Long-term complete remission in a patient with intravascular large B-cell lymphoma with central nervous system involvement.

abstract：BACKGROUND:Forkhead box Q1 (FOXQ1, also known as HFH1), a member of the forkhead transcription factor family, has been demonstrated to be overexpressed in multiple tumors and is thought to be an indicator of poor clinical outcomes. METHODS:A meta-analysis using qualified relevant literature was performed to evaluate t...

journal_title：OncoTargets and therapy

authors： Cui X,Zhang J,Lv J,Yan Y,Liu X,Wang J,Lv Y,Zhang J

更新日期：2017-03-23 00:00:00

abstract：:[This retracts the article on p. 1997 in vol. 9, PMID: 27103825.][This retracts the article on p. 841 in vol. 28.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2016-09-20 00:00:00

abstract：Purpose:Both obesity and gender are important etiological factors in renal cell carcinoma (RCC) development, suggesting a pivotal role of sex hormone signaling pathway and insulin-like growth factor (IGF) family in RCC carcinogenesis. Here, we aimed to investigate the effect of estrogen on RCC growth and the possible i...

journal_title：OncoTargets and therapy

authors： Sun L,Gao Z,Luo L,Tan H,Zhang G

更新日期：2018-09-17 00:00:00

abstract：BACKGROUND:"Gefitinib" is a first-generation epidermal growth factor receptor tyrosine-kinase inhibitor. More than half of patients receiving gefitinib develop acne-like eruption. Evozac(®) Calming Skin Spray (Evaux Laboratoires, Évaux-les-Bains, France) is made of Évaux thermal spring water and commonly used for the t...

journal_title：OncoTargets and therapy

authors： Wang Y,Yang Y,Xu J,Yu J,Liu X,Gao R,Zhang L

更新日期：2014-07-10 00:00:00

abstract：Introduction:The purpose of present study was to investigate the effect of limonin on tumor glycolysis and the underlying mechanisms in hepatocellular carcinoma (HCC). Methods:Cell proliferation and colony formation assays were performed to evaluate the potency of limonin against HCC cells in vitro. The glucose consum...

journal_title：OncoTargets and therapy

authors： Yao J,Liu J,Zhao W

更新日期：2018-07-03 00:00:00

abstract：Background:Sex-determining region Y-box protein 5 (SOX5) has been demonstrated to be implicated in oncogenic function in various types of cancers. However, the role of SOX5 in gastric cancer (GC) remains poorly elucidated. Herein, we investigated the role and the underlying mechanism of SOX5 in GC progression. Methods...

journal_title：OncoTargets and therapy

authors： You J,Zhao Q,Fan X,Wang J

更新日期：2019-04-03 00:00:00

abstract：BACKGROUND:Fibroblast growth factor receptor 4 (FGFR4) has been proved to be correlated with progression and prognosis in many cancers. However, the significance of FGFR4 in non-small-cell lung cancer (NSCLC) is still not well elucidated. METHODS:In our experiment, we detected FGFR4 expression in 237 samples of NSCLC ...

journal_title：OncoTargets and therapy

authors： Huang HP,Feng H,Qiao HB,Ren ZX,Zhu GD

更新日期：2015-05-22 00:00:00

abstract：Objective:Cumulative data from clinical trials suggest that Lin28 may contribute to poor survival in breast cancer patients. The purpose of this study was to investigate the relationship between Lin28 expression and breast cancer patients' clinicopathological parameters. Methods:Data from a total of 291 breast cancer ...

journal_title：OncoTargets and therapy

authors： Xu C,Jin S,Huang L

更新日期：2019-02-08 00:00:00

abstract：Background:Pulmonary carcinosarcomas (PCSs) are a heterogeneous group of non-small-cell lung carcinomas (NSCLCs) with aggressiveness and a poor prognosis. Although genetic mutations of some common lung cancer subtypes have been extensively studied, the molecular characteristics of PCSs and the existence of abnormal tar...

journal_title：OncoTargets and therapy

authors： Li F,Hu S,Kong K,Cao P,Han P,Deng Y,Zhao B

更新日期：2020-08-10 00:00:00

abstract：:Normal astrocytes are more resistant to radiation than glioma cells. Radiation-resistant glioma cells and normal astrocytes usuallly share similar mechanisms of radioresistance. Investigation of the underlying mechanisms of differential radiation response between normal astrocytes and glioma cells is thus significant ...

journal_title：OncoTargets and therapy

authors： Gong L,Gu J,Ge J,Wu X,Zhang C,Yang C,Weng W,Gao G,Feng J,Mao Q

更新日期：2017-12-04 00:00:00

abstract：BACKGROUND:Mast cells (MCs) can stimulate angiogenesis, releasing several proangiogenic cytokines stored in their cytoplasm. In particular MCs can release tryptase, a potent in vivo and in vitro proangiogenic factor via proteinase-activated receptor-2 (PAR-2) activation and mitogen-activated protein kinase phosphorylat...

