Molecular features of giant-cell carcinoma of the lung: a case report and literature review.

abstract：:Background: Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer morbidity and mortality worldwide. In the present study, we identified novel biomarkers associated with the pathogenesis of NSCLC aiming to provide new diagnostic and therapeutic approaches for NSCLC. Methods: The microarray datasets of...

journal_title：OncoTargets and therapy

authors： Wu Q,Zhang B,Sun Y,Xu R,Hu X,Ren S,Ma Q,Chen C,Shu J,Qi F,He T,Wang W,Wang Z

更新日期：2019-05-13 00:00:00

abstract：:Major advances in the understanding of the pathophysiology of melanoma have led to a new era of melanoma treatment with targeted therapy and immunotherapies. Since 2011, four new classes of medications with unique mechanisms of action have been approved, which allow melanoma to be treated at many different stages in i...

journal_title：OncoTargets and therapy

authors： Sun J,Zager JS,Eroglu Z

更新日期：2018-12-14 00:00:00

abstract：PURPOSE:We validated the use of expression sequence tags (ESTs) as an effective method of screening for DNA segments that could predict urothelial cell carcinoma and for identifying ESTs with such predictive value. PATIENTS AND METHODS:From 2004 to 2009, eleven patients were enrolled in this study: six with high-grade...

journal_title：OncoTargets and therapy

authors： Yang PS,Hsu YC,Lin YH,Hou CP,Chen CL,Chang PL,Juang HH,Tsui KH

更新日期：2014-09-30 00:00:00

abstract：Background:Intra-abdominal desmoplastic small round cell tumor (IADSRCT) is a highly invasive malignant tumor that is rare in clinical practice. Anlotinib is a multitarget receptor tyrosine kinase inhibitor which inhibits vascular endothelial growth factor receptor (VEGFR) 1-3, fibroblast growth factor receptor (FGFR) ...

journal_title：OncoTargets and therapy

authors： Chen HM,Feng G

更新日期：2018-12-18 00:00:00

abstract：BACKGROUND:The prognostic and predictive significance of the high-level microsatellite instability (MSI-H) phenotype in various malignancies is unclear. We describe the characteristics, clinical course, and outcomes of patients with MSI-H malignancies treated in a real-life hospital setting. PATIENTS AND METHODS:A ret...

journal_title：OncoTargets and therapy

authors： Halpern N,Goldberg Y,Kadouri L,Duvdevani M,Hamburger T,Peretz T,Hubert A

更新日期：2017-03-29 00:00:00

abstract：:Bladder cancer (BC) is a common urinary system tumor with high aggressiveness, and it results in relatively high mortality due to a lack of precise and suitable biomarkers. In this study, we applied the weighted gene coexpression network analysis method to miRNA expression data from BC patients, and screened for netwo...

journal_title：OncoTargets and therapy

authors： Zhao F,Ge YZ,Zhou LH,Xu LW,Xu Z,Ping WW,Wang M,Zhou CC,Wu R,Jia RP

更新日期：2017-11-22 00:00:00

abstract：BACKGROUND:Metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) is identified to be overexpressed in several cancers. However, the role of MALAT-1 in chondrosarcoma is poorly understood. METHODS:The expression of MALAT-1 and Notch-1 signaling pathway was detected in chondrosarcoma tissues and chondrosarcom...

journal_title：OncoTargets and therapy

authors： Xu F,Zhang ZQ,Fang YC,Li XL,Sun Y,Xiong CZ,Yan LQ,Wang Q

更新日期：2016-04-13 00:00:00

abstract：Purpose:Circulating tumor DNA (ctDNA) is a noninvasive and real-time marker for tumor diagnosis, prognosis, and prediction. However, further investigations about ctDNA prognostic and predictive value are still needed, and conclusions from several studies were inconsistent. Experimental design:We performed capture-base...

journal_title：OncoTargets and therapy

authors： Rao C,Nie L,Miao X,Xu Y,Li B,Zhang T

更新日期：2018-01-12 00:00:00

abstract：:Colorectal cancer continues to be an important public health concern, despite improvements in screening and better systemic chemotherapy. The integration of targeted therapies in the treatment of colon cancer has resulted in significant improvements in efficacy outcomes. Angiogenesis is important for tumor growth and ...

journal_title：OncoTargets and therapy

authors： Puthillath A,Patel A,Fakih MG

更新日期：2009-02-18 00:00:00

abstract：Background:Insulin-like growth factor binding protein-2 (IGFBP2) levels are significantly increased in the plasma of hepatocellular carcinoma (HCC) patients. However, the correlation between IGFBP2 levels and clinical parameters and the exact role of IGFBP2 in HCC are unclear. In this study, we identified the role and ...

