The efficacy and safety of irinotecan cisplatin and mitomycin chemotherapy in sunitinib pre-treated metastatic clear cell renal cancer.


BACKGROUND:Sunitinib is widely used as first-line treatment for metastatic clear cell renal cancer (MCRC). No reports are known of treatment after sunitinib failure. As irinotecan, cisplatin, and mitomycin-C (IPM) chemotherapy has been reported to influence MCRC after progression on cytokine therapy, we report on the outcome of 11 patients treated with IPM after sunitinib failure. PATIENTS AND METHODS:Eleven patients with progression of disease on sunitinib therapy were treated with 4, monthly cycles of monthly IPM. RESULTS:Nine out of 11 patients progressed during IPM therapy. The median time to progression was 1.4 months (95% CI: 0.7-2.1 months), while the overall survival was 4.2 months (95% CI: 0.9-2.3). Overall 10 patients have died of progressive renal cancer. One patient had a radiological response to therapy and remains progression free 11 months after treatment. Four of the 10 patients required a dose reduction for grade 3 or 4 toxicities. CONCLUSIONS:IPM alone does not appear to benefit patients with MCRC who previously progressed during sunitinib therapy. The median progression-free survival and overall survival for these patients is short.


Onco Targets Ther


OncoTargets and therapy


Powles T,McFaul S,Stebbing J,Wilson P,Oliver T,Tranter N,Shamash J




Has Abstract


2008-09-01 00:00:00








  • Antitumor activity of dichloroacetate on C6 glioma cell: in vitro and in vivo evaluation.

    abstract::Dichloroacetate (DCA), a small molecule mitochondria-targeting agent, can penetrate the blood-brain barrier, showing potential therapeutic effects on brain tumors. Considering the effects of DCA on tumor cellular metabolism, penetrating across the blood-brain barrier, as well as having potential antitumor activity on ...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Duan Y,Zhao X,Ren W,Wang X,Yu KF,Li D,Zhang X,Zhang Q

    更新日期:2013-01-01 00:00:00

  • Genome-Wide Microarray Analysis of circRNAs Revealed Novel Biomarkers for Glioma Treatment and Their Promoting Effect on Glioma Progression.

    abstract:Purpose:As a novel type of non-coding RNAs, circRNAs were found to play important roles in cancer progression. In this study, we aim to investigate genome-wide circRNAs expression and potential functions in glioma to find new therapeutic targets for glioma treatment. Patients and Methods:A total of 92 pairs of glioma ...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Lyu X,Zhou L,Fan F,Dong Z

    更新日期:2020-04-01 00:00:00

  • Unleashing The Potential Of Multiple-Targeted Therapies In Hepatobiliary Cancers: Two Cases, Cocktail Therapy With Nine Molecular Targeted Agents And Long-Lasting Survival.

    abstract::The mortality of hepatobiliary cancer still stays high around the world, with disappointing treatment status at advanced stage. Genomic analysis has identified the global spectrum of alterations in liver cancer, but the most common mutations are not actionable, meanwhile lacking potent molecular-targeted drugs for spe...

    journal_title:OncoTargets and therapy



    authors: Lin J,Yang X,Xie Y,Zhao H

    更新日期:2019-11-19 00:00:00

  • Potential New Cancer Immunotherapy: Anti-CD47-SIRPα Antibodies.

    abstract::CD47 belongs to immunoglobulin superfamily and is widely expressed on the surface of cell membrane, while another transmembrane protein SIRPα is restricted to the surface of macrophages, dendritic cells, and nerve cells. As a cell surface receptor and ligand, respectively, CD47 and SIRPα interact to regulate cell migr...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章,评审


    authors: Lu Q,Chen X,Wang S,Lu Y,Yang C,Jiang G

    更新日期:2020-09-22 00:00:00

  • Prognostic significance of circulating tumor cells in esophageal carcinoma: a meta-analysis.

    abstract:PURPOSE:The prognostic significance of circulating tumor cells (CTCs) in esophageal carcinoma (EC) is controversial. We aim to assess its association with clinicopathological and prognostic relevance in EC by using a meta-analysis. METHODS:We searched PubMed, Cochrane Database, Embase databases, and the references in ...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Qiao GL,Qi WX,Jiang WH,Chen Y,Ma LJ

    更新日期:2016-03-31 00:00:00

  • Lenvatinib Promotes the Antitumor Effect of Doxorubicin in Anaplastic Thyroid Cancer.

    abstract:Purpose:Anaplastic thyroid cancer (ATC) is a kind of rare thyroid cancer with very poor prognosis. Doxorubicin has been approved in ATC treatment as a single agent, but monotherapy still shows no improvement of the total survival in advanced ATC. Lenvatinib was investigated with encouraging results in treating patients...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Su X,Liu J,Zhang H,Gu Q,Zhou X,Ji M,Yao D

    更新日期:2020-11-02 00:00:00

  • Prognostic value of fever grade combined with neutrophil percentage in hepatocellular carcinoma patients presenting fever as the initial manifestation.

