Comparison of CHOP vs CHOPE for treatment of peripheral T-cell lymphoma: a meta-analysis.

abstract：Background:Tumour growth and development are dependent on many factors including long noncoding RNAs (lncRNAs). However, limited information is available on the involvement of lncRNAs in non-small cell lung cancer (NSCLC) and the molecular mechanisms have not been defined. Here, we examined the expression of small nucl...

journal_title：OncoTargets and therapy

authors： Zhao S,Gao X,Zhong C,Li Y,Wang M,Zang S

更新日期：2020-11-04 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is often diagnosed at late incurable stage and lacks effective treatment strategy. Bufadienolides are cardiotonic steroids isolated from the skin and parotid venom glands of the toad Bufo bufo gargarizans Cantor with novel anticancer activity. However, there is little informat...

journal_title：OncoTargets and therapy

authors： Lv J,Lin S,Peng P,Cai C,Deng J,Wang M,Li X,Lin R,Lin Y,Fang A,Li Q

更新日期：2017-02-28 00:00:00

abstract：Background:Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Long non-coding RNA taurine-upregulated gene 1 (lncRNA TUG1) has been discovered to participate in multiple cancers including AML. However, the detailed mechanism of TUG1 in AML remains obscure. Materials and methods:AML cell ...

journal_title：OncoTargets and therapy

authors： Li G,Zheng P,Wang H,Ai Y,Mao X

更新日期：2019-11-29 00:00:00

abstract：Backgrounds:microRNA-493-3p (miR-493) has been reported to be critically downregulated in multiple types of human cancer. However, the expression level, biological roles and underlying mechanism of miR‑493 in tongue squamous cell carcinoma (TSCC) remain to be elucidated. Methods:RT-qPCR was utilized for the determinat...

journal_title：OncoTargets and therapy

authors： Jiao D,Liu Y,Tian Z

更新日期：2019-08-28 00:00:00

abstract：OBJECTIVE:Malignant chest wall tumors are rare neoplasms. Resection with wide-free margins is an important prognostic factor, and massive chest wall resection and reconstruction are often necessary. A recent case series of 20 consecutive patients is reported in order to find any possible correlation between tumor histo...

journal_title：OncoTargets and therapy

authors： Foroulis CN,Kleontas AD,Tagarakis G,Nana C,Alexiou I,Grosomanidis V,Tossios P,Papadaki E,Kioumis I,Baka S,Zarogoulidis P,Anastasiadis K

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:Breast cancer stem cells with a CD44(+)CD24(-) phenotype are the origin of breast tumors. Strong CD44 expression in this population indicates its important role in maintaining the stem cell phenotype. Previous studies show that CD44 down-regulation causes CD44(+)CD24(-) breast cancer stem cells to differenti...

journal_title：OncoTargets and therapy

authors： Van Pham P,Vu NB,Duong TT,Nguyen TT,Truong NH,Phan NL,Vuong TG,Pham VQ,Nguyen HM,Nguyen KT,Nguyen NT,Nguyen KG,Khat LT,Van Le D,Truong KD,Phan NK

更新日期：2012-01-01 00:00:00

abstract：Background:The global Phase III LUX-Lung 8 trial (ClinicalTrials.gov: NCT01523587) identified significant improvements in progression-free survival (PFS), overall survival (OS), and patient-reported outcomes (PROs) with second-line afatinib vs erlotinib in patients with advanced squamous cell carcinoma (SCC) of the lun...

journal_title：OncoTargets and therapy

authors： Lu S,Li W,Zhou C,Hu CP,Qin S,Cheng G,Feng J,Wang J,Cseh A,Peil B,Gibson N,Ehrnrooth E,Zhang L

更新日期：2018-11-30 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. Since the discovery that the KIT and PDGFRA receptor tyrosine kinases are the primary oncogenic drivers in the vast majority of GISTs, targeted therapy with tyrosine kinase inhibitors has been the mainstay ...

journal_title：OncoTargets and therapy

authors： Li GZ,Raut CP

更新日期：2019-07-01 00:00:00

abstract：:Background: Carcinoma ex pleomorphic adenoma (CXPA), a very rare malignancy found mostly in the major salivary glands, has no established standardized treatment. Case presentation: This report describes a 67-year-old male with advanced CXPA who was effectively treated by anlotinib. Pleomorphic adenoma of the submandib...

journal_title：OncoTargets and therapy

authors： Song S,Sui P,Li M,Zhang L,Sun D

更新日期：2019-05-24 00:00:00

abstract：:Background: Seminoma accounts for the most part of cases of testicular germ cell tumor, which is the most common malignancy among males between ages 15 and 44 years. Understanding the molecular mechanism of tumorigenesis is important for better clinical diagnosis and treatment. Purpose: We performed bioinformatics ana...

