Long noncoding RNA and mRNA profiling in MDA-MB-231 cells following RNAi-mediated knockdown of SIRT7.

abstract：Background:Growth differentiation factor (GDF) acted as a factor that regulated proliferation, apoptosis and differentiation in several tumors. However, the effects of growth differentiation factor (GDF11) in pancreatic cancer remain unclear. Purpose:To investigate the expression and significance of GDF11 in pancreati...

journal_title：OncoTargets and therapy

authors： Liu Y,Shao L,Chen K,Wang Z,Wang J,Jing W,Hu M

更新日期：2018-11-27 00:00:00

abstract：:Lymphangioleiomyomatosis (LAM) is a rare disease that generally affects young women and involves the abnormal proliferation of smooth muscle-like cells (LAM cells) in the lungs (pulmonary LAM) and extrapulmonary sites (extrapulmonary LAM). This disease is rare in males. It is hard to distinguish between lung cancer an...

journal_title：OncoTargets and therapy

authors： Liu Y,Guo Z,Zhao C,Li X,Liu H,Chen J

更新日期：2018-08-31 00:00:00

abstract：:In the last decade, the advent of biological targeted therapies has revolutionized the management of several types of cancer, especially in the realm of hematologic malignancies. One of these pathways, and the center of this review, is the phosphatidylinositol-3-kinase (PI3K) pathway. The PI3K pathway seems to play an...

journal_title：OncoTargets and therapy

authors： Castillo JJ,Iyengar M,Kuritzky B,Bishop KD

更新日期：2014-02-21 00:00:00

abstract：PURPOSE:We validated the use of expression sequence tags (ESTs) as an effective method of screening for DNA segments that could predict urothelial cell carcinoma and for identifying ESTs with such predictive value. PATIENTS AND METHODS:From 2004 to 2009, eleven patients were enrolled in this study: six with high-grade...

journal_title：OncoTargets and therapy

authors： Yang PS,Hsu YC,Lin YH,Hou CP,Chen CL,Chang PL,Juang HH,Tsui KH

更新日期：2014-09-30 00:00:00

abstract：BACKGROUND:Chemotherapy is not limited to a single treatment, and the evidence demonstrates that different drug combinations can have positive results in patients. In this study, we sought to determine whether cordycepin combined with cisplatin and/or paclitaxel would have an additive effective on inducing apoptosis in...

journal_title：OncoTargets and therapy

authors： Kang FC,Chen PJ,Pan BS,Lai MS,Chen YC,Huang BM

更新日期：2015-09-01 00:00:00

abstract：Purpose:Tumor-associated macrophages (TAMs) originate from monocytes and differentiate into mature macrophages. The interaction between cancer cells and TAMs promotes tumor growth and suppresses immunosurveillance. However, this phenomenon has seldom been observed in ampullary cancer. Patients and Methods:TAMs in ampu...

journal_title：OncoTargets and therapy

authors： Cheng LC,Chao YJ,Wang CY,Phan NN,Chen YL,Wang TW,Hsu HP,Lin YJ,Shan YS,Lai MD

更新日期：2020-08-03 00:00:00

abstract：Background:Many studies have explored the prognostic value of T-cell lymphoma invasion and metastasis inducing factor 1 (Tiam1) and its association with lymphatic metastasis in malignant solid tumors, but the conclusions remain controversial. Therefore, we performed a meta-analysis to systematically assess the prognost...

journal_title：OncoTargets and therapy

authors： Yang C,Ma C,Li Y,Mo P,Yang Y

更新日期：2019-07-25 00:00:00

abstract：:The incidence rate of breast cancers in People's Republic of China has increased in the last decade, and many cases are responsive to hormone therapies. The third-generation aromatase inhibitor letrozole inhibits estrogen production, and is more efficacious than the estrogen receptor inhibitor tamoxifen. In recent yea...

journal_title：OncoTargets and therapy

authors： He DX,Ma X

更新日期：2016-03-01 00:00:00

abstract：Background and objective:Transcriptional coactivator with PDZ-binding motif (TAZ) has been found to be associated with tumor progression. Mitochondrial homeostasis regulates cancer cell viability and metastasis. However, the roles of TAZ and mitochondrial homeostasis in liver cancer viability have not been explored. Th...

journal_title：OncoTargets and therapy

authors： Hou Y,Lan C,Kong Y,Zhu C,Peng W,Huang Z,Zhang C

更新日期：2019-03-01 00:00:00

abstract：Background and objective:RNF6, an E3 ligase, has been reported to play an important role in the tumorigenesis in several tissues, but its role in gastric cancer is still unknown. In this study, we aimed to investigate the biological function and molecular mechanisms of RNF6 in gastric cancer. Materials and methods:The...

