Antitumor activity of larotrectinib in tumors harboring NTRK gene fusions: a short review on the current evidence.

abstract：BACKGROUND:The aim of this study was to examine the patterns of expression of epithelial-mesenchymal transition (EMT)-related proteins in intrahepatic cholangiocarcinoma. The clinicopathological and prognostic value of these markers was also evaluated. METHODS:We detected the expression status of three EMT-related pro...

journal_title：OncoTargets and therapy

authors： Yao X,Wang X,Wang Z,Dai L,Zhang G,Yan Q,Zhou W

更新日期：2012-01-01 00:00:00

abstract：:This retrospective study was conducted to evaluate the prognostic significance of the preoperative plasma D-dimer levels and platelet counts in patients with pancreatic adenocarcinoma. A total of 168 consecutive locally advanced pancreatic adenocarcinoma patients who underwent intensity modulated radiation therapy wit...

journal_title：OncoTargets and therapy

authors： Liu P,Zhu Y,Liu L

更新日期：2015-06-04 00:00:00

abstract：Background:Non-small-cell lung cancer (NSCLC) is the major leading cause of cancer-related death around the world. The resistance to chemotherapy limits the effects of clinical treatment. The aim of this study was to identify novel mechanisms involved in NSCLC chemoresistance. Materials and methods:We explored the pub...

journal_title：OncoTargets and therapy

authors： Wang W,Han T,Tong W,Zhao J,Qiu X

更新日期：2018-09-26 00:00:00

abstract：OBJECTIVES:The long-noncoding RNAs (lncRNAs) are identified as new crucial regulators of diverse cellular processes in glioblastoma (GBM) tissues. However, the expression pattern and biological function of lncRNAs remain largely unknown. Here, for the first time, the effects of lncRNA lymphoid enhancer-binding factor 1...

journal_title：OncoTargets and therapy

authors： Wang J,Liu X,Yan C,Liu J,Wang S,Hong Y,Gu A,Zhao P

更新日期：2017-08-28 00:00:00

abstract：Background:Pulmonary carcinosarcomas (PCSs) are a heterogeneous group of non-small-cell lung carcinomas (NSCLCs) with aggressiveness and a poor prognosis. Although genetic mutations of some common lung cancer subtypes have been extensively studied, the molecular characteristics of PCSs and the existence of abnormal tar...

journal_title：OncoTargets and therapy

authors： Li F,Hu S,Kong K,Cao P,Han P,Deng Y,Zhao B

更新日期：2020-08-10 00:00:00

abstract：:Esophageal carcinoma (EC) is a lethal disease with high morbidity and mortality worldwide, and the incidence has been increasing in recent years. Although the diagnosis and treatment of EC have improved considerably, EC has rapidly progressed in the clinical setting and has a poor prognosis for its metastasis and recu...

journal_title：OncoTargets and therapy

authors： Qian X,Tan C,Wang F,Yang B,Ge Y,Guan Z,Cai J

更新日期：2016-04-19 00:00:00

abstract：BACKGROUND:Laminin gamma2 (Ln-γ2) chain, a distinctive subunit of heterotrimeric laminin-332, is frequently upregulated in carcinomas and is of great importance in cell migration and invasion. Despite this, the status of circulating Ln-γ2 in lung cancer patients is still uncertain. PATIENTS AND METHODS:In this retrosp...

journal_title：OncoTargets and therapy

authors： Teng Y,Wang Z,Ma L,Zhang L,Guo Y,Gu M,Wang Z,Wang Y,Yue W

更新日期：2016-07-07 00:00:00

abstract：Background:Sesquiterpene lactones are plant-derived, natural, bioactive molecules often used against inflammatory diseases in traditional Chinese medicines. Recently, sesquiterpene lactones have been reported to exhibit potent anticancer activity. In the present study, we have investigated the anticancer activity of Br...

journal_title：OncoTargets and therapy

authors： Wang J,Li M,Cui X,Lv D,Jin L,Khan M,Ma T

更新日期：2018-10-16 00:00:00

abstract：Background:The aberrant expression of microRNA-139-3p (miR-139-3p) has been recently involved in the development of multiple tumor types, but its function in ovarian cancer remains not well investigated. In this study, we mainly investigated the function of miR-139-3p in the progression of ovarian cancer. Methods:The ...

journal_title：OncoTargets and therapy

authors： Xue F,Li QR,Xu YH,Zhou HB

更新日期：2019-11-05 00:00:00

abstract：BACKGROUND:Experimental disruption of the telomere overhang induces a potent DNA damage response and is the target of newly emerging cancer therapeutics. Introduction of T-oligo, an eleven-base oligonucleotide homologous to the 3'-telomeric overhang, mimics telomere disruption and induces DNA damage responses through a...

journal_title：OncoTargets and therapy

authors： Mulnix RE,Pitman RT,Retzer A,Bertram C,Arasi K,Crees Z,Girard J,Uppada SB,Stone AL,Puri N

