Clinical course and outcome of patients with high-level microsatellite instability cancers in a real-life setting: a retrospective analysis.

abstract：:Intracranial myeloid sarcoma is a very rare disease with poor prognosis. We report a case of a 28-year-old male patient who was admitted with intense headache, vision disturbance and severe vomiting in June 2017. He had a history of neurosurgical tumor resection operation in April 2017, and the pathological diagnosis ...

journal_title：OncoTargets and therapy

authors： Zhou L,Zhang X,Feng S,Zhao N,Hu X,Huang L,Zheng C

更新日期：2020-01-09 00:00:00

abstract：Background:Immunosenescence, the age-related decline of immunity, affects the immune responses of melanoma patients. Through immune responses, immune checkpoint inhibitors (ICIs) exert their antitumor robustness. In different ages of melanoma patients, especially the older patients, the effectiveness of ICIs remains un...

journal_title：OncoTargets and therapy

authors： Li P,Yang X,Feng Y,Wu L,Ma W,Ding G,Wei Y,Sun L

更新日期：2018-10-26 00:00:00

abstract：Background and aim:Despite several studies being conducted to examine the associations between the NUDT15 R139C polymorphism and thiopurine-induced leukopenia in the Asian population, the results remain inconsistent. This meta-analysis determined the risk of thiopurine-induced leukopenia conferred by the NUDT15 R139C p...

journal_title：OncoTargets and therapy

authors： Liu Y,Meng Y,Wang L,Liu Z,Li J,Dong W

更新日期：2018-11-23 00:00:00

abstract：Background:Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Long non-coding RNA taurine-upregulated gene 1 (lncRNA TUG1) has been discovered to participate in multiple cancers including AML. However, the detailed mechanism of TUG1 in AML remains obscure. Materials and methods:AML cell ...

journal_title：OncoTargets and therapy

authors： Li G,Zheng P,Wang H,Ai Y,Mao X

更新日期：2019-11-29 00:00:00

abstract：Purpose:Breast cancer (BC) is the most common cancer in women. Emerging evidence has demonstrated that lncRNAs play an important role in BC. The objective of this study was to investigate the impact of the long non-coding RNA (lncRNA), H19/miRNA-130a-3P/special AT-rich sequence-binding protein-1 (SATB1) axis on BC prog...

journal_title：OncoTargets and therapy

authors： Zhong G,Lin Y,Wang X,Wang K,Liu J,Wei W

更新日期：2020-12-07 00:00:00

abstract：Background:As a component of the EIF3 complex, EIF3C is essential for several steps in protein synthesis initiation. Recently, it has been addressed that EIF3C is overexpressed in several human cancers and plays a pivotal role in cell proliferation and tumorigenesis. Materials and methods:Immunohistochemistry, quantit...

journal_title：OncoTargets and therapy

authors： Gao W,Hu Y,Zhang Z,Du G,Yin L,Yin Z

更新日期：2019-02-14 00:00:00

abstract：AIM:To retrospectively evaluate the safety and efficacy of ultrasound-guided percutaneous microwave ablation (MWA) combined with simultaneous transarterial chemoembolization (TACE) in the treatment of patients with advanced intrahepatic cholangiocarcinoma (ICC). METHODS:All patients treated with ultrasound-guided perc...

journal_title：OncoTargets and therapy

authors： Yang GW,Zhao Q,Qian S,Zhu L,Qu XD,Zhang W,Yan ZP,Cheng JM,Liu QX,Liu R,Wang JH

更新日期：2015-05-26 00:00:00

abstract：BACKGROUND:Bevacizumab plus taxane chemotherapy improves progression-free survival (PFS) versus taxane monotherapy in the first-line treatment of HER2-negative metastatic breast cancer (MBC) and appears promising in the second-line setting. This retrospective analysis evaluated the efficacy and safety of this combinati...

journal_title：OncoTargets and therapy

authors： Redondo A,Martínez V,Zamora P,Castelo B,Pinto A,Cruz P,Higuera O,Mendiola M,Hardisson D,Espinosa E

更新日期：2014-11-27 00:00:00

abstract：BACKGROUND:Due to the hypervascular nature of glioblastoma (GBM), antiangiogenic treatments, such as vatalanib, have been added as an adjuvant to control angiogenesis and tumor growth. However, evidence of progressive tumor growth and resistance to antiangiogenic treatment has been observed. To counter the unwanted eff...

journal_title：OncoTargets and therapy

authors： Shankar A,Borin TF,Iskander A,Varma NR,Achyut BR,Jain M,Mikkelsen T,Guo AM,Chwang WB,Ewing JR,Bagher-Ebadian H,Arbab AS

更新日期：2016-03-09 00:00:00

abstract：:The identification of molecular genetic biomarkers considerably increased our current understanding of glioma genesis, prognostic evaluation, and treatment planning. In glioblastoma, the most malignant intrinsic brain tumor entity in adults, the promoter methylation status of the gene encoding for the repair enzyme O6...

