Abstract:
BACKGROUND:MDS1 and EVI1 complex locus protein EVI1 (MECOM) is an oncogenic transcription factor in several kinds of cancers. However, the clinical significance of MECOM in glioblastoma multiforme (GBM) has not been well elucidated. PATIENTS AND METHODS:Our study enrolled 86 resected samples of GBM in three medical centers. We detected the expression of MECOM in all the 86 samples by immunohistochemistry and compared the difference of MECOM mRNA between tumor tissues and adjacent tissues with real-time polymerase chain reaction. With immunoblotting, we detected the MECOM expression in different GBM cell lines. Moreover, we analyzed the correlation between MECOM expression and clinicopathologic factors with chi-square test, and evaluated the prognostic value of MECOM with univariate and multivariate analysis. RESULTS:In GBM tissue, the percentage of MECOM high expression is 41.9% (36/86). The mRNA of MECOM in tumor tissues is remarkably higher than that in adjacent tissues, indicating the oncogenic role of MECOM in GBM. MECOM exists in all the detected cell lines with different abundance. Moreover, MECOM is correlated with poorer overall survival rate (P=0.033) and can be identified as an independent prognostic factor in GBM (P=0.042). CONCLUSION:MECOM could be considered as an independent prognostic factor in GBM, predicting it as a potential and promising molecular drug target.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Hou A,Zhao L,Zhao F,Wang W,Niu J,Li B,Zhou Z,Zhu Ddoi
10.2147/OTT.S95831subject
Has Abstractpub_date
2016-01-13 00:00:00pages
315-20issn
1178-6930pii
ott-9-315journal_volume
9pub_type
杂志文章abstract:Purposes:The main aim of the study was to investigate the dosimetric difference between acuros XB algorithm (AXB), anisotropic analytic algorithm (AAA), and pencil beam convolution (PBC) algorithm in stereotactic body radiation therapy (SBRT) plan for non-small cell lung cancer (NSCLC). Patients and Methods:Thirty-eig...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S201473
更新日期:2019-08-12 00:00:00
abstract:Background:Our previous study demonstrated that Id-1 may promote the tumorigenicity of esophageal squamous cell carcinoma (ESCC). Id-4 is another member of Id family, which is rare to be studied in ESCC. In this study, we investigated the expression of Id-4 in human ESCC specimens and determined whether Id-4 expression...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S230678
更新日期:2020-02-12 00:00:00
abstract:AIM:This article discusses the current use of volumetric modulated arc therapy (VMAT) techniques in clinical practice and reviews the available data from clinical outcome studies in different clinical settings. An overview of available literature about clinical outcomes with VMAT stereotactic/radiosurgical treatment is...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S113119
更新日期:2017-07-26 00:00:00
abstract:Background:Bladder cancer is a serious threat to human health. It is meaningful to study the pathogenesis of bladder cancer. Long non-coding RNAs (lncRNAs) are reported to promote or inhibit bladder cancer development. However, the role of lncRNA BCAR4 in the regulation of bladder cancer remains unclear. Purpose:This ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S232965
更新日期:2020-03-24 00:00:00
abstract:BACKGROUND/AIM:To elucidate the mechanism responsible for developing acute kidney injury in patients with diabetes mellitus, we also evaluated the issue of whether advanced glycation endproducts (AGEs) influence the expressions of multi antimicrobial extrusion protein (MATE1/SLC47A1) in tubular cells. MATERIALS AND ME...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S86743
更新日期:2015-07-10 00:00:00
abstract:Purpose:Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide. Natural antisense transcripts (NATs) are pervasively expressed in human genome and have been confirmed to contribute to cancer progression. In our study, we aimed to investigate the expression and clinical pertinence of serine ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S163883
更新日期:2018-07-10 00:00:00
abstract:AIM:To investigate the clinical significance of cyclic adenosine monophosphate-responsive element-binding (CREB) and phosphorylated CREB (pCREB) expression in human hepatocellular carcinoma (HCC). MATERIALS AND METHODS:Immunohistochemistry and Western blot analyses were performed to detect the expression and subcellul...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S63594
更新日期:2014-05-29 00:00:00
