ODC1 promotes proliferation and mobility via the AKT/GSK3β/β-catenin pathway and modulation of acidotic microenvironment in human hepatocellular carcinoma.

abstract：PURPOSE:This study aimed to spare hematopoietical bone marrow (BM) identified by magnetic resonance (MR) radiation in order to alleviate acute hematologic toxicity (HT) for gastric cancer patients treated with postoperative chemoradiotherapy (CRT). METHODS:A prospective, open-label, single-arm Phase II study (Clinical...

journal_title：OncoTargets and therapy

authors： Wang J,Tian Y,Tang Y,Wang X,Li N,Ren H,Fang H,Feng Y,Wang S,Song Y,Liu Y,Wang W,Li Y,Jin J

更新日期：2016-05-05 00:00:00

abstract：Background:Although several long non-coding RNAs (lncRNAs) have been found to be involved in gastric cancer tumorigenesis, the more comprehensive contributions of lncRNAs to gastric cancer require further investigation. Here, we identify a cytoplasmic lncRNA, LINC01485, which promotes tumor growth and migration in gast...

journal_title：OncoTargets and therapy

authors： Zhou J,Wu L,Li W,Xu X,Ju F,Yu S,Guo J,Li G,Shi J,Zhou S

更新日期：2020-08-21 00:00:00

abstract：Background and aims:Gastric cancer (GC) is one of the most common cancers worldwide, and its pathogenesis is related to a complex network of gene interactions. The aims of our study were to find hub genes associated with the progression and prognosis of GC and illustrate the underlying mechanisms. Methods:Weighted gen...

journal_title：OncoTargets and therapy

authors： Chen PF,Wang F,Nie JY,Feng JR,Liu J,Zhou R,Wang HL,Zhao Q

更新日期：2018-10-02 00:00:00

abstract：:Bladder cancer (BC) is the most common urinary system malignancy and is a serious threat to human health. Circular RNAs (circRNAs) are members of a newly defined class of noncoding RNAs (ncRNAs) that can regulate gene expression at the transcriptional or posttranscriptional level. Studies have shown that circRNAs are ...

journal_title：OncoTargets and therapy

authors： Cai Z,Li H

更新日期：2020-09-29 00:00:00

abstract：Background:Gastric tumor (GT) is associated with high morbidity and mortality, with surgery among the most effective treatment methods. Accurate interoperative determination of the tumor margin is crucial. Methods:In this study, using internal extractive electrospray ionization-MS, mass spectral data of GT and gastric...

journal_title：OncoTargets and therapy

authors： Zhang J,Gao Q,Luo X,Zhang W,Wang N,Wei Y

更新日期：2019-10-17 00:00:00

abstract：:MicroRNA-126 (miR-126) has been found to promote angiogenesis, but the underlying mechanisms are still unclear. So, we conducted this study to explore the effect of miR-126 expression on angiogenesis in hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). The expression levels of miR-1...

journal_title：OncoTargets and therapy

authors： Ji JS,Xu M,Song JJ,Zhao ZW,Chen MJ,Chen WQ,Tu JF,Yang XM

更新日期：2016-07-19 00:00:00

abstract：:Melanoma develops from melanocytes and typically occurs on the skin and mucosa with a high degree of malignancy. Intensive local invasion and distant metastasis of melanoma result in poor patient prognosis, owing to frequent metastases to the lungs, bones, brains, and other parts of the body. In the present study, we ...

journal_title：OncoTargets and therapy

authors： Feng L,Qi DJ,Zhang QF

更新日期：2016-08-10 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are emerging as an important part of biological progress in cancers, yet the aberrant lncRNAs implicated in colorectal cancer (CRC) with lymph node metastasis remain unknown. In this study, a total of 390 lncRNA transcripts and 508 mRNA transcripts were dysregulated in tumor tissues compa...

journal_title：OncoTargets and therapy

authors： Yang P,Xu ZP,Chen T,He ZY

更新日期：2016-04-26 00:00:00

abstract：Background:Despite the breadth of understanding the noncoding RNAs' function in molecular biology, their functional roles in hepatocellular carcinoma (HCC) is poorly understood. In this study, we investigated the effect of hepatitis C virus (HCV) core upon the expression of noncoding RNAs. Methods:The lncRNAs, mRNAs, ...

journal_title：OncoTargets and therapy

authors： Wang X,Peng J,Wang J,Li M,Wu D,Wu S,Liao J,Dou J

更新日期：2018-03-02 00:00:00

abstract：Background:Erdheim-Chester Disease (ECD) is a clonal non-Langerhans histiocytosis, classified as a macrophage-dendritic cell neoplasm in the 2016 WHO classification. The exact cell of origin of ECD is unknown, although some limited evidence suggests that it arises from myeloid progenitors. Case Presentation:A 43-year-...

journal_title：OncoTargets and therapy

authors： Papageorgiou SG,Divane A,Roumelioti M,Kottaridi C,Bouchla A,Georgakopoulos A,Ieremiadou F,Daraki A,Bazani E,Thomopoulos TP,Chatziioannou S,Mavrogenis A,Panayiotidis P,Panayiotides IG,Pappa V,Foukas PG