journal_title：OncoTargets and therapy

authors： Thon N,Kreth S,Kreth FW

更新日期：2013-09-27 00:00:00

abstract：BACKGROUND:The grading of pancreatic neuroendocrine neoplasms (PanNENs) is associated with the choice of treatment strategy. The aim of this study is to identify the magnetic resonance imaging (MRI) features in differentiating pancreatic neuroendocrine tumors (PanNETs) grade 1/2 (G1/G2) and pancreatic neuroendocrine ca...

journal_title：OncoTargets and therapy

authors： Guo C,Chen X,Xiao W,Wang Q,Sun K,Wang Z

更新日期：2017-03-07 00:00:00

abstract：:Oncolytic viruses (OVs) have the ability to selectively replicate in and lyse cancer cells. Angiogenesis is an essential requirement for tumor growth. Like OVs, the therapeutic effect of many angiogenesis inhibitors has been limited, leading to the development of more effective approaches to combine antiangiogenic the...

journal_title：OncoTargets and therapy

authors： Tysome JR,Lemoine NR,Wang Y

更新日期：2013-07-31 00:00:00

abstract：Background:miRNA expression acts as a potential biomarker in many diseases including endometrial carcinoma (EC). miR-486-5p dysregulation is observed in several tumor types, but the roles of miR-486-5p in EC are hardly ever studied. Objective:This study aimed to analyze the expression profile of miR-486-5p in tumor ti...

journal_title：OncoTargets and therapy

authors： Zheng X,Xu K,Zhu L,Mao M,Zhang F,Cui L

更新日期：2020-05-28 00:00:00

abstract：:Recently, "ipilimumab," an anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) monoclonal antibody, has been demonstrated to improve overall survival in metastatic melanoma. "CTLA-4" is an immune-checkpoint molecule that downregulates pathways of T-cell activation. Ipilimumab, by targeting CTLA-4, is able to remove the CTL...

journal_title：OncoTargets and therapy

authors： Della Vittoria Scarpati G,Fusciello C,Perri F,Sabbatino F,Ferrone S,Carlomagno C,Pepe S

更新日期：2014-02-19 00:00:00

abstract：:This study aimed to investigate the expression and clinical significance of MYC-associated zinc finger protein (MAZ) in pancreatic carcinoma (PC), and the biological functions of MAZ in PC cells. MAZ expression was detected in 57 PC tissues and 41 paired adjacent nontumor tissues by immunohistochemistry. Compared to t...

journal_title：OncoTargets and therapy

authors： Zhu X,Luo W,Liang W,Tang F,Bei C,Ren Y,Qin L,Tan C,Zhang Y,Tan S

更新日期：2016-12-12 00:00:00

abstract：PURPOSE:The expression of an array of signaling molecules, along with the assessment of real-time cell proliferation, has been performed in U87 glioma cell line and in patients' glioblastoma established cell cultures in order to provide a better understanding of cellular and molecular events involved in glioblastoma pa...

journal_title：OncoTargets and therapy

authors： Cruceru ML,Enciu AM,Popa AC,Albulescu R,Neagu M,Tanase CP,Constantinescu SN

更新日期：2013-11-29 00:00:00

abstract：Background:Malignant glioma is the second leading cause of cancer-related death worldwide, and is known to exhibit a high degree of heterogeneity in its deregulation of different oncogenic pathways. The molecular subclasses of human glioma are not well known. Thus, it is crucial to identify vital oncogenic pathways in ...

journal_title：OncoTargets and therapy

authors： Hu T,Xi J

更新日期：2017-11-15 00:00:00

abstract：Objective:Long non-coding RNAs (lncRNAs) have been identified as important players in tumorigenesis. LncRNA highly upregulated in liver cancer (HULC) has been identified as a key regulator in the progression of various cancers. However, the functional role and the mechanisms of HULC in regulating cervical cancer cell b...

journal_title：OncoTargets and therapy

authors： Lu W,Wan X,Tao L,Wan J

更新日期：2020-02-05 00:00:00

abstract：:Iliac vein-ureteral fistula is a rare cause of hematuria. The diagnosis of an iliac vein-ureteral fistula can be elusive even with the use of multiple methods. With regards to the treatment, there appears to be a shift in management from primarily open surgical to primarily angiographic management. We present a unique...

journal_title：OncoTargets and therapy

authors： Luo JD,Liu B,Wang P,Zhou F,Xu XL,Li SQ,Cai SL,Wang YM

更新日期：2014-07-23 00:00:00

abstract：Objective:Multidrug resistance-associated protein 2 (MRP2), encoded by ABCC2 gene, is involved in the efflux of certain anticancer drugs. Here we observed whether the ABCC2 (G1249A) polymorphism impacts the transport abilities of MRP2-dependent paclitaxel, docetaxel, and doxorubicin in recombinant LLC-PK1 cell lines. ...

