Abstract:
Background and aim:Standard chemotherapy has limited clinical efficacy in patients with esophageal cancer and there is a significant and unmet clinical need for effective treatment options for these patients. The aim of this study was to compare the clinical efficacy of the novel, targeted drug apatinib combined with docetaxel, and docetaxel combined with S-1 as second- or further-line treatment for patients with advanced esophageal cancer. Methods:We enrolled 33 patients with advanced esophageal cancer in chemotherapy group or apatinib combined with chemotherapy group in this retrospective study. Apatinib (500 mg) was taken orally once daily; docetaxel was administered at a dose of 75 mg/m2; and S-1 was optional at a dose of 40-60 mg, based on body surface area. The primary endpoint of this study was progression-free survival (PFS). Secondary endpoints included objective response rate (ORR), disease control rate (DCR), and the incidence and severity of adverse events (AEs). Results:No complete response was observed in the two groups. However, two and five patients achieved partial response in the chemotherapy group and the apatinib combined with chemotherapy group, respectively. The ORR and DCR for the chemotherapy group was 11.1% and 33.3%, respectively. In the apatinib combination group, ORR and DCR was 88.9% and 93.3%, respectively. Anemia (11.1%) and neutropenia (5.6%) were the most frequent grade III/IV AEs observed in the chemotherapy group. In the apatinib combination group, the most frequent grade III/IV AEs were anemia (13.3%), hypertension (6.7%), and proteinuria (6.7%). Median PFS was significantly longer in the apatinib combination group than in the chemotherapy group (175 days vs 85 days, P=0.01). Conclusion:The combination of apatinib and docetaxel has a manageable toxicity profile and may prolong survival. Therefore, this combination may be used as as second- or further-line treatment for patients with advanced esophageal cancer.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Li J,Jia Y,Gao Y,Chang Z,Han H,Yan J,Qin Ydoi
10.2147/OTT.S191736subject
Has Abstractpub_date
2019-04-08 00:00:00pages
2577-2583issn
1178-6930pii
ott-12-2577journal_volume
12pub_type
杂志文章abstract::Introduction: In recent years, an increasing amount of literature has demonstrated the functional role of long non-coding RNA (lncRNA) in human diseases. LINC00515 is a newly defined lncRNA and is reported to act as an oncogene in multiple myeloma. However, the function of LINC00515 in glioma is still uncertain. Mater...
journal_title:OncoTargets and therapy
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journal_title:OncoTargets and therapy
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journal_title:OncoTargets and therapy
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journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
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abstract:BACKGROUND:The PI3K family participates in multiple signaling pathways to regulate cellular functions. PI3K/Akt signaling pathway plays an important role in tumorigenesis and development. O-GlcNAcylation, a posttranslational modification, is thought to modulate a wide range of biological processes, such as transcriptio...
journal_title:OncoTargets and therapy
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journal_title:OncoTargets and therapy
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abstract::Cutaneous metastasis from primary visceral malignancy is a relatively uncommon clinical entity, with a reported incidence ranging from 0.22% to 12% of all malignancies. Here we report a 64-year-old asymptomatic female patient with Peutz-Jeghers syndrome presenting with multiple scalp metastases as the initial manifest...
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journal_title:OncoTargets and therapy
pub_type: 杂志文章
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journal_title:OncoTargets and therapy
pub_type: 杂志文章
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journal_title:OncoTargets and therapy
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doi:10.2147/OTT.S160752
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journal_title:OncoTargets and therapy
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doi:10.2147/OTT.S161360
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journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S218796
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abstract::The study aimed to investigate the difference of setup errors on different registration in the treatment of nasopharyngeal carcinoma based on weekly cone-beam computed tomography (CBCT). Thirty nasopharyngeal cancer patients scheduled to undergo intensity-modulated radiotherapy (IMRT) were prospectively enrolled in th...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S87159
更新日期:2015-09-14 00:00:00
abstract:Introduction:Disulfiram (DSF), a drug used in the treatment of alcoholism since 1948, has been shown to have antitumor properties in various tumor types possibly due to the induction of a type cell death, ferroptosis, and the sensitization of cells to chemo- and radiotherapy. In this study, we explored the antitumor pr...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S272312
更新日期:2020-10-20 00:00:00
abstract:BACKGROUND:The association of cancer stem cells with epithelial-mesenchymal transition (EMT) is receiving attention. We found in our previous study that EMT existed from CD24- phenotype cells to their differentiated cells. It was shown that cyclin D1 functioned in sustaining self-renewal independent of CDK4/CDK6 activa...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S44177
更新日期:2013-06-20 00:00:00
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journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S189825
更新日期:2019-03-28 00:00:00
abstract::Hepatocellular carcinoma (HCC) with inferior vena cava (IVC) tumor thrombus rarely occurs, its prognosis is extremely poor. A 49-year-old locally advanced HCC male with tumor thrombus extension into the IVC and the right atrium was successfully treated with stereotactic body radiotherapy (SBRT). A radiation dose of 40...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S208560
更新日期:2019-07-04 00:00:00
abstract::Immune checkpoint inhibitors (ICIs) have transformed the therapeutic strategy and prognosis of advanced non-small cell lung cancer (NSCLC) patients. Nowadays, ICIs as monotherapy or in combination with chemotherapy are the standard of care treatment in advanced NSCLC, and in stage III, durvalumab (a programmed death l...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S259308
更新日期:2020-07-14 00:00:00
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journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S247655
更新日期:2020-04-28 00:00:00
abstract::Mammalian nuclear receptors (NRs) are transcription factors regulating the expression of target genes that play an important role in drug metabolism, transport, and cellular signaling pathways. The orphan and structurally unique receptor small heterodimer partner 1 (syn NR0B2) is not only known for its modulation of d...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S106926
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journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S212465
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journal_title:OncoTargets and therapy
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journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S161996
更新日期:2018-04-24 00:00:00
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journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S130365
更新日期:2017-08-28 00:00:00
abstract::Erastin was initially discovered as a small molecule compound that selectively kills tumor cells expressing ST and RASV12 and was later widely investigated as an inducer of ferroptosis. Ferroptosis is a recently discovered form of cell death caused by peroxidation induced by the accumulation of intracellular lipid rea...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S254995
更新日期:2020-06-11 00:00:00
abstract::Despite remarkable progress in cancer-drug discovery, the delivery of novel, safe, and sustainably effective products to the clinic has stalled. Using Src as a model, we examine key steps in drug development. The preclinical evidence on the relationship between Src and solid cancer is in sharp contrast with the modest...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S45177
更新日期:2013-06-26 00:00:00
abstract::Background: Carcinoma ex pleomorphic adenoma (CXPA), a very rare malignancy found mostly in the major salivary glands, has no established standardized treatment. Case presentation: This report describes a 67-year-old male with advanced CXPA who was effectively treated by anlotinib. Pleomorphic adenoma of the submandib...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S200324
更新日期:2019-05-24 00:00:00
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journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S153942
更新日期:2018-02-26 00:00:00
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journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S166878
更新日期:2018-10-25 00:00:00
abstract:Background:Large amounts of researches indicate that non-coding RNAs play a crucial role in many malignancies. However, the potential mechanisms of non-coding RNAs involved in osteosarcoma tumorigenesis remain elusive. Materials and Methods:The expression of long non-protein coding RNA 691 (lncRNA 691) in cell lines a...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S249827
更新日期:2020-05-22 00:00:00