ALDH1A1 induces resistance to CHOP in diffuse large B-cell lymphoma through activation of the JAK2/STAT3 pathway.

abstract：Background:Papillary thyroid cancer (PTC) is a common endocrine malignancy with relatively good prognosis. Radioactive iodine (RAI) is considered effective for patients with total or nearly total thyroidectomy, but the beneficial effects of RAI are still controversial. Materials and methods:To determine whether RAI th...

journal_title：OncoTargets and therapy

authors： Tang J,Kong D,Cui Q,Wang K,Zhang D,Liao X,Gong Y,Wu G

更新日期：2018-06-19 00:00:00

abstract：:Advanced gastric cancer (AGC) is difficult to treat with poor prognosis. Despite various possible treatments, the median survival time of such patients remains unsatisfactory. Therefore, new therapeutic approaches or combinations need to be further explored. We herein reported a case of a 54-year-old male patient who ...

journal_title：OncoTargets and therapy

authors： Yu S,Cai L,Lin F,Wu X,Zhang C,Liu X,Li W

更新日期：2019-09-19 00:00:00

abstract：Background:Few data have been published on the clinical and histopathological characteristics of advanced non-small-cell lung cancer (NSCLC) patients with high PD-L1 expression versus intermediate or none and the prognostic value of PD-L1 expression for patients treated with chemotherapy is unknown. This study was unde...

journal_title：OncoTargets and therapy

authors： Auliac JB,Guisier F,Bizieux A,Assouline P,Bernardini M,Lamy R,Justeau G,François G,Damotte D,Chouaïd C

更新日期：2020-12-30 00:00:00

abstract：Background:Gastric cancer (GC) is an aggressive malignancy with high lethality. Systematic chemotherapy is the main therapeutic strategy for advanced GC patients. The overexpression of Axl is associated with poor prognosis and regulates tumor growth and metastasis in many types of cancer. However, the role of Axl in GC...

journal_title：OncoTargets and therapy

authors： He L,Lei Y,Hou J,Wu J,Lv G

更新日期：2020-06-22 00:00:00

abstract：Background:Bone marrow stromal antigen 2 (BST2) is considered as a transmembrane glycoprotein and plays essential roles in innate immunity. It has been recently reported that up-regulation of BST2 was associated with the development of breast carcinoma. However, the clinical significance of BST2 in glioma has not been ...

journal_title：OncoTargets and therapy

authors： Shi H,Luo K,Huang W

更新日期：2020-08-26 00:00:00

abstract：BACKGROUND:Experimental disruption of the telomere overhang induces a potent DNA damage response and is the target of newly emerging cancer therapeutics. Introduction of T-oligo, an eleven-base oligonucleotide homologous to the 3'-telomeric overhang, mimics telomere disruption and induces DNA damage responses through a...

journal_title：OncoTargets and therapy

authors： Mulnix RE,Pitman RT,Retzer A,Bertram C,Arasi K,Crees Z,Girard J,Uppada SB,Stone AL,Puri N

更新日期：2013-12-18 00:00:00

abstract：:Background: Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer morbidity and mortality worldwide. In the present study, we identified novel biomarkers associated with the pathogenesis of NSCLC aiming to provide new diagnostic and therapeutic approaches for NSCLC. Methods: The microarray datasets of...

journal_title：OncoTargets and therapy

authors： Wu Q,Zhang B,Sun Y,Xu R,Hu X,Ren S,Ma Q,Chen C,Shu J,Qi F,He T,Wang W,Wang Z

更新日期：2019-05-13 00:00:00

abstract：OBJECTIVE:The objective of the present investigation was to study the clinical significances of the abnormal expressions of Piwil1 and Piwil2 protein in colonic adenoma and adenocarcinoma. METHODS:This study had applied immunohistochemical method to detect 45 cases of tissues adjacent to carcinoma (distance to cancero...

journal_title：OncoTargets and therapy

authors： Wang HL,Chen BB,Cao XG,Wang J,Hu XF,Mu XQ,Chen XB

更新日期：2015-05-27 00:00:00

abstract：Background:It has been reported that ribophorin II (RPN2) expression is increased in many cancers, but the role of RPN2 in nasopharyngeal carcinoma (NPC) remains unclear. Patients and methods:This study found that the expression of RPN2 is increased dramatically in NPC tissues of patients compared with that in the adj...

journal_title：OncoTargets and therapy

authors： Hong F,Li Y,Ni H,Li J

更新日期：2018-06-15 00:00:00

abstract：:Follicular dendritic cell sarcoma (FDCS) is a rare malignant tumor recognized in recent years. It accounts for only 0.4% of soft-tissue sarcomas, and its underlying causes are largely unknown. A correct diagnosis can be difficult to make. Diagnosis of FDCS depends on the combined clinical examination, histopathologic ...

