The Role of Erastin in Ferroptosis and Its Prospects in Cancer Therapy.

abstract：:[This retracts the article on p. 2215 in vol. 8, PMID: 26345468.]. ...

journal_title：OncoTargets and therapy

authors：

更新日期：2016-02-04 00:00:00

abstract：Background:Gastric tumor (GT) is associated with high morbidity and mortality, with surgery among the most effective treatment methods. Accurate interoperative determination of the tumor margin is crucial. Methods:In this study, using internal extractive electrospray ionization-MS, mass spectral data of GT and gastric...

journal_title：OncoTargets and therapy

authors： Zhang J,Gao Q,Luo X,Zhang W,Wang N,Wei Y

更新日期：2019-10-17 00:00:00

abstract：:Circulating tumor cells (CTCs) possess profound influence on tumor metastases and disease progression. This study aimed to investigate the correlation of CTCs with clinical characteristics and T-cell immunity, and to explore whether CTCs and the subpopulations can serve as an independent prognostic factor in advanced ...

journal_title：OncoTargets and therapy

authors： Sun WW,Xu ZH,Lian P,Gao BL,Hu JA

更新日期：2017-05-04 00:00:00

abstract：Aim:The use of bevacizumab in combination therapy is an emerging trend in metastatic colorectal cancer treatment. However, the clinical value of different combination types remains under debate. Thus, a meta-analysis of randomized controlled trials (RCTs) comparing bevacizumab-based combination therapy with monotherapy...

journal_title：OncoTargets and therapy

authors： Xu R,Xu C,Liu C,Cui C,Zhu J

更新日期：2018-12-04 00:00:00

abstract：Purpose:DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has attracted extensive attention in various types of malignant tumors. However, the role of DNA-PKcs in cutaneous squamous cell carcinoma (cSCC) development has not been elucidated. In this study, we investigated the role of DNA-PKcs in cSCC and the mol...

journal_title：OncoTargets and therapy

authors： Zhang J,Jiang H,Xu D,Wu WJ,Chen HD,He L

更新日期：2019-11-07 00:00:00

abstract：BACKGROUND:This meta-analysis aimed to assess available evidence on possible associations of interleukin-28B polymorphisms rs8099917 and rs12979860 with development of hepatitis virus-related hepatocellular carcinoma (HCC). METHODS:PubMed, EMBASE, Google Scholar, and the Chinese National Knowledge Infrastructure datab...

journal_title：OncoTargets and therapy

authors： Zhang Y,Zhu SL,Chen J,Li LQ

更新日期：2016-05-30 00:00:00

abstract：:Background: CD19-directed chimeric antigen receptor (CAR) T cells have substantial benefit in the treatment of patients with B-cell malignancies. However, despite encouraging therapeutic efficiency, there is limited overall response rate when anti-CD19 CAR-T cells are used to treat patients with relapsed and refractor...

journal_title：OncoTargets and therapy

authors： Li S,Xue L,Wang M,Qiang P,Xu H,Zhang X,Kang W,You F,Xu H,Wang Y,Liu X,Yang L,Wang X

更新日期：2019-07-12 00:00:00

abstract：:The use of additional radiotherapy for resected stage IIIA N2 non-small-cell lung cancer in the setting of standard adjuvant chemotherapy remains controversial. A comprehensive search (last search updated in March 2015) for relevant studies comparing patients with stage IIIA N2 non-small-cell lung cancer undergoing re...

journal_title：OncoTargets and therapy

authors： Lei T,Xu XL,Chen W,Xu YP,Mao WM

更新日期：2016-02-24 00:00:00

abstract：Introduction:A disintegrin and metallopeptidase with thrombospondin motifs (ADAMTSs), whose expression is dysregulated in various cancers, is implicated in cancer development. Herein, we aimed to investigate the functional role of ADAMTS8 in breast cancer (BC) and explore the underlying mechanisms. Methods:The protein...

journal_title：OncoTargets and therapy

authors： Zhang K,Tian R,Wang G,Zhang J,Ma H,Hu X,Xi J,Wang G

更新日期：2020-08-21 00:00:00

abstract：BACKGROUND:MDS1 and EVI1 complex locus protein EVI1 (MECOM) is an oncogenic transcription factor in several kinds of cancers. However, the clinical significance of MECOM in glioblastoma multiforme (GBM) has not been well elucidated. PATIENTS AND METHODS:Our study enrolled 86 resected samples of GBM in three medical ce...

