Abstract:
OBJECTIVE:To explore the clinical significance of 3-phosphoinositide-dependent protein kinase-1 (PDK1) expression in hepatocellular carcinoma (HCC) and its association with clinicopathologic features and prognosis in HCC patients. MATERIALS AND METHODS:A total of 128 HCC patients who received radical resection were enrolled from Wenling Maternal and Child Health Care Hospital between May 2005 and December 2008, and tumor and adjacent tissue samples were collected. Expression of PDK1 was detected by immunohistochemistry method. Correlation of PDK1 expression with clinicopathological features and prognosis was determined by Spearman's correlation analysis. Impact of expression of PDK1 on overall survival and recurrence was determined by Kaplan-Meier analysis. RESULTS:Immunohistochemistry results showed that PDK1 expression in HCC tissues was significantly higher than that in the corresponding adjacent cancer tissues. Univariate analysis showed that PDK1 messenger RNA expression can predict time to recurrence with diagnostic significance (P=0.001). Univariate analysis showed that alpha-fetoprotein level, tumor number, tumor encapsulation, microvascular invasion, and tumor-node-metastasis stage were also unfavorable prognostic variables for recurrence (P<0.05). Kaplan-Meier analysis showed that overexpression of PDK1 correlates with significantly shorter postoperative overall survival and higher recurrence rates (hazard ratio =2.68; 95% confidence interval: 2.46-4.42, P=0.001) in HCC patients after curative resection. CONCLUSION:Our study indicated that PDK1 may serve as a candidate pro-oncogene and a potential prognostic biomarker for HCC.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Wang J,Liu F,Ao P,Li X,Zheng H,Wu D,Zhang N,She J,Yuan J,Wu Xdoi
10.2147/OTT.S110646subject
Has Abstractpub_date
2016-09-09 00:00:00pages
5597-602issn
1178-6930pii
ott-9-5597journal_volume
9pub_type
杂志文章abstract::Despite remarkable progress in cancer-drug discovery, the delivery of novel, safe, and sustainably effective products to the clinic has stalled. Using Src as a model, we examine key steps in drug development. The preclinical evidence on the relationship between Src and solid cancer is in sharp contrast with the modest...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S45177
更新日期:2013-06-26 00:00:00
abstract:Purpose:To evaluate the capability of 18F-fluorodeoxyglucose positron emission tomography/ computed tomography (18F-FDG-PET/CT) to predict the clinical response of metastatic lymph node (mLN) to definitive chemoradiotherapy (dCRT) and guide personalized radiation dose in esophageal squamous cell carcinoma (ESCC) patien...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S160456
更新日期:2018-07-25 00:00:00
abstract:Introduction:Melanoma is a common skin cancer that is usually associated with poor clinical outcomes. Recently, the immune checkpoint GITR has been identified as a promising target for immunotherapy of melanoma. In this study, we aimed to investigate the post-translational regulation mechanism of GITR in melanoma. Met...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S212317
更新日期:2019-12-04 00:00:00
abstract:OBJECTIVE:To investigate the effects of microRNA-122 (miR-122) on proliferation, migration, and invasion in human hepatocellular carcinoma (HCC) cells by activating epithelial-mesenchymal transition (EMT) pathways. METHODS:miR-122 mimics, miR-122 inhibitors, relevant control oligonucleotides, and Wnt1 were transfected...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S92378
更新日期:2016-04-06 00:00:00
abstract::Recently, the human gene NOTCH1 has been found to be implicated in cancer cell metastasis and the maintenance of cancer stem cells. However, for breast cancer in particular, an association between NOTCH1 levels and metastasis has not been determined. In this study, we investigated the expression status and correlation...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S109606
更新日期:2016-11-07 00:00:00
abstract:Background:Ovarian cancer (OC) is the most common type of gynecological malignant tumors with poor prognosis. The spen paralogue and orthologue C-terminal domain containing 1 (SPOCD1) is a newly identified molecule that has been indicated to discriminate progressive in human solid tumors. However, the role of SPOCD1 in...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S200317
更新日期:2020-01-15 00:00:00
abstract:Background:Renal cell cancer (RCC) is one of the most lethal malignancies of the kidney in adults. mTOR (mammalian target of rapamycin) signaling pathway plays a pivotal role in RCC tumorigenesis and progression and inhibitors targeting the mTOR pathway have been widely used in advanced RCC treatment. Therefore, it is ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S266095
