Abstract:
:Hodgkin lymphoma (HL) and anaplastic large-cell lymphoma (ALCL) account for ~10% and 2%-3% of all cases of lymphoid neoplasms, respectively. Up to 30% of patients with HL are refractory or relapse after first-line therapy, and elderly patients with HL represent a subgroup of patients with suboptimal responses to the currently available treatments. Five-year overall survival for ALCL patients is 50%-80% with conventional chemotherapy. Therefore, new therapeutic approaches are needed for these groups of patients. Brentuximab vedotin is a chimeric IgG1 anti-CD30 antibody-drug conjugate that has all the features that are necessary to make a substantive difference with the standard therapies in patients with HL and ALCL: a novel mechanism of action, single-agent activity, non-cross-resistance, and safety both in the relapsed-refractory and in the front-line setting. This review provides an update of the results of the most relevant clinical trials including brentuximab vedotin for patients with HL and ALCL conducted to date.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Donato EM,Fernández-Zarzoso M,Hueso JA,de la Rubia Jdoi
10.2147/OTT.S141053subject
Has Abstractpub_date
2018-08-06 00:00:00pages
4583-4590issn
1178-6930pii
ott-11-4583journal_volume
11pub_type
杂志文章,评审abstract:Introduction:Previous trials demonstrated that anti-angiogenesis or anti-programmed death protein 1 (PD-1) monotherapy showed unsatisfied effect in advanced hepatocellular carcinoma (HCC). No study existed that focus on the effects of camrelizumab and apatinib ("C+A") combination therapy for HCC patients with the locat...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S286169
更新日期:2020-12-09 00:00:00
abstract:Background:Triple-negative breast cancer has become an intricate part and hotspot in the clinical and experimental research. Connexins, serving as functional proteins in gap junctions, play an important role in tumorigenesis, cell proliferation and metastasis. Methods:We constructed and employed the Connexin 43 (Cx43)...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S229076
更新日期:2020-06-10 00:00:00
abstract::Long noncoding RNAs (lncRNAs) are emerging as an important part of biological progress in cancers, yet the aberrant lncRNAs implicated in colorectal cancer (CRC) with lymph node metastasis remain unknown. In this study, a total of 390 lncRNA transcripts and 508 mRNA transcripts were dysregulated in tumor tissues compa...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S102348
更新日期:2016-04-26 00:00:00
abstract:OBJECTIVE:High-mobility group protein 2 (HMGA2) and epithelial-mesenchymal transition (EMT)-associated proteins play key roles in cancer progression and metastasis. However, the clinical significance of HMGA2 and its relationship with EMT markers in nasopharyngeal carcinoma (NPC) is unclear. This study aimed to assess ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S74397
更新日期:2015-01-17 00:00:00
abstract:BACKGROUND:The purpose of this study was to compare the efficacy of intensity-modulated radiotherapy (IMRT) and helical tomotherapy for endometrial cancer. METHODS:Between November 1, 2006 and November 31, 2010, 31 patients with histologically confirmed endometrial cancer were enrolled. All enrolled patients received ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S35958
更新日期:2012-01-01 00:00:00
abstract:Introduction:The purpose of present study was to investigate the effect of limonin on tumor glycolysis and the underlying mechanisms in hepatocellular carcinoma (HCC). Methods:Cell proliferation and colony formation assays were performed to evaluate the potency of limonin against HCC cells in vitro. The glucose consum...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S165220
更新日期:2018-07-03 00:00:00
abstract:Background:LncRNA EMX2OS (EMX2 opposite strand/antisense RNA) is notably downregulated in prostate cancer (PCa) tissues and may be regarded as a potential molecular biomarker for diagnosis and prognosis. However, its exact role in regulating the development of PCa is obscure. Methods:The EMX2OS expression was assessed...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S243552
更新日期:2020-07-21 00:00:00
abstract::Gastric cancer (GC) is one of the leading causes of tumor-related mortality. In addition to surgery and endoscopic resection, systemic therapy remains the main treatment option for GC, especially for advanced-stage disease and for cases not suitable for surgical therapy. Hence, improving the efficacy of systemic thera...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S221354