journal_title：OncoTargets and therapy

authors： Ma Y,Sun J,Yang C,Yuan D,Liu J

更新日期：2015-07-24 00:00:00

abstract：:This study aimed to identify the genes and pathways associated with smoking-related lung adenocarcinoma. Three lung adenocarcinoma associated datasets (GSE43458, GSE10072, and GSE50081), the subjects of which included smokers and nonsmokers, were downloaded to screen the differentially expressed feature genes between ...

journal_title：OncoTargets and therapy

authors： Liu Y,Ni R,Zhang H,Miao L,Wang J,Jia W,Wang Y

更新日期：2016-12-07 00:00:00

abstract：INTRODUCTION:The purpose of this study was to evaluate the use of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) to identify the presence of cervical lymph nodes metastases and extracapsular spread with histologic correlations in head and neck squamous cell carcinoma. METH...

journal_title：OncoTargets and therapy

authors： Dequanter D,Shahla M,Aubert C,Deniz Y,Lothaire P

更新日期：2015-08-26 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate an intravoxel incoherent motion (IVIM) model-based analysis of diffusion-weighted imaging (DWI) for assessing the response of hepatocellular carcinoma (HCC) to locoregional therapy. PATIENTS AND METHODS:Respiratory-gated DWI (b=0, 50, and 800 s/mm2) was retrospectively ana...

journal_title：OncoTargets and therapy

authors： Mürtz P,Penner AH,Pfeiffer AK,Sprinkart AM,Pieper CC,König R,Block W,Schild HH,Willinek WA,Kukuk GM

更新日期：2016-10-19 00:00:00

abstract：Background and aim:Standard chemotherapy has limited clinical efficacy in patients with esophageal cancer and there is a significant and unmet clinical need for effective treatment options for these patients. The aim of this study was to compare the clinical efficacy of the novel, targeted drug apatinib combined with d...

journal_title：OncoTargets and therapy

authors： Li J,Jia Y,Gao Y,Chang Z,Han H,Yan J,Qin Y

更新日期：2019-04-08 00:00:00

abstract：:During the past decade, immunotherapy targeting immune checkpoints has become an important component of the treatment paradigm for numerous malignancies, especially PD-1/PD-L1 blockade which was demonstrated to rejuvenate disabled T cells in cancer patients to achieve long-term remissions. However, the clinical outcom...

journal_title：OncoTargets and therapy

authors： Cai J,Wang D,Zhang G,Guo X

更新日期：2019-10-15 00:00:00

abstract：:Several members of the sirtuin (SIRT) family, a highly conserved family of NAD+-dependent enzymes, have been shown to play a critical role in both promoting and/or suppressing tumorigenesis. In this study, recent progress in the field concerning SIRT4 and cancer was reviewed, and the relationship between SIRT4 and tum...

journal_title：OncoTargets and therapy

authors： Huang G,Zhu G

更新日期：2018-06-11 00:00:00

abstract：Background:Esophageal cancer (EC) is one of the aggressive gastrointestinal malignancies. It has been reported that microRNAs (miRNAs) play key roles during the tumorigenesis of EC. To identify novel potential targets for EC, differential expressed miRNAs (DEG) between EC and adjacent normal tissues were analyzed with ...

journal_title：OncoTargets and therapy

authors： Shi W,Song J,Gao Z,Liu X,Wang W

更新日期：2020-09-24 00:00:00

abstract：PURPOSE:This study aimed to explore the molecular mechanisms associated with bisphosphonate (BP)-related osteonecrosis of the jaw (ONJ) in patients with multiple myeloma (MM). METHODS:The gene expression profile GSE7116 was downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) fro...

journal_title：OncoTargets and therapy

authors： Sun J,Wen X,Jin F,Li Y,Hu J,Sun Y

更新日期：2015-09-22 00:00:00

abstract：PURPOSE:This study aims to investigate the prognostic value of pretreatment C-reactive protein/albumin ratio (CAR) in human malignancies by an updated meta-analysis. METHODS:PubMed, Web of Science, Cochrane Library and Wanfang databases were searched. Pooled hazard ratios (HRs) and odds ratios (ORs) with their corresp...

journal_title：OncoTargets and therapy

authors： Xu HJ,Ma Y,Deng F,Ju WB,Sun XY,Wang H

更新日期：2017-06-19 00:00:00

abstract：PURPOSE:Hypoxia is a common phenomenon encountered in solid cancers, leading to chemotherapy resistance and therefore to aggressiveness of the disease. The homeostatic response to hypoxia is mediated by hypoxiainducible factor-1 (HIF-1). The aim of this study was to investigate the impact of HIF1α in patients with prim...

journal_title：OncoTargets and therapy

authors： Braicu EI,Luketina H,Richter R,Cacsire Castillo-Tong D,Lambrechts S,Mahner S,Concin N,Mentze M,Zeillinger R,Vergote I,Sehouli J