journal_title：OncoTargets and therapy

authors： Ammendola M,Sacco R,Sammarco G,Piardi T,Zuccalà V,Patruno R,Zullo A,Zizzo N,Nardo B,Marech I,Crovace A,Gadaleta CD,Pessaux P,Ranieri G

更新日期：2016-07-21 00:00:00

abstract：:Large granular lymphocytic leukemia (LGLL) is a rare lymphoproliferative disorder of transformed natural killer or T-cells attributed to chronic exposure to the proinflammatory cytokine IL-15. Diagnosis of the majority of T-cell LGLL is established by documenting clonal large granular lymphocytes (LGLs) in peripheral ...

journal_title：OncoTargets and therapy

authors： Bagacean C,Tempescul A,Patiu M,Fetica B,Bumbea H,Zdrenghea M

更新日期：2016-12-19 00:00:00

abstract：Background:Growth differentiation factor (GDF) acted as a factor that regulated proliferation, apoptosis and differentiation in several tumors. However, the effects of growth differentiation factor (GDF11) in pancreatic cancer remain unclear. Purpose:To investigate the expression and significance of GDF11 in pancreati...

journal_title：OncoTargets and therapy

authors： Liu Y,Shao L,Chen K,Wang Z,Wang J,Jing W,Hu M

更新日期：2018-11-27 00:00:00

abstract：:Historically, patients with locally advanced or metastatic melanoma have an extremely poor prognosis. In recent years, major breakthroughs in cutaneous melanoma treatment have led to remarkable improvements in patient outcomes. However, there are limited published data on the efficacy of these novel therapies in the t...

journal_title：OncoTargets and therapy

authors： Yu Z,Quiroz E,Shen Y,Jaiyesimi IA

更新日期：2018-12-04 00:00:00

abstract：Background:Bone marrow stromal antigen 2 (BST2) is considered as a transmembrane glycoprotein and plays essential roles in innate immunity. It has been recently reported that up-regulation of BST2 was associated with the development of breast carcinoma. However, the clinical significance of BST2 in glioma has not been ...

journal_title：OncoTargets and therapy

authors： Shi H,Luo K,Huang W

更新日期：2020-08-26 00:00:00

abstract：BACKGROUND:Experimental disruption of the telomere overhang induces a potent DNA damage response and is the target of newly emerging cancer therapeutics. Introduction of T-oligo, an eleven-base oligonucleotide homologous to the 3'-telomeric overhang, mimics telomere disruption and induces DNA damage responses through a...

journal_title：OncoTargets and therapy

authors： Mulnix RE,Pitman RT,Retzer A,Bertram C,Arasi K,Crees Z,Girard J,Uppada SB,Stone AL,Puri N

更新日期：2013-12-18 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate an intravoxel incoherent motion (IVIM) model-based analysis of diffusion-weighted imaging (DWI) for assessing the response of hepatocellular carcinoma (HCC) to locoregional therapy. PATIENTS AND METHODS:Respiratory-gated DWI (b=0, 50, and 800 s/mm2) was retrospectively ana...

journal_title：OncoTargets and therapy

authors： Mürtz P,Penner AH,Pfeiffer AK,Sprinkart AM,Pieper CC,König R,Block W,Schild HH,Willinek WA,Kukuk GM

更新日期：2016-10-19 00:00:00

abstract：:Two decades ago, lymphatic mapping of sentinel lymph nodes (SLN) was introduced into surgical cancer management and was termed sentinel node navigated surgery. Although this technique is now routinely performed in the management of breast cancer and malignant melanoma, it is still under investigation for use in other ...

journal_title：OncoTargets and therapy

authors： Tausch C,Baege A,Rageth C

更新日期：2014-06-24 00:00:00

abstract：Background/Aims:The effects of lncRNA-NORAD/mir-520a-3p on proliferation and invasion of non-small cell lung cancer (NSCLC) were studied, and its potential molecular mechanism was discussed. Methods:qRT-PCR was used to detect the expression of lncRNA NORAD and miR-520a-3p in non-small cell lung cancer tissues and cell...

journal_title：OncoTargets and therapy

authors： Wan Y,Yao Z,Chen W,Li D

更新日期：2020-02-19 00:00:00

abstract：Introduction:Multiple myeloma (MM) remains an incurable disease, and patient survival requires a better understanding of this malignancy's molecular aspects. Heparanase (HPSE) is highly expressed in aggressive MM cells and related to tumor growth, metastasis, and bortezomib (BTZ) resistance. Thus, targeting HPSE seems ...