更新日期:2019-12-24 00:00:00
abstract:Background:Anti-programmed cell death-1/programmed cell death ligand-1 monoclonal antibodies have been widely used in non-small-cell lung cancer (NSCLC), but not every patient can get benefits from them. Whether other molecular markers can predict the results of programmed cell death-1/programmed cell death ligand-1 in...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S164178
更新日期:2018-08-13 00:00:00
abstract:Purpose:Radioresistance is a vital obstacle for the prognosis of human nasopharyngeal carcinoma (NPC), but the underlying mechanism is still unknown. Here, we explored the role of the NRF2/KEAP1 pathway in radioresistance of NPC cell lines. Materials and Methods:We selected NPC cell lines CNE-1 and CNE-2, treated them...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S260169
更新日期:2020-09-11 00:00:00
abstract:Background:Our previous study demonstrated that Id-1 may promote the tumorigenicity of esophageal squamous cell carcinoma (ESCC). Id-4 is another member of Id family, which is rare to be studied in ESCC. In this study, we investigated the expression of Id-4 in human ESCC specimens and determined whether Id-4 expression...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S230678
更新日期:2020-02-12 00:00:00
abstract:Background:Mounting evidences reveal that circular RNAs (circRNAs) are critical to regulate biological behavior and process of tumor. Our objective is to explore the role of circRNA-PTN (circPTN) and explain the exact mechanism in hepatocellular carcinoma (HCC). Methods:Real-time polymerase chain reaction assay was us...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S251300
更新日期:2020-05-29 00:00:00
abstract:AIM:To investigate the clinical significance of cyclic adenosine monophosphate-responsive element-binding (CREB) and phosphorylated CREB (pCREB) expression in human hepatocellular carcinoma (HCC). MATERIALS AND METHODS:Immunohistochemistry and Western blot analyses were performed to detect the expression and subcellul...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S63594
更新日期:2014-05-29 00:00:00
abstract::[This corrects the article DOI: 10.2147/OTT.S196910.]. ...
journal_title:OncoTargets and therapy
pub_type: 已发布勘误
doi:10.2147/OTT.S229714
更新日期:2019-09-19 00:00:00
abstract:BACKGROUND:Nivolumab (BMS-936558/ONO-4538) was the first monoclonal antibody targeting programmed death (PD)-1. So far, a number of clinical trials on nivolumab have showed satisfactory efficacy in treating non-small-cell lung cancer (NSCLC). Herein, we present a meta-analysis evaluating the efficacy and safety of nivo...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S115262
更新日期:2016-09-23 00:00:00
abstract::The aim of this study was to evaluate the efficacy and toxicity of stereotactic body radiation therapy (SBRT) in the treatment of patients with liver metastases. Between August 2006 and July 2011, patients with 1-4 liver metastases were enrolled and treated with SBRT using the CyberKnife(®) system at Tianjin Medical U...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S58409
更新日期:2014-06-12 00:00:00
abstract:AIM:This article discusses the current use of volumetric modulated arc therapy (VMAT) techniques in clinical practice and reviews the available data from clinical outcome studies in different clinical settings. An overview of available literature about clinical outcomes with VMAT stereotactic/radiosurgical treatment is...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S113119
更新日期:2017-07-26 00:00:00
abstract:Background:Tumour growth and development are dependent on many factors including long noncoding RNAs (lncRNAs). However, limited information is available on the involvement of lncRNAs in non-small cell lung cancer (NSCLC) and the molecular mechanisms have not been defined. Here, we examined the expression of small nucl...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S263637
更新日期:2020-11-04 00:00:00
abstract:Background:This study investigated the effect of hyaluronic acid (HA)-CD44st on the invasive ability of human breast cancer MCF-7 cells and the correlation between the expression of CD44st and human epidermal growth factor receptor-2 (HER-2) in postoperative breast cancer patients. Materials and methods:MCF-7 cells tr...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S160531
更新日期:2018-09-10 00:00:00
