SNHG3 Knockdown Suppresses Proliferation, Migration and Invasion, and Promotes Apoptosis in Non-Small Cell Lung Cancer Through Regulating miR-216a/ZEB1 Axis.

abstract：Purpose:The aim was to investigate resveratrol effects on A549 cells proliferation. Methods:A total of 104 lung adenocarcinoma tissues and nontumor tissues were collected. BEAS-2B cells were cultured in RPMI 1640 medium (group A). A549 cells were treated with RPMI 1640 medium containing different resveratrol concentra...

journal_title：OncoTargets and therapy

authors： Li X,Li F,Wang F,Li J,Lin C,Du J

更新日期：2018-05-22 00:00:00

abstract：Purpose:Tumor drug resistance limits the response to chemotherapy. Interestingly, sequential combination therapy enhances the anticancer efficacy of drugs like cisplatin (CDDP) via synergistic effects. We assayed the synergistic effects of combined photodynamic therapy programmed death receptor-ligand 1 (PDT) and chemo...

journal_title：OncoTargets and therapy

authors： Xue K,Wang YN,Zhao X,Zhang HX,Yu D,Jin CS

更新日期：2019-07-10 00:00:00

abstract：:This study aimed to identify the genes and pathways associated with smoking-related lung adenocarcinoma. Three lung adenocarcinoma associated datasets (GSE43458, GSE10072, and GSE50081), the subjects of which included smokers and nonsmokers, were downloaded to screen the differentially expressed feature genes between ...

journal_title：OncoTargets and therapy

authors： Liu Y,Ni R,Zhang H,Miao L,Wang J,Jia W,Wang Y

更新日期：2016-12-07 00:00:00

abstract：Purpose:The molecular mechanism of perineural invasion (PNI) in stage II colorectal cancer (CRC) remains not to be defined clearly. This study aims to identify the genomic aberrations related to PNI in stage II CRC. Patients and Methods:Using array-based comparative genomic hybridization (array-CGH), primary tumor tis...

journal_title：OncoTargets and therapy

authors： Su H,Chang C,Hao J,Xu X,Bao M,Luo S,Zhao C,Liu Q,Wang X,Zhou Z,Zhou H

更新日期：2020-11-11 00:00:00

abstract：OBJECTIVE:Malignant chest wall tumors are rare neoplasms. Resection with wide-free margins is an important prognostic factor, and massive chest wall resection and reconstruction are often necessary. A recent case series of 20 consecutive patients is reported in order to find any possible correlation between tumor histo...

journal_title：OncoTargets and therapy

authors： Foroulis CN,Kleontas AD,Tagarakis G,Nana C,Alexiou I,Grosomanidis V,Tossios P,Papadaki E,Kioumis I,Baka S,Zarogoulidis P,Anastasiadis K

更新日期：2016-04-19 00:00:00

abstract：Purpose:Long intergenic non-protein coding RNA 519 (LINC00519) promotes the development of lung squamous cell carcinoma. In this study, we detected the expression of LINC00519 in tongue squamous cell carcinoma (TSCC) and examined its clinical significance. Additionally, the regulatory effects of LINC00519 on behaviors ...

journal_title：OncoTargets and therapy

authors： Liu D,Zhao J,Wang H,Li H,Li Y,Qin W

更新日期：2020-11-20 00:00:00

abstract：:Background/Aims: MiR-145 and Smad2 have been widely reported in the development and progression of human malignancies. In the present study, we investigated the correlation between miR-145 and Smad2 in human glioblastoma multiforme (GBM). Methods: The epithelial-mesenchymal transition (EMT) biomarkers and Smad2 were a...

journal_title：OncoTargets and therapy

authors： Chen W,Huang B,Wang E,Wang X

更新日期：2019-04-23 00:00:00

abstract：Background:miR520a-3p has previously had its antitumorigenic role in various types of cancers revealed, and been predicted as a posttranscriptional regulator of the NFκB-subunit RELA gene. Thus, miR520a-3p could function in carcinogenesis through suppressing RELA. Methods:Expression of miR520a-3p and RELA mRNA was qua...

journal_title：OncoTargets and therapy

authors： Zhang JQ,Hong B

更新日期：2019-08-14 00:00:00

abstract：:Preclinical studies have demonstrated that Apatinib, major targeting vascular endothelial growth factor receptor-2 (VEGFR-2), could inhibit the proliferation of anaplastic thyroid carcinoma (ATC) cells in vitro and in vivo. The efficacy and safety in ATC patients, however, remains unknown. Here, we report the case of ...

journal_title：OncoTargets and therapy

authors： Cheng L,Jiao Q,Jin Y,Fu H,Zhang H,Chen L

更新日期：2019-12-02 00:00:00

abstract：:The study aimed to investigate the difference of setup errors on different registration in the treatment of nasopharyngeal carcinoma based on weekly cone-beam computed tomography (CBCT). Thirty nasopharyngeal cancer patients scheduled to undergo intensity-modulated radiotherapy (IMRT) were prospectively enrolled in th...

