HMGA2 Gene rs8756 A>C Polymorphism Reduces Neuroblastoma Risk in Chinese Children: A Four-Center Case-Control Study.

abstract：Objective:To explore the regulatory effects of circZNF609 on proliferative and migratory capacities of gastric cancer (GC) and its underlying mechanism. Methods:Expression level of circZNF609, CDK6 and miR-483-3p in GC tissues and cells were detected qRT-PCR verification. CCK-8 and transwell assay were conducted the c...

journal_title：OncoTargets and therapy

authors： Wu W,Wei N,Shao G,Jiang C,Zhang S,Wang L

更新日期：2019-10-04 00:00:00

abstract：Objective:To compare cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and CHOP plus etoposide (CHOPE) with regard to outcomes including efficacy and safety for patients with peripheral T-cell lymphoma (PTCL). Methods:Relevant literature was searched using PubMed, Embase, Wanfang, and CNKI for eligible...

journal_title：OncoTargets and therapy

authors： Deng S,Lin S,Shen J,Zeng Y

更新日期：2019-03-28 00:00:00

abstract：:Gastric cancer (GC) is one of the leading causes of tumor-related mortality. In addition to surgery and endoscopic resection, systemic therapy remains the main treatment option for GC, especially for advanced-stage disease and for cases not suitable for surgical therapy. Hence, improving the efficacy of systemic thera...

journal_title：OncoTargets and therapy

authors： Zhao X,Hu GF,Shi YF,Xu W

更新日期：2019-12-24 00:00:00

abstract：Purpose:Non-small cell lung cancer (NSCLC) patients with EGFR mutation are suffering from a high incidence of brain metastasis (BM). It is still controversial whether cranial radiotherapy could be delayed when the EGFR-tyrosine kinase inhibitors (TKIs) used as first-line therapy for EGFR-positive patients with BM. This...

journal_title：OncoTargets and therapy

authors： An N,Wang H,Li J,Zhai X,Jing W,Jia W,Kong L,Zhu H,Yu J

更新日期：2019-10-08 00:00:00

abstract：Purpose:Breast cancer (BC) is the most common cancer in women. Emerging evidence has demonstrated that lncRNAs play an important role in BC. The objective of this study was to investigate the impact of the long non-coding RNA (lncRNA), H19/miRNA-130a-3P/special AT-rich sequence-binding protein-1 (SATB1) axis on BC prog...

journal_title：OncoTargets and therapy

authors： Zhong G,Lin Y,Wang X,Wang K,Liu J,Wei W

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:The prognostic value of inflammatory index in esophageal cancer (EC) has not been established. In the present study, therefore, we initially evaluated a novel prognostic system, named the COCC (COmbination of C-reactive protein [CRP] and carcinoembryonic antigen [CEA]), for making a prognosis in patients wit...

journal_title：OncoTargets and therapy

authors： Huang Y,Liu JS,Feng JF

更新日期：2015-04-10 00:00:00

abstract：OBJECTIVE:Even though the primary mediastinal extragonadal germ cell tumors (EGCTs) are rare, they are noteworthy in the differential diagnosis of mediastinal masses. In this study, we aimed to identify the clinical features of mediastinal malignant GCTs and compare the results of hematopoietic stem cell transplantatio...

journal_title：OncoTargets and therapy

authors： Ocal N,Yildiz B,Karadurmus N,Dogan D,Ozaydin S,Ocal R,Ozturk M,Arpaci F,Bilgic H

更新日期：2016-12-09 00:00:00

abstract：Purpose:Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer and its incidence continues to rise yearly. Photodynamic therapy (PDT) is a non-invasive form of cancer therapy, which utilizes the combined action of a photosensitizer, light, and oxygen molecules to selectively cause cellul...

journal_title：OncoTargets and therapy

authors： Shi S,Zheng G,Yang C,Chen X,Yan Q,Jiang F,Jiang X,Xin Y,Jiang G

更新日期：2019-12-31 00:00:00

abstract：BACKGROUND:Bevacizumab plus taxane chemotherapy improves progression-free survival (PFS) versus taxane monotherapy in the first-line treatment of HER2-negative metastatic breast cancer (MBC) and appears promising in the second-line setting. This retrospective analysis evaluated the efficacy and safety of this combinati...

journal_title：OncoTargets and therapy

authors： Redondo A,Martínez V,Zamora P,Castelo B,Pinto A,Cruz P,Higuera O,Mendiola M,Hardisson D,Espinosa E

更新日期：2014-11-27 00:00:00

abstract：:MicroRNAs (miRs) have been demonstrated to play key roles in the development and progression of hepatocellular carcinoma (HCC). However, the regulatory mechanism of miR-503 in HCC has not been fully uncovered. In this study, we found that miR-503 was significantly downregulated in HCC tissues compared to nontumorous l...

