified by magnetic resonance (MR) radiation in order to alleviate acute hematologic toxicity (HT) for gastric cancer patients treated with postoperative chemoradiotherapy (CRT). METHODS:A prospective, open-label, single-arm Phase II study (Clinical...

journal_title：OncoTargets and therapy

authors： Wang J,Tian Y,Tang Y,Wang X,Li N,Ren H,Fang H,Feng Y,Wang S,Song Y,Liu Y,Wang W,Li Y,Jin J

更新日期：2016-05-05 00:00:00

abstract：Background:Bladder cancer is a serious threat to human health. It is meaningful to study the pathogenesis of bladder cancer. Long non-coding RNAs (lncRNAs) are reported to promote or inhibit bladder cancer development. However, the role of lncRNA BCAR4 in the regulation of bladder cancer remains unclear. Purpose:This ...

journal_title：OncoTargets and therapy

authors： Wang X,He H,Rui W,Xie X,Wang D,Zhu Y

更新日期：2020-03-24 00:00:00

abstract：:Multiple drug resistance is still an unsolved problem in cancer therapy. Our previous study demonstrated that the chemotherapeutic drug doxorubicin (Dox) induced upregulation of P-glycoprotein (P-gp) in endothelial cells, resulting in a 20-fold increase in drug resistance and reduced efficiency of Dox treatment in a m...

journal_title：OncoTargets and therapy

authors： Huang L,Hu C,Di Benedetto M,Varin R,Liu J,Wang L,Vannier JP,Jin J,Janin A,Lu H,Li H

更新日期：2014-12-04 00:00:00

abstract：Objective:Multidrug resistance-associated protein 2 (MRP2), encoded by ABCC2 gene, is involved in the efflux of certain anticancer drugs. Here we observed whether the ABCC2 (G1249A) polymorphism impacts the transport abilities of MRP2-dependent paclitaxel, docetaxel, and doxorubicin in recombinant LLC-PK1 cell lines. ...

journal_title：OncoTargets and therapy

authors： Lian G,Yuan J,Gao Y

更新日期：2020-02-17 00:00:00

abstract：Objective:This study aimed to evaluate the safety and efficacy of intensity-modulated radiotherapy (IMRT) plus nimotuzumab with or without concurrent chemotherapy (CCT) for patients with locally advanced nasopharyngeal carcinoma (LA-NPC). Patients and methods:A total of 50 newly diagnosed patients with LA-NPC treated ...

journal_title：OncoTargets and therapy

authors： Huang J,Zou Q,Qian D,Zhou L,Yang B,Chu J,Pang Q,Wang K,Zhang F

更新日期：2017-12-08 00:00:00

abstract：Background:Immunosenescence, the age-related decline of immunity, affects the immune responses of melanoma patients. Through immune responses, immune checkpoint inhibitors (ICIs) exert their antitumor robustness. In different ages of melanoma patients, especially the older patients, the effectiveness of ICIs remains un...

journal_title：OncoTargets and therapy

authors： Li P,Yang X,Feng Y,Wu L,Ma W,Ding G,Wei Y,Sun L

更新日期：2018-10-26 00:00:00

abstract：Background:Several trials evaluated the role of intensive regimens, made of triplet chemotherapies plus bevacizumab, as first-line treatment for patients with metastatic colorectal cancer (mCRC). We previously reported, in a Phase II prospective study, the efficacy and the tolerability of FIrB/FOx regimen, reporting in...

journal_title：OncoTargets and therapy

authors： Cortellini A,Cannita K,Parisi A,Lanfiuti Baldi P,Venditti O,D'Orazio C,Dal Mas A,Calvisi G,Giordano AV,Vicentini V,Vicentini R,Felicioni L,Marchetti A,Buttitta F,Russo A,Ficorella C

