Bone Marrow Stromal Antigen 2 is a Potential Unfavorable Prognostic Factor for High-Grade Glioma.

abstract：Backgrounds:microRNA-493-3p (miR-493) has been reported to be critically downregulated in multiple types of human cancer. However, the expression level, biological roles and underlying mechanism of miR‑493 in tongue squamous cell carcinoma (TSCC) remain to be elucidated. Methods:RT-qPCR was utilized for the determinat...

journal_title：OncoTargets and therapy

authors： Jiao D,Liu Y,Tian Z

更新日期：2019-08-28 00:00:00

abstract：Background:This study was designed to research the potential function of lncRNA ANRIL in osteosarcoma (OS). Materials and methods:Quantitative real-time PCR, cell counting kit-8, wound healing assay, Transwell assay, flow cytometric analysis, caspase activity analysis, and Western blot were carried out. Results:ANRIL...

journal_title：OncoTargets and therapy

authors： Guan H,Mei Y,Mi Y,Li C,Sun X,Zhao X,Liu J,Cao W,Li Y,Wang Y

更新日期：2018-08-14 00:00:00

abstract：:Iliac vein-ureteral fistula is a rare cause of hematuria. The diagnosis of an iliac vein-ureteral fistula can be elusive even with the use of multiple methods. With regards to the treatment, there appears to be a shift in management from primarily open surgical to primarily angiographic management. We present a unique...

journal_title：OncoTargets and therapy

authors： Luo JD,Liu B,Wang P,Zhou F,Xu XL,Li SQ,Cai SL,Wang YM

更新日期：2014-07-23 00:00:00

abstract：Background:Previous studies have reported that nuclear receptor subfamily 5, group A, member 2 (NR5A2) polymorphisms (rs3790843 G>A, rs3790844 T>C, rs12029406 C>T) are associated with the risk of pancreatic cancer. However, the results of epidemiological investigations are still controversial. In order to explore its p...

journal_title：OncoTargets and therapy

authors： Chen Q,Yuan H,Shi GD,Wu Y,Liu DF,Lin YT,Chen L,Ge WL,Jiang K,Miao Y

更新日期：2018-05-09 00:00:00

abstract：BACKGROUND/AIM:To elucidate the mechanism responsible for developing acute kidney injury in patients with diabetes mellitus, we also evaluated the issue of whether advanced glycation endproducts (AGEs) influence the expressions of multi antimicrobial extrusion protein (MATE1/SLC47A1) in tubular cells. MATERIALS AND ME...

journal_title：OncoTargets and therapy

authors： Mizuno T,Sato W,Ishikawa K,Terao Y,Takahashi K,Noda Y,Yuzawa Y,Nagamatsu T

更新日期：2015-07-10 00:00:00

abstract：:Neuroendocrine tumors are a rare and heterogeneous group of tumors with a variety of primary origins and variable aggressiveness. Platinum-based chemotherapy has been the cornerstone of treatment for the poorly differentiated tumors. However, well-differentiated neuroendocrine tumors are quite chemoresistant and thera...

journal_title：OncoTargets and therapy

authors： Kotteas EA,Syrigos KN,Saif MW

更新日期：2016-02-09 00:00:00

abstract：:[This corrects the article on p. 5203 in vol. 9, PMID: 27578986.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2017-04-27 00:00:00

abstract：Background:Addiction to aerobic glycolysis is a common metabolic phenotype in human non-small cell lung cancer (NSCLC). The natural product Sinomenine (Sin) exhibits significant anti-tumor effects in various human cancers. However, the underlying mechanism remains elusive. Methods:The inhibitory effect of Sin on NSCLC...

journal_title：OncoTargets and therapy

authors： Liu W,Yu X,Zhou L,Li J,Li M,Li W,Gao F

更新日期：2020-04-16 00:00:00

abstract：OBJECTIVES:Long non-coding RNA (lncRNA) associated with microvascular invasion in hepatocellular carcinoma (MVIH) has been recently reported to act as a predictor for the poor recurrence-free survival of hepatocellular carcinoma (HCC) after hepatectomy. However, the biological role of MVIH in the tumorigenesis of HCC i...

journal_title：OncoTargets and therapy

authors： Shi Y,Song Q,Yu S,Hu D,Zhuang X

更新日期：2015-08-27 00:00:00

abstract：Aim:To explore the expression and clinical significance of long noncoding RNA (lncRNA) gastric cancer-associated transcript 3 (GACAT3) in human colorectal cancer (CRC). Methods:Expression of GACAT3 in CRC tissues and cell lines was measured using quantitative real-time PCR. CCK-8 and colony formation assays were used ...

