HIF1α is an independent prognostic factor for overall survival in advanced primary epithelial ovarian cancer - a study of the OVCAD Consortium.

abstract：:The use of additional radiotherapy for resected stage IIIA N2 non-small-cell lung cancer in the setting of standard adjuvant chemotherapy remains controversial. A comprehensive search (last search updated in March 2015) for relevant studies comparing patients with stage IIIA N2 non-small-cell lung cancer undergoing re...

journal_title：OncoTargets and therapy

authors： Lei T,Xu XL,Chen W,Xu YP,Mao WM

更新日期：2016-02-24 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are emerging as an important part of biological progress in cancers, yet the aberrant lncRNAs implicated in colorectal cancer (CRC) with lymph node metastasis remain unknown. In this study, a total of 390 lncRNA transcripts and 508 mRNA transcripts were dysregulated in tumor tissues compa...

journal_title：OncoTargets and therapy

authors： Yang P,Xu ZP,Chen T,He ZY

更新日期：2016-04-26 00:00:00

abstract：Background:Emerging researches have demonstrated that aberrantly expressed long non-coding RNAs (lncRNAs) have great significance in non-small cell lung cancer (NSCLC) progression. The aim of this study was to explore the role of lncRNA AZIN1 antisense RNA 1 (AZIN1-AS1) in NSCLC and the related mechanism. Methods:Expr...

journal_title：OncoTargets and therapy

authors： Cai Y,Wu Q,Liu Y,Wang J

更新日期：2020-10-09 00:00:00

abstract：BACKGROUND:Experimental disruption of the telomere overhang induces a potent DNA damage response and is the target of newly emerging cancer therapeutics. Introduction of T-oligo, an eleven-base oligonucleotide homologous to the 3'-telomeric overhang, mimics telomere disruption and induces DNA damage responses through a...

journal_title：OncoTargets and therapy

authors： Mulnix RE,Pitman RT,Retzer A,Bertram C,Arasi K,Crees Z,Girard J,Uppada SB,Stone AL,Puri N

更新日期：2013-12-18 00:00:00

abstract：Background:miRNA expression acts as a potential biomarker in many diseases including endometrial carcinoma (EC). miR-486-5p dysregulation is observed in several tumor types, but the roles of miR-486-5p in EC are hardly ever studied. Objective:This study aimed to analyze the expression profile of miR-486-5p in tumor ti...

journal_title：OncoTargets and therapy

authors： Zheng X,Xu K,Zhu L,Mao M,Zhang F,Cui L

更新日期：2020-05-28 00:00:00

abstract：:Historically, patients with locally advanced or metastatic melanoma have an extremely poor prognosis. In recent years, major breakthroughs in cutaneous melanoma treatment have led to remarkable improvements in patient outcomes. However, there are limited published data on the efficacy of these novel therapies in the t...

journal_title：OncoTargets and therapy

authors： Yu Z,Quiroz E,Shen Y,Jaiyesimi IA

更新日期：2018-12-04 00:00:00

abstract：Background:Circular RNAs (circRNAs) are a special class of noncoding RNAs that are involved in gene regulation and compete with mRNA for miRNA binding sites. The roles of circRNAs in cancer, especially breast cancer (BC), are poorly understood. Materials and Methods:The expression levels of circRNA 0001073 (circ-1073)...

journal_title：OncoTargets and therapy

authors： Yi Z,Li Y,Wu Y,Zeng B,Li H,Ren G,Wang X

更新日期：2020-06-29 00:00:00

abstract：:Dichloroacetate (DCA), a small molecule mitochondria-targeting agent, can penetrate the blood-brain barrier, showing potential therapeutic effects on brain tumors. Considering the effects of DCA on tumor cellular metabolism, penetrating across the blood-brain barrier, as well as having potential antitumor activity on ...

journal_title：OncoTargets and therapy

authors： Duan Y,Zhao X,Ren W,Wang X,Yu KF,Li D,Zhang X,Zhang Q

更新日期：2013-01-01 00:00:00

abstract：:The study aimed to investigate the difference of setup errors on different registration in the treatment of nasopharyngeal carcinoma based on weekly cone-beam computed tomography (CBCT). Thirty nasopharyngeal cancer patients scheduled to undergo intensity-modulated radiotherapy (IMRT) were prospectively enrolled in th...

journal_title：OncoTargets and therapy

authors： Su J,Chen W,Yang H,Hong J,Zhang Z,Yang G,Li L,Wei R

更新日期：2015-09-14 00:00:00

abstract：Purpose:Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide. Natural antisense transcripts (NATs) are pervasively expressed in human genome and have been confirmed to contribute to cancer progression. In our study, we aimed to investigate the expression and clinical pertinence of serine ...

journal_title：OncoTargets and therapy

authors： Li C,Li W,Zhang Y,Zhang X,Liu T,Zhang Y,Yang Y,Wang L,Pan H,Ji J,Wang C

更新日期：2018-07-10 00:00:00

abstract：:Orbital metastasis as the initial presentation of lung adenocarcinoma is very rare, and so the lack of knowledge about this phenomenon can easily result in misdiagnosis, either as a orbital primary tumor or benign lesion. Here, we report a rare case in which the orbital symptom appeared first without any pulmonary man...

