Significance of tertiary Gleason pattern 5 in patients with Gleason score 7 after radical prostatectomy: a retrospective cohort study.

abstract：:Background: Circ-SHPRH is a novel circular RNA which was down-regulated in various cancer tissues. Several recent studies hinted that circ-SHPRH might function as a diagnostic and prognostic biomarker for solid cancers. This meta-analysis was performed to determine the diagnostic and prognostic roles of circ-SHPRH for...

journal_title：OncoTargets and therapy

authors： Li F,Huang Q,Gong Z,Wang H,Chen J

更新日期：2019-05-31 00:00:00

abstract：:Over the last decades, a better understanding of breast cancer heterogeneity provided tools for a biologically based personalization of anticancer treatments. In particular, the overexpression of the human epidermal growth factor receptor 2 (HER2) by tumor cells provided a specific target in these HER2-positive tumors...

journal_title：OncoTargets and therapy

authors： Kourie HR,El Rassy E,Clatot F,de Azambuja E,Lambertini M

更新日期：2017-07-10 00:00:00

abstract：Purpose:Sorafenib has revolutionized treatment of hepatocellular carcinoma (HCC), but its efficacy is limited by drug resistance. Autophagy is the process by which cellular components are transported to lysosomes for degradation, which promotes energy production and production of macromolecular precursors. Studies have...

journal_title：OncoTargets and therapy

authors： Yang S,Wang M,Yang L,Li Y,Ma Y,Peng X,Li X,Li B,Jin H,Li H

更新日期：2020-04-28 00:00:00

abstract：Background:Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide. LINC00460, a novel long non-coding RNA (lncRNA), was recently confirmed as an oncogene in various cancers. However, the biological function and underlying mechanism of LINC00460 in HCC is largely obscure. Methods:Fifty pa...

journal_title：OncoTargets and therapy

authors： Yang J,Li K,Chen J,Hu X,Wang H,Zhu X

更新日期：2020-03-06 00:00:00

abstract：:Patients diagnosed as lung adenocarcinoma with brain metastasis usually result in poor prognosis with limited survival time. Palliative systematic therapy has emerged as the primary choice for non-small cell lung cancer patients with brain metastasis harboring wild-type drive genes. However, the objective response rat...

journal_title：OncoTargets and therapy

authors： Chen J,Wang J,Zheng Q,Weng M,Wu X

更新日期：2019-11-11 00:00:00

abstract：:Whether the addition of induction chemotherapy (IC) or adjuvant chemotherapy (AC) to concurrent chemoradiotherapy (CCRT) is superior to CCRT alone for locally advanced nasopharyngeal cancer is unknown. A Bayesian network meta-analysis was performed to investigate the efficacy of CCRT, IC + CCRT, and CCRT + AC on local...

journal_title：OncoTargets and therapy

authors： Yu H,Gu D,He X,Gao X,Bian X

更新日期：2016-01-05 00:00:00

abstract：Objective:To compare cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and CHOP plus etoposide (CHOPE) with regard to outcomes including efficacy and safety for patients with peripheral T-cell lymphoma (PTCL). Methods:Relevant literature was searched using PubMed, Embase, Wanfang, and CNKI for eligible...

journal_title：OncoTargets and therapy

authors： Deng S,Lin S,Shen J,Zeng Y

更新日期：2019-03-28 00:00:00

abstract：:Understanding of molecular mechanisms of tumor growth has an increasing impact on the development of diagnostics and targeted therapy of human neoplasia. In this review, we summarize the current knowledge on molecular mechanisms and their clinical implications in von Hippel-Lindau (VHL) disease. This autosomal dominan...

journal_title：OncoTargets and therapy

authors： Gläsker S,Vergauwen E,Koch CA,Kutikov A,Vortmeyer AO

更新日期：2020-06-16 00:00:00

abstract：:The aim of this study was to investigate the clinical characteristics and efficacy of chronic myeloid leukemia (CML) onset with extreme thrombocytosis. A total of 121 newly diagnosed and untreated CML patients in chronic phase with complete clinical information from the First Hospital of Jilin University, from January...

journal_title：OncoTargets and therapy

authors： Liu Z,Fan H,Li Y,Liu C

更新日期：2017-07-17 00:00:00

abstract：Background:Emerging researches have demonstrated that aberrantly expressed long non-coding RNAs (lncRNAs) have great significance in non-small cell lung cancer (NSCLC) progression. The aim of this study was to explore the role of lncRNA AZIN1 antisense RNA 1 (AZIN1-AS1) in NSCLC and the related mechanism. Methods:Expr...

