The effect of antiviral therapy on patients with hepatitis B virus-related hepatocellular carcinoma after curative resection: a systematic review and meta-analysis.

abstract：:Hodgkin lymphoma (HL) and anaplastic large-cell lymphoma (ALCL) account for ~10% and 2%-3% of all cases of lymphoid neoplasms, respectively. Up to 30% of patients with HL are refractory or relapse after first-line therapy, and elderly patients with HL represent a subgroup of patients with suboptimal responses to the c...

journal_title：OncoTargets and therapy

authors： Donato EM,Fernández-Zarzoso M,Hueso JA,de la Rubia J

更新日期：2018-08-06 00:00:00

abstract：BACKGROUND:Permanent prostate brachytherapy (PPB) is an effective treatment choice for low and intermediate risk prostate cancer (PCa). However, the impact of PPB on tumor immune status is still poorly understood. This study aimed to assess the immune status in PCa patients before and at different time points after PPB...

journal_title：OncoTargets and therapy

authors： Du E,Wang L,Li CY,Zhang CW,Qu YC,Liu RL,Xu Y,Yang K,Zhang ZH

更新日期：2017-05-15 00:00:00

abstract：:Patients with Lynch Syndrome (LS) are at high risk of developing colorectal cancer at an early age. Germline mutations in DNA mismatch repair genes and microsatellite instability are clear signatures of this autosomal dominant disorder. Here, we report the clinical history of a 38-year-old patient with LS-related meta...

journal_title：OncoTargets and therapy

authors： Salman P,Panay S,Fernández R,Mahave M,Soza-Ried C

更新日期：2018-10-23 00:00:00

abstract：:The aim of this study was to investigate the clinical characteristics and efficacy of chronic myeloid leukemia (CML) onset with extreme thrombocytosis. A total of 121 newly diagnosed and untreated CML patients in chronic phase with complete clinical information from the First Hospital of Jilin University, from January...

journal_title：OncoTargets and therapy

authors： Liu Z,Fan H,Li Y,Liu C

更新日期：2017-07-17 00:00:00

abstract：Purpose:This study is aimed to investigate the combined treating efficacy of sodium butyrate and docetaxel on proliferation and apoptosis of the lung adenocarcinoma A549 cell line based on Gli1 regulation in vitro and in vivo. Materials and Methods:RNA interference method was used to overexpress Gli1 in A549 cells. Ce...

journal_title：OncoTargets and therapy

authors： Chen M,Jiang W,Xiao C,Yang W,Qin Q,Mao A,Tan Q,Lian B,Wei C

更新日期：2020-09-04 00:00:00

abstract：:Triple-negative breast cancer is associated with a poor prognosis, and effective biomarkers for targeted diagnosis and treatment are lacking. The tumorigenicity of the provirus integration site for Moloney murine leukemia virus 1 (PIM-1) gene has been studied for many years. However, its significance in breast cancer ...

journal_title：OncoTargets and therapy

authors： Chen J,Tang G

更新日期：2019-08-08 00:00:00

abstract：Background:Gastric cancer (GC) is one of the most common malignant tumors and the second most frequent cause of cancer death worldwide. Crocin is a kind of bioactive constituent found in the stigmas of saffron, which has shown various pharmacological activities. Methods:In this study, we investigated the inhibitory ef...

journal_title：OncoTargets and therapy

authors： Luo Y,Yu P,Zhao J,Guo Q,Fan B,Diao Y,Jin Y,Wu J,Zhang C

更新日期：2021-01-07 00:00:00

abstract：Purpose:The molecular mechanism of perineural invasion (PNI) in stage II colorectal cancer (CRC) remains not to be defined clearly. This study aims to identify the genomic aberrations related to PNI in stage II CRC. Patients and Methods:Using array-based comparative genomic hybridization (array-CGH), primary tumor tis...

journal_title：OncoTargets and therapy

authors： Su H,Chang C,Hao J,Xu X,Bao M,Luo S,Zhao C,Liu Q,Wang X,Zhou Z,Zhou H

更新日期：2020-11-11 00:00:00

abstract：:Angiogenesis (the growth of new blood vessels) is essential in most of the body's physiological processes, such as in the normal functioning of the endometrium during and after the menstrual cycle. Vascular endothelial growth factor (VEGF) and matrix metalloproteinase (MMP) are the mostly expressed angiogenic factors,...

journal_title：OncoTargets and therapy

authors： Mahecha AM,Wang H

更新日期：2017-09-19 00:00:00

abstract：Purpose:Programmed death ligand 1 (PD-L1) is widely used for predicting immune checkpoint inhibitors but has a limited effect on predicting clinical response. The aim of this study was to examine the prognostic value and PD-1 inhibitor therapeutic efficiency of SNX20 in lung adenocarcinoma. Methods:We evaluated the mR...