更新日期：2020-11-16 00:00:00

abstract：Background and objective:RNF6, an E3 ligase, has been reported to play an important role in the tumorigenesis in several tissues, but its role in gastric cancer is still unknown. In this study, we aimed to investigate the biological function and molecular mechanisms of RNF6 in gastric cancer. Materials and methods:The...

journal_title：OncoTargets and therapy

authors： Huang Z,Cai Y,Yang C,Chen Z,Sun H,Xu Y,Chen W,Xu D,Tian W,Wang H

更新日期：2018-10-05 00:00:00

abstract：Background:Breast cancer (BC) has been the commonest malignant tumor with a low survival rate among woman. Long non-coding RNA hypoxia-inducible factor-1 alpha antisense RNA-2 (HIF1A-AS2) was correlated with various cancers. Purpose:The study aimed to investigate the roles and related underlying molecular mechanisms o...

journal_title：OncoTargets and therapy

authors： Guo X,Lee S,Cao P

更新日期：2019-01-24 00:00:00

abstract：BACKGROUND:Permanent prostate brachytherapy (PPB) is an effective treatment choice for low and intermediate risk prostate cancer (PCa). However, the impact of PPB on tumor immune status is still poorly understood. This study aimed to assess the immune status in PCa patients before and at different time points after PPB...

journal_title：OncoTargets and therapy

authors： Du E,Wang L,Li CY,Zhang CW,Qu YC,Liu RL,Xu Y,Yang K,Zhang ZH

更新日期：2017-05-15 00:00:00

abstract：Background:Large amounts of researches indicate that non-coding RNAs play a crucial role in many malignancies. However, the potential mechanisms of non-coding RNAs involved in osteosarcoma tumorigenesis remain elusive. Materials and Methods:The expression of long non-protein coding RNA 691 (lncRNA 691) in cell lines a...

journal_title：OncoTargets and therapy

authors： Yao P,Ni Y,Liu C

更新日期：2020-05-22 00:00:00

abstract：Background:Our previous study demonstrated that Id-1 may promote the tumorigenicity of esophageal squamous cell carcinoma (ESCC). Id-4 is another member of Id family, which is rare to be studied in ESCC. In this study, we investigated the expression of Id-4 in human ESCC specimens and determined whether Id-4 expression...

journal_title：OncoTargets and therapy

authors： Wang X,Lu Q,Fei X,Zhao Y,Shi B,Li C,Chen H

更新日期：2020-02-12 00:00:00

abstract：:Background: Previous studies have reported that the albumin-to-alkaline phosphatase ratio (AAPR), a novel blood biomarker-based index, is associated with clinical outcome in several cancers. However, data relating to lung cancer are rare. This study was performed to clarify the clinical significance of AAPR in patient...

journal_title：OncoTargets and therapy

authors： Li D,Yu H,Li W

更新日期：2019-07-02 00:00:00

abstract：Objective:This study aims to uncover the progression of thyroid carcinoma influenced by the m6A methyltransferase METTL3 through regulating m6A methylation on TCF1 mRNA and the activated Wnt pathway. Methods:Thyroid carcinoma tissues and paracancerous ones were collected for detecting levels of METTL3 and TCF1. Potent...

journal_title：OncoTargets and therapy

authors： Wang K,Jiang L,Zhang Y,Chen C

更新日期：2020-02-21 00:00:00

abstract：Background:Patients with BRAF (v-Raf murine sarcoma viral oncogene homolog B) V600E-mutated metastatic colorectal cancer (mCRC) have a poor prognosis. The Southwest Oncology Group (SWOG) 1406 study evaluated the efficacy of vemurafenib in combination with irinotecan and cetuximab for simultaneous inhibition of epiderma...

journal_title：OncoTargets and therapy

authors： Wang Z,Dai WP,Zang YS

更新日期：2019-01-08 00:00:00

abstract：Background:The immunosuppressive facet and tumorigenic role of TNF-α have been revealed in osteosarcoma (OS). Long noncoding RNA THRIL is identified to regulate TNF-α expression and participates in immune response. Thus, investigations on the clinical expression pattern of THRIL/TNF-α signal in OS would provide a poten...

journal_title：OncoTargets and therapy

authors： Xu B,Jin X,Yang T,Zhang Y,Liu S,Wu L,Ying H,Wang Z

更新日期：2020-01-07 00:00:00

abstract：Background:Previous reports show that SIRT6 serves as a critical modulator of the development of multiple malignancies as well as other disorders. However, its role in nasopharyngeal carcinoma (NPC) is unknown. Thus, we elucidated the effects of SIRT6 on the survival of NPC cells, and modulation of cell death. Methods...

journal_title：OncoTargets and therapy

authors： Ouyang L,Yi L,Li J,Yi S,Li S,Liu P,Yang X

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Repetitive genotyping is useful to assess the genetic evolution of non-small-cell lung cancer (NSCLC) during treatment, but the need for sampling by biopsy is a major obstacle. Digital polymerase chain reaction (PCR) is a promising procedure for the detection of mutant alleles in plasma of cancer patients. ...