journal_title：OncoTargets and therapy

authors： Chen YH,Lin TT,Wu YP,Li XD,Chen SH,Xue XY,Wei Y,Zheng QS,Huang JB,Xu N

更新日期：2019-05-14 00:00:00

abstract：:Background: Altered expression of the BCL-2 family member MCL-1 has been linked to the progression and outcome of various malignancies. Recently, MCL-1 inhibitor S63845 was reported to kill MCL-1-dependent cancer cells and has potential value in clinical application. Purpose: Herein, we reported MCL-1 expression patte...

journal_title：OncoTargets and therapy

authors： Li XX,Zhou JD,Wen XM,Zhang TJ,Wu DH,Deng ZQ,Zhang ZH,Lian XY,He PF,Yao XY,Lin J,Qian J

更新日期：2019-05-01 00:00:00

abstract：:Understanding of molecular mechanisms of tumor growth has an increasing impact on the development of diagnostics and targeted therapy of human neoplasia. In this review, we summarize the current knowledge on molecular mechanisms and their clinical implications in von Hippel-Lindau (VHL) disease. This autosomal dominan...

journal_title：OncoTargets and therapy

authors： Gläsker S,Vergauwen E,Koch CA,Kutikov A,Vortmeyer AO

更新日期：2020-06-16 00:00:00

abstract：:Prostate cancer is the leading malignancy and the second most common cause of cancer-related death in men. Despite high cure rates with surgery and/or radiation, 30%-40% of patients eventually develop advanced cancer. Docetaxel is one of the most effective and well established chemotherapeutic agents for prostate canc...

journal_title：OncoTargets and therapy

authors： Zhou F,Chen X,Fan S,Tai S,Jiang C,Zhang Y,Hao Z,Zhou J,Shi H,Zhang L,Liang C

更新日期：2015-04-10 00:00:00

abstract：PURPOSE:Randomized trials showing a clear survival benefit of intensity-modulated radiotherapy (IMRT) over 3-dimensional conformal radiotherapy (3D-CRT) in the treatment of lung cancer are lacking. This study compared the survival rates of patients with stage III non-small cell lung cancer who were treated with either ...

journal_title：OncoTargets and therapy

authors： Kong M,Hong SE

更新日期：2016-11-24 00:00:00

abstract：AIM:To retrospectively evaluate the safety and efficacy of ultrasound-guided percutaneous microwave ablation (MWA) combined with simultaneous transarterial chemoembolization (TACE) in the treatment of patients with advanced intrahepatic cholangiocarcinoma (ICC). METHODS:All patients treated with ultrasound-guided perc...

journal_title：OncoTargets and therapy

authors： Yang GW,Zhao Q,Qian S,Zhu L,Qu XD,Zhang W,Yan ZP,Cheng JM,Liu QX,Liu R,Wang JH

更新日期：2015-05-26 00:00:00

abstract：BACKGROUND:Everolimus, an inhibitor of the mammalian target of rapamycin, shows promising antitumor activity when combined with trastuzumab and chemotherapy for human epidermal growth factor receptor-2 (HER2)-positive breast cancer or when combined with endocrine agents for hormone receptor (HR)-positive tumors. Howeve...

journal_title：OncoTargets and therapy

authors： Sun B,Ding L,Wu S,Meng X,Song S

更新日期：2016-07-01 00:00:00

abstract：Background:Previous studies have indicated that tooth loss is associated with colorectal cancer risk but have presented controversial results. Methods:We conducted a dose-response meta-analysis in order to investigate the correlation between tooth loss and colorectal cancer risk. Up to August 2017, six eligible studie...

journal_title：OncoTargets and therapy

authors： Ma P,Dai S,Jin C,Yao Y,Zou C

更新日期：2018-03-21 00:00:00

abstract：:Melanoma develops from melanocytes and typically occurs on the skin and mucosa with a high degree of malignancy. Intensive local invasion and distant metastasis of melanoma result in poor patient prognosis, owing to frequent metastases to the lungs, bones, brains, and other parts of the body. In the present study, we ...

journal_title：OncoTargets and therapy

authors： Feng L,Qi DJ,Zhang QF

更新日期：2016-08-10 00:00:00

abstract：BACKGROUND/AIM:To elucidate the mechanism responsible for developing acute kidney injury in patients with diabetes mellitus, we also evaluated the issue of whether advanced glycation endproducts (AGEs) influence the expressions of multi antimicrobial extrusion protein (MATE1/SLC47A1) in tubular cells. MATERIALS AND ME...

journal_title：OncoTargets and therapy

authors： Mizuno T,Sato W,Ishikawa K,Terao Y,Takahashi K,Noda Y,Yuzawa Y,Nagamatsu T

更新日期：2015-07-10 00:00:00

abstract：BACKGROUND:CD155, an immunoglobulin-like adhesion molecule, plays an important role in carcinoma such as cells migration, proliferation, metastasis, and tumor immune. The upregulation of CD155 has been found in several human malignancies, but its expression in cholangiocarcinoma (CCA) still remains unclear. The aim of ...