journal_title：OncoTargets and therapy

authors： Fan L,Li L,Huang C,Huang S,Deng J,Xiong J

更新日期：2020-10-09 00:00:00

abstract：:Patients with papillary thyroid cancer (PTC) generally have good prognosis, but inoperable and radioactive iodine-refractory PTC still poses significant clinical challenges due to lack of effective treatment and higher mortality rates. Given the important role of integrins in multiple steps of tumor development, integ...

journal_title：OncoTargets and therapy

authors： Cheng W,Feng F,Ma C,Wang H

更新日期：2016-03-11 00:00:00

abstract：:Large granular lymphocytic leukemia (LGLL) is a rare lymphoproliferative disorder of transformed natural killer or T-cells attributed to chronic exposure to the proinflammatory cytokine IL-15. Diagnosis of the majority of T-cell LGLL is established by documenting clonal large granular lymphocytes (LGLs) in peripheral ...

journal_title：OncoTargets and therapy

authors： Bagacean C,Tempescul A,Patiu M,Fetica B,Bumbea H,Zdrenghea M

更新日期：2016-12-19 00:00:00

abstract：:Primary urethral non-Hodgkin's lymphoma (NHL) is uncommon. This case study reports the case of a 52-year-old woman with a light red mass at the urethral orifice. Her clinical manifestations included frequent urination, urgency, dysuria, and occasionally blood in urine. The tumor was surgically removed, and the patholo...

journal_title：OncoTargets and therapy

authors： Zeng H,Wang J,Deng R,Chen Z

更新日期：2020-12-21 00:00:00

abstract：Purpose:DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has attracted extensive attention in various types of malignant tumors. However, the role of DNA-PKcs in cutaneous squamous cell carcinoma (cSCC) development has not been elucidated. In this study, we investigated the role of DNA-PKcs in cSCC and the mol...

journal_title：OncoTargets and therapy

authors： Zhang J,Jiang H,Xu D,Wu WJ,Chen HD,He L

更新日期：2019-11-07 00:00:00

abstract：:Aberrant methylation of CpG dinucleotides is a commonly observed epigenetic modification in human cancer. Thus, detection of aberrant gene promoter methylation as a tool for diagnosis of tumors or as a prognostic marker has been widely described for many types of cancers, including nonsmall cell lung cancer (NSCLC). E...

journal_title：OncoTargets and therapy

authors： Xue R,Yang C,Zhao F,Li D

更新日期：2014-10-31 00:00:00

abstract：:The use of additional radiotherapy for resected stage IIIA N2 non-small-cell lung cancer in the setting of standard adjuvant chemotherapy remains controversial. A comprehensive search (last search updated in March 2015) for relevant studies comparing patients with stage IIIA N2 non-small-cell lung cancer undergoing re...

journal_title：OncoTargets and therapy

authors： Lei T,Xu XL,Chen W,Xu YP,Mao WM

更新日期：2016-02-24 00:00:00

abstract：BACKGROUND:Persistent infection with high-risk human papillomavirus (HPV) is a predominant cause of cervical cancer, and HPV58 is the third most common virus detected in the patients with cervical cancer in Asia. E6 and E7 are the viral oncogenes which are constitutively expressed in HPV-associated tumor cells and can ...

journal_title：OncoTargets and therapy

authors： Wang H,Yu J,Li L

更新日期：2015-10-23 00:00:00

abstract：Background and aim:Despite several studies being conducted to examine the associations between the NUDT15 R139C polymorphism and thiopurine-induced leukopenia in the Asian population, the results remain inconsistent. This meta-analysis determined the risk of thiopurine-induced leukopenia conferred by the NUDT15 R139C p...

journal_title：OncoTargets and therapy

authors： Liu Y,Meng Y,Wang L,Liu Z,Li J,Dong W

更新日期：2018-11-23 00:00:00

abstract：:Extramedullary plasmacytoma (EMP) is an infrequent form of plasma cell dyscrasia that presents as a mass of monoclonal plasma cells located in extramedullary soft tissues with no skeletal component. EMP constitutes ~4% of all plasma cell neoplasms and occurs mostly in the upper respiratory tract. Here, we report a rar...

journal_title：OncoTargets and therapy

authors： Tang RR,Wang Y,Liang CN,Li W,Pei L,Kang J,Hou G

更新日期：2019-02-20 00:00:00

abstract：Introduction:Systemic inflammation is associated with prognosis in solid tumors. The neutrophil-to-lymphocyte ratio (NLR) is a marker for the general immune response to various stress stimuli. Studies have shown correlation of NLR to outcomes in immune checkpoint blockade, peripheral neutrophil count to intratumor neut...

journal_title：OncoTargets and therapy

authors： Sacdalan DB,Lucero JA,Sacdalan DL

更新日期：2018-02-23 00:00:00

abstract：BACKGROUND:Gallbladder carcinoma is a highly malignant tumor and a public health problem in some parts of the world. It is characterized by a poor prognosis and its resistance to radio and chemotherapy. There is an urgent need to develop novel therapeutic alternatives for the treatment of gallbladder carcinoma. The mam...