journal_title：OncoTargets and therapy

authors： Zhou W,Wang L,Miao Y,Xing R

更新日期：2018-03-19 00:00:00

abstract：Background and Objective:Metabolomics has recently been applied in the field of oncology. In this study, we aimed to use metabolomics to explore biomarkers in peritoneal metastasis of gastric cancer. Methods:Peritoneal lavage fluid (PLF) of 65 gastric cancer patients and related clinical data were collected from the F...

journal_title：OncoTargets and therapy

authors： Pan G,Ma Y,Suo J,Li W,Zhang Y,Qin S,Jiao Y,Zhang S,Li S,Kong Y,Du Y,Gao S,Wang D

更新日期：2020-07-27 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. Since the discovery that the KIT and PDGFRA receptor tyrosine kinases are the primary oncogenic drivers in the vast majority of GISTs, targeted therapy with tyrosine kinase inhibitors has been the mainstay ...

journal_title：OncoTargets and therapy

authors： Li GZ,Raut CP

更新日期：2019-07-01 00:00:00

abstract：:Patients diagnosed as lung adenocarcinoma with brain metastasis usually result in poor prognosis with limited survival time. Palliative systematic therapy has emerged as the primary choice for non-small cell lung cancer patients with brain metastasis harboring wild-type drive genes. However, the objective response rat...

journal_title：OncoTargets and therapy

authors： Chen J,Wang J,Zheng Q,Weng M,Wu X

更新日期：2019-11-11 00:00:00

abstract：Background:Several intracellular signaling pathways that are deregulated during hepatocarcinogenesis might constitute potential targets for hepatocellular carcinoma (HCC) therapy. The aim of this study was to test the potential synergic antitumor effect of salirasib and sorafenib in a diethylnitrosamine (DEN)-induced H...

journal_title：OncoTargets and therapy

authors： Ciccarelli O,Colson A,De Saeger C,Reding R,Sempoux C,Leclercq IA,Stärkel P

更新日期：2018-10-17 00:00:00

abstract：Background:Long non-coding RNAs (lncRNAs) have been verified to have a vital role in the progression of glioblastoma multiforme (GBM). Our research was about to identify the potential lncRNAs which was closely associated with the pathogenesis and prognosis of glioblastoma multiforme. Methods:All RNA sequence profiling...

journal_title：OncoTargets and therapy

authors： Li Y,Guo D

更新日期：2020-02-04 00:00:00

abstract：:The aim of this study was to evaluate the efficacy and toxicity of stereotactic body radiation therapy (SBRT) in the treatment of patients with liver metastases. Between August 2006 and July 2011, patients with 1-4 liver metastases were enrolled and treated with SBRT using the CyberKnife(®) system at Tianjin Medical U...

journal_title：OncoTargets and therapy

authors： Yuan ZY,Meng MB,Liu CL,Wang HH,Jiang C,Song YC,Zhuang HQ,Yang D,Wang JS,Wei W,Li FT,Zhao LJ,Wang P

更新日期：2014-06-12 00:00:00

abstract：PURPOSE:Programmed death-ligand 1 (PD-L1) is found to be overexpressed in non-small cell lung cancer. The present study intended to evaluate the status of PD-L1 expression in patients with resection and recurrent lung adenocarcinoma. PATIENTS AND METHODS:Matched resection and recurrent tumor samples were harvested fro...

journal_title：OncoTargets and therapy

authors： Chen J,Li H,Pang R,Huang J

更新日期：2017-04-06 00:00:00

abstract：:Mammalian nuclear receptors (NRs) are transcription factors regulating the expression of target genes that play an important role in drug metabolism, transport, and cellular signaling pathways. The orphan and structurally unique receptor small heterodimer partner 1 (syn NR0B2) is not only known for its modulation of d...

journal_title：OncoTargets and therapy

authors： Prestin K,Olbert M,Hussner J,Isenegger TL,Gliesche DG,Böttcher K,Zimmermann U,Meyer Zu Schwabedissen HE

更新日期：2016-08-08 00:00:00

abstract：:[This retracts the article on p. 1997 in vol. 9, PMID: 27103825.][This retracts the article on p. 841 in vol. 28.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2016-09-20 00:00:00

abstract：Background:Ovarian cancer (OC) is the most common type of gynecological malignant tumors with poor prognosis. The spen paralogue and orthologue C-terminal domain containing 1 (SPOCD1) is a newly identified molecule that has been indicated to discriminate progressive in human solid tumors. However, the role of SPOCD1 in...

journal_title：OncoTargets and therapy

authors： Liu D,Yang Y,Yan A,Yang Y

更新日期：2020-01-15 00:00:00

abstract：Background:Previous studies have indicated that tooth loss is associated with colorectal cancer risk but have presented controversial results. Methods:We conducted a dose-response meta-analysis in order to investigate the correlation between tooth loss and colorectal cancer risk. Up to August 2017, six eligible studie...

