Abstract:
Purpose:Non-small cell lung cancer (NSCLC) patients with EGFR mutation are suffering from a high incidence of brain metastasis (BM). It is still controversial whether cranial radiotherapy could be delayed when the EGFR-tyrosine kinase inhibitors (TKIs) used as first-line therapy for EGFR-positive patients with BM. This study aims to investigate the therapeutic effect of TKIs combined with concurrent cranial radiotherapy on BM. Patients and methods:NSCLC patients with EGFR mutation and BM were retrospectively analyzed from January 2013 to December 2016 in Shandong Cancer Hospital. Identified cases were treated with first-line EGFR-TKIs with or without concurrent cranial radiation. Results:A total of 64 eligible patients were enrolled in this study, while 35 patients received first-line EGFR-TKIs plus cranial radiotherapy (RT+TKI group) and 29 patients received first-line EGFR-TKIs only (TKI alone group). The intracranial progression-free survival (PFS) of the RT+TKI group was significantly longer than the TKI alone group (25 vs 16 months; p=0.019), but no significant differences were observed between the two groups on extracranial PFS (20 vs 17 months, p=0.660). The median overall survival was also longer in the RT+TKI group (31 vs 24 months, p=0.019). Conclusion:Our retrospective data suggest that first-line TKIs plus concurrent cranial radiotherapy is a promising therapeutic strategy that led to remarkable intracranial PFS improvement and survival benefits for EGFR-mutant NSCLC with BM. Hence, it should be considered as a crucial treatment method during clinical management.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
An N,Wang H,Li J,Zhai X,Jing W,Jia W,Kong L,Zhu H,Yu Jdoi
10.2147/OTT.S223216subject
Has Abstractpub_date
2019-10-08 00:00:00pages
8311-8318issn
1178-6930pii
223216journal_volume
12pub_type
杂志文章abstract:Background:The oncogenic potential of special AT-rich binding protein 1 (SATB1) has been reported in various types of cancer, but its function in cervical cancer remains not fully investigated. This study aimed to investigate the effect of SATB1 mRNA expression on tumor progression and outcomes in the cervical cancer p...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S191414
更新日期:2019-01-30 00:00:00
abstract::Neuroendocrine tumors are a rare and heterogeneous group of tumors with a variety of primary origins and variable aggressiveness. Platinum-based chemotherapy has been the cornerstone of treatment for the poorly differentiated tumors. However, well-differentiated neuroendocrine tumors are quite chemoresistant and thera...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S72155
更新日期:2016-02-09 00:00:00
abstract:Introduction:Cervical cancer, one of the most common malignant gynecological tumors, is a significant burden on the health of females worldwide. The purpose of this study was to investigate genes associated with lymph node metastasis in cervical cancer. Methods:We report on the lymph node metastasis-associated gene, s...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S175808
更新日期:2018-10-15 00:00:00
abstract:Background:Renal cell cancer (RCC) is one of the most lethal malignancies of the kidney in adults. mTOR (mammalian target of rapamycin) signaling pathway plays a pivotal role in RCC tumorigenesis and progression and inhibitors targeting the mTOR pathway have been widely used in advanced RCC treatment. Therefore, it is ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S266095
更新日期:2020-10-15 00:00:00
abstract:Background:Few data have been published on the clinical and histopathological characteristics of advanced non-small-cell lung cancer (NSCLC) patients with high PD-L1 expression versus intermediate or none and the prognostic value of PD-L1 expression for patients treated with chemotherapy is unknown. This study was unde...
