Abstract:
Introduction:Odd-skipped related transcription factor 1 (OSR1) is a newly identified tumor suppressor in many tumor types. However, the role and mechanism of OSR1 in colon adenocarcinoma (COAD) remain unknown. Methods:OSR1 expression was detected in COAD tissues and cells. COAD cells with OSR1 overexpression or knockdown were analyzed by in vitro CCK-8, transwell and flow cytometry assays, and by in vivo xenograft model. Results:OSR1 expression was downregulated in COAD and low expression level of OSR1 was positively correlated with tumor stage and lymph node metastasis. Furthermore, low OSR1 expression was significantly associated with poor overall survival (OS) and distant metastasis-free survival (DMFS). Lentivirus-mediated restoration of OSR1 expression-inhibited proliferation, invasion and migration while induced cell cycle arrest and apoptosis in COAD cells in vitro, and inhibited tumor growth in vivo. In contrast, OSR1 knockdown promoted proliferation, invasion and migration in COAD cells in vitro. Mechanistically, OSR1 exerted anticancer effects by inhibiting FAK-mediated activation of Akt and MAPK pathways. Conclusion:Our findings suggest that OSR1 functions as a tumor suppressor in COAD by suppressing FAK-mediated activation of Akt and MAPK pathways.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Zhang F,Jiang Zdoi
10.2147/OTT.S242386subject
Has Abstractpub_date
2020-04-24 00:00:00pages
3489-3500issn
1178-6930pii
242386journal_volume
13pub_type
杂志文章abstract::Metastatic colorectal cancer (mCRC) is a highly heterogeneous disease. Its treatment outcome has been significantly improved over the last decade with the incorporation of biological targeted therapies, including anti-EGFR antibodies, cetuximab and panitumumab, and VEGF inhibitors, bevacizumab, ramucirumab, and aflibe...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S79145
更新日期:2015-10-15 00:00:00
abstract:Background:PD-1 checkpoint inhibitors have shown a robust tumor response in the treatment of various cancers. Pembrolizumab is an anti-PD-1 checkpoint antibody approved for the treatment of unresectable or metastatic melanoma in more than 40 countries. Although autoimmune pneumonitis is considered a common immune-relat...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S178246
更新日期:2018-10-24 00:00:00
abstract::Pancreatic cancer is a formidable malignancy with poor outcomes. The majority of patients are unable to undergo resection, which remains the only potentially curative treatment option. The management of locally advanced (unresectable) pancreatic cancer is controversial; however, treatment with either chemotherapy or c...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S99826
更新日期:2016-10-31 00:00:00
abstract:Purpose:Long intergenic non-protein coding RNA 519 (LINC00519) promotes the development of lung squamous cell carcinoma. In this study, we detected the expression of LINC00519 in tongue squamous cell carcinoma (TSCC) and examined its clinical significance. Additionally, the regulatory effects of LINC00519 on behaviors ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S279798
更新日期:2020-11-20 00:00:00
abstract:BACKGROUND/AIM:To elucidate the mechanism responsible for developing acute kidney injury in patients with diabetes mellitus, we also evaluated the issue of whether advanced glycation endproducts (AGEs) influence the expressions of multi antimicrobial extrusion protein (MATE1/SLC47A1) in tubular cells. MATERIALS AND ME...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S86743
更新日期:2015-07-10 00:00:00
abstract:BACKGROUNDS:Sitting time and physical activity are associated with cancer risk; however, their roles in the development of esophageal squamous cell carcinoma (ESCC) are inconclusive. This study aimed to investigate the effects of total sitting time, occupational activity time (OAT), and recreational activity time (RAT)...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S147711
更新日期:2017-09-27 00:00:00
abstract:Purpose:Tumor-associated macrophages (TAMs) originate from monocytes and differentiate into mature macrophages. The interaction between cancer cells and TAMs promotes tumor growth and suppresses immunosurveillance. However, this phenomenon has seldom been observed in ampullary cancer. Patients and Methods:TAMs in ampu...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S246714
更新日期:2020-08-03 00:00:00