abstract::Interleukin-8 (IL-8) is a kind of chemokine that plays an important role in the development and progression of many human malignancies. Previous studies have uncovered that polymorphisms in IL-8 is associated with the risk of many cancer types, but the results were inconsistent and inconclusive. In the present study, ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S103159
更新日期:2016-06-22 00:00:00
abstract::The epidermal growth-factor receptor (EGFR) is overexpressed in the majority of epithelial ovarian cancers and promotes cell proliferation, migration and invasion, and angiogenesis, as well as resistance to apoptosis. This makes EGFR an attractive therapeutic target in this disease. A number of strategies to block EGF...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S30373
更新日期:2013-04-18 00:00:00
abstract::Breast cancer is one of the most common malignant cancers among women and a major clinical obstacle. Although studies have reported the abnormal expression of SIRT7 in breast cancer, whether the function of SIRT7 regulates the expression of long noncoding RNAs (lncRNAs) in breast cancer remains unknown. We aimed to de...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S149048
更新日期:2017-10-24 00:00:00
abstract:Background:Hepatocellular carcinoma is a common malignant cancer and the second most common cause of cancer-related deaths worldwide. Collagen triple helix repeat containing 1 (CTHRC1) has been increasingly reported to be involved in tumorigenesis and/or tumor progression. However, limited data are available regarding ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S219429
更新日期:2019-09-23 00:00:00
abstract:BACKGROUND:We investigated the functional roles of microRNA-125a-5p in regulating human prostate carcinoma. METHODS:Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was conducted to evaluate the gene expression levels of miR-125a-5p in eight prostate cancer cell lines and nine biopsy specimens fr...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S92314
更新日期:2015-12-17 00:00:00
abstract::CD47 belongs to immunoglobulin superfamily and is widely expressed on the surface of cell membrane, while another transmembrane protein SIRPα is restricted to the surface of macrophages, dendritic cells, and nerve cells. As a cell surface receptor and ligand, respectively, CD47 and SIRPα interact to regulate cell migr...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S249822
更新日期:2020-09-22 00:00:00
abstract:Introduction:Immune-based and antibody-drug conjugate therapies have shown promise in the treatment of patients with small cell lung cancer (SCLC). However, better predictive biomarkers are needed for selection of the appropriate SCLC patients for these advanced therapies and also for evaluation of the efficacy of thes...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S216362
更新日期:2019-11-21 00:00:00
abstract:AIM:The aim of this study was to assess if the expression of Notch 1 receptor is associated with tumor aggressiveness in papillary thyroid carcinomas (PTCs). PATIENTS AND METHODS:By searching the electronic medical record system of Xin Hua Hospital, all cases of PTC patients who underwent thyroidectomy in the hospital...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S98239
更新日期:2016-03-15 00:00:00
abstract:Background:Nicotinamide phosphoribosyltransferase (NAMPT) and the transforming growth factor-β (TGF-β) signaling pathway play important roles in colorectal tumorigenesis and progress. However, the underlying regulatory mechanisms between NAMPT and TGF-β signaling in colorectal cancer (CRC) remain poorly understood. Me...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S282367
更新日期:2021-01-08 00:00:00
abstract:Background/aim:Urothelial bladder cancer arises from the accumulation of multiple epigenetic and genetic changes. We aimed to investigate the specificity and sensitivity of gene-specific promoter methylation of CDH1 and p14ARF genes in the early diagnosis of bladder cancer and compare those with other diagnostic tests ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S158259
更新日期:2018-07-19 00:00:00
abstract:BACKGROUND:The association of cancer stem cells with epithelial-mesenchymal transition (EMT) is receiving attention. We found in our previous study that EMT existed from CD24- phenotype cells to their differentiated cells. It was shown that cyclin D1 functioned in sustaining self-renewal independent of CDK4/CDK6 activa...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S44177
更新日期:2013-06-20 00:00:00