更新日期：2014-09-11 00:00:00

abstract：Background:The global Phase III LUX-Lung 8 trial (ClinicalTrials.gov: NCT01523587) identified significant improvements in progression-free survival (PFS), overall survival (OS), and patient-reported outcomes (PROs) with second-line afatinib vs erlotinib in patients with advanced squamous cell carcinoma (SCC) of the lun...

journal_title：OncoTargets and therapy

authors： Lu S,Li W,Zhou C,Hu CP,Qin S,Cheng G,Feng J,Wang J,Cseh A,Peil B,Gibson N,Ehrnrooth E,Zhang L

更新日期：2018-11-30 00:00:00

abstract：BACKGROUND:Primary angiosarcoma of breast (PAOB) is a rare and highly aggressive malignancy. There is no general agreement on optimal treatments or prognostic factors for this orphan disease. The objective of this study was to investigate the clinicopathologic features and management experiences of PAOB. METHODS:We pe...

journal_title：OncoTargets and therapy

authors： Hu QC,Mei X,Feng Y,Ma JL,Yang ZZ,Shao ZM,Yu XL,Guo XM

更新日期：2015-11-04 00:00:00

abstract：Purpose:Cervical squamous cell carcinoma (CSCC) seriously affects women's health worldwide, and it is of great significance to illuminate the specific role of circRNAs in CSCC. Materials and Methods:Three mRNA datasets, two miRNA datasets and one circRNA dataset of CSCC, downloaded from GEO, were utilized in this stud...

journal_title：OncoTargets and therapy

authors： Wu Q,Liu P,Lao G,Liu Y,Zhang W,Ma C

更新日期：2020-08-25 00:00:00

abstract：Background:With the purpose of elevating the risk of cholangiocarcinoma (CCA), alcoholic liver disease (ALD) was shown. Nonetheless, the findings were controversial. Herein, a meta-analysis and a systematic review were conducted to study the relation as mentioned above. Methods:This study searched PubMed, EMBASE, and ...

journal_title：OncoTargets and therapy

authors： Xiong J,Yin Z,Xu W,Shen Z,Li Y,Lu X

更新日期：2018-11-20 00:00:00

abstract：Background:Galangin (GLN), a pure natural flavonoid compound found in plants, has been shown to exert anti-cancer effects against multiple cancer types, including glioma. However, its underlying molecular mechanism remains unclear. Epithelial-to-mesenchymal transition (EMT) performs an important function in the genesis...

journal_title：OncoTargets and therapy

authors： Xiong Y,Lai X,Xiang W,Zhou J,Han J,Li H,Deng H,Liu L,Peng J,Chen L

更新日期：2020-09-17 00:00:00

abstract：:Despite remarkable progress in cancer-drug discovery, the delivery of novel, safe, and sustainably effective products to the clinic has stalled. Using Src as a model, we examine key steps in drug development. The preclinical evidence on the relationship between Src and solid cancer is in sharp contrast with the modest...

journal_title：OncoTargets and therapy

authors： Rösel D,Brábek J,Veselý P,Fernandes M

更新日期：2013-06-26 00:00:00

abstract：PURPOSE:Telomere shortening occurs in tumor tissues and peripheral blood lymphocytes of many common human malignancies, including lung cancer, but its variation in T-cells has never been investigated. Thus, the aim of this study was to assess telomere length in T-cells and its correlation with the clinical characterist...

journal_title：OncoTargets and therapy

authors： Qian Y,Ding T,Wei L,Cao S,Yang L

更新日期：2016-05-04 00:00:00

abstract：Background:The relationship of inflammation and tumor is becoming more and more important in the study on the pathogenesis of colorectal cancer. The role of TLR9-mediated immune inflammation reaction in the process is not currently clear. The purpose of the study was to discuss the correlation of TLR9 signal activation...

journal_title：OncoTargets and therapy

authors： Gao C,Qiao T,Zhang B,Yuan S,Zhuang X,Luo Y

更新日期：2018-09-18 00:00:00

abstract：Objective:Multidrug resistance-associated protein 2 (MRP2), encoded by ABCC2 gene, is involved in the efflux of certain anticancer drugs. Here we observed whether the ABCC2 (G1249A) polymorphism impacts the transport abilities of MRP2-dependent paclitaxel, docetaxel, and doxorubicin in recombinant LLC-PK1 cell lines. ...

journal_title：OncoTargets and therapy

authors： Lian G,Yuan J,Gao Y

更新日期：2020-02-17 00:00:00

abstract：Background:Paclitaxel is widely used in the treatment of cancer and has a good effect in the treatment of non-small cell lung cancer. The combination of TMT proteomics and bioinformatics is used to systematically analyze the molecular mechanism of paclitaxel in the treatment of lung adenocarcinoma A549 cell, which is h...

journal_title：OncoTargets and therapy

authors： Zheng W,Xu S

更新日期：2020-10-13 00:00:00