journal_title：OncoTargets and therapy

authors： Su J,Chen W,Yang H,Hong J,Zhang Z,Yang G,Li L,Wei R

更新日期：2015-09-14 00:00:00

abstract：BACKGROUND:Repetitive genotyping is useful to assess the genetic evolution of non-small-cell lung cancer (NSCLC) during treatment, but the need for sampling by biopsy is a major obstacle. Digital polymerase chain reaction (PCR) is a promising procedure for the detection of mutant alleles in plasma of cancer patients. ...

journal_title：OncoTargets and therapy

authors： Nakahara Y,Takagi Y,Hosomi Y,Kagei A,Yamamoto T,Sawada T,Yomota M,Okuma Y,Mikura S,Okamura T

更新日期：2016-08-24 00:00:00

abstract：:This report describes a patient with intravascular large B-cell lymphoma (IVLBCL) with central nervous system involvement at the time of diagnosis who achieved complete remission for over 5 years in response to therapy. The patient, a 71 year-old woman, was previously healthy with the exception of taking verapamil for...

journal_title：OncoTargets and therapy

authors： Sawada T,Omuro Y,Kobayashi T,Hishima T,Koizumi F,Kanemasa Y,Shimoyama T,Sasaki E,Maeda Y

更新日期：2014-11-18 00:00:00

abstract：:Fibroblast growth factor receptor (FGFR) family includes four highly conserved receptor tyrosine kinases. Particularly, FGFR2 has been identified as a potential target for tyrosine kinase inhibitor (TKI) treatment. Except for immunohistochemistry and fluorescence in situ hybridization, next-generation sequencing (NGS)...

journal_title：OncoTargets and therapy

authors： Ying X,Tu J,Wang W,Li X,Xu C,Ji J

更新日期：2019-11-06 00:00:00

abstract：Background:Malignant glioma is the second leading cause of cancer-related death worldwide, and is known to exhibit a high degree of heterogeneity in its deregulation of different oncogenic pathways. The molecular subclasses of human glioma are not well known. Thus, it is crucial to identify vital oncogenic pathways in ...

journal_title：OncoTargets and therapy

authors： Hu T,Xi J

更新日期：2017-11-15 00:00:00

abstract：BACKGROUND:Breast cancer is one of the most frequently occurring cancers in women. In recent years, Dendrobium candidum has played a part in antihyperthyroidism and anticancer drugs. This study aims to examine the antitumor effect of D. candidum on breast cancer. METHODS:Human breast cancer cell line MCF-7 and normal ...

journal_title：OncoTargets and therapy

authors： Sun J,Guo Y,Fu X,Wang Y,Liu Y,Huo B,Sheng J,Hu X

更新日期：2015-12-21 00:00:00

abstract：BACKGROUND:Recurrent laryngeal nerve (RLN) invasion in papillary thyroid carcinoma (PTC) is one of the main predictors of poor prognosis. The present study investigated the risk factors for RLN invasion in PTC patients. METHODS:A total of 3,236 patients who received thyroidectomy due to PTC in Thyroid and Parathyroid ...

journal_title：OncoTargets and therapy

authors： Chen W,Lei J,You J,Lei Y,Li Z,Gong R,Tang H,Zhu J

更新日期：2017-09-11 00:00:00

abstract：PURPOSE:To evaluate whether the addition of two biological markers (MYC and BCL-2 protein overexpression) improves the stratification of high-risk patients with diffuse large B-cell lymphoma (DLBCL). METHOD:Seven risk factors were identified at diagnosis, and a maximum of 7 points were assigned to each patient. The pa...

journal_title：OncoTargets and therapy

authors： Wang J,Zhou M,Xu JY,Chen B,Ouyang J

更新日期：2015-09-18 00:00:00

abstract：Background:Although several long non-coding RNAs (lncRNAs) have been found to be involved in gastric cancer tumorigenesis, the more comprehensive contributions of lncRNAs to gastric cancer require further investigation. Here, we identify a cytoplasmic lncRNA, LINC01485, which promotes tumor growth and migration in gast...

journal_title：OncoTargets and therapy

authors： Zhou J,Wu L,Li W,Xu X,Ju F,Yu S,Guo J,Li G,Shi J,Zhou S

更新日期：2020-08-21 00:00:00

abstract：Purpose:Circulating tumor DNA (ctDNA) is a noninvasive and real-time marker for tumor diagnosis, prognosis, and prediction. However, further investigations about ctDNA prognostic and predictive value are still needed, and conclusions from several studies were inconsistent. Experimental design:We performed capture-base...

journal_title：OncoTargets and therapy

authors： Rao C,Nie L,Miao X,Xu Y,Li B,Zhang T

更新日期：2018-01-12 00:00:00

abstract：Background:Chemotherapy remains a major clinical option for the successful treatment of cancer by eliminating fast-growing populations of cancer cells. However, drug resistance causes the failure of antitumor treatment. Increasing evidence suggests that a small subpopulation of cancer cells will enter a "persister stat...