journal_title：OncoTargets and therapy

authors： Huang Z,Cai Y,Yang C,Chen Z,Sun H,Xu Y,Chen W,Xu D,Tian W,Wang H

更新日期：2018-10-05 00:00:00

abstract：Aim:The use of bevacizumab in combination therapy is an emerging trend in metastatic colorectal cancer treatment. However, the clinical value of different combination types remains under debate. Thus, a meta-analysis of randomized controlled trials (RCTs) comparing bevacizumab-based combination therapy with monotherapy...

journal_title：OncoTargets and therapy

authors： Xu R,Xu C,Liu C,Cui C,Zhu J

更新日期：2018-12-04 00:00:00

abstract：:Colorectal cancer continues to be an important public health concern, despite improvements in screening and better systemic chemotherapy. The integration of targeted therapies in the treatment of colon cancer has resulted in significant improvements in efficacy outcomes. Angiogenesis is important for tumor growth and ...

journal_title：OncoTargets and therapy

authors： Puthillath A,Patel A,Fakih MG

更新日期：2009-02-18 00:00:00

abstract：Background:The neutrophil-lymphocyte ratio (NLR), a biomarker for systematic inflammation, has been recently identified as a prognostic factor for various types of both solid and hematologic malignancies. Our study presented here was the first meta-analysis assessing the prognostic role of NLR in multiple myeloma (MM)....

journal_title：OncoTargets and therapy

authors： Mu S,Ai L,Fan F,Sun C,Hu Y

更新日期：2018-01-23 00:00:00

abstract：Objective:To explore the regulatory effects of circZNF609 on proliferative and migratory capacities of gastric cancer (GC) and its underlying mechanism. Methods:Expression level of circZNF609, CDK6 and miR-483-3p in GC tissues and cells were detected qRT-PCR verification. CCK-8 and transwell assay were conducted the c...

journal_title：OncoTargets and therapy

authors： Wu W,Wei N,Shao G,Jiang C,Zhang S,Wang L

更新日期：2019-10-04 00:00:00

abstract：Background:Esophageal cancer (EC) is one of the aggressive gastrointestinal malignancies. It has been reported that microRNAs (miRNAs) play key roles during the tumorigenesis of EC. To identify novel potential targets for EC, differential expressed miRNAs (DEG) between EC and adjacent normal tissues were analyzed with ...

journal_title：OncoTargets and therapy

authors： Shi W,Song J,Gao Z,Liu X,Wang W

更新日期：2020-09-24 00:00:00

abstract：Purpose:miR-497-5p can inhibit cervical cancer cell proliferation. However, the underlying mechanism remains to be elucidated. Methods:Bioinformatics was used to analyze the target genes of miR-497-5p. qRT-PCR and Western blot were used to analyze mRNA and protein expression, respectively. Dual-luciferase reporter ass...

journal_title：OncoTargets and therapy

authors： Chen Y,Du J,Wang Y,Shi H,Jiang Q,Wang Y,Zhang H,Wei Y,Xue W,Pu Z,Gao Y,Li D,Feng Y,Yan J,Zhang J

更新日期：2019-12-02 00:00:00

abstract：Purpose:Circular RNAs (circRNAs) have been found to regulate several human tumors. The present study was to explore the mechanism of hsa_circ_0087862 in regulating non-small cell lung cancer (NSCLC). Methods:Totally 102 NSCLC cases were enrolled. NCI-H1359 and A549 cells were transfected. Cells viability, apoptosis, m...

journal_title：OncoTargets and therapy

authors： Li L,Wan K,Xiong L,Liang S,Tou F,Guo S

更新日期：2020-04-03 00:00:00

abstract：:Quercetin, a flavone, is multifaceted, having anti-oxidative, anti-inflammatory, and anticancer properties. In the present study, we explored the effects of quercetin on the epithelial-mesenchymal transition (EMT) and invasion of pancreatic cancer cells and the underlying mechanisms. We noted that quercetin exerted pr...

journal_title：OncoTargets and therapy

authors： Yu D,Ye T,Xiang Y,Shi Z,Zhang J,Lou B,Zhang F,Chen B,Zhou M

更新日期：2017-09-25 00:00:00

abstract：:Trastuzumab is a monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2). HER2 is amplified or overexpressed in about 15% of breast cancers and is associated with aggressive disease. Clinical benefits of trastuzumab have been established in the treatment of both early and metastatic HE...

journal_title：OncoTargets and therapy

authors： Hamizi S,Freyer G,Bakrin N,Henin E,Mohtaram A,Le Saux O,Falandry C

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Computed tomography-guided transthoracic needle aspiration (TTNA) and biopsy (TTNB) is a well established, safe, and rapid method of reaching a definitive diagnosis for most thoracic lesions. The present study aimed to determine the roles of TTNA and TTNB in the diagnosis of pulmonary diseases and to compare...