journal_title：OncoTargets and therapy

authors： Ma P,Dai S,Jin C,Yao Y,Zou C

更新日期：2018-03-21 00:00:00

abstract：Background:Hepatocellular carcinoma is a common malignant cancer and the second most common cause of cancer-related deaths worldwide. Collagen triple helix repeat containing 1 (CTHRC1) has been increasingly reported to be involved in tumorigenesis and/or tumor progression. However, limited data are available regarding ...

journal_title：OncoTargets and therapy

authors： Zhou H,Su L,Liu C,Li B,Li H,Xie Y,Sun D

更新日期：2019-09-23 00:00:00

abstract：:Background: During the past decades, great efforts have been built to develop lung cancer vaccines. Whole tumor cell lysate (TCL) are ideal sources of antigens for cancer vaccine design, which however have limited efficacy due to insufficient immunogenicity. Recently, radiotherapy has been closely related to immunothe...

journal_title：OncoTargets and therapy

authors： Luo L,Lv M,Zhuang X,Zhang Q,Qiao T

更新日期：2019-05-16 00:00:00

abstract：:Preclinical studies have demonstrated that Apatinib, major targeting vascular endothelial growth factor receptor-2 (VEGFR-2), could inhibit the proliferation of anaplastic thyroid carcinoma (ATC) cells in vitro and in vivo. The efficacy and safety in ATC patients, however, remains unknown. Here, we report the case of ...

journal_title：OncoTargets and therapy

authors： Cheng L,Jiao Q,Jin Y,Fu H,Zhang H,Chen L

更新日期：2019-12-02 00:00:00

abstract：Purpose:Cervical squamous cell carcinoma (CSCC) seriously affects women's health worldwide, and it is of great significance to illuminate the specific role of circRNAs in CSCC. Materials and Methods:Three mRNA datasets, two miRNA datasets and one circRNA dataset of CSCC, downloaded from GEO, were utilized in this stud...

journal_title：OncoTargets and therapy

authors： Wu Q,Liu P,Lao G,Liu Y,Zhang W,Ma C

更新日期：2020-08-25 00:00:00

abstract：:Angiogenesis (the growth of new blood vessels) is essential in most of the body's physiological processes, such as in the normal functioning of the endometrium during and after the menstrual cycle. Vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP) are the mostly expressed angiogenic factors,...

journal_title：OncoTargets and therapy

authors： Mahecha AM,Wang H

更新日期：2017-09-19 00:00:00

abstract：Purpose:Non-small cell lung cancer (NSCLC) patients with EGFR mutation are suffering from a high incidence of brain metastasis (BM). It is still controversial whether cranial radiotherapy could be delayed when the EGFR-tyrosine kinase inhibitors (TKIs) used as first-line therapy for EGFR-positive patients with BM. This...

journal_title：OncoTargets and therapy

authors： An N,Wang H,Li J,Zhai X,Jing W,Jia W,Kong L,Zhu H,Yu J

更新日期：2019-10-08 00:00:00

abstract：PURPOSE:One of the most challenging aspects of breast carcinoma chemotherapy is the rapid acquirement of drug resistance. Improving the sensitivity to chemotherapeutic drugs is very important for successful treatment. Mus81 plays an important role in maintaining the stability of the genome and DNA repair. However, rece...

journal_title：OncoTargets and therapy

authors： Qian Y,Liu Y,Yan Q,Lv J,Ni X,Wu Y,Dong X

更新日期：2014-10-21 00:00:00

abstract：BACKGROUND:To evaluate the benefit of second-line chemotherapy with platinum-based treatment in patients with recurrent small cell lung cancer (SCLC). PATIENTS AND METHODS:A total of 535 patients continued with follow-up or best supportive care if needed, and 229 patients who progressed after the completion of first-l...

journal_title：OncoTargets and therapy

authors： Zarogoulidis K,Boutsikou E,Zarogoulidis P,Darwiche K,Freitag L,Porpodis K,Latsios D,Kontakiotis T,Huang H,Li Q,Hohenforst-Schmidt W,Kipourou M,Turner JF,Spyratos D

更新日期：2013-10-22 00:00:00

abstract：BACKGROUND:Recent studies show that epithelial-mesenchymal transition (EMT) and tumor-associated macrophages (TAMs) contribute to the progression and poor prognosis of carcinoma through multiple mechanisms. Both inflammation and changing of epithelium have a close relationship with tumorigenesis of gastric cancer. Howe...

journal_title：OncoTargets and therapy

authors： Yan Y,Zhang J,Li JH,Liu X,Wang JZ,Qu HY,Wang JS,Duan XY

更新日期：2016-06-30 00:00:00