更新日期：2013-12-18 00:00:00

abstract：:The aim of this study was to evaluate the efficacy and toxicity of stereotactic body radiation therapy (SBRT) in the treatment of patients with liver metastases. Between August 2006 and July 2011, patients with 1-4 liver metastases were enrolled and treated with SBRT using the CyberKnife(®) system at Tianjin Medical U...

journal_title：OncoTargets and therapy

authors： Yuan ZY,Meng MB,Liu CL,Wang HH,Jiang C,Song YC,Zhuang HQ,Yang D,Wang JS,Wei W,Li FT,Zhao LJ,Wang P

更新日期：2014-06-12 00:00:00

abstract：:Pleiotropy in biological systems and their targeting allows many pharmaceuticals to be used for multiple therapeutic purposes. Fully exploiting the therapeutic properties of drugs that are already marketed would be highly advantageous. This is especially the case in the field of oncology, where the ineffectiveness of ...

journal_title：OncoTargets and therapy

authors： Papanagnou P,Papadopoulos GE,Stivarou T,Pappas A

更新日期：2018-12-31 00:00:00

abstract：:Circulating tumor DNA (ctDNA) can be identified in the peripheral blood of patients and harbors the genomic alterations found in tumor tissues, which provides a noninvasive approach for detection of gene mutations. We conducted this meta-analysis to investigate whether ctDNA can be used for monitoring KRAS gene mutati...

journal_title：OncoTargets and therapy

authors： Hao YX,Fu Q,Guo YY,Ye M,Zhao HX,Wang Q,Peng XM,Li QW,Wang RL,Xiao WH

更新日期：2017-02-16 00:00:00

abstract：Purpose:Circular RNAs (circRNAs) are emerging as promising biomarkers for various human malignancies. However, the application of circRNAs as non-invasive biomarkers in high-grade serous ovarian cancer (SOC) remains to be elucidated. Here, we aim to investigate the feasibility of using serum circSETDB1, a tumor-promoti...

journal_title：OncoTargets and therapy

authors： Wang W,Wang J,Zhang X,Liu G

更新日期：2019-09-11 00:00:00

abstract：:Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor, and surgical resection is the first choice for the treatment of the disease, but since the advent of tyrosine kinase inhibitors (TKIs) such as imatinib (IM), the prognosis of the disease has undergone revolutionary changes. According to the cu...

journal_title：OncoTargets and therapy

authors： Xu H,Liu Q

更新日期：2021-01-05 00:00:00

abstract：Introduction:Ribosome binding protein 1 (RRBP1) is reported to be correlated with tumor formation and progression. However, the role of RRBP1 in bladder cancer is unclear. In this study, we aimed to investigate the expression of RRBP1 and its influence on cell proliferation in bladder cancer. Methods:Quantification re...

journal_title：OncoTargets and therapy

authors： Lv SW,Shi ZG,Wang XH,Zheng PY,Li HB,Han QJ,Li ZJ

更新日期：2020-07-07 00:00:00

abstract：:Glioblastoma is the most aggressive type of brain tumor with a very poor prognosis. Therefore, it is always of great importance to explore and develop new potential treatment for glioblastoma. Quercetin, a flavonoid present in a variety of human foods, has been shown to inhibit various tumor cell proliferation. In thi...

journal_title：OncoTargets and therapy

authors： Liu Y,Tang ZG,Yang JQ,Zhou Y,Meng LH,Wang H,Li CL

更新日期：2017-08-11 00:00:00

abstract：PURPOSE:Randomized trials showing a clear survival benefit of intensity-modulated radiotherapy (IMRT) over 3-dimensional conformal radiotherapy (3D-CRT) in the treatment of lung cancer are lacking. This study compared the survival rates of patients with stage III non-small cell lung cancer who were treated with either ...

journal_title：OncoTargets and therapy

authors： Kong M,Hong SE

更新日期：2016-11-24 00:00:00

abstract：Introduction:Dynamin 3 (DNM3) is a large GTPase that possesses mechanochemical properties and has been shown to be involved in malignancies. However, most studies about DNM3 are observational, and knowledge of the precise molecular mechanism of DNM3 remains limited. Materials and methods:We constructed a PCDH-CMV-MCS-...

journal_title：OncoTargets and therapy

authors： Jiang L,Liang QL,Liang WM,Zhang HJ,Huang J,Yuan GL,Peng XX,Cheng SA,Huang ZG,Zhang XN

更新日期：2018-10-09 00:00:00

abstract：:Several members of the sirtuin (SIRT) family, a highly conserved family of NAD+-dependent enzymes, have been shown to play a critical role in both promoting and/or suppressing tumorigenesis. In this study, recent progress in the field concerning SIRT4 and cancer was reviewed, and the relationship between SIRT4 and tum...