journal_title：OncoTargets and therapy

authors： Nakahara Y,Takagi Y,Hosomi Y,Kagei A,Yamamoto T,Sawada T,Yomota M,Okuma Y,Mikura S,Okamura T

更新日期：2016-08-24 00:00:00

abstract：BACKGROUNDS:Sitting time and physical activity are associated with cancer risk; however, their roles in the development of esophageal squamous cell carcinoma (ESCC) are inconclusive. This study aimed to investigate the effects of total sitting time, occupational activity time (OAT), and recreational activity time (RAT)...

journal_title：OncoTargets and therapy

authors： Chen P,Song Q,Han J,Xu H,Chen T,Xu J,Cheng Y

更新日期：2017-09-27 00:00:00

abstract：PURPOSE:Liver metastasis is one of the leading causes of death in colorectal cancer (CRC) patients. The present study aimed to evaluate the value of eIF4E as a prognostic marker of colorectal liver metastasis (CLM) and identify the functional role of eIF4E in CRC metastasis. PATIENTS AND METHODS:The expression level o...

journal_title：OncoTargets and therapy

authors： Xu T,Zong Y,Peng L,Kong S,Zhou M,Zou J,Liu J,Miao R,Sun X,Li L

更新日期：2016-02-19 00:00:00

abstract：BACKGROUND:Associations between Arg399Gln single-nucleotide polymorphism (SNP) in the XRCC1 gene and leukemia susceptibility have been studied extensively, however, the results are inconsistent. The aim of this study was to determine these associations using meta-analytical methods. METHODS:A meta-analysis was perform...

journal_title：OncoTargets and therapy

authors： Wang F,Zhao Q,He HR,Zhai YJ,Lu J,Hu HB,Zhou JS,Yang YH,Li YJ

更新日期：2015-11-06 00:00:00

abstract：Purpose:DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has attracted extensive attention in various types of malignant tumors. However, the role of DNA-PKcs in cutaneous squamous cell carcinoma (cSCC) development has not been elucidated. In this study, we investigated the role of DNA-PKcs in cSCC and the mol...

journal_title：OncoTargets and therapy

authors： Zhang J,Jiang H,Xu D,Wu WJ,Chen HD,He L

更新日期：2019-11-07 00:00:00

abstract：BACKGROUND:The association of cancer stem cells with epithelial-mesenchymal transition (EMT) is receiving attention. We found in our previous study that EMT existed from CD24- phenotype cells to their differentiated cells. It was shown that cyclin D1 functioned in sustaining self-renewal independent of CDK4/CDK6 activa...

journal_title：OncoTargets and therapy

authors： Jiao J,Huang L,Ye F,Shi M,Cheng X,Wang X,Hu D,Xie X,Lu W

更新日期：2013-06-20 00:00:00

abstract：Purpose:The microRNA (miRNA) profile changes in the tumor-associated macrophages. However, the role of miR-106b-5p in the glioblastoma-associated macrophages is poorly understood. Materials and Methods:In our study, miR-106b-5p and M2 macrophage markers were detected by qRT-PCR and Western blotting in THP1 cells, with...

journal_title：OncoTargets and therapy

authors： Shi Y,Zhang B,Zhu J,Huang W,Han B,Wang Q,Qi C,Wang M,Liu F

更新日期：2020-07-30 00:00:00

abstract：:Purpose: Wolf-Hirschhorn syndrome candidate 1 (WHSC1) is an epigenetic modifier, considered to play a driving role in oncogenesis. However, very little is known about the roles of WHSC1 and its prognostic impacts in cervical cancer. This study aimed to investigate the role of WHSC1 in the prognosis of cervical cancer ...

journal_title：OncoTargets and therapy

authors： Wu J,Luo M,Duan Z,Jia Y,Linghu H,Tian P,Qi H

更新日期：2019-06-17 00:00:00

abstract：BACKGROUND:Nivolumab (BMS-936558/ONO-4538) was the first monoclonal antibody targeting programmed death (PD)-1. So far, a number of clinical trials on nivolumab have showed satisfactory efficacy in treating non-small-cell lung cancer (NSCLC). Herein, we present a meta-analysis evaluating the efficacy and safety of nivo...

journal_title：OncoTargets and therapy

authors： Huang J,Zhang Y,Sheng J,Zhang H,Fang W,Zhan J,Zhou T,Chen Y,Liu L,Zhang L

更新日期：2016-09-23 00:00:00

abstract：Background:Intra-abdominal desmoplastic small round cell tumor (IADSRCT) is a highly invasive malignant tumor that is rare in clinical practice. Anlotinib is a multitarget receptor tyrosine kinase inhibitor which inhibits vascular endothelial growth factor receptor (VEGFR) 1-3, fibroblast growth factor receptor (FGFR) ...

journal_title：OncoTargets and therapy

authors： Chen HM,Feng G

更新日期：2018-12-18 00:00:00