journal_title：OncoTargets and therapy

authors： Xiao Y,Tian Q,He J,Huang M,Yang C,Gong L

更新日期：2016-06-15 00:00:00

abstract：:This report describes a patient with intravascular large B-cell lymphoma (IVLBCL) with central nervous system involvement at the time of diagnosis who achieved complete remission for over 5 years in response to therapy. The patient, a 71 year-old woman, was previously healthy with the exception of taking verapamil for...

journal_title：OncoTargets and therapy

authors： Sawada T,Omuro Y,Kobayashi T,Hishima T,Koizumi F,Kanemasa Y,Shimoyama T,Sasaki E,Maeda Y

更新日期：2014-11-18 00:00:00

abstract：Purpose:Strategies to increase radiosensitivity are urgently needed. Combining radiosensitizing reagents with radiotherapy could improve the outcome of cancer treatment. Some preclinical studies showed that sepantronium bromide (YM155) could sensitize cancer cells to radiation by inhibiting the survivin protein. In thi...

journal_title：OncoTargets and therapy

authors： Liu X,Zhao Y,Zhang W,Gao Y,Huo M,Liu M,Xiao Z,Liang S,Xu N,Zhu H

更新日期：2018-05-24 00:00:00

abstract：Background:Bladder cancer (BC) is one of the most prevalent malignancies of the genitourinary system, yet the underlying mechanism of BC progression still remains unclear. Growth arrest and DNA damage-inducible 45 alpha (GADD45a) is a repressive gene implicated in cell cycle regulation, as well as in human cancers deve...

journal_title：OncoTargets and therapy

authors： Han N,Yuan F,Xian P,Liu N,Liu J,Zhang H,Zhang H,Yao K,Yuan G

更新日期：2019-09-16 00:00:00

abstract：:We report a case of a 68-year-old man diagnosed with pulmonary pleomorphic carcinoma who showed partial response after a single treatment with camrelizumab (PD1 monoclonal antibody). The patient's tumor was positive for programmed cell death ligand 1 (PD-L1) and progressed rapidly after a course of chemotherapy. Fortu...

journal_title：OncoTargets and therapy

authors： Chen Y,Zhang H,Shi J,Wang T

更新日期：2020-12-03 00:00:00

abstract：Background:Nasopharyngeal carcinoma (NPC) is a common malignant cancer that is distributed particularly in Southeastern Asia. Previous studies have manifested that long noncoding RNA urothelial carcinoma associated 1 (UCA1) was involved in NPC tumorigenesis and metastasis. However, the biological mechanism of UCA1 for ...

journal_title：OncoTargets and therapy

authors： Liu C,Zhang H,Liu H

更新日期：2019-10-11 00:00:00

abstract：:Erastin was initially discovered as a small molecule compound that selectively kills tumor cells expressing ST and RASV12 and was later widely investigated as an inducer of ferroptosis. Ferroptosis is a recently discovered form of cell death caused by peroxidation induced by the accumulation of intracellular lipid rea...

journal_title：OncoTargets and therapy

authors： Zhao Y,Li Y,Zhang R,Wang F,Wang T,Jiao Y

更新日期：2020-06-11 00:00:00

abstract：Objective:This study aimed to evaluate the safety and efficacy of intensity-modulated radiotherapy (IMRT) plus nimotuzumab with or without concurrent chemotherapy (CCT) for patients with locally advanced nasopharyngeal carcinoma (LA-NPC). Patients and methods:A total of 50 newly diagnosed patients with LA-NPC treated ...

journal_title：OncoTargets and therapy

authors： Huang J,Zou Q,Qian D,Zhou L,Yang B,Chu J,Pang Q,Wang K,Zhang F

更新日期：2017-12-08 00:00:00

abstract：Background:Chemotherapy remains a major clinical option for the successful treatment of cancer by eliminating fast-growing populations of cancer cells. However, drug resistance causes the failure of antitumor treatment. Increasing evidence suggests that a small subpopulation of cancer cells will enter a "persister stat...

journal_title：OncoTargets and therapy

authors： Wang L,Yang Q,Peng S,Liu X

更新日期：2019-07-08 00:00:00

abstract：OBJECTIVE:To investigate the effects of microRNA-122 (miR-122) on proliferation, migration, and invasion in human hepatocellular carcinoma (HCC) cells by activating epithelial-mesenchymal transition (EMT) pathways. METHODS:miR-122 mimics, miR-122 inhibitors, relevant control oligonucleotides, and Wnt1 were transfected...

journal_title：OncoTargets and therapy

authors： Wang N,Wang Q,Shen D,Sun X,Cao X,Wu D

更新日期：2016-04-06 00:00:00

abstract：OBJECTIVE:Despite advances in the early diagnosis of gastrointestinal (GI) cancers, these cancers are often being detected rather late in their course. Emerging published data on the accuracy of dickkopf-1 (DKK1) for diagnosing GI cancers are inconsistent. The purpose of this systematic review and meta-analysis was to ...

