Disulfiram, a Ferroptosis Inducer, Triggers Lysosomal Membrane Permeabilization by Up-Regulating ROS in Glioblastoma.

abstract：Background:Malignant glioma is the second leading cause of cancer-related death worldwide, and is known to exhibit a high degree of heterogeneity in its deregulation of different oncogenic pathways. The molecular subclasses of human glioma are not well known. Thus, it is crucial to identify vital oncogenic pathways in ...

journal_title：OncoTargets and therapy

authors： Hu T,Xi J

更新日期：2017-11-15 00:00:00

abstract：OBJECTIVES:This study aimed to analyze incidence and mortality trends in breast cancer (BC), corpus uteri cancer (CUC), and ovarian cancer (OC) in Poland in the context of sociodemographic changes. MATERIALS AND METHODS:Incidence and mortality data (1980-2013) were retrieved from the Polish National Cancer Registry, w...

journal_title：OncoTargets and therapy

authors： Banas T,Juszczyk G,Pitynski K,Nieweglowska D,Ludwin A,Czerw A

更新日期：2016-09-07 00:00:00

abstract：Background:Several EGFR-tyrosine kinase inhibitors (TKIs), such as gefitinib (Gef), have been used as effective clinical therapies for patients with non-small cell lung cancer (NSCLC). However, due to acquired resistance, the efficacy of Gef treatment is severely blocked. Our preliminary study found that epigallocatech...

journal_title：OncoTargets and therapy

authors： Meng J,Chang C,Chen Y,Bi F,Ji C,Liu W

更新日期：2019-07-26 00:00:00

abstract：Purpose:Although cisplatin-based adjuvant chemotherapy improves the survival of patients with resected non-small-cell lung cancer, not all patients show a survival benefit, and some patients experience severe toxicity. Therefore, identifying biomarkers is important for selecting subgroups of patients who may show impro...

journal_title：OncoTargets and therapy

authors： Katono K,Sato Y,Kobayashi M,Nagashio R,Ryuge S,Igawa S,Ichinoe M,Murakumo Y,Saegusa M,Masuda N

更新日期：2017-11-02 00:00:00

abstract：:Glioma is the most common and aggressive human primary tumor in the central nervous system. Despite present clinical advancements, median survival time remains poor in this malignant tumor. Serpin peptidase inhibitor, clade A member 3 (SERPINA3), is a member of the serpin superfamily of protease inhibitors. Its aberra...

journal_title：OncoTargets and therapy

authors： Luo D,Chen W,Tian Y,Li J,Xu X,Chen C,Li F

更新日期：2017-04-18 00:00:00

abstract：Purpose:Intraoperative identification of rectal cancer (RC) can be challenging, especially because of fibrosis after treatment with preoperative chemo- and radiotherapy (CRT). Tumor-targeted fluorescence imaging can enhance the contrast between tumor and normal tissue during surgery. Promising targets for RC imaging ar...

journal_title：OncoTargets and therapy

authors： Boogerd LS,van der Valk MJ,Boonstra MC,Prevoo HA,Hilling DE,van de Velde CJ,Sier CF,Fariña Sarasqueta A,Vahrmeijer AL

更新日期：2018-03-23 00:00:00

abstract：:Armillaria mellea is a honey mushroom often used in the traditional Chinese medicine "Tianma". Currently, this medicinal mushroom is also used as a dietary supplement in numerous Western and Eastern countries. Armillarikin was isolated from A. mellea, and we previously discovered that it induced cytotoxicity in human ...

journal_title：OncoTargets and therapy

authors： Chen YJ,Chen CC,Huang HL

更新日期：2016-08-01 00:00:00

abstract：:The study is designed to explore the correlations of microvascular blood flow of contrast-enhanced ultrasound (CEUS) and hepatocyte growth factor (HGF)/c-Met signaling pathway with clinicopathological features and prognosis of patients with hepatocellular carcinoma (HCC). One hundred and eighteen patients pathological...

journal_title：OncoTargets and therapy

authors： Zhuang PH,Xu L,Gao L,Lu W,Ruan LT,Yang J

更新日期：2017-02-14 00:00:00

abstract：Background and aims:Studies show that the long non-coding RNA, SBF2-AS1, plays a critical role in cancer progression, but the role of SBF2-AS1 in gastric cancer has not been reported. Therefore, this study aimed to elucidate the mechanism of SBF2-AS1 in gastric cancer (GC). Methods:A meta-analysis, based on the gene e...

journal_title：OncoTargets and therapy

authors： Liang C,Yue C,Liang C,Ge H,Wei Z,Li G,Wu J,Huang H,Guo J

更新日期：2019-10-30 00:00:00

abstract：Background and objective:HSF1 is reported to be overexpressed in various solid tumors and play a pivotal role in cancer progression. A meta-analysis was conducted to assess the potential prognostic role of HSF1 in patients with solid tumors. Methods:An extensive electronic search of three databases was performed for r...