journal_title：OncoTargets and therapy

authors： Rodrigues-Junior DM,Pelarin MFA,Nader HB,Vettore AL,Pinhal MAS

更新日期：2021-01-15 00:00:00

abstract：:The prevalence of cancer remains high. With the improvement of diagnosis and treatment level and the increase of cancer survivors after treatment, multiple primary tumors are more common than before. The diagnosis and treatment of synchronous multiple primary tumors is more complicated than that of single or metachron...

journal_title：OncoTargets and therapy

authors： Zhang Y,Ge Y,Wu X,Liu S

更新日期：2019-04-02 00:00:00

abstract：:Cancers of the stomach and gastro-esophageal junction represent a significant challenge in oncology. Despite some recent advances in genetic categorization and the development of novel agents, outcomes remain poor. The vascular endothelial growth factor receptor 2 monoclonal antibody ramucirumab is the first targeted ...

journal_title：OncoTargets and therapy

authors： Davidson M,Smyth EC,Cunningham D

更新日期：2016-07-25 00:00:00

abstract：:The antidiabetic drug metformin has been shown to possess antitumor functions in many types of cancers. Although studies have revealed its beneficial effects on the prognosis of hepatocellular carcinoma (HCC), the detailed molecular mechanism underlying this event remains largely unknown. In this work, we showed that ...

journal_title：OncoTargets and therapy

authors： Sun Y,Tao C,Huang X,He H,Shi H,Zhang Q,Wu H

更新日期：2016-05-12 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are emerging as an important part of biological progress in cancers, yet the aberrant lncRNAs implicated in colorectal cancer (CRC) with lymph node metastasis remain unknown. In this study, a total of 390 lncRNA transcripts and 508 mRNA transcripts were dysregulated in tumor tissues compa...

journal_title：OncoTargets and therapy

authors： Yang P,Xu ZP,Chen T,He ZY

更新日期：2016-04-26 00:00:00

abstract：Background:A biosynthetic ginsenoside, 3-O-β-D-glucopyranosyl-12-O-β-D-glucopyranosyl-dammar-24-ene-3β, 12β, 20S-triol (C3C12PPD), showed antitumor activity against many tumor cells in vitro, especially had better anti-lung cancer activity than Rg3 in vitro and in vivo. However, the effects and molecular mechanisms of ...

journal_title：OncoTargets and therapy

authors： Huang LL,Tang M,Du QQ,Liu CX,Yan C,Yang JL,Li Y

更新日期：2019-09-09 00:00:00

abstract：Purpose:Stomach cancer is one of the highest incidence and mortality malignancies worldwide. Our study aimed to illustrate the somatic mutation landscape and identify molecular markers of stomach cancer. Materials and Methods:By integrated analysis of sequencing data and clinical data of stomach adenocarcinoma (STAD) ...

journal_title：OncoTargets and therapy

authors： Zhang X,Zheng P,Li Z,Gao S,Liu G

更新日期：2020-08-04 00:00:00

abstract：BACKGROUND AND PURPOSE:Vandetanib is a promising anticancer targeted agent for treating advanced carcinomas, such as non-small-cell lung cancer, small-cell lung cancer, breast cancer, malignant glioma, hepatocellular cancer, and unresectable, locally advanced, or metastatic medullary thyroid cancer. However, diarrhea i...

journal_title：OncoTargets and therapy

authors： Huo Z,Yu S,Hong S,Cao X,Xiu L,Liao Z,Li Y,Xiao H

更新日期：2016-06-20 00:00:00

abstract：:Extramedullary plasmacytoma (EMP) is an infrequent form of plasma cell dyscrasia that presents as a mass of monoclonal plasma cells located in extramedullary soft tissues with no skeletal component. EMP constitutes ~4% of all plasma cell neoplasms and occurs mostly in the upper respiratory tract. Here, we report a rar...

journal_title：OncoTargets and therapy

authors： Tang RR,Wang Y,Liang CN,Li W,Pei L,Kang J,Hou G

更新日期：2019-02-20 00:00:00

abstract：BACKGROUND:Metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) is identified to be overexpressed in several cancers. However, the role of MALAT-1 in chondrosarcoma is poorly understood. METHODS:The expression of MALAT-1 and Notch-1 signaling pathway was detected in chondrosarcoma tissues and chondrosarcom...

journal_title：OncoTargets and therapy

authors： Xu F,Zhang ZQ,Fang YC,Li XL,Sun Y,Xiong CZ,Yan LQ,Wang Q

更新日期：2016-04-13 00:00:00

abstract：:POEMS syndrome (acronym consisting of: polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) is an uncommon disorder associated with an underlying plasma cell dyscrasia. There is no single specific test for POEMS, and due to its rarity and heterogeneity, patients are often mis- or underdiagnosed. ...

journal_title：OncoTargets and therapy

authors： Găman M,Vlădăreanu AM,Dobrea C,Onisâi M,Marinescu C,Cîşleanu D,Ciufu C,Vasile D,Bumbea H,Voican I

更新日期：2018-09-27 00:00:00