Induction of multiple drug resistance in HMEC-1 endothelial cells after long-term exposure to sunitinib.

abstract：:Circulating tumor DNA (ctDNA) can be identified in the peripheral blood of patients and harbors the genomic alterations found in tumor tissues, which provides a noninvasive approach for detection of gene mutations. We conducted this meta-analysis to investigate whether ctDNA can be used for monitoring KRAS gene mutati...

journal_title：OncoTargets and therapy

authors： Hao YX,Fu Q,Guo YY,Ye M,Zhao HX,Wang Q,Peng XM,Li QW,Wang RL,Xiao WH

更新日期：2017-02-16 00:00:00

abstract：Introduction:Colorectal cancer (CRC) is the fourth most common cause of cancer-related mortality worldwide. The tumor, node, metastasis (TNM) stage remains the standard for CRC prognostication. Identification of meaningful microRNA (miRNA) and gene modules or representative biomarkers related to the pathological stage ...

journal_title：OncoTargets and therapy

authors： Zhou XG,Huang XL,Liang SY,Tang SM,Wu SK,Huang TT,Mo ZN,Wang QY

更新日期：2018-05-15 00:00:00

abstract：:Advanced gastric cancer (AGC) is difficult to treat with poor prognosis. Despite various possible treatments, the median survival time of such patients remains unsatisfactory. Therefore, new therapeutic approaches or combinations need to be further explored. We herein reported a case of a 54-year-old male patient who ...

journal_title：OncoTargets and therapy

authors： Yu S,Cai L,Lin F,Wu X,Zhang C,Liu X,Li W

更新日期：2019-09-19 00:00:00

abstract：:During the past decade, immunotherapy targeting immune checkpoints has become an important component of the treatment paradigm for numerous malignancies, especially PD-1/PD-L1 blockade which was demonstrated to rejuvenate disabled T cells in cancer patients to achieve long-term remissions. However, the clinical outcom...

journal_title：OncoTargets and therapy

authors： Cai J,Wang D,Zhang G,Guo X

更新日期：2019-10-15 00:00:00

abstract：:Hormone-receptor-positive breast cancer is the most common subtype of breast cancer among patients with both early-stage and metastatic disease. Recent advances in the understanding of its pathophysiology have led to the discovery and utilization of targeted inhibitors to cyclin-dependent kinases 4 and 6 (CDK4/6). The...

journal_title：OncoTargets and therapy

authors： Martin JM,Goldstein LJ

更新日期：2018-08-29 00:00:00

abstract：:Normal astrocytes are more resistant to radiation than glioma cells. Radiation-resistant glioma cells and normal astrocytes usuallly share similar mechanisms of radioresistance. Investigation of the underlying mechanisms of differential radiation response between normal astrocytes and glioma cells is thus significant ...

journal_title：OncoTargets and therapy

authors： Gong L,Gu J,Ge J,Wu X,Zhang C,Yang C,Weng W,Gao G,Feng J,Mao Q

更新日期：2017-12-04 00:00:00

abstract：Purpose:Long intergenic non-protein coding RNA 519 (LINC00519) promotes the development of lung squamous cell carcinoma. In this study, we detected the expression of LINC00519 in tongue squamous cell carcinoma (TSCC) and examined its clinical significance. Additionally, the regulatory effects of LINC00519 on behaviors ...

journal_title：OncoTargets and therapy

authors： Liu D,Zhao J,Wang H,Li H,Li Y,Qin W

更新日期：2020-11-20 00:00:00

abstract：PURPOSE:To investigate the biological effect of gyromagnetic fields (GMFs) on cell proliferation and apoptosis of human prostatic adenocarcinoma cells and explore the underlying mechanisms. METHODS:PC-3 cells were grouped into normal control (NC) and GMF treatment groups. Cell proliferation was analyzed with kit-8 and...

journal_title：OncoTargets and therapy

authors： Lei H,Xu Y,Guan R,Li M,Hui Y,Gao Z,Yang B,Xin Z

更新日期：2015-11-24 00:00:00

abstract：:POEMS syndrome (acronym consisting of: polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) is an uncommon disorder associated with an underlying plasma cell dyscrasia. There is no single specific test for POEMS, and due to its rarity and heterogeneity, patients are often mis- or underdiagnosed. ...

journal_title：OncoTargets and therapy

authors： Găman M,Vlădăreanu AM,Dobrea C,Onisâi M,Marinescu C,Cîşleanu D,Ciufu C,Vasile D,Bumbea H,Voican I

更新日期：2018-09-27 00:00:00

abstract：Aim:The use of bevacizumab in combination therapy is an emerging trend in metastatic colorectal cancer treatment. However, the clinical value of different combination types remains under debate. Thus, a meta-analysis of randomized controlled trials (RCTs) comparing bevacizumab-based combination therapy with monotherapy...