journal_title：OncoTargets and therapy

authors： Wan T,Shao J,Hu B,Liu G,Luo P,Zhou Y

更新日期：2018-01-17 00:00:00

abstract：OBJECTIVE:To explore the clinical significance of 3-phosphoinositide-dependent protein kinase-1 (PDK1) expression in hepatocellular carcinoma (HCC) and its association with clinicopathologic features and prognosis in HCC patients. MATERIALS AND METHODS:A total of 128 HCC patients who received radical resection were en...

journal_title：OncoTargets and therapy

authors： Wang J,Liu F,Ao P,Li X,Zheng H,Wu D,Zhang N,She J,Yuan J,Wu X

更新日期：2016-09-09 00:00:00

abstract：:p125 is one of four subunits of human DNA polymerases - DNA Pol δ as well as one of p53 target protein encoded by POLD1. However, the function and significance of p125 and the role that p53 plays in regulating p125 expression are not fully understood in breast cancer. Tissue sections of human breast cancer obtained fr...

journal_title：OncoTargets and therapy

authors： Zhang L,Yang W,Zhu X,Wei C

更新日期：2016-03-10 00:00:00

abstract：Background:Hepatocellular carcinoma is a common malignant cancer and the second most common cause of cancer-related deaths worldwide. Collagen triple helix repeat containing 1 (CTHRC1) has been increasingly reported to be involved in tumorigenesis and/or tumor progression. However, limited data are available regarding ...

journal_title：OncoTargets and therapy

authors： Zhou H,Su L,Liu C,Li B,Li H,Xie Y,Sun D

更新日期：2019-09-23 00:00:00

abstract：:Activation of the transcription factor, signal transducers and activators of transcription 3 (STAT3), has been linked to the proliferation and migration of a variety of human cancer cells. These actions occur via the upregulation or downregulation of cell survival and tumor suppressor genes, respectively. Importantly,...

journal_title：OncoTargets and therapy

authors： Wang G,Jing Y,Cao L,Gong C,Gong Z,Cao X

更新日期：2016-12-20 00:00:00

abstract：:Despite remarkable progress in cancer-drug discovery, the delivery of novel, safe, and sustainably effective products to the clinic has stalled. Using Src as a model, we examine key steps in drug development. The preclinical evidence on the relationship between Src and solid cancer is in sharp contrast with the modest...

journal_title：OncoTargets and therapy

authors： Rösel D,Brábek J,Veselý P,Fernandes M

更新日期：2013-06-26 00:00:00

abstract：:Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare myeloid malignancy, for which conventional chemotherapy has poor outcomes. CD123, the α-subunit of interleukin (IL)-3 receptor, is constantly overexpressed at the surface of tumoral cells. Tagraxofusp (or SL-401) is a recombinant cytotoxin which consists o...

journal_title：OncoTargets and therapy

authors： Beziat G,Ysebaert L

更新日期：2020-06-09 00:00:00

abstract：Purpose:Tumor drug resistance limits the response to chemotherapy. Interestingly, sequential combination therapy enhances the anticancer efficacy of drugs like cisplatin (CDDP) via synergistic effects. We assayed the synergistic effects of combined photodynamic therapy programmed death receptor-ligand 1 (PDT) and chemo...

journal_title：OncoTargets and therapy

authors： Xue K,Wang YN,Zhao X,Zhang HX,Yu D,Jin CS

更新日期：2019-07-10 00:00:00

abstract：Background:New evidence suggests that histidine triad nucleotide-binding protein 1 (Hint1) exerts a tumor suppressor effect in various human tumors, such as colorectal cancer and gastric cancer. However, it has not been reported whether Hint1 is involved in the occurrence and development of osteosarcoma (OS). Material...

journal_title：OncoTargets and therapy

authors： Duan DD,Xie H,Shi HF,Huang WW,Ding F,Hong JK,Fan JS,Hu SY,Wang QW,Zhou MQ

更新日期：2020-08-19 00:00:00

abstract：:ISL1 plays a key role in several cancers, including pheochromocytoma, gastrointestinal, pancreatic, and lung tumors and bile duct carcinoma. In order to elucidate the role of ISL1 in breast cancer, we performed quantitative real-time polymerase chain reaction and Western blotting analysis, and we found that ISL1 was u...

journal_title：OncoTargets and therapy

authors： Li L,Sun F,Chen X,Zhang M

更新日期：2018-02-14 00:00:00

abstract：Background:Galangin (GLN), a pure natural flavonoid compound found in plants, has been shown to exert anti-cancer effects against multiple cancer types, including glioma. However, its underlying molecular mechanism remains unclear. Epithelial-to-mesenchymal transition (EMT) performs an important function in the genesis...

journal_title：OncoTargets and therapy

authors： Xiong Y,Lai X,Xiang W,Zhou J,Han J,Li H,Deng H,Liu L,Peng J,Chen L

更新日期：2020-09-17 00:00:00

abstract：Background:Chemotherapy remains a major clinical option for the successful treatment of cancer by eliminating fast-growing populations of cancer cells. However, drug resistance causes the failure of antitumor treatment. Increasing evidence suggests that a small subpopulation of cancer cells will enter a "persister stat...