journal_title：OncoTargets and therapy

authors： Ma Y,Cui D,Zhang Y,Han CC,Wei W

更新日期：2020-06-08 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) patients with anaplastic lymphoma kinase (ALK) rearrangement benefit from treatment with ALK inhibitors. Therefore, the identification of druggable ALK fusions is necessary for NSCLC treatment. More than 90 fusion partners of ALK have been reported in NSCLC patients, but the striatin...

journal_title：OncoTargets and therapy

authors： Su C,Jiang Y,Jiang W,Wang H,Liu S,Shao Y,Zhao W,Ning R,Yu Q

更新日期：2020-12-04 00:00:00

abstract：:Gastric cancer (GC) is one of the leading causes of tumor-related mortality. In addition to surgery and endoscopic resection, systemic therapy remains the main treatment option for GC, especially for advanced-stage disease and for cases not suitable for surgical therapy. Hence, improving the efficacy of systemic thera...

journal_title：OncoTargets and therapy

authors： Zhao X,Hu GF,Shi YF,Xu W

更新日期：2019-12-24 00:00:00

abstract：BACKGROUND:To evaluate the benefit of second-line chemotherapy with platinum-based treatment in patients with recurrent small cell lung cancer (SCLC). PATIENTS AND METHODS:A total of 535 patients continued with follow-up or best supportive care if needed, and 229 patients who progressed after the completion of first-l...

journal_title：OncoTargets and therapy

authors： Zarogoulidis K,Boutsikou E,Zarogoulidis P,Darwiche K,Freitag L,Porpodis K,Latsios D,Kontakiotis T,Huang H,Li Q,Hohenforst-Schmidt W,Kipourou M,Turner JF,Spyratos D

更新日期：2013-10-22 00:00:00

abstract：Introduction:Melanoma has been reported as the most common malignancy in skin cancer. The small nucleolar RNA host gene 5 (SNHG5), an lncRNA, has been proven as a vital regulator in several types of carcinoma. This study was designed to investigate the detailed roles and possible mechanisms of SNHG5 in melanoma progres...

journal_title：OncoTargets and therapy

authors： Gao J,Zeng K,Liu Y,Gao L,Liu L

更新日期：2018-12-24 00:00:00

abstract：Background:Deleted in breast cancer 1 (DBC1) is believed to be involved in human cancers. However, it is still uncertain whether DBC1 expression can be regarded as a prognostic factor in patients with various cancers. This meta-analysis aimed to evaluate the relationship between high levels of DBC1 and prognosis in tum...

journal_title：OncoTargets and therapy

authors： Liu G,Wu Q,Wang Y,Xiong Q,Fu F

更新日期：2019-02-22 00:00:00

abstract：BACKGROUND:CD155, an immunoglobulin-like adhesion molecule, plays an important role in carcinoma such as cells migration, proliferation, metastasis, and tumor immune. The upregulation of CD155 has been found in several human malignancies, but its expression in cholangiocarcinoma (CCA) still remains unclear. The aim of ...

journal_title：OncoTargets and therapy

authors： Huang DW,Huang M,Lin XS,Huang Q

更新日期：2017-07-31 00:00:00

abstract：:Huaier (Trametes robiniophila Murr), a Chinese traditional herb of medicine, has demonstrated promising curative effects in clinical treatment for various tumors. There are documented experiments showing the biological functions of Huaier with its antineoplastic molecular mechanisms: restraining proliferation and meta...

journal_title：OncoTargets and therapy

authors： Qi T,Dong Y,Gao Z,Xu J

更新日期：2020-12-08 00:00:00

abstract：:ALK rearrangements account for ~5% of non-small-cell lung cancer (NSCLC). Numerous rearrangement partners have been discovered. Here, we describe a 53-year-old nonsmoker with NSCLC, in whom we identified four novel rearrangements. The patient was diagnosed as adenocarcinoma in the right middle lobe of lung, with metas...

journal_title：OncoTargets and therapy

authors： Cai C,Long Y,Li Y,Huang M

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:Recent studies have demonstrated that the clock gene PER1 regulates various tumor-related genes. Abnormal expressions and circadian rhythm alterations of PER1 are closely related to carcinogenesis. However, the dynamic circadian variations of PER1 and tumor-related genes at different stages of carcinogenesis...

journal_title：OncoTargets and therapy

authors： Ye H,Yang K,Tan XM,Fu XJ,Li HX

更新日期：2015-06-11 00:00:00

abstract：:Background/Aims: MiR-145 and Smad2 have been widely reported in the development and progression of human malignancies. In the present study, we investigated the correlation between miR-145 and Smad2 in human glioblastoma multiforme (GBM). Methods: The epithelial-mesenchymal transition (EMT) biomarkers and Smad2 were a...