journal_title：OncoTargets and therapy

authors： Cai Y,Wu Q,Liu Y,Wang J

更新日期：2020-10-09 00:00:00

abstract：Background:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors and exhibit a high frequency of oncogenic KIT or PDGFRA mutations. Tyrosine kinase inhibitors (TKIs) have been mainly used in the treatment of GISTs bearing KIT/PDGFRA mutations. However, other mutation profiles have been found to...

journal_title：OncoTargets and therapy

authors： Chen Q,Li R,Zhang ZG,Deng QT,Li K,Wang H,Yang XX,Wu YS

更新日期：2018-04-20 00:00:00

abstract：Purpose:Breast cancer (BC) is the most common cancer in women. Emerging evidence has demonstrated that lncRNAs play an important role in BC. The objective of this study was to investigate the impact of the long non-coding RNA (lncRNA), H19/miRNA-130a-3P/special AT-rich sequence-binding protein-1 (SATB1) axis on BC prog...

journal_title：OncoTargets and therapy

authors： Zhong G,Lin Y,Wang X,Wang K,Liu J,Wei W

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:The prognostic value of inflammatory index in esophageal cancer (EC) has not been established. In the present study, therefore, we initially evaluated a novel prognostic system, named the COCC (COmbination of C-reactive protein [CRP] and carcinoembryonic antigen [CEA]), for making a prognosis in patients wit...

journal_title：OncoTargets and therapy

authors： Huang Y,Liu JS,Feng JF

更新日期：2015-04-10 00:00:00

abstract：Background:Renal cell cancer (RCC) is one of the most lethal malignancies of the kidney in adults. mTOR (mammalian target of rapamycin) signaling pathway plays a pivotal role in RCC tumorigenesis and progression and inhibitors targeting the mTOR pathway have been widely used in advanced RCC treatment. Therefore, it is ...

journal_title：OncoTargets and therapy

authors： Zhu X,Xu A,Zhang Y,Huo N,Cong R,Ma L,Chu Z,Tang Z,Kang X,Xian S,Xu X

更新日期：2020-10-15 00:00:00

abstract：:Basal cell carcinoma (BCC) is a common malignant tumor throughout the world. One of the known risk factors of BCC is intense exposure to ultraviolet radiation. More than 50% of BCCs of the eyelid initially occur on the lower lid. The gold standard of diagnosis of BCC is histopathology. Treatment options for BCC consis...

journal_title：OncoTargets and therapy

authors： Shi Y,Jia R,Fan X

更新日期：2017-05-08 00:00:00

abstract：Objective:The objective of this study was to investigate the safety of robotic stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC) patients and its related factors. Methods:A total of 74 HCC patients with Child-Turcotte-Pugh (CTP) Class A were included in a multi-institutional, single-arm Pha...

journal_title：OncoTargets and therapy

authors： Liu X,Song Y,Liang P,Su T,Zhang H,Zhao X,Yuan Z,Wang P

更新日期：2017-11-06 00:00:00

abstract：BACKGROUND:We aimed to investigate the patterns of failure (locoregional and distant metastasis), associated factors, and treatment outcomes in nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy (IMRT) combined with chemotherapy. PATIENTS AND METHODS:From April 2006 to December 2011, ...

journal_title：OncoTargets and therapy

authors： Maklad AM,Bayoumi Y,Senosy Hassan MA,Elawadi AA,AlHussain H,Elyamany A,Aldhahri SF,Al-Qahtani KH,AlQahtani M,Tunio MA

更新日期：2016-10-25 00:00:00

abstract：:Two decades ago, lymphatic mapping of sentinel lymph nodes (SLN) was introduced into surgical cancer management and was termed sentinel node navigated surgery. Although this technique is now routinely performed in the management of breast cancer and malignant melanoma, it is still under investigation for use in other ...

journal_title：OncoTargets and therapy

authors： Tausch C,Baege A,Rageth C

更新日期：2014-06-24 00:00:00

abstract：:Tumor development is closely related to angiogenesis, and VEGFR2 plays an important role in tumor angiogenesis. It is broadly expressed in the blood vessels, especially in the microvessels of tumor tissues. Furthermore, VEGFR2 is detected on the surface of the cell membrane in various immune cells, such as dendritic c...

journal_title：OncoTargets and therapy

authors： Zhu P,Hu C,Hui K,Jiang X

更新日期：2017-09-01 00:00:00

abstract：:The chemokine receptor 4/chemokine ligand 12 (CXCR4/CXCL12) axis plays an important role in tumorigenesis, metastasis, and recurrence of tumors. Its single nucleotide polymorphisms (SNPs) are associated with patient survival in several types of cancer. However, the prognostic value of SNPs in nasopharyngeal carcinoma ...