journal_title：OncoTargets and therapy

authors： Xu R,Xu C,Liu C,Cui C,Zhu J

更新日期：2018-12-04 00:00:00

abstract：Background and aims:Gastric cancer (GC) is one of the most common cancers worldwide, and its pathogenesis is related to a complex network of gene interactions. The aims of our study were to find hub genes associated with the progression and prognosis of GC and illustrate the underlying mechanisms. Methods:Weighted gen...

journal_title：OncoTargets and therapy

authors： Chen PF,Wang F,Nie JY,Feng JR,Liu J,Zhou R,Wang HL,Zhao Q

更新日期：2018-10-02 00:00:00

abstract：INTRODUCTION:To investigate the clinical features, diagnosis, treatment, and prognosis of ductal adenocarcinoma of the prostate. METHODS:The clinicopathological and immunohistochemical data of seven patients with ductal adenocarcinoma of the prostate were retrospectively analyzed. All patients underwent physical exami...

journal_title：OncoTargets and therapy

authors： Sha J,Bo J,Pan J,Zhang L,Xuan H,Chen W,Li D,Wang Z,Liu D,Huang Y

更新日期：2013-10-24 00:00:00

abstract：:The clinicopathological and prognostic significance of telomerase reverse transcriptase (TERT) promoter mutations have been widely investigated in thyroid cancer; however, the results are still discrepant. Systematic searches were performed in PubMed, Web of Science, Scopus, Ovid, and the Cochran Library databases for...

journal_title：OncoTargets and therapy

authors： Su X,Jiang X,Wang W,Wang H,Xu X,Lin A,Teng X,Wu H,Teng L

更新日期：2016-11-11 00:00:00

abstract：OBJECTIVE:High-mobility group protein 2 (HMGA2) and epithelial-mesenchymal transition (EMT)-associated proteins play key roles in cancer progression and metastasis. However, the clinical significance of HMGA2 and its relationship with EMT markers in nasopharyngeal carcinoma (NPC) is unclear. This study aimed to assess ...

journal_title：OncoTargets and therapy

authors： Xia YY,Yin L,Tian H,Guo WJ,Jiang N,Jiang XS,Wu J,Chen M,Wu JZ,He X

更新日期：2015-01-17 00:00:00

abstract：:This study aimed to investigate the expression and clinical significance of MYC-associated zinc finger protein (MAZ) in pancreatic carcinoma (PC), and the biological functions of MAZ in PC cells. MAZ expression was detected in 57 PC tissues and 41 paired adjacent nontumor tissues by immunohistochemistry. Compared to t...

journal_title：OncoTargets and therapy

authors： Zhu X,Luo W,Liang W,Tang F,Bei C,Ren Y,Qin L,Tan C,Zhang Y,Tan S

更新日期：2016-12-12 00:00:00

abstract：Purpose:This study is aimed to investigate the combined treating efficacy of sodium butyrate and docetaxel on proliferation and apoptosis of the lung adenocarcinoma A549 cell line based on Gli1 regulation in vitro and in vivo. Materials and Methods:RNA interference method was used to overexpress Gli1 in A549 cells. Ce...

journal_title：OncoTargets and therapy

authors： Chen M,Jiang W,Xiao C,Yang W,Qin Q,Mao A,Tan Q,Lian B,Wei C

更新日期：2020-09-04 00:00:00

abstract：Background:LncRNA cancer susceptibility candidate 15 (CASC15) has been demonstrated to act as an oncogene in different cancers; however, its role in ovarian cancer remains elusive. Methods:Quantitative real-time PCR (qRT-PCR) was performed to examine the expression of lncRNA CASC15. Kaplan-Meier survival analysis was ...

journal_title：OncoTargets and therapy

authors： Shi Y,Gao S,Zheng Y,Yao M,Ruan F

更新日期：2019-10-23 00:00:00

abstract：Objective:To explore the regulatory effects of circZNF609 on proliferative and migratory capacities of gastric cancer (GC) and its underlying mechanism. Methods:Expression level of circZNF609, CDK6 and miR-483-3p in GC tissues and cells were detected qRT-PCR verification. CCK-8 and transwell assay were conducted the c...

journal_title：OncoTargets and therapy

authors： Wu W,Wei N,Shao G,Jiang C,Zhang S,Wang L

更新日期：2019-10-04 00:00:00

abstract：:The study aimed to investigate the difference of setup errors on different registration in the treatment of nasopharyngeal carcinoma based on weekly cone-beam computed tomography (CBCT). Thirty nasopharyngeal cancer patients scheduled to undergo intensity-modulated radiotherapy (IMRT) were prospectively enrolled in th...

journal_title：OncoTargets and therapy

authors： Su J,Chen W,Yang H,Hong J,Zhang Z,Yang G,Li L,Wei R

更新日期：2015-09-14 00:00:00

abstract：Background:Bromodomain and extra-terminal domain inhibitors like JQ1 have proved to be promising epigenetic agents for the treatment of malignant ovarian carcinoma. However, the resistance of ovarian cancer cells to BET inhibitors has not been elucidated. In this study, we investigated the potential mechanisms underlyi...