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) patients with fever as the initial presentation are extremely rare. Our aim was to investigate the clinical characteristics and prognosis of patients with this disease. PATIENTS AND METHODS:The clinical features were analyzed in a retrospective study of 63 HCC patients with fe...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Gong ZJ,Guo W,Sun YF,Zhang X,Qiu SJ,Zhou J,Fan J,Yang XR

    更新日期:2016-10-13 00:00:00

  • Cordycepin induces apoptosis in human pancreatic cancer cells via the mitochondrial-mediated intrinsic pathway and suppresses tumor growth in vivo.

    abstract:Background:Cordycepin, the main active ingredient of a traditional Chinese herbal remedy - extracted from Cordyceps sinensis - has been demonstrated as a very effective anti-inflammatory and antitumor drug. The present study investigated its antitumor effect on pancreatic cancer, a highly aggressive cancer with extreme...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Zhang Y,Zhang XX,Yuan RY,Ren T,Shao ZY,Wang HF,Cai WL,Chen LT,Wang XA,Wang P

    更新日期:2018-08-01 00:00:00

  • The impact of tumor size change after target therapy on survival: analysis of patients enrolled onto three clinical trials of advanced NSCLC from one institution.

    abstract:PURPOSE:To explore whether changes in tumor size impact survival in advanced non-small-cell lung cancer (NSCLC) after target therapy, especially in patients with evaluation of stable disease (SD), and to review the applicability of the Response Evaluation Criteria in Solid Tumors (RECIST) criteria in target therapy. P...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Zhang J,Huang Y,Li X,Guo Y,Zhao Y,Xue C,Hu Z,Zhang L,Zhao H

    更新日期:2012-01-01 00:00:00

  • Elevated pretreatment plasma D-dimer levels and platelet counts predict poor prognosis in pancreatic adenocarcinoma.

    abstract::This retrospective study was conducted to evaluate the prognostic significance of the preoperative plasma D-dimer levels and platelet counts in patients with pancreatic adenocarcinoma. A total of 168 consecutive locally advanced pancreatic adenocarcinoma patients who underwent intensity modulated radiation therapy wit...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Liu P,Zhu Y,Liu L

    更新日期:2015-06-04 00:00:00

  • Partial stereotactic ablative boost radiotherapy in bulky non-small cell lung cancer: a retrospective study.

    abstract:Purpose:Bulky non-small cell lung cancer (NSCLC) is difficult to achieve effective local control by conventionally fractionated radiotherapy (CRT). The present work aims to evaluate the safety and efficacy of partial stereotactic ablative boost radiotherapy (P-SABR) in bulky NSCLC. Patients and methods:From December 2...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Bai Y,Gao XS,Qin SB,Chen JY,Su MM,Liu Q,Qin XB,Ma MW,Zhao B,Gu XB,Xie M,Cui M,Qi X,Li XY

    更新日期:2018-05-08 00:00:00

  • Downregulation of OSR1 Promotes Colon Adenocarcinoma Progression via FAK-Mediated Akt and MAPK Signaling.

    abstract:Introduction:Odd-skipped related transcription factor 1 (OSR1) is a newly identified tumor suppressor in many tumor types. However, the role and mechanism of OSR1 in colon adenocarcinoma (COAD) remain unknown. Methods:OSR1 expression was detected in COAD tissues and cells. COAD cells with OSR1 overexpression or knockd...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Zhang F,Jiang Z

    更新日期:2020-04-24 00:00:00

  • Follicular dendritic cell sarcoma: two rare cases and a brief review of the literature.

    abstract::Follicular dendritic cell sarcoma (FDCS) is a rare malignant tumor recognized in recent years. It accounts for only 0.4% of soft-tissue sarcomas, and its underlying causes are largely unknown. A correct diagnosis can be difficult to make. Diagnosis of FDCS depends on the combined clinical examination, histopathologic ...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Ma Y,Sun J,Yang C,Yuan D,Liu J

    更新日期:2015-07-24 00:00:00

  • Sustained response of malignant pericardial effusion to intrapericardial bevacizumab in an advanced lung cancer patient: a case report and literature review.