journal_title：OncoTargets and therapy

authors： Chen W,Huang B,Wang E,Wang X

更新日期：2019-04-23 00:00:00

abstract：Background and objective:RNF6, an E3 ligase, has been reported to play an important role in the tumorigenesis in several tissues, but its role in gastric cancer is still unknown. In this study, we aimed to investigate the biological function and molecular mechanisms of RNF6 in gastric cancer. Materials and methods:The...

journal_title：OncoTargets and therapy

authors： Huang Z,Cai Y,Yang C,Chen Z,Sun H,Xu Y,Chen W,Xu D,Tian W,Wang H

更新日期：2018-10-05 00:00:00

abstract：Background:The immune environment of lung cancer is complex, and the critical immune factors that promote lung cancer progression need to be explored. Granulocytic myeloid-derived suppressor cells (G-MDSCs) are regarded as immune suppressing cells. However, they also promote tumor progression through other ways, which ...

journal_title：OncoTargets and therapy

authors： Zhou JH,Yao ZX,Zheng Z,Yang J,Wang R,Fu SJ,Pan XF,Liu ZH,Wu K

更新日期：2020-09-30 00:00:00

abstract：:Cutaneous metastasis from primary visceral malignancy is a relatively uncommon clinical entity, with a reported incidence ranging from 0.22% to 12% of all malignancies. Here we report a 64-year-old asymptomatic female patient with Peutz-Jeghers syndrome presenting with multiple scalp metastases as the initial manifest...

journal_title：OncoTargets and therapy

authors： Yu Q,Subedi S,Tong Y,Wei Q,Xu H,Wang Y,Gong Y,Shi Y

更新日期：2018-09-21 00:00:00

abstract：:Background: Previous studies have reported that the albumin-to-alkaline phosphatase ratio (AAPR), a novel blood biomarker-based index, is associated with clinical outcome in several cancers. However, data relating to lung cancer are rare. This study was performed to clarify the clinical significance of AAPR in patient...

journal_title：OncoTargets and therapy

authors： Li D,Yu H,Li W

更新日期：2019-07-02 00:00:00

abstract：BACKGROUND:Met and HER-2 are proto-oncogenes encoding receptor tyrosine kinase c-Met and HER-2, respectively. Hepatocyte growth factor (HGF) is a ligand of c-Met. The frequency of c-Met, HGF, and HER-2 expressions in gastric cancer and their association with other clinicopathological factors have not been fully underst...

journal_title：OncoTargets and therapy

authors： Yıldız Y,Sokmensuer C,Yalcin S

更新日期：2016-09-22 00:00:00

abstract：Aim:This systematic review was designed to evaluate the efficacy of neoadjuvant chemotherapy with radical surgery vs radical surgery alone for cervical cancer. Methods:A computerized search was done for trials from PubMed, EMBASE, CENTRAL, and Cochrane Database of Systematic Reviews. The trials included neoadjuvant ch...

journal_title：OncoTargets and therapy

authors： Zhao H,He Y,Yang SL,Zhao Q,Wu YM

更新日期：2019-03-07 00:00:00

abstract：PURPOSE:The expression of an array of signaling molecules, along with the assessment of real-time cell proliferation, has been performed in U87 glioma cell line and in patients' glioblastoma established cell cultures in order to provide a better understanding of cellular and molecular events involved in glioblastoma pa...

journal_title：OncoTargets and therapy

authors： Cruceru ML,Enciu AM,Popa AC,Albulescu R,Neagu M,Tanase CP,Constantinescu SN

更新日期：2013-11-29 00:00:00

abstract：Introduction:Ribosome binding protein 1 (RRBP1) is reported to be correlated with tumor formation and progression. However, the role of RRBP1 in bladder cancer is unclear. In this study, we aimed to investigate the expression of RRBP1 and its influence on cell proliferation in bladder cancer. Methods:Quantification re...

journal_title：OncoTargets and therapy

authors： Lv SW,Shi ZG,Wang XH,Zheng PY,Li HB,Han QJ,Li ZJ

更新日期：2020-07-07 00:00:00

abstract：PURPOSE:To explore whether changes in tumor size impact survival in advanced non-small-cell lung cancer (NSCLC) after target therapy, especially in patients with evaluation of stable disease (SD), and to review the applicability of the Response Evaluation Criteria in Solid Tumors (RECIST) criteria in target therapy. P...

journal_title：OncoTargets and therapy

authors： Zhang J,Huang Y,Li X,Guo Y,Zhao Y,Xue C,Hu Z,Zhang L,Zhao H

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The authors conducted this prospective study to analyze the amount of interfractional prostate bed motion (PBM) and quantify its components with the use of an endorectal balloon (ERB). METHODS:A total of 1,348 cone beam computed tomography images from 46 patients who underwent postprostatectomy radiotherapy...

journal_title：OncoTargets and therapy

authors： Joo JH,Kim YJ,Kim YS,Cho YP,Lee HY,Jeong CY,Kwak J,Cho BC

更新日期：2016-05-24 00:00:00