更新日期:2020-10-15 00:00:00
abstract:Background:LncRNA cancer susceptibility candidate 15 (CASC15) has been demonstrated to act as an oncogene in different cancers; however, its role in ovarian cancer remains elusive. Methods:Quantitative real-time PCR (qRT-PCR) was performed to examine the expression of lncRNA CASC15. Kaplan-Meier survival analysis was ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S219900
更新日期:2019-10-23 00:00:00
abstract::The development of deep-sequencing methods is now unveiling a new landscape of previously undetected gene fusion across different tumor types. Chromosomal translocation involving the NTRK gene family occur across a wide range of cancers in both children and adults. Preclinical studies have demonstrated that chimeric p...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S177051
更新日期:2019-04-30 00:00:00
abstract::Acute pancreatitis is a rare complication in postoperative colorectal cancer patients after FOLFOX6 (oxaliplatin + calcium folinate +5-FU [5-fluorouracil]) chemotherapy. In this paper, a total of 62 patients with gastrointestinal cancer were observed after the burst of acute pancreatitis. Surgery of the 62 cases of co...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S88857
更新日期:2015-09-11 00:00:00
abstract:PURPOSE:The expression of an array of signaling molecules, along with the assessment of real-time cell proliferation, has been performed in U87 glioma cell line and in patients' glioblastoma established cell cultures in order to provide a better understanding of cellular and molecular events involved in glioblastoma pa...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S52365
更新日期:2013-11-29 00:00:00
abstract:Purpose:The molecular mechanism of perineural invasion (PNI) in stage II colorectal cancer (CRC) remains not to be defined clearly. This study aims to identify the genomic aberrations related to PNI in stage II CRC. Patients and Methods:Using array-based comparative genomic hybridization (array-CGH), primary tumor tis...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S264616
更新日期:2020-11-11 00:00:00
abstract::[This corrects the article DOI: 10.2147/OTT.S196910.]. ...
journal_title:OncoTargets and therapy
pub_type: 已发布勘误
doi:10.2147/OTT.S229714
更新日期:2019-09-19 00:00:00
abstract:Background:A growing body of evidence supports the involvement of long noncoding RNA 00152 (LINC00152) in the progression and metastasis of multiple cancers. However, the exact roles of LINC00152 in the progression of human retinoblastoma (RB) remain unknown. We explored the expression and biological function of human ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S160428
更新日期:2018-06-06 00:00:00
abstract::Purpose: Ornithine decarboxylase 1 (ODC1)-an oncogene involved in the biosynthesis of polyamines-is commonly upregulated and associated with poor prognosis in numerous cancers. However, the role and mechanism of ODC1 in hepatocellular carcinoma (HCC) remains unclear. The aim of the present study was to investigate the...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S198341
更新日期:2019-05-27 00:00:00
abstract:OBJECTIVE:To analyze the management and prognosis of primary choriocarcinoma (PCC) in male patients. METHODS:The clinical records of males with PCC who were treated at Peking Union Medical College Hospital between 1990 and 2012 were analyzed retrospectively. The literature regarding this clinical condition was also re...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S62561
更新日期:2014-06-20 00:00:00
abstract:OBJECTIVES:MicroRNA (miRNA)-related single-nucleotide polymorphisms (SNPs) in miRNA processing machinery genes can affect cancer risk, treatment efficacy, and patient prognosis. A miR-SNP of rs11077 located in the 3' untranslated region (3' UTR) of the miRNA processing machinery gene XPO5 was examined in 112 advanced n...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S48284
更新日期:2013-07-11 00:00:00
abstract:Introduction:Microfibril-associated protein 2 (MFAP2) is an extracellular matrix protein that interacts with fibrillin to modulate the function of microfibrils. MFAP2 has been reported to play a significant role in obesity, diabetes, and osteopenia, and has been shown to be upregulated in head and neck squamous cell ca...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S160831
更新日期:2018-07-12 00:00:00
abstract::[This retracts the article on p. 2215 in vol. 8, PMID: 26345468.]. ...