journal_title：OncoTargets and therapy

authors： Tuna T,Ozkaya S,Dirican A,Findik S,Atici AG,Erkan L

更新日期：2013-11-05 00:00:00

abstract：:Huaier (Trametes robiniophila Murr), a Chinese traditional herb of medicine, has demonstrated promising curative effects in clinical treatment for various tumors. There are documented experiments showing the biological functions of Huaier with its antineoplastic molecular mechanisms: restraining proliferation and meta...

journal_title：OncoTargets and therapy

authors： Qi T,Dong Y,Gao Z,Xu J

更新日期：2020-12-08 00:00:00

abstract：:Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor, and surgical resection is the first choice for the treatment of the disease, but since the advent of tyrosine kinase inhibitors (TKIs) such as imatinib (IM), the prognosis of the disease has undergone revolutionary changes. According to the cu...

journal_title：OncoTargets and therapy

authors： Xu H,Liu Q

更新日期：2021-01-05 00:00:00

abstract：Background:Papillary thyroid cancer (PTC) is a common endocrine malignancy with relatively good prognosis. Radioactive iodine (RAI) is considered effective for patients with total or nearly total thyroidectomy, but the beneficial effects of RAI are still controversial. Materials and methods:To determine whether RAI th...

journal_title：OncoTargets and therapy

authors： Tang J,Kong D,Cui Q,Wang K,Zhang D,Liao X,Gong Y,Wu G

更新日期：2018-06-19 00:00:00

abstract：PURPOSE:Randomized trials showing a clear survival benefit of intensity-modulated radiotherapy (IMRT) over 3-dimensional conformal radiotherapy (3D-CRT) in the treatment of lung cancer are lacking. This study compared the survival rates of patients with stage III non-small cell lung cancer who were treated with either ...

journal_title：OncoTargets and therapy

authors： Kong M,Hong SE

更新日期：2016-11-24 00:00:00

abstract：Purpose:The aim of this study was to investigate the antitumor effect of chidamide in combination with bortezomib on gastric cancer cell lines. Materials and Methods:First, the sensitivity and IC50 values of chidamide and bortezomib in several gastric cancer cell lines (MGC-803, BGC-823, SGC-7901, and MKN45) were meas...

journal_title：OncoTargets and therapy

authors： Zhang W,Niu J,Ma Y,Yang X,Cao H,Guo H,Bao F,Haw A,Chen Y,Sun K

更新日期：2020-05-06 00:00:00

abstract：:Interleukin-8 (IL-8) is a kind of chemokine that plays an important role in the development and progression of many human malignancies. Previous studies have uncovered that polymorphisms in IL-8 is associated with the risk of many cancer types, but the results were inconsistent and inconclusive. In the present study, ...

journal_title：OncoTargets and therapy

authors： Zhang M,Fang T,Wang K,Mei H,Lv Z,Wang F,Cai Z,Liang C

更新日期：2016-06-22 00:00:00

abstract：:Pancreatic cancer is a formidable malignancy with poor outcomes. The majority of patients are unable to undergo resection, which remains the only potentially curative treatment option. The management of locally advanced (unresectable) pancreatic cancer is controversial; however, treatment with either chemotherapy or c...

journal_title：OncoTargets and therapy

authors： Hong JC,Czito BG,Willett CG,Palta M

更新日期：2016-10-31 00:00:00

abstract：Purpose:LINC00680 was reported to be involved in various cancers through multiple mechanisms. Therefore, we intended to investigate its role in the progression of non-small cell lung cancer (NSCLC). Materials and Methods:Firstly, quantitative real-time polymerase chain reaction (qRT-PCR) was used to test LINC00680 in ...

journal_title：OncoTargets and therapy

authors： Wang H,Feng L,Zheng Y,Li W,Liu L,Xie S,Zhou Y,Chen C,Cheng D

更新日期：2020-08-18 00:00:00

abstract：:Normal astrocytes are more resistant to radiation than glioma cells. Radiation-resistant glioma cells and normal astrocytes usuallly share similar mechanisms of radioresistance. Investigation of the underlying mechanisms of differential radiation response between normal astrocytes and glioma cells is thus significant ...

journal_title：OncoTargets and therapy

authors： Gong L,Gu J,Ge J,Wu X,Zhang C,Yang C,Weng W,Gao G,Feng J,Mao Q

更新日期：2017-12-04 00:00:00

abstract：Aim:This systematic review was designed to evaluate the efficacy of neoadjuvant chemotherapy with radical surgery vs radical surgery alone for cervical cancer. Methods:A computerized search was done for trials from PubMed, EMBASE, CENTRAL, and Cochrane Database of Systematic Reviews. The trials included neoadjuvant ch...

journal_title：OncoTargets and therapy

authors： Zhao H,He Y,Yang SL,Zhao Q,Wu YM

更新日期：2019-03-07 00:00:00