journal_title：OncoTargets and therapy

authors： Sun L,Qi Y,Sun X,Yu J,Meng X

更新日期：2016-05-09 00:00:00

abstract：Background:Tumour growth and development are dependent on many factors including long noncoding RNAs (lncRNAs). However, limited information is available on the involvement of lncRNAs in non-small cell lung cancer (NSCLC) and the molecular mechanisms have not been defined. Here, we examined the expression of small nucl...

journal_title：OncoTargets and therapy

authors： Zhao S,Gao X,Zhong C,Li Y,Wang M,Zang S

更新日期：2020-11-04 00:00:00

abstract：Background:Breast cancer is the most common tumor among women. miR-638 has been demonstrated to play an important role in various cancers. Purpose:In this study, we aimed to investigate the function and prognostic value of miR-638 in breast cancer. Methods:Quantitative real-time polymerase chain reaction analysis was...

journal_title：OncoTargets and therapy

authors： Li M,Wang J,Liu H

更新日期：2018-10-12 00:00:00

abstract：:MicroRNA-126 (miR-126) has been found to promote angiogenesis, but the underlying mechanisms are still unclear. So, we conducted this study to explore the effect of miR-126 expression on angiogenesis in hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). The expression levels of miR-1...

journal_title：OncoTargets and therapy

authors： Ji JS,Xu M,Song JJ,Zhao ZW,Chen MJ,Chen WQ,Tu JF,Yang XM

更新日期：2016-07-19 00:00:00

abstract：BACKGROUND:Mast cells (MCs) can stimulate angiogenesis, releasing several proangiogenic cytokines stored in their cytoplasm. In particular MCs can release tryptase, a potent in vivo and in vitro proangiogenic factor via proteinase-activated receptor-2 (PAR-2) activation and mitogen-activated protein kinase phosphorylat...

journal_title：OncoTargets and therapy

authors： Ammendola M,Sacco R,Sammarco G,Piardi T,Zuccalà V,Patruno R,Zullo A,Zizzo N,Nardo B,Marech I,Crovace A,Gadaleta CD,Pessaux P,Ranieri G

更新日期：2016-07-21 00:00:00

abstract：OBJECTIVE:To analyze the management and prognosis of primary choriocarcinoma (PCC) in male patients. METHODS:The clinical records of males with PCC who were treated at Peking Union Medical College Hospital between 1990 and 2012 were analyzed retrospectively. The literature regarding this clinical condition was also re...

journal_title：OncoTargets and therapy

authors： Jiang F,Xiang Y,Feng FZ,Ren T,Cui ZM,Wan XR

更新日期：2014-06-20 00:00:00

abstract：PURPOSE:To investigate the biological effect of gyromagnetic fields (GMFs) on cell proliferation and apoptosis of human prostatic adenocarcinoma cells and explore the underlying mechanisms. METHODS:PC-3 cells were grouped into normal control (NC) and GMF treatment groups. Cell proliferation was analyzed with kit-8 and...

journal_title：OncoTargets and therapy

authors： Lei H,Xu Y,Guan R,Li M,Hui Y,Gao Z,Yang B,Xin Z

更新日期：2015-11-24 00:00:00

abstract：Background:Sex-determining region Y-box protein 5 (SOX5) has been demonstrated to be implicated in oncogenic function in various types of cancers. However, the role of SOX5 in gastric cancer (GC) remains poorly elucidated. Herein, we investigated the role and the underlying mechanism of SOX5 in GC progression. Methods...

journal_title：OncoTargets and therapy

authors： You J,Zhao Q,Fan X,Wang J

更新日期：2019-04-03 00:00:00

abstract：:CD47 belongs to immunoglobulin superfamily and is widely expressed on the surface of cell membrane, while another transmembrane protein SIRPα is restricted to the surface of macrophages, dendritic cells, and nerve cells. As a cell surface receptor and ligand, respectively, CD47 and SIRPα interact to regulate cell migr...

journal_title：OncoTargets and therapy

authors： Lu Q,Chen X,Wang S,Lu Y,Yang C,Jiang G

更新日期：2020-09-22 00:00:00

abstract：Objective:Sanguinarine (SNG) is a benzophenanthridine alkaloid obtained from the roots of Sanguinaria canadensis and has an anticancer effect. The aim of this study was to explore the mechanism of SNG in inhibiting macrophages via regulating the exosomes derived from lung carcinoma cells to reduce metastasis and prolif...

journal_title：OncoTargets and therapy

authors： Yu Y,Luo Y,Fang Z,Teng W,Yu Y,Tian J,Guo P,Xu R,Wu J,Li Y

更新日期：2020-09-10 00:00:00

abstract：BACKGROUND:Two types of epidermal growth factor receptor (EGFR) mutations in exon 19 and exon 21 (ex19del and L858R) are prevalent in lung cancer patients and sensitive to targeted EGFR inhibition. A resistance mutation in exon 20 (T790M) has been found to accompany drug treatment when patients relapse. These three mut...