    abstract::Malignant pericardial effusion (MPCE) is a common complication of advanced malignant tumors, and interferes severely with patient prognosis and quality of life. The standard treatment for this complication is intracavitary perfusion of chemotherapeutic drugs, which is limited by unsatisfactory therapeutic effects and ...

    journal_title:OncoTargets and therapy



    authors: Chen D,Zhang Y,Shi F,Li M,Zhu H,Kong L,Yu J

    更新日期:2015-10-01 00:00:00

  • A blockade of PD-L1 produced antitumor and antimetastatic effects in an orthotopic mouse pancreatic cancer model via the PI3K/Akt/mTOR signaling pathway.

    abstract:BACKGROUND:Pancreatic cancer is one of the most aggressive and intractable malignant tumors, and most deaths from pancreatic cancer are related to metastases. It has been demonstrated in vitro that overexpression of programmed death-ligand 1 (PD-L1) correlates with a lack of phosphatase and tensin homologue (PTEN) expr...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Zhao L,Li C,Liu F,Zhao Y,Liu J,Hua Y,Liu J,Huang J,Ge C

    更新日期:2017-04-12 00:00:00

  • XPA A23G polymorphism and risk of digestive system cancers: a meta-analysis.

    abstract:BACKGROUND:Several studies have reported an association between the A23G polymorphism (rs 1800975) in the xeroderma pigmentosum group A (XPA) gene and risk of digestive system cancers. However, the results are inconsistent. In this study, we performed a meta-analysis to assess the association between XPA A23G polymorph...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: He L,Deng T,Luo H

    更新日期:2015-02-05 00:00:00

  • Cervical Cancer: Emerging Immune Landscape and Treatment.

    abstract::Immune cells are essential for defending the body's balance and have increasingly been implicated in controlling tumor growth. In cervical cancer (CC), the immune landscape is extensively connected with human papillomavirus (HPV) status. Recent insights from studies have revealed that as a result of infection with HPV...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章,评审


    authors: Guo L,Hua K

    更新日期:2020-08-12 00:00:00

  • CircRNA-PTN Sponges miR-326 to Promote Proliferation in Hepatocellular Carcinoma.

    abstract:Background:Mounting evidences reveal that circular RNAs (circRNAs) are critical to regulate biological behavior and process of tumor. Our objective is to explore the role of circRNA-PTN (circPTN) and explain the exact mechanism in hepatocellular carcinoma (HCC). Methods:Real-time polymerase chain reaction assay was us...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Jia B,Yin X,Wang Y,Qian J,He Y,Yang C,Yu G,Guo B,Meng X

    更新日期:2020-05-29 00:00:00

  • Ductal adenocarcinoma of the prostate: immunohistochemical findings and clinical significance.

    abstract:INTRODUCTION:To investigate the clinical features, diagnosis, treatment, and prognosis of ductal adenocarcinoma of the prostate. METHODS:The clinicopathological and immunohistochemical data of seven patients with ductal adenocarcinoma of the prostate were retrospectively analyzed. All patients underwent physical exami...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Sha J,Bo J,Pan J,Zhang L,Xuan H,Chen W,Li D,Wang Z,Liu D,Huang Y

    更新日期:2013-10-24 00:00:00

  • MicroRNA-125a-5p regulates cancer cell proliferation and migration through NAIF1 in prostate carcinoma.

    abstract:BACKGROUND:We investigated the functional roles of microRNA-125a-5p in regulating human prostate carcinoma. METHODS:Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was conducted to evaluate the gene expression levels of miR-125a-5p in eight prostate cancer cell lines and nine biopsy specimens fr...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Fu Y,Cao F

    更新日期:2015-12-17 00:00:00

  • Correlation of SASH1 expression and ultrasonographic features in breast cancer.

    abstract:OBJECTIVE:SASH1 is a member of the SH3/SAM adapter molecules family and has been identified as a new tumor suppressor and critical protein in signal transduction. An ectopic expression of SASH1 is associated with decreased cell viability of breast cancer. The aim of this study was to explore the association between SAS...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Gong X,Wu J,Wu J,Liu J,Gu H,Shen H

    更新日期:2017-01-10 00:00:00

  • Update on the role of trabectedin in the treatment of intractable soft tissue sarcomas.

    abstract::Soft tissue sarcomas (STS) represent a variety of tumors of mesenchymal origin, accounting for about 1% of all adult cancers. This group of tumors comprises over 60 different histotypes with different biology showing different sensitivity to therapeutic agents. For decades, the standard first-line systemic treatment o...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章,评审


    authors: Recine F,Bongiovanni A,Riva N,Fausti V,De Vita A,Mercatali L,Liverani C,Miserocchi G,Amadori D,Ibrahim T