abstract:Purpose:Breast cancer (BC) is the most common cancer in women. Emerging evidence has demonstrated that lncRNAs play an important role in BC. The objective of this study was to investigate the impact of the long non-coding RNA (lncRNA), H19/miRNA-130a-3P/special AT-rich sequence-binding protein-1 (SATB1) axis on BC prog...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S280142
更新日期:2020-12-07 00:00:00
abstract:BACKGROUND:Nivolumab (BMS-936558/ONO-4538) was the first monoclonal antibody targeting programmed death (PD)-1. So far, a number of clinical trials on nivolumab have showed satisfactory efficacy in treating non-small-cell lung cancer (NSCLC). Herein, we present a meta-analysis evaluating the efficacy and safety of nivo...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S115262
更新日期:2016-09-23 00:00:00
abstract::Bladder cancer (BC) is the most common urinary system malignancy and is a serious threat to human health. Circular RNAs (circRNAs) are members of a newly defined class of noncoding RNAs (ncRNAs) that can regulate gene expression at the transcriptional or posttranscriptional level. Studies have shown that circRNAs are ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S268859
更新日期:2020-09-29 00:00:00
abstract:AIM:To retrospectively evaluate the safety and efficacy of ultrasound-guided percutaneous microwave ablation (MWA) combined with simultaneous transarterial chemoembolization (TACE) in the treatment of patients with advanced intrahepatic cholangiocarcinoma (ICC). METHODS:All patients treated with ultrasound-guided perc...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S84764
更新日期:2015-05-26 00:00:00
abstract:AIM:To investigate the significance of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER)2, and HER3 expression on survival outcomes in Chinese gastric cancer patients. MATERIALS AND METHODS:Formalin-fixed, paraffin-embedded specimens from 121 patients who underwent gastrectomy at Sh...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S70922
更新日期:2014-12-16 00:00:00
abstract:Objective:This study aimed to evaluate the safety and efficacy of intensity-modulated radiotherapy (IMRT) plus nimotuzumab with or without concurrent chemotherapy (CCT) for patients with locally advanced nasopharyngeal carcinoma (LA-NPC). Patients and methods:A total of 50 newly diagnosed patients with LA-NPC treated ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S151554
更新日期:2017-12-08 00:00:00
abstract:BACKGROUND:Repetitive genotyping is useful to assess the genetic evolution of non-small-cell lung cancer (NSCLC) during treatment, but the need for sampling by biopsy is a major obstacle. Digital polymerase chain reaction (PCR) is a promising procedure for the detection of mutant alleles in plasma of cancer patients. ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S105976
更新日期:2016-08-24 00:00:00
abstract:Background:Erlotinib is a commonly used molecular-targeted drug for the treatment of tongue cancer. However, the development of acquired resistance to erlotinib hampers its therapeutic use. Materials and methods:To analyze the erlotinib resistance, long-term and short term survival assay were used to compare the resis...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S167936
更新日期:2018-09-05 00:00:00
abstract::[This corrects the article DOI: 10.2147/OTT.S262089.]. ...
journal_title:OncoTargets and therapy
pub_type: 已发布勘误
doi:10.2147/OTT.S292577
更新日期:2020-11-27 00:00:00
abstract:Background/Aims:The effects of lncRNA-NORAD/mir-520a-3p on proliferation and invasion of non-small cell lung cancer (NSCLC) were studied, and its potential molecular mechanism was discussed. Methods:qRT-PCR was used to detect the expression of lncRNA NORAD and miR-520a-3p in non-small cell lung cancer tissues and cell...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S230954
更新日期:2020-02-19 00:00:00
abstract:Background and aims:Gastric cancer (GC) is one of the most common cancers worldwide, and its pathogenesis is related to a complex network of gene interactions. The aims of our study were to find hub genes associated with the progression and prognosis of GC and illustrate the underlying mechanisms. Methods:Weighted gen...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S176511
更新日期:2018-10-02 00:00:00
abstract:PURPOSE:Randomized trials showing a clear survival benefit of intensity-modulated radiotherapy (IMRT) over 3-dimensional conformal radiotherapy (3D-CRT) in the treatment of lung cancer are lacking. This study compared the survival rates of patients with stage III non-small cell lung cancer who were treated with either ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S124311
更新日期:2016-11-24 00:00:00