journal_title：OncoTargets and therapy

authors： Lian G,Yuan J,Gao Y

更新日期：2020-02-17 00:00:00

abstract：Purpose:Circulating tumor DNA (ctDNA) is a noninvasive and real-time marker for tumor diagnosis, prognosis, and prediction. However, further investigations about ctDNA prognostic and predictive value are still needed, and conclusions from several studies were inconsistent. Experimental design:We performed capture-base...

journal_title：OncoTargets and therapy

authors： Rao C,Nie L,Miao X,Xu Y,Li B,Zhang T

更新日期：2018-01-12 00:00:00

abstract：BACKGROUND:Paxillin is implicated in tumorigenesis, progression and aggressive phenotypes of various malignancies, highlighting its functions in cellular adhesion, migration and survival. However, the roles of paxillin in human gliomas remain unclear. The aim of this study was to evaluate the clinical implication of pa...

journal_title：OncoTargets and therapy

authors： Chen B,Xia L,Xu CS,Xiao F,Wang YF

更新日期：2016-11-09 00:00:00

abstract：PURPOSE:The prognostic significance of circulating tumor cells (CTCs) in esophageal carcinoma (EC) is controversial. We aim to assess its association with clinicopathological and prognostic relevance in EC by using a meta-analysis. METHODS:We searched PubMed, Cochrane Database, Embase databases, and the references in ...

journal_title：OncoTargets and therapy

authors： Qiao GL,Qi WX,Jiang WH,Chen Y,Ma LJ

更新日期：2016-03-31 00:00:00

abstract：BACKGROUND:Sunitinib is widely used as first-line treatment for metastatic clear cell renal cancer (MCRC). No reports are known of treatment after sunitinib failure. As irinotecan, cisplatin, and mitomycin-C (IPM) chemotherapy has been reported to influence MCRC after progression on cytokine therapy, we report on the o...

journal_title：OncoTargets and therapy

authors： Powles T,McFaul S,Stebbing J,Wilson P,Oliver T,Tranter N,Shamash J

更新日期：2008-09-01 00:00:00

abstract：Purpose:Radioresistance is a vital obstacle for the prognosis of human nasopharyngeal carcinoma (NPC), but the underlying mechanism is still unknown. Here, we explored the role of the NRF2/KEAP1 pathway in radioresistance of NPC cell lines. Materials and Methods:We selected NPC cell lines CNE-1 and CNE-2, treated them...

journal_title：OncoTargets and therapy

authors： Zhou J,Ding J,Ma X,Zhang M,Huo Z,Yao Y,Li D,Wang Z

更新日期：2020-09-11 00:00:00

abstract：Purpose:B7 homologue 6 (B7-H6) has been found at an up-regulated level in multiple cancer cells and identified to be positively correlated with inferior clinical features. In non-Hodgkin lymphoma (NHL), however, the roles of B7-H6 and the underlying mechanism of action remain unclear. Through in vivo and in vitro exper...

journal_title：OncoTargets and therapy

authors： Yang S,Yuan L,Wang Y,Zhu M,Wang J,Ke X

更新日期：2020-06-18 00:00:00

abstract：BACKGROUNDS:Sitting time and physical activity are associated with cancer risk; however, their roles in the development of esophageal squamous cell carcinoma (ESCC) are inconclusive. This study aimed to investigate the effects of total sitting time, occupational activity time (OAT), and recreational activity time (RAT)...

journal_title：OncoTargets and therapy

authors： Chen P,Song Q,Han J,Xu H,Chen T,Xu J,Cheng Y

更新日期：2017-09-27 00:00:00

abstract：BACKGROUND:Activating transcription factor 5 (ATF5) is a member of the activating transcription/cAMP response element-binding protein family of basic leucine zipper proteins that plays an important role in cell survival, differentiation, proliferation, and apoptosis. The ATF5 gene generates two transcripts: ATF5 isofor...

journal_title：OncoTargets and therapy

authors： Vicari L,La Rosa C,Forte S,Calabrese G,Colarossi C,Aiello E,Salluzzo S,Memeo L

更新日期：2016-10-11 00:00:00

abstract：Backgrounds:microRNA-493-3p (miR-493) has been reported to be critically downregulated in multiple types of human cancer. However, the expression level, biological roles and underlying mechanism of miR‑493 in tongue squamous cell carcinoma (TSCC) remain to be elucidated. Methods:RT-qPCR was utilized for the determinat...

journal_title：OncoTargets and therapy

authors： Jiao D,Liu Y,Tian Z

更新日期：2019-08-28 00:00:00

abstract：Aim:To explore the expression and clinical significance of long noncoding RNA (lncRNA) gastric cancer-associated transcript 3 (GACAT3) in human colorectal cancer (CRC). Methods:Expression of GACAT3 in CRC tissues and cell lines was measured using quantitative real-time PCR. CCK-8 and colony formation assays were used ...

journal_title：OncoTargets and therapy

authors： Zhou W,Wang L,Miao Y,Xing R

更新日期：2018-03-19 00:00:00