journal_title：OncoTargets and therapy

authors： Chen R,Xu Y,Du X,Liu N,Li Y,He Q,Tang L,Mao Y,Sun Y,Chen L,Ma J

更新日期：2015-10-08 00:00:00

abstract：:[This retracts the article on p. 2215 in vol. 8, PMID: 26345468.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2016-02-04 00:00:00

abstract：Background:Abnormal miR-27a-3p expression has been frequently reported in several types of human cancer and contributes to tumor progression. However, the role and potential molecular mechanism of miR-27a-3p in the progression of pancreatic carcinoma have not been clarified. Materials and methods:The expression of miR...

journal_title：OncoTargets and therapy

authors： Rao X,Wan L,Jie Z,Zhu X,Yin J,Cao H

更新日期：2019-12-19 00:00:00

abstract：:Pancreatic cancer is a formidable malignancy with poor outcomes. The majority of patients are unable to undergo resection, which remains the only potentially curative treatment option. The management of locally advanced (unresectable) pancreatic cancer is controversial; however, treatment with either chemotherapy or c...

journal_title：OncoTargets and therapy

authors： Hong JC,Czito BG,Willett CG,Palta M

更新日期：2016-10-31 00:00:00

abstract：Aim:The use of bevacizumab in combination therapy is an emerging trend in metastatic colorectal cancer treatment. However, the clinical value of different combination types remains under debate. Thus, a meta-analysis of randomized controlled trials (RCTs) comparing bevacizumab-based combination therapy with monotherapy...

journal_title：OncoTargets and therapy

authors： Xu R,Xu C,Liu C,Cui C,Zhu J

更新日期：2018-12-04 00:00:00

abstract：PURPOSE:This study aims to investigate the prognostic value of pretreatment C-reactive protein/albumin ratio (CAR) in human malignancies by an updated meta-analysis. METHODS:PubMed, Web of Science, Cochrane Library and Wanfang databases were searched. Pooled hazard ratios (HRs) and odds ratios (ORs) with their corresp...

journal_title：OncoTargets and therapy

authors： Xu HJ,Ma Y,Deng F,Ju WB,Sun XY,Wang H

更新日期：2017-06-19 00:00:00

abstract：BACKGROUND/AIM:To elucidate the mechanism responsible for developing acute kidney injury in patients with diabetes mellitus, we also evaluated the issue of whether advanced glycation endproducts (AGEs) influence the expressions of multi antimicrobial extrusion protein (MATE1/SLC47A1) in tubular cells. MATERIALS AND ME...

journal_title：OncoTargets and therapy

authors： Mizuno T,Sato W,Ishikawa K,Terao Y,Takahashi K,Noda Y,Yuzawa Y,Nagamatsu T

更新日期：2015-07-10 00:00:00

abstract：BACKGROUND:This meta-analysis aimed to assess available evidence on possible associations of interleukin-28B polymorphisms rs8099917 and rs12979860 with development of hepatitis virus-related hepatocellular carcinoma (HCC). METHODS:PubMed, EMBASE, Google Scholar, and the Chinese National Knowledge Infrastructure datab...

journal_title：OncoTargets and therapy

authors： Zhang Y,Zhu SL,Chen J,Li LQ

更新日期：2016-05-30 00:00:00

abstract：Background:The non-receptor tyrosine kinase Fyn-related kinase (FRK) has been reported to affect cell proliferation in several cancer types. However, its effect on the proliferation of clear cell renal cell carcinoma (ccRCC) remains largely unknown. Purpose:The objective of this study was to investigate the expression...

journal_title：OncoTargets and therapy

authors： Jing ZF,Bi JB,Li ZL,Liu XK,Li J,Zhu YY,Zhang XT,Zhang Z,Li ZH,Kong CZ

更新日期：2019-04-10 00:00:00

abstract：:Survivin is a member of the inhibitor-of-apoptosis proteins (IAPs) family; its overexpression has been widely demonstrated to occur in various types of cancer. Overexpression of survivin also correlates with tumor progression and induces anticancer drug resistance. Interestingly, recent studies reveal that survivin ex...

journal_title：OncoTargets and therapy

authors： Cheung CH,Huang CC,Tsai FY,Lee JY,Cheng SM,Chang YC,Huang YC,Chen SH,Chang JY

更新日期：2013-10-16 00:00:00

abstract：:[This corrects the article DOI: 10.2147/OTT.S196910.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2019-09-19 00:00:00