Albumin-to-alkaline phosphatase ratio at diagnosis predicts survival in patients with metastatic non-small-cell lung cancer.

abstract：Background:The mortality rate associated with ovarian cancer ranks the highest among gynecological malignancies. However, the cause and underlying molecular events of ovarian cancer are not clear. Here, we applied integrated bioinformatics to identify key pathogenic genes involved in ovarian cancer and reveal potential...

journal_title：OncoTargets and therapy

authors： Yang X,Zhu S,Li L,Zhang L,Xian S,Wang Y,Cheng Y

更新日期：2018-03-15 00:00:00

abstract：Background:Breast cancer (BC) has been the commonest malignant tumor with a low survival rate among woman. Long non-coding RNA hypoxia-inducible factor-1 alpha antisense RNA-2 (HIF1A-AS2) was correlated with various cancers. Purpose:The study aimed to investigate the roles and related underlying molecular mechanisms o...

journal_title：OncoTargets and therapy

authors： Guo X,Lee S,Cao P

更新日期：2019-01-24 00:00:00

abstract：Background:Several trials evaluated the role of intensive regimens, made of triplet chemotherapies plus bevacizumab, as first-line treatment for patients with metastatic colorectal cancer (mCRC). We previously reported, in a Phase II prospective study, the efficacy and the tolerability of FIrB/FOx regimen, reporting in...

journal_title：OncoTargets and therapy

authors： Cortellini A,Cannita K,Parisi A,Lanfiuti Baldi P,Venditti O,D'Orazio C,Dal Mas A,Calvisi G,Giordano AV,Vicentini V,Vicentini R,Felicioni L,Marchetti A,Buttitta F,Russo A,Ficorella C

更新日期：2019-03-25 00:00:00

abstract：PURPOSE:One of the most challenging aspects of breast carcinoma chemotherapy is the rapid acquirement of drug resistance. Improving the sensitivity to chemotherapeutic drugs is very important for successful treatment. Mus81 plays an important role in maintaining the stability of the genome and DNA repair. However, rece...

journal_title：OncoTargets and therapy

authors： Qian Y,Liu Y,Yan Q,Lv J,Ni X,Wu Y,Dong X

更新日期：2014-10-21 00:00:00

abstract：Background:Bromodomain and extra-terminal domain inhibitors like JQ1 have proved to be promising epigenetic agents for the treatment of malignant ovarian carcinoma. However, the resistance of ovarian cancer cells to BET inhibitors has not been elucidated. In this study, we investigated the potential mechanisms underlyi...

journal_title：OncoTargets and therapy

authors： Luan W,Pang Y,Li R,Wei X,Jiao X,Shi J,Yu J,Mao H,Liu P

更新日期：2019-10-03 00:00:00

abstract：Purpose:Minimally invasive esophagectomy is increasingly performed for esophageal or gastroesophageal junctional cancer, with advantages of improved perioperative outcomes in comparison with open esophagectomy. McKeown and Ivor Lewis are widely used procedures of minimally invasive esophagectomy, and there have been co...

journal_title：OncoTargets and therapy

authors： Deng J,Su Q,Ren Z,Wen J,Xue Z,Zhang L,Chu X

更新日期：2018-09-20 00:00:00

abstract：Introduction:Systemic inflammation is associated with prognosis in solid tumors. The neutrophil-to-lymphocyte ratio (NLR) is a marker for the general immune response to various stress stimuli. Studies have shown correlation of NLR to outcomes in immune checkpoint blockade, peripheral neutrophil count to intratumor neut...

journal_title：OncoTargets and therapy

authors： Sacdalan DB,Lucero JA,Sacdalan DL

更新日期：2018-02-23 00:00:00

abstract：Background:Ovarian cancer (OC) is the most common type of gynecological malignant tumors with poor prognosis. The spen paralogue and orthologue C-terminal domain containing 1 (SPOCD1) is a newly identified molecule that has been indicated to discriminate progressive in human solid tumors. However, the role of SPOCD1 in...

journal_title：OncoTargets and therapy

authors： Liu D,Yang Y,Yan A,Yang Y

更新日期：2020-01-15 00:00:00

abstract：AIM:This article discusses the current use of volumetric modulated arc therapy (VMAT) techniques in clinical practice and reviews the available data from clinical outcome studies in different clinical settings. An overview of available literature about clinical outcomes with VMAT stereotactic/radiosurgical treatment is...

journal_title：OncoTargets and therapy

authors： Macchia G,Deodato F,Cilla S,Cammelli S,Guido A,Ferioli M,Siepe G,Valentini V,Morganti AG,Ferrandina G

更新日期：2017-07-26 00:00:00

abstract：:Philadelphia-chromosome negative myeloproliferative neoplasms (MPN) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by an increased risk of thrombosis and progression to acute myeloid leukemia. MPN are associated with driver mutations in JAK2, CALR and MPL which are crucial for the ...