abstract:BACKGROUND:Recurrent laryngeal nerve (RLN) invasion in papillary thyroid carcinoma (PTC) is one of the main predictors of poor prognosis. The present study investigated the risk factors for RLN invasion in PTC patients. METHODS:A total of 3,236 patients who received thyroidectomy due to PTC in Thyroid and Parathyroid ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S142799
更新日期:2017-09-11 00:00:00
abstract:BACKGROUND:Studies on the association between two single nucleotide polymorphisms (SNPs) in estrogen receptor α (ERα), PvuII (rs2234693 T>C) and XbaI (rs9340799 A>G), and the prostate cancer risk are inconsistent. Therefore, we performed a meta-analysis to derive a more accurate estimation of this relationship. METHOD...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S132419
更新日期:2017-06-29 00:00:00
abstract::Hodgkin lymphoma (HL) and anaplastic large-cell lymphoma (ALCL) account for ~10% and 2%-3% of all cases of lymphoid neoplasms, respectively. Up to 30% of patients with HL are refractory or relapse after first-line therapy, and elderly patients with HL represent a subgroup of patients with suboptimal responses to the c...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S141053
更新日期:2018-08-06 00:00:00
abstract::Over the last decades, a better understanding of breast cancer heterogeneity provided tools for a biologically based personalization of anticancer treatments. In particular, the overexpression of the human epidermal growth factor receptor 2 (HER2) by tumor cells provided a specific target in these HER2-positive tumors...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S122397
更新日期:2017-07-10 00:00:00
abstract::Advanced gastric cancer (AGC) is difficult to treat with poor prognosis. Despite various possible treatments, the median survival time of such patients remains unsatisfactory. Therefore, new therapeutic approaches or combinations need to be further explored. We herein reported a case of a 54-year-old male patient who ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S221436
更新日期:2019-09-19 00:00:00
abstract::Forkhead box protein O1 (FOXO1) is a multifunctional transcription factor of the forkhead family. It may function as a tumor suppressor through its ability to regulate cellular events, including cell proliferation, apoptosis, and cell cycle control. As reported, FOXO1 is downregulated in papillary thyroid carcinoma (P...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S95395
更新日期:2015-12-01 00:00:00
abstract:Background:Pancreatic cancer (PC) is one of the fatal cancers globally. CircDEAD-box helicase 42 (circDDX42) has been reported to play an oncogenic role in many cancers. The purpose of our study was to explore the relationship between circDDX42 and PC development and the potential mechanism by which circDDX42 modulatin...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S233000
更新日期:2020-10-28 00:00:00
abstract:Purpose:The aim was to investigate resveratrol effects on A549 cells proliferation. Methods:A total of 104 lung adenocarcinoma tissues and nontumor tissues were collected. BEAS-2B cells were cultured in RPMI 1640 medium (group A). A549 cells were treated with RPMI 1640 medium containing different resveratrol concentra...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S157613
更新日期:2018-05-22 00:00:00
abstract::The use of additional radiotherapy for resected stage IIIA N2 non-small-cell lung cancer in the setting of standard adjuvant chemotherapy remains controversial. A comprehensive search (last search updated in March 2015) for relevant studies comparing patients with stage IIIA N2 non-small-cell lung cancer undergoing re...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S95517
更新日期:2016-02-24 00:00:00
abstract::Purpose: Numerous microRNAs (miRNAs) are aberrantly expressed in breast cancer, and the dysregulation of miRNAs may affect the aggressiveness of this cancer. Aberrant expression of miRNA-937 (miR-937) in gastric and lung cancers has been reported, which plays tumor-suppressive or oncogenic roles in carcinogenesis incl...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S207593
更新日期:2019-06-20 00:00:00
abstract:BACKGROUND:Chemotherapy is not limited to a single treatment, and the evidence demonstrates that different drug combinations can have positive results in patients. In this study, we sought to determine whether cordycepin combined with cisplatin and/or paclitaxel would have an additive effective on inducing apoptosis in...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S87010
更新日期:2015-09-01 00:00:00