journal_title：OncoTargets and therapy

authors： Wang L,Yang Q,Peng S,Liu X

更新日期：2019-07-08 00:00:00

abstract：OBJECTIVE:High-mobility group protein 2 (HMGA2) and epithelial-mesenchymal transition (EMT)-associated proteins play key roles in cancer progression and metastasis. However, the clinical significance of HMGA2 and its relationship with EMT markers in nasopharyngeal carcinoma (NPC) is unclear. This study aimed to assess ...

journal_title：OncoTargets and therapy

authors： Xia YY,Yin L,Tian H,Guo WJ,Jiang N,Jiang XS,Wu J,Chen M,Wu JZ,He X

更新日期：2015-01-17 00:00:00

abstract：Background:Triple-negative breast cancer has become an intricate part and hotspot in the clinical and experimental research. Connexins, serving as functional proteins in gap junctions, play an important role in tumorigenesis, cell proliferation and metastasis. Methods:We constructed and employed the Connexin 43 (Cx43)...

journal_title：OncoTargets and therapy

authors： Fu Y,Sun X,Gu Z,Zhuang Z

更新日期：2020-06-10 00:00:00

abstract：:The use of additional radiotherapy for resected stage IIIA N2 non-small-cell lung cancer in the setting of standard adjuvant chemotherapy remains controversial. A comprehensive search (last search updated in March 2015) for relevant studies comparing patients with stage IIIA N2 non-small-cell lung cancer undergoing re...

journal_title：OncoTargets and therapy

authors： Lei T,Xu XL,Chen W,Xu YP,Mao WM

更新日期：2016-02-24 00:00:00

abstract：Introduction:Upper tract urothelial carcinoma (UTUC) is a relatively uncommon urologic malignancy for which there has not been significant improvement in survival over the past few decades, highlighting the need for optimal multi-modality management. Methods:A non-systematic review of the latest literature was perform...

journal_title：OncoTargets and therapy

authors： Leow JJ,Liu Z,Tan TW,Lee YM,Yeo EK,Chong YL

更新日期：2020-01-06 00:00:00

abstract：Background:Bromodomain and extra-terminal domain inhibitors like JQ1 have proved to be promising epigenetic agents for the treatment of malignant ovarian carcinoma. However, the resistance of ovarian cancer cells to BET inhibitors has not been elucidated. In this study, we investigated the potential mechanisms underlyi...

journal_title：OncoTargets and therapy

authors： Luan W,Pang Y,Li R,Wei X,Jiao X,Shi J,Yu J,Mao H,Liu P

更新日期：2019-10-03 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the therapeutic efficacy and safety of trastuzumab emtansine (T-DM1) for the treatment of patients with human epidermal growth factor receptor 2-positive breast cancer. METHODS:We performed a systemic review and meta-analysis of the relevant published clinical studies. A c...

journal_title：OncoTargets and therapy

authors： Ma B,Ma Q,Wang H,Zhang G,Zhang H,Wang X

更新日期：2016-02-29 00:00:00

abstract：BACKGROUND:To evaluate the benefit of second-line chemotherapy with platinum-based treatment in patients with recurrent small cell lung cancer (SCLC). PATIENTS AND METHODS:A total of 535 patients continued with follow-up or best supportive care if needed, and 229 patients who progressed after the completion of first-l...

journal_title：OncoTargets and therapy

authors： Zarogoulidis K,Boutsikou E,Zarogoulidis P,Darwiche K,Freitag L,Porpodis K,Latsios D,Kontakiotis T,Huang H,Li Q,Hohenforst-Schmidt W,Kipourou M,Turner JF,Spyratos D

更新日期：2013-10-22 00:00:00

abstract：PURPOSE:To investigate the biological effect of gyromagnetic fields (GMFs) on cell proliferation and apoptosis of human prostatic adenocarcinoma cells and explore the underlying mechanisms. METHODS:PC-3 cells were grouped into normal control (NC) and GMF treatment groups. Cell proliferation was analyzed with kit-8 and...

journal_title：OncoTargets and therapy

authors： Lei H,Xu Y,Guan R,Li M,Hui Y,Gao Z,Yang B,Xin Z

更新日期：2015-11-24 00:00:00

abstract：Background and aim:Despite several studies being conducted to examine the associations between the NUDT15 R139C polymorphism and thiopurine-induced leukopenia in the Asian population, the results remain inconsistent. This meta-analysis determined the risk of thiopurine-induced leukopenia conferred by the NUDT15 R139C p...

journal_title：OncoTargets and therapy

authors： Liu Y,Meng Y,Wang L,Liu Z,Li J,Dong W

更新日期：2018-11-23 00:00:00

abstract：BACKGROUND:In patients with gastric cancer (GC), survival is poor, given the late diagnosis. Risk-stratifying these patients earlier could help improve care. We determined whether combining preoperative albumin concentration and the neutrophil lymphocyte ratio (COA-NLR) could predict overall survival (OS) better than o...

journal_title：OncoTargets and therapy

authors： Sun X,Wang J,Liu J,Chen S,Liu X

更新日期：2016-07-27 00:00:00