journal_title：OncoTargets and therapy

authors： Luan W,Pang Y,Li R,Wei X,Jiao X,Shi J,Yu J,Mao H,Liu P

更新日期：2019-10-03 00:00:00

abstract：Background:Papillary thyroid cancer (PTC) is a common endocrine malignancy with relatively good prognosis. Radioactive iodine (RAI) is considered effective for patients with total or nearly total thyroidectomy, but the beneficial effects of RAI are still controversial. Materials and methods:To determine whether RAI th...

journal_title：OncoTargets and therapy

authors： Tang J,Kong D,Cui Q,Wang K,Zhang D,Liao X,Gong Y,Wu G

更新日期：2018-06-19 00:00:00

abstract：Background:LncRNA EMX2OS (EMX2 opposite strand/antisense RNA) is notably downregulated in prostate cancer (PCa) tissues and may be regarded as a potential molecular biomarker for diagnosis and prognosis. However, its exact role in regulating the development of PCa is obscure. Methods:The EMX2OS expression was assessed...

journal_title：OncoTargets and therapy

authors： Wang Z,Zhang C,Chang J,Tian X,Zhu C,Xu W

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:Studies on the association between two single nucleotide polymorphisms (SNPs) in estrogen receptor α (ERα), PvuII (rs2234693 T>C) and XbaI (rs9340799 A>G), and the prostate cancer risk are inconsistent. Therefore, we performed a meta-analysis to derive a more accurate estimation of this relationship. METHOD...

journal_title：OncoTargets and therapy

authors： Zhao Y,Zheng X,Zhang L,Hu Q,Guo Y,Jiang H,Shi S,Zhang X

更新日期：2017-06-29 00:00:00

abstract：:The aim of this study was to investigate the clinical characteristics and efficacy of chronic myeloid leukemia (CML) onset with extreme thrombocytosis. A total of 121 newly diagnosed and untreated CML patients in chronic phase with complete clinical information from the First Hospital of Jilin University, from January...

journal_title：OncoTargets and therapy

authors： Liu Z,Fan H,Li Y,Liu C

更新日期：2017-07-17 00:00:00

abstract：:[This corrects the article DOI: 10.2147/OTT.S196910.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2019-09-19 00:00:00

abstract：:The mitogen-activated protein kinase (MAPK) pathway is a critical oncogenic driver signal in a number of malignancies. The discovery of activating mutations in the MAPK pathway has led to the development of MAPK pathway inhibitors. Selumetinib is a potent and selective inhibitor of MEK1 and MEK2, which are essential d...

journal_title：OncoTargets and therapy

authors： Kim DW,Patel SP

更新日期：2014-09-19 00:00:00

abstract：OBJECTIVE:To investigate the effects of microRNA-122 (miR-122) on proliferation, migration, and invasion in human hepatocellular carcinoma (HCC) cells by activating epithelial-mesenchymal transition (EMT) pathways. METHODS:miR-122 mimics, miR-122 inhibitors, relevant control oligonucleotides, and Wnt1 were transfected...

journal_title：OncoTargets and therapy

authors： Wang N,Wang Q,Shen D,Sun X,Cao X,Wu D

更新日期：2016-04-06 00:00:00

abstract：Background/aim:Urothelial bladder cancer arises from the accumulation of multiple epigenetic and genetic changes. We aimed to investigate the specificity and sensitivity of gene-specific promoter methylation of CDH1 and p14ARF genes in the early diagnosis of bladder cancer and compare those with other diagnostic tests ...

journal_title：OncoTargets and therapy

authors： Bayramov B,Gunes S,Buyukalpelli R,Aydın O,Henkel R

更新日期：2018-07-19 00:00:00

abstract：BACKGROUND:Leucine-rich glioma inactivated 3 (LGI3) is a secreted protein member of LGI family. We previously reported that LGI3 was expressed in brain, adipose tissues and skin, where it played roles as a multifunctional cytokine. We postulated that LGI3 may be involved in cytokine network in cancers. AIM:This study ...

journal_title：OncoTargets and therapy

authors： Kwon NS,Kim DS,Yun HY

更新日期：2017-05-24 00:00:00

abstract：:Breast cancer is one of the most common malignant cancers among women and a major clinical obstacle. Although studies have reported the abnormal expression of SIRT7 in breast cancer, whether the function of SIRT7 regulates the expression of long noncoding RNAs (lncRNAs) in breast cancer remains unknown. We aimed to de...

journal_title：OncoTargets and therapy

authors： Chen KL,Li L,Wang YR,Li CM,Badri TM,Wang GL

更新日期：2017-10-24 00:00:00