    更新日期:2017-02-23 00:00:00

  • Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells.

    abstract:Background:Celastrol is a major active component of the thunder god vine (Tripterygium wilfordii) used in traditional Chinese medicine to treat chronic inflammatory and autoimmune diseases. Celastrol inhibits PI3K-Akt-mTOR signaling, which is frequently dysregulated in tumors and critical for tumor-cell proliferation a...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Li X,Zhu G,Yao X,Wang N,Hu R,Kong Q,Zhou D,Long L,Cai J,Zhou W

    更新日期:2018-12-11 00:00:00

  • Novel long noncoding RNA GACAT3 promotes colorectal cancer cell proliferation, invasion, and migration through miR-149.

    abstract:Aim:To explore the expression and clinical significance of long noncoding RNA (lncRNA) gastric cancer-associated transcript 3 (GACAT3) in human colorectal cancer (CRC). Methods:Expression of GACAT3 in CRC tissues and cell lines was measured using quantitative real-time PCR. CCK-8 and colony formation assays were used ...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Zhou W,Wang L,Miao Y,Xing R

    更新日期:2018-03-19 00:00:00

  • Tyrosine kinase inhibitor combination therapy in first-line treatment of non-small-cell lung cancer: systematic review and network meta-analysis.

    abstract:INTRODUCTION:The introduction of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) has improved the outlook for patients with advanced non-small-cell lung cancer (NSCLC) with EGFR+ mutations. However, most patients develop resistance, with the result that median progression-free survival (PFS) iŝ1...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Batson S,Mitchell SA,Windisch R,Damonte E,Munk VC,Reguart N

    更新日期:2017-05-05 00:00:00

  • Profile of selumetinib and its potential in the treatment of melanoma.

    abstract::The mitogen-activated protein kinase (MAPK) pathway is a critical oncogenic driver signal in a number of malignancies. The discovery of activating mutations in the MAPK pathway has led to the development of MAPK pathway inhibitors. Selumetinib is a potent and selective inhibitor of MEK1 and MEK2, which are essential d...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章,评审


    authors: Kim DW,Patel SP

    更新日期:2014-09-19 00:00:00

  • Sichong formula inhibits the proliferation and migration of human gastric cancer cells.

    abstract:Purpose:Traditional Chinese medicine (TCM) has gained increasing attention for the treatment of multiple chronic diseases, such as cancer. Here we aim to identify the antitumor activity of Sichong formula, a novel TCM, in human gastric cancer cells and investigate the underlying mechanisms. Methods:The AGS and MKN45 g...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Wang M,Tian Z,Zhu Y,Ding J,Li C,Zhou Y,Zhang Y

    更新日期:2019-07-16 00:00:00

  • Bioinformatics analyses of differentially expressed genes associated with bisphosphonate-related osteonecrosis of the jaw in patients with multiple myeloma.

    abstract:PURPOSE:This study aimed to explore the molecular mechanisms associated with bisphosphonate (BP)-related osteonecrosis of the jaw (ONJ) in patients with multiple myeloma (MM). METHODS:The gene expression profile GSE7116 was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) fro...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Sun J,Wen X,Jin F,Li Y,Hu J,Sun Y

    更新日期:2015-09-22 00:00:00

  • O-GlcNAcylation enhances the invasion of thyroid anaplastic cancer cells partially by PI3K/Akt1 pathway.

    abstract:BACKGROUND:The PI3K family participates in multiple signaling pathways to regulate cellular functions. PI3K/Akt signaling pathway plays an important role in tumorigenesis and development. O-GlcNAcylation, a posttranslational modification, is thought to modulate a wide range of biological processes, such as transcriptio...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Zhang P,Wang C,Ma T,You S

    更新日期:2015-11-09 00:00:00

  • Decitabine enhances cytotoxic effect of T cells with an anti-CD19 chimeric antigen receptor in treatment of lymphoma.

    abstract::Background: CD19-directed chimeric antigen receptor (CAR) T cells have substantial benefit in the treatment of patients with B-cell malignancies. However, despite encouraging therapeutic efficiency, there is limited overall response rate when anti-CD19 CAR-T cells are used to treat patients with relapsed and refractor...

    journal_title:OncoTargets and therapy

    pub_type: 杂志文章


    authors: Li S,Xue L,Wang M,Qiang P,Xu H,Zhang X,Kang W,You F,Xu H,Wang Y,Liu X,Yang L,Wang X

    更新日期:2019-07-12 00:00:00