journal_title：OncoTargets and therapy

authors： Hou A,Zhao L,Zhao F,Wang W,Niu J,Li B,Zhou Z,Zhu D

更新日期：2016-01-13 00:00:00

abstract：Objective:This study aimed to evaluate the safety and efficacy of intensity-modulated radiotherapy (IMRT) plus nimotuzumab with or without concurrent chemotherapy (CCT) for patients with locally advanced nasopharyngeal carcinoma (LA-NPC). Patients and methods:A total of 50 newly diagnosed patients with LA-NPC treated ...

journal_title：OncoTargets and therapy

authors： Huang J,Zou Q,Qian D,Zhou L,Yang B,Chu J,Pang Q,Wang K,Zhang F

更新日期：2017-12-08 00:00:00

abstract：:The identification of molecular genetic biomarkers considerably increased our current understanding of glioma genesis, prognostic evaluation, and treatment planning. In glioblastoma, the most malignant intrinsic brain tumor entity in adults, the promoter methylation status of the gene encoding for the repair enzyme O6...

journal_title：OncoTargets and therapy

authors： Thon N,Kreth S,Kreth FW

更新日期：2013-09-27 00:00:00

abstract：BACKGROUND:The grading of pancreatic neuroendocrine neoplasms (PanNENs) is associated with the choice of treatment strategy. The aim of this study is to identify the magnetic resonance imaging (MRI) features in differentiating pancreatic neuroendocrine tumors (PanNETs) grade 1/2 (G1/G2) and pancreatic neuroendocrine ca...

journal_title：OncoTargets and therapy

authors： Guo C,Chen X,Xiao W,Wang Q,Sun K,Wang Z

更新日期：2017-03-07 00:00:00

abstract：:Background/Aims: MiR-145 and Smad2 have been widely reported in the development and progression of human malignancies. In the present study, we investigated the correlation between miR-145 and Smad2 in human glioblastoma multiforme (GBM). Methods: The epithelial-mesenchymal transition (EMT) biomarkers and Smad2 were a...

journal_title：OncoTargets and therapy

authors： Chen W,Huang B,Wang E,Wang X

更新日期：2019-04-23 00:00:00

abstract：Introduction:Forkhead box (FOX) superfamily members were recently shown to play important roles in tumor development and progression. Forkhead box S1 (FOXS1), a member of the FOX family, has been reported to be closely associated with malignant neoplasms. However, its expression and effect on hepatocellular carcinoma r...

journal_title：OncoTargets and therapy

authors： Lei D,Hu G,Chen Y,Hao T,Gao Y,Luo F

更新日期：2020-11-17 00:00:00

abstract：Purpose:This study is aimed to investigate the combined treating efficacy of sodium butyrate and docetaxel on proliferation and apoptosis of the lung adenocarcinoma A549 cell line based on Gli1 regulation in vitro and in vivo. Materials and Methods:RNA interference method was used to overexpress Gli1 in A549 cells. Ce...

journal_title：OncoTargets and therapy

authors： Chen M,Jiang W,Xiao C,Yang W,Qin Q,Mao A,Tan Q,Lian B,Wei C

更新日期：2020-09-04 00:00:00

abstract：BACKGROUND:The purpose of this research was to investigate the relationship between epidermal growth factor receptor (EGFR) mutations and the response to first-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). METHODS:A total of 266 patients with stage IIIB or IV NSCLC who received platin...

journal_title：OncoTargets and therapy

authors： Fang S,Wang Z,Guo J,Liu J,Li C,Liu L,Shi H,Liu L,Li H,Xie C,Zhang X,Sun W,Li M

更新日期：2014-07-01 00:00:00

abstract：Background:Although several long non-coding RNAs (lncRNAs) have been found to be involved in gastric cancer tumorigenesis, the more comprehensive contributions of lncRNAs to gastric cancer require further investigation. Here, we identify a cytoplasmic lncRNA, LINC01485, which promotes tumor growth and migration in gast...

journal_title：OncoTargets and therapy

authors： Zhou J,Wu L,Li W,Xu X,Ju F,Yu S,Guo J,Li G,Shi J,Zhou S

更新日期：2020-08-21 00:00:00

abstract：:Breast cancer is one of the most common malignant cancers among women and a major clinical obstacle. Although studies have reported the abnormal expression of SIRT7 in breast cancer, whether the function of SIRT7 regulates the expression of long noncoding RNAs (lncRNAs) in breast cancer remains unknown. We aimed to de...

