The efficacy and safety of irinotecan cisplatin and mitomycin chemotherapy in sunitinib pre-treated metastatic clear cell renal cancer.

Abstract:

BACKGROUND:Sunitinib is widely used as first-line treatment for metastatic clear cell renal cancer (MCRC). No reports are known of treatment after sunitinib failure. As irinotecan, cisplatin, and mitomycin-C (IPM) chemotherapy has been reported to influence MCRC after progression on cytokine therapy, we report on the outcome of 11 patients treated with IPM after sunitinib failure. PATIENTS AND METHODS:Eleven patients with progression of disease on sunitinib therapy were treated with 4, monthly cycles of monthly IPM. RESULTS:Nine out of 11 patients progressed during IPM therapy. The median time to progression was 1.4 months (95% CI: 0.7-2.1 months), while the overall survival was 4.2 months (95% CI: 0.9-2.3). Overall 10 patients have died of progressive renal cancer. One patient had a radiological response to therapy and remains progression free 11 months after treatment. Four of the 10 patients required a dose reduction for grade 3 or 4 toxicities. CONCLUSIONS:IPM alone does not appear to benefit patients with MCRC who previously progressed during sunitinib therapy. The median progression-free survival and overall survival for these patients is short.

journal_name

Onco Targets Ther

journal_title

OncoTargets and therapy

authors

Powles T,McFaul S,Stebbing J,Wilson P,Oliver T,Tranter N,Shamash J

doi

10.2147/ott.s3590

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

35-9

issn

1178-6930

journal_volume

1

pub_type

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