abstract:Background and objective:HSF1 is reported to be overexpressed in various solid tumors and play a pivotal role in cancer progression. A meta-analysis was conducted to assess the potential prognostic role of HSF1 in patients with solid tumors. Methods:An extensive electronic search of three databases was performed for r...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S153682
更新日期:2018-01-17 00:00:00
abstract::Giant-cell carcinoma of the lung (GCCL) is a rare histological form of poorly differentiated non-small-cell lung cancer, which is classified as a subtype of pulmonary sarcomatoid carcinomas. In this case report, we describe the case of a 50-year-old Chinese male who presented with a pulmonary nodule in the right upper...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S150124
更新日期:2018-02-09 00:00:00
abstract:Background:Immunosenescence, the age-related decline of immunity, affects the immune responses of melanoma patients. Through immune responses, immune checkpoint inhibitors (ICIs) exert their antitumor robustness. In different ages of melanoma patients, especially the older patients, the effectiveness of ICIs remains un...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S165368
更新日期:2018-10-26 00:00:00
abstract::[This retracts the article DOI: 10.2147/OTT.S215674.]. ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,撤回出版物
doi:10.2147/OTT.S273162
更新日期:2020-07-28 00:00:00
abstract::The central nervous system (CNS) is regarded as an immune privileged environment; however, changes in the neuroimmunology paradigm have led to an increased interest in systematic immunotherapy in lung cancer therapy. The presence of the lymphatic system in the CNS as well as the physiological and biochemical changes i...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S235714
更新日期:2020-01-23 00:00:00
abstract::Neuroendocrine tumors are a rare and heterogeneous group of tumors with a variety of primary origins and variable aggressiveness. Platinum-based chemotherapy has been the cornerstone of treatment for the poorly differentiated tumors. However, well-differentiated neuroendocrine tumors are quite chemoresistant and thera...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S72155
更新日期:2016-02-09 00:00:00
abstract:OBJECTIVE:SASH1 is a member of the SH3/SAM adapter molecules family and has been identified as a new tumor suppressor and critical protein in signal transduction. An ectopic expression of SASH1 is associated with decreased cell viability of breast cancer. The aim of this study was to explore the association between SAS...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S119244
更新日期:2017-01-10 00:00:00
abstract::Prostate cancer is the leading malignancy and the second most common cause of cancer-related death in men. Despite high cure rates with surgery and/or radiation, 30%-40% of patients eventually develop advanced cancer. Docetaxel is one of the most effective and well established chemotherapeutic agents for prostate canc...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S79105
更新日期:2015-04-10 00:00:00
abstract:Objectives:We aimed to demonstrate the clinical characteristics and risk factors associated with recurrence of adult granulosa cell tumor (AGCT), as well as the pregnancy and long-term outcomes among patients in a single institution in China. Patients and methods:We reviewed 141 patients with AGCT in Peking Union Medi...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S155473
更新日期:2018-03-07 00:00:00
abstract:Background:Exosomes are nano-sized biological vesicles released by many kinds of cells, which play an important role in tumor metastasis through transporting cytokines, RNAs and proteins. However, the molecular mechanisms of exosomes in hepatocellular carcinoma (HCC) metastasis are not completely understood. Materials...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S209413
更新日期:2019-08-23 00:00:00
abstract:Purpose:To evaluate the capability of 18F-fluorodeoxyglucose positron emission tomography/ computed tomography (18F-FDG-PET/CT) to predict the clinical response of metastatic lymph node (mLN) to definitive chemoradiotherapy (dCRT) and guide personalized radiation dose in esophageal squamous cell carcinoma (ESCC) patien...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S160456
更新日期:2018-07-25 00:00:00
abstract:Introduction:Melanoma is a common skin cancer that is usually associated with poor clinical outcomes. Recently, the immune checkpoint GITR has been identified as a promising target for immunotherapy of melanoma. In this study, we aimed to investigate the post-translational regulation mechanism of GITR in melanoma. Met...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S212317
更新日期:2019-12-04 00:00:00