journal_title：OncoTargets and therapy

authors： Leal P,Garcia P,Sandoval A,Buchegger K,Weber H,Tapia O,Roa JC

更新日期：2013-10-03 00:00:00

abstract：Background:Bromodomain and extra-terminal domain inhibitors like JQ1 have proved to be promising epigenetic agents for the treatment of malignant ovarian carcinoma. However, the resistance of ovarian cancer cells to BET inhibitors has not been elucidated. In this study, we investigated the potential mechanisms underlyi...

journal_title：OncoTargets and therapy

authors： Luan W,Pang Y,Li R,Wei X,Jiao X,Shi J,Yu J,Mao H,Liu P

更新日期：2019-10-03 00:00:00

abstract：BACKGROUND:C-X-C chemokine receptor type 4 (CXCR4) is involved in tumor progression including angiogenesis, metastasis, and survival. However, whether serum CXCR4 levels in metastatic or recurrent colorectal cancer have a prognostic role, have not been evaluated. METHODS:We analyzed serum samples from 55 patients with...

journal_title：OncoTargets and therapy

authors： Choi YJ,Chang WJ,Shin SW,Park KH,Kim ST,Kim YH

更新日期：2016-06-01 00:00:00

abstract：Background:Patients with BRAF (v-Raf murine sarcoma viral oncogene homolog B) V600E-mutated metastatic colorectal cancer (mCRC) have a poor prognosis. The Southwest Oncology Group (SWOG) 1406 study evaluated the efficacy of vemurafenib in combination with irinotecan and cetuximab for simultaneous inhibition of epiderma...

journal_title：OncoTargets and therapy

authors： Wang Z,Dai WP,Zang YS

更新日期：2019-01-08 00:00:00

abstract：Background:Recent studies showed that aberrant expression of miRNAs causes tumor-suppressing or promoting effects in various cancers including gastric cancer (GC). Our previous studies showed that lots of miRNAs and mRNA expressed differentially in GC and normal tissues. However, the critical miRNAs and mRNA need to be...

journal_title：OncoTargets and therapy

authors： Wang Z,Li Y,Cao J,Zhang W,Wang Q,Zhang Z,Gao Z,Ye Y,Jiang K,Wang S

更新日期：2020-03-03 00:00:00

abstract：BACKGROUND:Recent studies show that epithelial-mesenchymal transition (EMT) and tumor-associated macrophages (TAMs) contribute to the progression and poor prognosis of carcinoma through multiple mechanisms. Both inflammation and changing of epithelium have a close relationship with tumorigenesis of gastric cancer. Howe...

journal_title：OncoTargets and therapy

authors： Yan Y,Zhang J,Li JH,Liu X,Wang JZ,Qu HY,Wang JS,Duan XY

更新日期：2016-06-30 00:00:00

abstract：:This study aimed to investigate the expression and clinical significance of MYC-associated zinc finger protein (MAZ) in pancreatic carcinoma (PC), and the biological functions of MAZ in PC cells. MAZ expression was detected in 57 PC tissues and 41 paired adjacent nontumor tissues by immunohistochemistry. Compared to t...

journal_title：OncoTargets and therapy

authors： Zhu X,Luo W,Liang W,Tang F,Bei C,Ren Y,Qin L,Tan C,Zhang Y,Tan S

更新日期：2016-12-12 00:00:00

abstract：:Cutaneous metastasis from primary visceral malignancy is a relatively uncommon clinical entity, with a reported incidence ranging from 0.22% to 12% of all malignancies. Here we report a 64-year-old asymptomatic female patient with Peutz-Jeghers syndrome presenting with multiple scalp metastases as the initial manifest...

journal_title：OncoTargets and therapy

authors： Yu Q,Subedi S,Tong Y,Wei Q,Xu H,Wang Y,Gong Y,Shi Y

更新日期：2018-09-21 00:00:00

abstract：Objective:The biological functions and molecular mechanisms of miR-935 have been widely investigated in various types of cancer. The aim of the present study was to explore the function of miR-935 in glioma. Methods:Bioinformatic analysis and quantitative real-time fluorescent PCR (qRT-PCR) were used to determine the ...

journal_title：OncoTargets and therapy

authors： Huang G,Chen J,Liu J,Zhang X,Duan H,Fang Q

更新日期：2020-10-23 00:00:00

abstract：:CXCL12 (also named SDF1), a member of the chemokine family, has been demonstrated to play an important role in the progression of multiple types of hematological malignancy. Several recent studies have shown that SDF1-3'A polymorphism (rs1801157) is associated with susceptibility to hematological malignancy, but publi...

journal_title：OncoTargets and therapy

authors： Zhang X,Fan Y,Li Z

更新日期：2017-03-14 00:00:00