journal_title：OncoTargets and therapy

authors： Liang B,Zhong L,He Q,Wang S,Pan Z,Wang T,Zhao Y

更新日期：2015-10-22 00:00:00

abstract：Purpose:To evaluate the association between tertiary Gleason pattern 5 (TGP5) and biochemical recurrence (BCR) in patients with prostate cancer (PCa) with a Gleason score (GS) of 7 after radical prostatectomy (RP). Patients and methods:This retrospective study identified 350 patients who received RP and were graded as...

journal_title：OncoTargets and therapy

authors： Li J,Guo Y,Qiu S,He M,Jin K,Zheng X,Tu X,Liao X,Yang L,Wei Q

更新日期：2019-09-02 00:00:00

abstract：:Background: During the past decades, great efforts have been built to develop lung cancer vaccines. Whole tumor cell lysate (TCL) are ideal sources of antigens for cancer vaccine design, which however have limited efficacy due to insufficient immunogenicity. Recently, radiotherapy has been closely related to immunothe...

journal_title：OncoTargets and therapy

authors： Luo L,Lv M,Zhuang X,Zhang Q,Qiao T

更新日期：2019-05-16 00:00:00

abstract：Background:The aberrant expression of circular RNAs (circRNAs) has been identified as a novel trait of cancers. However, the role of circRNAs in colorectal cancer (CRC) remains to be elucidated. Methods:Informatic analysis was performed to identify circRNAs in CRC tissues and adjacent tissues. Gain- and loss-of-functi...

journal_title：OncoTargets and therapy

authors： Sun J,Liu J,Zhu Q,Xu F,Kang L,Shi X

更新日期：2020-06-30 00:00:00

abstract：Background:Exosomes are nano-sized biological vesicles released by many kinds of cells, which play an important role in tumor metastasis through transporting cytokines, RNAs and proteins. However, the molecular mechanisms of exosomes in hepatocellular carcinoma (HCC) metastasis are not completely understood. Materials...

journal_title：OncoTargets and therapy

authors： Qu Z,Feng J,Pan H,Jiang Y,Duan Y,Fa Z

更新日期：2019-08-23 00:00:00

abstract：BACKGROUND:The PI3K family participates in multiple signaling pathways to regulate cellular functions. PI3K/Akt signaling pathway plays an important role in tumorigenesis and development. O-GlcNAcylation, a posttranslational modification, is thought to modulate a wide range of biological processes, such as transcriptio...

journal_title：OncoTargets and therapy

authors： Zhang P,Wang C,Ma T,You S

更新日期：2015-11-09 00:00:00

abstract：Purpose:Circular RNAs (circRNAs) have been found to regulate several human tumors. The present study was to explore the mechanism of hsa_circ_0087862 in regulating non-small cell lung cancer (NSCLC). Methods:Totally 102 NSCLC cases were enrolled. NCI-H1359 and A549 cells were transfected. Cells viability, apoptosis, m...

journal_title：OncoTargets and therapy

authors： Li L,Wan K,Xiong L,Liang S,Tou F,Guo S

更新日期：2020-04-03 00:00:00

abstract：Introduction:Gastric cancer (GC) is one of the most malignancies leading to human mortality due to its development, progress, metastasis and poor prognosis, despite the development of remarkable chemotherapy and surgery. The 5-fluorouracil (5-Fu) is an effective anti-gastric cancer agent. However, a fraction of GC patie...

journal_title：OncoTargets and therapy

authors： Gao S,Song D,Liu Y,Yan H,Chen X

更新日期：2020-07-01 00:00:00

abstract：:Purpose: Several microRNAs (miRNAs) that are aberrantly expressed in glioblastoma multiforme (GBM) play a significant role in GBM formation and progression. The expression profile and functions of miR-559 in GBM remain unclear. Here, we quantified the expression and investigated the involvement of miR-559 in the oncog...

journal_title：OncoTargets and therapy

authors： Yang F,Zhang C,Xu C,Fu F,Han D,Li H

更新日期：2019-06-05 00:00:00

abstract：:Background and aims: HOXD antisense growth-associated long noncoding RNA (HOXD-AS1) was reported to be upregulated in various cancers, such as gastric cancer, hepatocellular carcinoma, colorectal cancer, and glioma. Here, we conducted a meta-analysis and The Cancer Genome Atlas data review to investigate the clinicopa...

journal_title：OncoTargets and therapy

authors： Zhang F,Chen X,Xi K,Qiu Z,Wang Y,Gui Y,Hou Y,Chen K,Zhang X

更新日期：2018-11-05 00:00:00

abstract：:Despite multimodal therapeutic treatments of osteosarcoma (OS), some patients develop resistance to currently available regimens and eventually end up with recurrent or metastatic outcomes. Many attempts have been made to discover effective drugs for improving outcome; however, due to the heterogeneity of the disease,...

journal_title：OncoTargets and therapy

authors： Chaiyawat P,Settakorn J,Sangsin A,Teeyakasem P,Klangjorhor J,Soongkhaw A,Pruksakorn D

更新日期：2017-02-01 00:00:00