journal_title：OncoTargets and therapy

authors： Xu Q,Zhu Y,Bai Y,Wei X,Zheng X,Mao M,Zheng G

更新日期：2015-06-22 00:00:00

abstract：Purpose:Gastric cancer has a high mortality rate worldwide. Although treatments, such as molecular-targeted therapy, have been introduced, the resulting long-term survival and prognosis remain unsatisfactory. Downregulation of the target genes using lentivirus-mediated short hairpin RNA (shRNA) can be an effective ther...

journal_title：OncoTargets and therapy

authors： Park JH,Seo JH,Jeon HY,Seo SM,Lee HK,Park JI,Kim JY,Choi YK

更新日期：2020-02-13 00:00:00

abstract：:Preclinical studies have demonstrated that Apatinib, major targeting vascular endothelial growth factor receptor-2 (VEGFR-2), could inhibit the proliferation of anaplastic thyroid carcinoma (ATC) cells in vitro and in vivo. The efficacy and safety in ATC patients, however, remains unknown. Here, we report the case of ...

journal_title：OncoTargets and therapy

authors： Cheng L,Jiao Q,Jin Y,Fu H,Zhang H,Chen L

更新日期：2019-12-02 00:00:00

abstract：Introduction:Microfibril-associated protein 2 (MFAP2) is an extracellular matrix protein that interacts with fibrillin to modulate the function of microfibrils. MFAP2 has been reported to play a significant role in obesity, diabetes, and osteopenia, and has been shown to be upregulated in head and neck squamous cell ca...

journal_title：OncoTargets and therapy

authors： Wang JK,Wang WJ,Cai HY,Du BB,Mai P,Zhang LJ,Ma W,Hu YG,Feng SF,Miao GY

更新日期：2018-07-12 00:00:00

abstract：Background and aim:Studies suggest that antiviral therapy performed after curative resection improves the postoperative prognosis of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), but the evidence has been contradictory. The aim of this meta-analysis was to assess the effect of antiviral therapy with n...

journal_title：OncoTargets and therapy

authors： Chen XX,Cheng JW,Huang A,Zhang X,Wang J,Fan J,Zhou J,Yang XR

更新日期：2017-11-10 00:00:00

abstract：Background:Recent studies showed that aberrant expression of miRNAs causes tumor-suppressing or promoting effects in various cancers including gastric cancer (GC). Our previous studies showed that lots of miRNAs and mRNA expressed differentially in GC and normal tissues. However, the critical miRNAs and mRNA need to be...

journal_title：OncoTargets and therapy

authors： Wang Z,Li Y,Cao J,Zhang W,Wang Q,Zhang Z,Gao Z,Ye Y,Jiang K,Wang S

更新日期：2020-03-03 00:00:00

abstract：Introduction:Previous trials demonstrated that anti-angiogenesis or anti-programmed death protein 1 (PD-1) monotherapy showed unsatisfied effect in advanced hepatocellular carcinoma (HCC). No study existed that focus on the effects of camrelizumab and apatinib ("C+A") combination therapy for HCC patients with the locat...

journal_title：OncoTargets and therapy

authors： Yuan G,Cheng X,Li Q,Zang M,Huang W,Fan W,Wu T,Ruan J,Dai W,Yu W,Chen M,Guo Y,Hu X,Chen J

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:Recurrent laryngeal nerve (RLN) invasion in papillary thyroid carcinoma (PTC) is one of the main predictors of poor prognosis. The present study investigated the risk factors for RLN invasion in PTC patients. METHODS:A total of 3,236 patients who received thyroidectomy due to PTC in Thyroid and Parathyroid ...

journal_title：OncoTargets and therapy

authors： Chen W,Lei J,You J,Lei Y,Li Z,Gong R,Tang H,Zhu J

更新日期：2017-09-11 00:00:00

abstract：Background:Pulmonary carcinosarcomas (PCSs) are a heterogeneous group of non-small-cell lung carcinomas (NSCLCs) with aggressiveness and a poor prognosis. Although genetic mutations of some common lung cancer subtypes have been extensively studied, the molecular characteristics of PCSs and the existence of abnormal tar...

journal_title：OncoTargets and therapy

authors： Li F,Hu S,Kong K,Cao P,Han P,Deng Y,Zhao B

更新日期：2020-08-10 00:00:00

abstract：:Follicular dendritic cell sarcoma (FDCS) is a rare malignant tumor recognized in recent years. It accounts for only 0.4% of soft-tissue sarcomas, and its underlying causes are largely unknown. A correct diagnosis can be difficult to make. Diagnosis of FDCS depends on the combined clinical examination, histopathologic ...

journal_title：OncoTargets and therapy

authors： Ma Y,Sun J,Yang C,Yuan D,Liu J

更新日期：2015-07-24 00:00:00