journal_title：OncoTargets and therapy

authors： Loscocco GG,Guglielmelli P,Vannucchi AM

更新日期：2020-12-01 00:00:00

abstract：Background:Immunosenescence, the age-related decline of immunity, affects the immune responses of melanoma patients. Through immune responses, immune checkpoint inhibitors (ICIs) exert their antitumor robustness. In different ages of melanoma patients, especially the older patients, the effectiveness of ICIs remains un...

journal_title：OncoTargets and therapy

authors： Li P,Yang X,Feng Y,Wu L,Ma W,Ding G,Wei Y,Sun L

更新日期：2018-10-26 00:00:00

abstract：:Interleukin-8 (IL-8) is a kind of chemokine that plays an important role in the development and progression of many human malignancies. Previous studies have uncovered that polymorphisms in IL-8 is associated with the risk of many cancer types, but the results were inconsistent and inconclusive. In the present study, ...

journal_title：OncoTargets and therapy

authors： Zhang M,Fang T,Wang K,Mei H,Lv Z,Wang F,Cai Z,Liang C

更新日期：2016-06-22 00:00:00

abstract：Purpose:Programmed death ligand 1 (PD-L1) is widely used for predicting immune checkpoint inhibitors but has a limited effect on predicting clinical response. The aim of this study was to examine the prognostic value and PD-1 inhibitor therapeutic efficiency of SNX20 in lung adenocarcinoma. Methods:We evaluated the mR...

journal_title：OncoTargets and therapy

authors： Fan L,Li L,Huang C,Huang S,Deng J,Xiong J

更新日期：2020-10-09 00:00:00

abstract：BACKGROUND:Due to the hypervascular nature of glioblastoma (GBM), antiangiogenic treatments, such as vatalanib, have been added as an adjuvant to control angiogenesis and tumor growth. However, evidence of progressive tumor growth and resistance to antiangiogenic treatment has been observed. To counter the unwanted eff...

journal_title：OncoTargets and therapy

authors： Shankar A,Borin TF,Iskander A,Varma NR,Achyut BR,Jain M,Mikkelsen T,Guo AM,Chwang WB,Ewing JR,Bagher-Ebadian H,Arbab AS

更新日期：2016-03-09 00:00:00

abstract：:Quercetin is proven to have anticancer effects for many cancers. However, the role of tumor suppressor p53 on quercetin's radiosensitization and regulation of endoplasmic reticulum (ER) stress response in this process remains obscure. Here, quercetin exposure resulted in ER stress, prolonged DNA repair, and the expres...

journal_title：OncoTargets and therapy

authors： Gong C,Yang Z,Zhang L,Wang Y,Gong W,Liu Y

更新日期：2017-12-21 00:00:00

abstract：:Two decades ago, lymphatic mapping of sentinel lymph nodes (SLN) was introduced into surgical cancer management and was termed sentinel node navigated surgery. Although this technique is now routinely performed in the management of breast cancer and malignant melanoma, it is still under investigation for use in other ...

journal_title：OncoTargets and therapy

authors： Tausch C,Baege A,Rageth C

更新日期：2014-06-24 00:00:00

abstract：Background:Growing evidence suggests that miR-150 plays an inhibitory role in various types of cancer. However, the function and underlying mechanisms of miR-150 in triple-negative breast cancer (TNBC) remain unknown. Patients and methods:miR-150 expression was detected by qRT-PCR and ISH in TNBC tumor and adjacent no...

journal_title：OncoTargets and therapy

authors： Tang W,Xu P,Wang H,Niu Z,Zhu D,Lin Q,Tang L,Ren L

更新日期：2018-04-24 00:00:00

abstract：BACKGROUND:Experimental disruption of the telomere overhang induces a potent DNA damage response and is the target of newly emerging cancer therapeutics. Introduction of T-oligo, an eleven-base oligonucleotide homologous to the 3'-telomeric overhang, mimics telomere disruption and induces DNA damage responses through a...

journal_title：OncoTargets and therapy

authors： Mulnix RE,Pitman RT,Retzer A,Bertram C,Arasi K,Crees Z,Girard J,Uppada SB,Stone AL,Puri N

更新日期：2013-12-18 00:00:00

abstract：Purpose:Circular RNAs (circRNAs) are emerging as promising biomarkers for various human malignancies. However, the application of circRNAs as non-invasive biomarkers in high-grade serous ovarian cancer (SOC) remains to be elucidated. Here, we aim to investigate the feasibility of using serum circSETDB1, a tumor-promoti...

journal_title：OncoTargets and therapy

authors： Wang W,Wang J,Zhang X,Liu G

更新日期：2019-09-11 00:00:00

abstract：:ALK rearrangements account for ~5% of non-small-cell lung cancer (NSCLC). Numerous rearrangement partners have been discovered. Here, we describe a 53-year-old nonsmoker with NSCLC, in whom we identified four novel rearrangements. The patient was diagnosed as adenocarcinoma in the right middle lobe of lung, with metas...