journal_title:OncoTargets and therapy
pub_type: 撤回出版物
doi:10.2147/OTT.S100941
更新日期:2016-02-04 00:00:00
abstract:Background and Objectives:Non-small cell lung cancer (NSCLC) patients with an epidermal growth factor receptor (EGFR) mutation demonstrate only a median progression-free survival (PFS) of 8 to 10 months and undergo EGFR tyrosine kinase inhibitors (EGFR-TKIs) therapy. For decades, bilirubin has been reported to be assoc...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S266477
更新日期:2020-10-29 00:00:00
abstract:Purpose:Circular RNAs (circRNAs) are emerging as promising biomarkers for various human malignancies. However, the application of circRNAs as non-invasive biomarkers in high-grade serous ovarian cancer (SOC) remains to be elucidated. Here, we aim to investigate the feasibility of using serum circSETDB1, a tumor-promoti...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S220700
更新日期:2019-09-11 00:00:00
abstract::Recent studies have shown that microRNAs play a pivotal role in the pathogenesis of cancer. In our current study, the expression levels of microRNA-211 (miR-211) were measured in human non-small-cell lung cancer (NSCLC) tissues and cell lines. We found that miR-211 expression levels were increased in NSCLC tissues and...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S143084
更新日期:2017-11-28 00:00:00
abstract:Purpose:Numerous metabolomics studies have been conducted to detect the metabolic mechanisms and biomarkers related to gastric cancer and colorectal cancer. Because of the common metabolic features between gastric cancer and colorectal cancer, a differential diagnosis is difficult. Here, we performed a systematic revie...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S247393
更新日期:2020-06-25 00:00:00
abstract:Background:Few data have been published on the clinical and histopathological characteristics of advanced non-small-cell lung cancer (NSCLC) patients with high PD-L1 expression versus intermediate or none and the prognostic value of PD-L1 expression for patients treated with chemotherapy is unknown. This study was unde...
journal_title:OncoTargets and therapy
pub_type: 临床试验
doi:10.2147/OTT.S288825
更新日期:2020-12-30 00:00:00
abstract:Purpose:LINC00680 was reported to be involved in various cancers through multiple mechanisms. Therefore, we intended to investigate its role in the progression of non-small cell lung cancer (NSCLC). Materials and Methods:Firstly, quantitative real-time polymerase chain reaction (qRT-PCR) was used to test LINC00680 in ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S259232
更新日期:2020-08-18 00:00:00
abstract::Despite multimodal therapeutic treatments of osteosarcoma (OS), some patients develop resistance to currently available regimens and eventually end up with recurrent or metastatic outcomes. Many attempts have been made to discover effective drugs for improving outcome; however, due to the heterogeneity of the disease,...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S119993
更新日期:2017-02-01 00:00:00
abstract::The study aimed to investigate the difference of setup errors on different registration in the treatment of nasopharyngeal carcinoma based on weekly cone-beam computed tomography (CBCT). Thirty nasopharyngeal cancer patients scheduled to undergo intensity-modulated radiotherapy (IMRT) were prospectively enrolled in th...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S87159
更新日期:2015-09-14 00:00:00
abstract:PURPOSE:Subsets of non-small-cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations carry uncommon subtypes. We evaluated the efficacy of first-generation EGFR-tyrosine kinase inhibitors (TKIs; erlotinib, gefitinib, and icotinib) in patients with non-small-cell lung cancer carrying insertions ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S108242
更新日期:2016-07-08 00:00:00
abstract:INTRODUCTION:The introduction of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) has improved the outlook for patients with advanced non-small-cell lung cancer (NSCLC) with EGFR+ mutations. However, most patients develop resistance, with the result that median progression-free survival (PFS) iŝ1...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S134382
更新日期:2017-05-05 00:00:00
abstract:BACKGROUND:Associations between Arg399Gln single-nucleotide polymorphism (SNP) in the XRCC1 gene and leukemia susceptibility have been studied extensively, however, the results are inconsistent. The aim of this study was to determine these associations using meta-analytical methods. METHODS:A meta-analysis was perform...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S92752
更新日期:2015-11-06 00:00:00