journal_title:OncoTargets and therapy
pub_type: 临床试验
doi:10.2147/OTT.S288825
更新日期:2020-12-30 00:00:00
abstract:Background:Previous studies have reported that nuclear receptor subfamily 5, group A, member 2 (NR5A2) polymorphisms (rs3790843 G>A, rs3790844 T>C, rs12029406 C>T) are associated with the risk of pancreatic cancer. However, the results of epidemiological investigations are still controversial. In order to explore its p...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S157759
更新日期:2018-05-09 00:00:00
abstract:Background:Minichromosome maintenance protein 2 (MCM2), which is a member of MCM family, has been found to be a relevant marker for progression and prognosis in a variety of human cancers. Due to lack of effective therapeutic target in lung squamous cell carcinoma (LUSC) patients, the aim of our study was to screen and...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S169002
更新日期:2018-08-20 00:00:00
abstract::Erastin was initially discovered as a small molecule compound that selectively kills tumor cells expressing ST and RASV12 and was later widely investigated as an inducer of ferroptosis. Ferroptosis is a recently discovered form of cell death caused by peroxidation induced by the accumulation of intracellular lipid rea...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S254995
更新日期:2020-06-11 00:00:00
abstract:Background:Breast cancer resistance protein BCRP, belonging to superfamily G of the adenosine triphosphate-binding cassette (ABC) transporters, is an efflux pump and plays a critical role in protecting cells against xenobiotics and toxic compounds including (pro)carcinogens. BCRP is expressed in many tissues, including...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S195245
更新日期:2019-02-27 00:00:00
abstract:Background:Insulin-like growth factor binding protein-2 (IGFBP2) levels are significantly increased in the plasma of hepatocellular carcinoma (HCC) patients. However, the correlation between IGFBP2 levels and clinical parameters and the exact role of IGFBP2 in HCC are unclear. In this study, we identified the role and ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S249527
更新日期:2020-06-08 00:00:00
abstract:Background:Penile squamous cell carcinoma (PSCC) bears poor prognosis due to its rarity and limited treatment options, especially after failure of standard treatments. Effective therapeutic options were desperately needed. Case Presentation:We report a recurrent metastatic PSCC patient with positive programmed death l...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S231258
更新日期:2020-04-21 00:00:00
abstract::ISL1 plays a key role in several cancers, including pheochromocytoma, gastrointestinal, pancreatic, and lung tumors and bile duct carcinoma. In order to elucidate the role of ISL1 in breast cancer, we performed quantitative real-time polymerase chain reaction and Western blotting analysis, and we found that ISL1 was u...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S144241
更新日期:2018-02-14 00:00:00
abstract:Introduction:Gastric cancer (GC) is one of the most malignancies leading to human mortality due to its development, progress, metastasis and poor prognosis, despite the development of remarkable chemotherapy and surgery. The 5-fluorouracil (5-Fu) is an effective anti-gastric cancer agent. However, a fraction of GC patie...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S230875
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:Although numerous studies have demonstrated associations between the preoperative neutrophil-to-lymphocyte ratio (NLR) and long-term outcomes in patients with non-small cell lung cancer (NSCLC), the prognostic significance of postoperative NLR and change in NLR (ΔNLR) is unknown for patients who underwent compl...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S117290
更新日期:2016-10-21 00:00:00
abstract::The incidence rate of breast cancers in People's Republic of China has increased in the last decade, and many cases are responsive to hormone therapies. The third-generation aromatase inhibitor letrozole inhibits estrogen production, and is more efficacious than the estrogen receptor inhibitor tamoxifen. In recent yea...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S81087
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Sunitinib is widely used as first-line treatment for metastatic clear cell renal cancer (MCRC). No reports are known of treatment after sunitinib failure. As irinotecan, cisplatin, and mitomycin-C (IPM) chemotherapy has been reported to influence MCRC after progression on cytokine therapy, we report on the o...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/ott.s3590
更新日期:2008-09-01 00:00:00
abstract::Aberrant promoter methylation of RUNX3 has been reported in several tumors including human breast cancer (BC). However, the association between RUNX3 hypermethylation and incidence of BC remains elusive. In this study, a detailed literature search was performed in Medline and Google Scholar for related research public...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S77828
更新日期:2016-08-26 00:00:00