journal_title：OncoTargets and therapy

authors： Huang DW,Huang M,Lin XS,Huang Q

更新日期：2017-07-31 00:00:00

abstract：Purpose:Hepatocellular carcinoma (HCC) has a high incidence in China and exploring effective ways for early diagnosis is an important method to improve the prognosis of patients with HCC. Additional studies reported that. Some kinds of microRNA (miRNA) in plasma will change accordingly during HCC progress, and this cha...

journal_title：OncoTargets and therapy

authors： Wang S,Yang Y,Sun L,Qiao G,Song Y,Liu B

更新日期：2020-03-09 00:00:00

abstract：Background:LncRNA cancer susceptibility candidate 15 (CASC15) has been demonstrated to act as an oncogene in different cancers; however, its role in ovarian cancer remains elusive. Methods:Quantitative real-time PCR (qRT-PCR) was performed to examine the expression of lncRNA CASC15. Kaplan-Meier survival analysis was ...

journal_title：OncoTargets and therapy

authors： Shi Y,Gao S,Zheng Y,Yao M,Ruan F

更新日期：2019-10-23 00:00:00

abstract：Introduction:Ribosome binding protein 1 (RRBP1) is reported to be correlated with tumor formation and progression. However, the role of RRBP1 in bladder cancer is unclear. In this study, we aimed to investigate the expression of RRBP1 and its influence on cell proliferation in bladder cancer. Methods:Quantification re...

journal_title：OncoTargets and therapy

authors： Lv SW,Shi ZG,Wang XH,Zheng PY,Li HB,Han QJ,Li ZJ

更新日期：2020-07-07 00:00:00

abstract：Background:Lung cancer is one of the most common malignancies in the world and is at the forefront of causes of all cancer deaths. Identification of new prognostic predictors or therapeutic targets might improve a patient's survival rate. Purpose:The Homeodomain interacting protein kinases (HIPKs) function as modulato...

journal_title：OncoTargets and therapy

authors： Liu Y,Qian L,Yang J,Huang H,Feng J,Li X,Bian T,Ke H,Liu J,Zhang J

更新日期：2018-10-25 00:00:00

abstract：Purpose:Pathological complete response (pCR) to neoadjuvant chemotherapy (NACT) is associated with favourable outcomes of patients with triple-negative breast cancer (TNBC). However, a proportion of TNBC patients with the residual disease do not relapse and achieve long-term survival. The aim of this study was to ident...

journal_title：OncoTargets and therapy

authors： Wei LY,Zhang XJ,Wang L,Hu LN,Zhang XD,Li L,Gao JN

更新日期：2020-07-03 00:00:00

abstract：Background:Our previous study demonstrated that Id-1 may promote the tumorigenicity of esophageal squamous cell carcinoma (ESCC). Id-4 is another member of Id family, which is rare to be studied in ESCC. In this study, we investigated the expression of Id-4 in human ESCC specimens and determined whether Id-4 expression...

journal_title：OncoTargets and therapy

authors： Wang X,Lu Q,Fei X,Zhao Y,Shi B,Li C,Chen H

更新日期：2020-02-12 00:00:00

abstract：:Circulating tumor DNA (ctDNA) can be identified in the peripheral blood of patients and harbors the genomic alterations found in tumor tissues, which provides a noninvasive approach for detection of gene mutations. We conducted this meta-analysis to investigate whether ctDNA can be used for monitoring KRAS gene mutati...

journal_title：OncoTargets and therapy

authors： Hao YX,Fu Q,Guo YY,Ye M,Zhao HX,Wang Q,Peng XM,Li QW,Wang RL,Xiao WH

更新日期：2017-02-16 00:00:00

abstract：:Ovarian cancer (OC) is the most lethal cancer of all gynecological malignancies, while endometrial cancer (EC) is the most common one. Current strategies for OC/EC diagnosis consist of the extraction of a solid tissue from the affected area. This sample enables the study of specific biomarkers and the genetic nature o...

journal_title：OncoTargets and therapy

authors： Chen Q,Zhang ZH,Wang S,Lang JH

更新日期：2019-12-27 00:00:00

abstract：:The central nervous system (CNS) is regarded as an immune privileged environment; however, changes in the neuroimmunology paradigm have led to an increased interest in systematic immunotherapy in lung cancer therapy. The presence of the lymphatic system in the CNS as well as the physiological and biochemical changes i...

journal_title：OncoTargets and therapy

authors： Wang S,Hu C,Xie F,Liu Y

更新日期：2020-01-23 00:00:00

abstract：Purpose:The TRMT12 is a novel oncogene involved in breast cancer. However, the association between TRMT12 and head and neck squamous cell carcinoma (HNSCC) remains unclear. Materials and methods:The levels of TRMT12 mRNA in HNSCC and normal tissues were analyzed using data from the Cancer Genome Atlas-HNSC. The expres...

journal_title：OncoTargets and therapy

authors： Wang K,Zheng M,Ren Y

更新日期：2019-09-05 00:00:00