journal_title：OncoTargets and therapy

authors： Cai C,Long Y,Li Y,Huang M

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate clinical outcomes of conventional fractionated helical tomotherapy in patients with small to medium hepatocellular carcinomas (HCCs) without portal vein tumor thrombosis. METHODS:Patients with up to four HCC lesions not treatable by surgery or percutaneous ablative ...

journal_title：OncoTargets and therapy

authors： Jung J,Kong M,Hong SE

更新日期：2014-09-26 00:00:00

abstract：BACKGROUND:Two types of epidermal growth factor receptor (EGFR) mutations in exon 19 and exon 21 (ex19del and L858R) are prevalent in lung cancer patients and sensitive to targeted EGFR inhibition. A resistance mutation in exon 20 (T790M) has been found to accompany drug treatment when patients relapse. These three mut...

journal_title：OncoTargets and therapy

authors： Xu Q,Zhu Y,Bai Y,Wei X,Zheng X,Mao M,Zheng G

更新日期：2015-06-22 00:00:00

abstract：:Purpose: Numerous microRNAs (miRNAs) are aberrantly expressed in breast cancer, and the dysregulation of miRNAs may affect the aggressiveness of this cancer. Aberrant expression of miRNA-937 (miR-937) in gastric and lung cancers has been reported, which plays tumor-suppressive or oncogenic roles in carcinogenesis incl...

journal_title：OncoTargets and therapy

authors： Han X,Guo X,Zhang W,Cong Q

更新日期：2019-06-20 00:00:00

abstract：:Cutaneous metastasis from primary visceral malignancy is a relatively uncommon clinical entity, with a reported incidence ranging from 0.22% to 12% of all malignancies. Here we report a 64-year-old asymptomatic female patient with Peutz-Jeghers syndrome presenting with multiple scalp metastases as the initial manifest...

journal_title：OncoTargets and therapy

authors： Yu Q,Subedi S,Tong Y,Wei Q,Xu H,Wang Y,Gong Y,Shi Y

更新日期：2018-09-21 00:00:00

abstract：:Oncolytic viruses (OVs) have the ability to selectively replicate in and lyse cancer cells. Angiogenesis is an essential requirement for tumor growth. Like OVs, the therapeutic effect of many angiogenesis inhibitors has been limited, leading to the development of more effective approaches to combine antiangiogenic the...

journal_title：OncoTargets and therapy

authors： Tysome JR,Lemoine NR,Wang Y

更新日期：2013-07-31 00:00:00

abstract：Objective:Long non-coding RNA (lncRNA) ANRIL is emerging as a crucial role in ovarian cancer progression and prognosis. However, the precise molecular mechanism of ANRIL on ovarian cancer is not known. Thus, we aim to study the underlying mechanism of ANRIL on the action. Methods:The MTT assay assessed cell viability....

journal_title：OncoTargets and therapy

authors： Wang K,Hu YB,Zhao Y,Ye C

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:Associations between Arg399Gln single-nucleotide polymorphism (SNP) in the XRCC1 gene and leukemia susceptibility have been studied extensively, however, the results are inconsistent. The aim of this study was to determine these associations using meta-analytical methods. METHODS:A meta-analysis was perform...

journal_title：OncoTargets and therapy

authors： Wang F,Zhao Q,He HR,Zhai YJ,Lu J,Hu HB,Zhou JS,Yang YH,Li YJ

更新日期：2015-11-06 00:00:00

abstract：BACKGROUND:Primary angiosarcoma of breast (PAOB) is a rare and highly aggressive malignancy. There is no general agreement on optimal treatments or prognostic factors for this orphan disease. The objective of this study was to investigate the clinicopathologic features and management experiences of PAOB. METHODS:We pe...

journal_title：OncoTargets and therapy

authors： Hu QC,Mei X,Feng Y,Ma JL,Yang ZZ,Shao ZM,Yu XL,Guo XM

更新日期：2015-11-04 00:00:00

abstract：:Armillaria mellea is a honey mushroom often used in the traditional Chinese medicine "Tianma". Currently, this medicinal mushroom is also used as a dietary supplement in numerous Western and Eastern countries. Armillarikin was isolated from A. mellea, and we previously discovered that it induced cytotoxicity in human ...

journal_title：OncoTargets and therapy

authors： Chen YJ,Chen CC,Huang HL

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Nivolumab (BMS-936558/ONO-4538) was the first monoclonal antibody targeting programmed death (PD)-1. So far, a number of clinical trials on nivolumab have showed satisfactory efficacy in treating non-small-cell lung cancer (NSCLC). Herein, we present a meta-analysis evaluating the efficacy and safety of nivo...

journal_title：OncoTargets and therapy

authors： Huang J,Zhang Y,Sheng J,Zhang H,Fang W,Zhan J,Zhou T,Chen Y,Liu L,Zhang L

更新日期：2016-09-23 00:00:00