abstract:Objective:This study aimed to evaluate the safety and efficacy of intensity-modulated radiotherapy (IMRT) plus nimotuzumab with or without concurrent chemotherapy (CCT) for patients with locally advanced nasopharyngeal carcinoma (LA-NPC). Patients and methods:A total of 50 newly diagnosed patients with LA-NPC treated ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S151554
更新日期:2017-12-08 00:00:00
abstract:Background and objective:Endometrial carcinoma (EC) is one of the most frequently diagnosed malignancies in females. Dysregulation of lncRNA TDRG1 has been widely documented in several cancers, including EC. However, the mechanism of this lncRNA involving in EC progression remains to be further elucidated. Materials a...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S228168
更新日期:2019-12-11 00:00:00
abstract:OBJECTIVES:This study aimed to analyze incidence and mortality trends in breast cancer (BC), corpus uteri cancer (CUC), and ovarian cancer (OC) in Poland in the context of sociodemographic changes. MATERIALS AND METHODS:Incidence and mortality data (1980-2013) were retrieved from the Polish National Cancer Registry, w...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S112187
更新日期:2016-09-07 00:00:00
abstract::Two decades ago, lymphatic mapping of sentinel lymph nodes (SLN) was introduced into surgical cancer management and was termed sentinel node navigated surgery. Although this technique is now routinely performed in the management of breast cancer and malignant melanoma, it is still under investigation for use in other ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S50394
更新日期:2014-06-24 00:00:00
abstract:Background:Several EGFR-tyrosine kinase inhibitors (TKIs), such as gefitinib (Gef), have been used as effective clinical therapies for patients with non-small cell lung cancer (NSCLC). However, due to acquired resistance, the efficacy of Gef treatment is severely blocked. Our preliminary study found that epigallocatech...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S209441
更新日期:2019-07-26 00:00:00
abstract:Background:Naloxone is viewed as a specific competitive opioid antagonist acting at the level of opioid receptors (μ, δ, and κ) with blended agonist-adversary or agonist action. The role of naloxone in tumor cell growth has been poorly studied in human cancer cell lines. Materials and methods:In the present study, we ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S145780
更新日期:2018-01-03 00:00:00
abstract::The incidence of lung neuroendocrine carcinomas, which originate from lung neuroendocrine cells, is 1.35/100,000, among which mixed neuroendocrine carcinomas are very rare. Because of the heterogeneity and significant differences in sensitivity to treatments, there is no effective treatment, and the prognosis is poor....
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S210699
更新日期:2019-11-14 00:00:00
abstract::Recently, "ipilimumab," an anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) monoclonal antibody, has been demonstrated to improve overall survival in metastatic melanoma. "CTLA-4" is an immune-checkpoint molecule that downregulates pathways of T-cell activation. Ipilimumab, by targeting CTLA-4, is able to remove the CTL...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S57335
更新日期:2014-02-19 00:00:00
abstract:Background:Since colorectal cancer (CRC) is one of the most common malignant tumors worldwide, we aimed to identify the role of sex determining region Y (SRY)-box 18 (SOX18) in CRC. Methods:RT-PCR and immunohistochemistry were employed to detect the expression of SOX18 in CRC samples. We then identified the effect of ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S178916
更新日期:2018-11-29 00:00:00
abstract::Targeted therapies against EGFR, vascular endothelial growth factor, and vascular endothelial growth factor receptor have expanded treatment options for patients with metastatic colorectal cancer (mCRC). Unfortunately, biomarkers to identify patients that are most likely to derive benefit from targeted therapies in th...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S68558
更新日期:2015-12-30 00:00:00
abstract:Purpose:Stomach cancer is one of the highest incidence and mortality malignancies worldwide. Our study aimed to illustrate the somatic mutation landscape and identify molecular markers of stomach cancer. Materials and Methods:By integrated analysis of sequencing data and clinical data of stomach adenocarcinoma (STAD) ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S263733
更新日期:2020-08-04 00:00:00