journal_title：OncoTargets and therapy

authors： Wang L,Yang Q,Peng S,Liu X

更新日期：2019-07-08 00:00:00

abstract：BACKGROUND:The prognostic and predictive significance of the high-level microsatellite instability (MSI-H) phenotype in various malignancies is unclear. We describe the characteristics, clinical course, and outcomes of patients with MSI-H malignancies treated in a real-life hospital setting. PATIENTS AND METHODS:A ret...

journal_title：OncoTargets and therapy

authors： Halpern N,Goldberg Y,Kadouri L,Duvdevani M,Hamburger T,Peretz T,Hubert A

更新日期：2017-03-29 00:00:00

abstract：:The aim of this study was to investigate the clinical characteristics and efficacy of chronic myeloid leukemia (CML) onset with extreme thrombocytosis. A total of 121 newly diagnosed and untreated CML patients in chronic phase with complete clinical information from the First Hospital of Jilin University, from January...

journal_title：OncoTargets and therapy

authors： Liu Z,Fan H,Li Y,Liu C

更新日期：2017-07-17 00:00:00

abstract：Introduction:Previous trials demonstrated that anti-angiogenesis or anti-programmed death protein 1 (PD-1) monotherapy showed unsatisfied effect in advanced hepatocellular carcinoma (HCC). No study existed that focus on the effects of camrelizumab and apatinib ("C+A") combination therapy for HCC patients with the locat...

journal_title：OncoTargets and therapy

authors： Yuan G,Cheng X,Li Q,Zang M,Huang W,Fan W,Wu T,Ruan J,Dai W,Yu W,Chen M,Guo Y,Hu X,Chen J

更新日期：2020-12-09 00:00:00

abstract：BACKGROUND:Two types of epidermal growth factor receptor (EGFR) mutations in exon 19 and exon 21 (ex19del and L858R) are prevalent in lung cancer patients and sensitive to targeted EGFR inhibition. A resistance mutation in exon 20 (T790M) has been found to accompany drug treatment when patients relapse. These three mut...

journal_title：OncoTargets and therapy

authors： Xu Q,Zhu Y,Bai Y,Wei X,Zheng X,Mao M,Zheng G

更新日期：2015-06-22 00:00:00

abstract：OBJECTIVES:Talimogene laherparepvec is the first oncolytic immunotherapy to receive approval in Europe, the USA and Australia. In the randomized, open-label Phase III OPTiM trial (NCT00769704), talimogene laherparepvec significantly improved durable response rate (DRR) versus granulocyte-macrophage colony-stimulating f...

journal_title：OncoTargets and therapy

authors： Harrington KJ,Andtbacka RH,Collichio F,Downey G,Chen L,Szabo Z,Kaufman HL

更新日期：2016-11-16 00:00:00

abstract：:Patients with Lynch Syndrome (LS) are at high risk of developing colorectal cancer at an early age. Germline mutations in DNA mismatch repair genes and microsatellite instability are clear signatures of this autosomal dominant disorder. Here, we report the clinical history of a 38-year-old patient with LS-related meta...

journal_title：OncoTargets and therapy

authors： Salman P,Panay S,Fernández R,Mahave M,Soza-Ried C

更新日期：2018-10-23 00:00:00

abstract：:Follicular dendritic cell sarcoma (FDCS) is a rare malignant tumor recognized in recent years. It accounts for only 0.4% of soft-tissue sarcomas, and its underlying causes are largely unknown. A correct diagnosis can be difficult to make. Diagnosis of FDCS depends on the combined clinical examination, histopathologic ...

journal_title：OncoTargets and therapy

authors： Ma Y,Sun J,Yang C,Yuan D,Liu J

更新日期：2015-07-24 00:00:00

abstract：Background:Non-small-cell lung cancer (NSCLC) is the major leading cause of cancer-related death around the world. The resistance to chemotherapy limits the effects of clinical treatment. The aim of this study was to identify novel mechanisms involved in NSCLC chemoresistance. Materials and methods:We explored the pub...

journal_title：OncoTargets and therapy

authors： Wang W,Han T,Tong W,Zhao J,Qiu X

更新日期：2018-09-26 00:00:00

abstract：PURPOSE:Liver metastasis is one of the leading causes of death in colorectal cancer (CRC) patients. The present study aimed to evaluate the value of eIF4E as a prognostic marker of colorectal liver metastasis (CLM) and identify the functional role of eIF4E in CRC metastasis. PATIENTS AND METHODS:The expression level o...

journal_title：OncoTargets and therapy

authors： Xu T,Zong Y,Peng L,Kong S,Zhou M,Zou J,Liu J,Miao R,Sun X,Li L

更新日期：2016-02-19 00:00:00