abstract::Low-grade fetal lung adenocarcinoma (L-FLAC) is an exceptionally rare pulmonary tumor, presenting with unclear histological and molecular features. In particular, the potential driver genes of L-FLAC remain elusive. To date, only five reports have documented genetic aberrations in L-FLAC. In the current study, we desc...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S260993
更新日期:2020-07-07 00:00:00
abstract:Background:Emerging researches have demonstrated that aberrantly expressed long non-coding RNAs (lncRNAs) have great significance in non-small cell lung cancer (NSCLC) progression. The aim of this study was to explore the role of lncRNA AZIN1 antisense RNA 1 (AZIN1-AS1) in NSCLC and the related mechanism. Methods:Expr...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S261497
更新日期:2020-10-09 00:00:00
abstract:Purpose:To evaluate the capability of 18F-fluorodeoxyglucose positron emission tomography/ computed tomography (18F-FDG-PET/CT) to predict the clinical response of metastatic lymph node (mLN) to definitive chemoradiotherapy (dCRT) and guide personalized radiation dose in esophageal squamous cell carcinoma (ESCC) patien...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S160456
更新日期:2018-07-25 00:00:00
abstract:OBJECTIVE:To explore the clinical significance of 3-phosphoinositide-dependent protein kinase-1 (PDK1) expression in hepatocellular carcinoma (HCC) and its association with clinicopathologic features and prognosis in HCC patients. MATERIALS AND METHODS:A total of 128 HCC patients who received radical resection were en...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S110646
更新日期:2016-09-09 00:00:00
abstract:Background:It was previously reported that downregulation of miR-218 promoted thyroid cancer cell invasion, migration, and proliferation. However, the biological functions of miR-218 and its possible regulatory mechanisms in papillary thyroid cancer (PTC) cells are still elusive. Materials and methods:The expression l...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S172152
更新日期:2018-09-28 00:00:00
abstract:BACKGROUND:Gallbladder carcinoma is a highly malignant tumor and a public health problem in some parts of the world. It is characterized by a poor prognosis and its resistance to radio and chemotherapy. There is an urgent need to develop novel therapeutic alternatives for the treatment of gallbladder carcinoma. The mam...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S46897
更新日期:2013-10-03 00:00:00
abstract:BACKGROUND:Studies on the association between two single nucleotide polymorphisms (SNPs) in estrogen receptor α (ERα), PvuII (rs2234693 T>C) and XbaI (rs9340799 A>G), and the prostate cancer risk are inconsistent. Therefore, we performed a meta-analysis to derive a more accurate estimation of this relationship. METHOD...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S132419
更新日期:2017-06-29 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) patients with fever as the initial presentation are extremely rare. Our aim was to investigate the clinical characteristics and prognosis of patients with this disease. PATIENTS AND METHODS:The clinical features were analyzed in a retrospective study of 63 HCC patients with fe...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S109023
更新日期:2016-10-13 00:00:00
abstract:Background:Bone marrow stromal antigen 2 (BST2) is considered as a transmembrane glycoprotein and plays essential roles in innate immunity. It has been recently reported that up-regulation of BST2 was associated with the development of breast carcinoma. However, the clinical significance of BST2 in glioma has not been ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S258631
更新日期:2020-08-26 00:00:00
abstract:Purpose:The molecular mechanism of perineural invasion (PNI) in stage II colorectal cancer (CRC) remains not to be defined clearly. This study aims to identify the genomic aberrations related to PNI in stage II CRC. Patients and Methods:Using array-based comparative genomic hybridization (array-CGH), primary tumor tis...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S264616
更新日期:2020-11-11 00:00:00
abstract::Esophageal carcinoma (EC) is a lethal disease with high morbidity and mortality worldwide, and the incidence has been increasing in recent years. Although the diagnosis and treatment of EC have improved considerably, EC has rapidly progressed in the clinical setting and has a poor prognosis for its metastasis and recu...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S103179
更新日期:2016-04-19 00:00:00
abstract:Purpose:MicroRNA-939 (miR-939) has crucial roles in several types of human cancer. However, the expression profile and precise functions of miR-939 in prostate cancer (PCa) are still unclear. This study aimed to determine miR-939 expression in PCa and explore its roles in PCa tumorigenesis. Methods:miR-939 expression ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S250101
更新日期:2020-05-18 00:00:00
abstract:Objective:Long non-coding RNAs (lncRNAs) have been identified as important players in tumorigenesis. LncRNA highly upregulated in liver cancer (HULC) has been identified as a key regulator in the progression of various cancers. However, the functional role and the mechanisms of HULC in regulating cervical cancer cell b...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S232914
更新日期:2020-02-05 00:00:00