更新日期：2019-03-25 00:00:00

abstract：:Understanding of molecular mechanisms of tumor growth has an increasing impact on the development of diagnostics and targeted therapy of human neoplasia. In this review, we summarize the current knowledge on molecular mechanisms and their clinical implications in von Hippel-Lindau (VHL) disease. This autosomal dominan...

journal_title：OncoTargets and therapy

authors： Gläsker S,Vergauwen E,Koch CA,Kutikov A,Vortmeyer AO

更新日期：2020-06-16 00:00:00

abstract：Background:Previous studies have reported that nuclear receptor subfamily 5, group A, member 2 (NR5A2) polymorphisms (rs3790843 G>A, rs3790844 T>C, rs12029406 C>T) are associated with the risk of pancreatic cancer. However, the results of epidemiological investigations are still controversial. In order to explore its p...

journal_title：OncoTargets and therapy

authors： Chen Q,Yuan H,Shi GD,Wu Y,Liu DF,Lin YT,Chen L,Ge WL,Jiang K,Miao Y

更新日期：2018-05-09 00:00:00

abstract：Background:Renal cell cancer (RCC) is one of the most lethal malignancies of the kidney in adults. mTOR (mammalian target of rapamycin) signaling pathway plays a pivotal role in RCC tumorigenesis and progression and inhibitors targeting the mTOR pathway have been widely used in advanced RCC treatment. Therefore, it is ...

journal_title：OncoTargets and therapy

authors： Zhu X,Xu A,Zhang Y,Huo N,Cong R,Ma L,Chu Z,Tang Z,Kang X,Xian S,Xu X

更新日期：2020-10-15 00:00:00

abstract：Purpose:Hepatocellular carcinoma (HCC) has a high incidence in China and exploring effective ways for early diagnosis is an important method to improve the prognosis of patients with HCC. Additional studies reported that. Some kinds of microRNA (miRNA) in plasma will change accordingly during HCC progress, and this cha...

journal_title：OncoTargets and therapy

authors： Wang S,Yang Y,Sun L,Qiao G,Song Y,Liu B

更新日期：2020-03-09 00:00:00

abstract：BACKGROUND:Persistent infection with high-risk human papillomavirus (HPV) is a predominant cause of cervical cancer, and HPV58 is the third most common virus detected in the patients with cervical cancer in Asia. E6 and E7 are the viral oncogenes which are constitutively expressed in HPV-associated tumor cells and can ...

journal_title：OncoTargets and therapy

authors： Wang H,Yu J,Li L

更新日期：2015-10-23 00:00:00

abstract：Background:Many studies have explored the prognostic value of T-cell lymphoma invasion and metastasis inducing factor 1 (Tiam1) and its association with lymphatic metastasis in malignant solid tumors, but the conclusions remain controversial. Therefore, we performed a meta-analysis to systematically assess the prognost...

journal_title：OncoTargets and therapy

authors： Yang C,Ma C,Li Y,Mo P,Yang Y

更新日期：2019-07-25 00:00:00

abstract：Background:Breast cancer (BC) has been the commonest malignant tumor with a low survival rate among woman. Long non-coding RNA hypoxia-inducible factor-1 alpha antisense RNA-2 (HIF1A-AS2) was correlated with various cancers. Purpose:The study aimed to investigate the roles and related underlying molecular mechanisms o...

journal_title：OncoTargets and therapy

authors： Guo X,Lee S,Cao P

更新日期：2019-01-24 00:00:00

abstract：BACKGROUND:Fibroblast growth factor receptor 4 (FGFR4) has been proved to be correlated with progression and prognosis in many cancers. However, the significance of FGFR4 in non-small-cell lung cancer (NSCLC) is still not well elucidated. METHODS:In our experiment, we detected FGFR4 expression in 237 samples of NSCLC ...

journal_title：OncoTargets and therapy

authors： Huang HP,Feng H,Qiao HB,Ren ZX,Zhu GD

更新日期：2015-05-22 00:00:00