journal_title：OncoTargets and therapy

authors： Huang G,Zhu G

更新日期：2018-06-11 00:00:00

abstract：Introduction:Colorectal cancer (CRC) is the fourth most common cause of cancer-related mortality worldwide. The tumor, node, metastasis (TNM) stage remains the standard for CRC prognostication. Identification of meaningful microRNA (miRNA) and gene modules or representative biomarkers related to the pathological stage ...

journal_title：OncoTargets and therapy

authors： Zhou XG,Huang XL,Liang SY,Tang SM,Wu SK,Huang TT,Mo ZN,Wang QY

更新日期：2018-05-15 00:00:00

abstract：:Bladder cancer (BC) is the most common urinary system malignancy and is a serious threat to human health. Circular RNAs (circRNAs) are members of a newly defined class of noncoding RNAs (ncRNAs) that can regulate gene expression at the transcriptional or posttranscriptional level. Studies have shown that circRNAs are ...

journal_title：OncoTargets and therapy

authors： Cai Z,Li H

更新日期：2020-09-29 00:00:00

abstract：Background:Abnormal miR-27a-3p expression has been frequently reported in several types of human cancer and contributes to tumor progression. However, the role and potential molecular mechanism of miR-27a-3p in the progression of pancreatic carcinoma have not been clarified. Materials and methods:The expression of miR...

journal_title：OncoTargets and therapy

authors： Rao X,Wan L,Jie Z,Zhu X,Yin J,Cao H

更新日期：2019-12-19 00:00:00

abstract：Background:Leukemia related protein 16 (LRP16), one of the genes belonging to the macro domain family, has been found up-regulated in various tumors including testicles, ovaries and mucosa of colon and is associated with poor clinical outcomes. Purpose:The objective of this study was to investigate expression pattern ...

journal_title：OncoTargets and therapy

authors： Mo Z,Hu M,Yu F,Shao L,Fan K,Jiao S

更新日期：2018-03-05 00:00:00

abstract：:MicroRNAs (miRs) have been demonstrated to play key roles in the development and progression of hepatocellular carcinoma (HCC). However, the regulatory mechanism of miR-503 in HCC has not been fully uncovered. In this study, we found that miR-503 was significantly downregulated in HCC tissues compared to nontumorous l...

journal_title：OncoTargets and therapy

authors： Xiao Y,Tian Q,He J,Huang M,Yang C,Gong L

更新日期：2016-06-15 00:00:00

abstract：:Increasing evidence has shown that aldehyde dehydrogenase 1A1 (ALDH1A1), a detoxifying enzyme, is responsible for chemoresistance in a variety of tumors. Although the majority of patients with diffuse large B-cell lymphoma (DLBCL) can be cured with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), che...

journal_title：OncoTargets and therapy

authors： Jiang J,Liu Y,Tang Y,Li L,Zeng R,Zeng S,Zhong M

更新日期：2016-08-29 00:00:00

abstract：Background:The neutrophil-lymphocyte ratio (NLR), a biomarker for systematic inflammation, has been recently identified as a prognostic factor for various types of both solid and hematologic malignancies. Our study presented here was the first meta-analysis assessing the prognostic role of NLR in multiple myeloma (MM)....

journal_title：OncoTargets and therapy

authors： Mu S,Ai L,Fan F,Sun C,Hu Y

更新日期：2018-01-23 00:00:00

abstract：OBJECTIVE:To analyze the management and prognosis of primary choriocarcinoma (PCC) in male patients. METHODS:The clinical records of males with PCC who were treated at Peking Union Medical College Hospital between 1990 and 2012 were analyzed retrospectively. The literature regarding this clinical condition was also re...

journal_title：OncoTargets and therapy

authors： Jiang F,Xiang Y,Feng FZ,Ren T,Cui ZM,Wan XR

更新日期：2014-06-20 00:00:00

abstract：BACKGROUND:MDS1 and EVI1 complex locus protein EVI1 (MECOM) is an oncogenic transcription factor in several kinds of cancers. However, the clinical significance of MECOM in glioblastoma multiforme (GBM) has not been well elucidated. PATIENTS AND METHODS:Our study enrolled 86 resected samples of GBM in three medical ce...

journal_title：OncoTargets and therapy

authors： Hou A,Zhao L,Zhao F,Wang W,Niu J,Li B,Zhou Z,Zhu D

更新日期：2016-01-13 00:00:00

abstract：Introduction:Hypoxia and tumor-associated macrophage (TAM) are key regulators in remodeling the microenvironment of esophageal squamous cell carcinoma (ESCC). Hypoxia could stimulate tumor cells to secrete more exosomes and activate TAMs to M2 type. Here, we investigated the function and the underlying mechanism of tum...

journal_title：OncoTargets and therapy

authors： Lu Q,Wang X,Zhu J,Fei X,Chen H,Li C

更新日期：2020-11-18 00:00:00