journal_title：OncoTargets and therapy

authors： Chen KL,Li L,Wang YR,Li CM,Badri TM,Wang GL

更新日期：2017-10-24 00:00:00

abstract：Background:Breast cancer resistance protein BCRP, belonging to superfamily G of the adenosine triphosphate-binding cassette (ABC) transporters, is an efflux pump and plays a critical role in protecting cells against xenobiotics and toxic compounds including (pro)carcinogens. BCRP is expressed in many tissues, including...

journal_title：OncoTargets and therapy

authors： Niebudek K,Balcerczak E,Mirowski M,Pietrzak J,Zawadzka I,Żebrowska-Nawrocka M

更新日期：2019-02-27 00:00:00

abstract：:Hodgkin lymphoma (HL) and anaplastic large-cell lymphoma (ALCL) account for ~10% and 2%-3% of all cases of lymphoid neoplasms, respectively. Up to 30% of patients with HL are refractory or relapse after first-line therapy, and elderly patients with HL represent a subgroup of patients with suboptimal responses to the c...

journal_title：OncoTargets and therapy

authors： Donato EM,Fernández-Zarzoso M,Hueso JA,de la Rubia J

更新日期：2018-08-06 00:00:00

abstract：BACKGROUND:The association of cancer stem cells with epithelial-mesenchymal transition (EMT) is receiving attention. We found in our previous study that EMT existed from CD24- phenotype cells to their differentiated cells. It was shown that cyclin D1 functioned in sustaining self-renewal independent of CDK4/CDK6 activa...

journal_title：OncoTargets and therapy

authors： Jiao J,Huang L,Ye F,Shi M,Cheng X,Wang X,Hu D,Xie X,Lu W

更新日期：2013-06-20 00:00:00

abstract：Introduction:Odd-skipped related transcription factor 1 (OSR1) is a newly identified tumor suppressor in many tumor types. However, the role and mechanism of OSR1 in colon adenocarcinoma (COAD) remain unknown. Methods:OSR1 expression was detected in COAD tissues and cells. COAD cells with OSR1 overexpression or knockd...

journal_title：OncoTargets and therapy

authors： Zhang F,Jiang Z

更新日期：2020-04-24 00:00:00

abstract：Background:Cervical cancer (CC) is a highly prevalent cancer and one of the main causes of death among women worldwide. The miR-181 family has turned out to be associated with tumorigenesis in a variety of tumors by regulating the expression of tumor-related genes. However, the mechanisms and biological function of miR...

journal_title：OncoTargets and therapy

authors： Li N,Cheng C,Wang T

更新日期：2020-05-21 00:00:00

abstract：:Despite multimodal therapeutic treatments of osteosarcoma (OS), some patients develop resistance to currently available regimens and eventually end up with recurrent or metastatic outcomes. Many attempts have been made to discover effective drugs for improving outcome; however, due to the heterogeneity of the disease,...

journal_title：OncoTargets and therapy

authors： Chaiyawat P,Settakorn J,Sangsin A,Teeyakasem P,Klangjorhor J,Soongkhaw A,Pruksakorn D

更新日期：2017-02-01 00:00:00

abstract：Purpose:Circular RNAs (circRNAs) are emerging as promising biomarkers for various human malignancies. However, the application of circRNAs as non-invasive biomarkers in high-grade serous ovarian cancer (SOC) remains to be elucidated. Here, we aim to investigate the feasibility of using serum circSETDB1, a tumor-promoti...

journal_title：OncoTargets and therapy

authors： Wang W,Wang J,Zhang X,Liu G

更新日期：2019-09-11 00:00:00

abstract：:HES1 is the target of Notch signaling which is reported to affect cell differentiation and maintain the cells in G0 phase in various tissues including the hematopoietic tissue. HES1 expression appears to be an independent prognostic factor for survival in a heterogeneous group of acute myeloid leukemia (AML) patients....

journal_title：OncoTargets and therapy

authors： Tian C,Tang Y,Wang T,Yu Y,Wang X,Wang Y,Zhang Y

更新日期：2015-04-22 00:00:00

abstract：:Background: Seminoma accounts for the most part of cases of testicular germ cell tumor, which is the most common malignancy among males between ages 15 and 44 years. Understanding the molecular mechanism of tumorigenesis is important for better clinical diagnosis and treatment. Purpose: We performed bioinformatics ana...

journal_title：OncoTargets and therapy

authors： Chen YH,Lin TT,Wu YP,Li XD,Chen SH,Xue XY,Wei Y,Zheng QS,Huang JB,Xu N

更新日期：2019-05-14 00:00:00

abstract：BACKGROUND:Increasing evidence suggests that the dysregulation of certain microRNAs plays an important role in tumorigenesis and metastasis. MiR-200c exhibits a disordered expression in many tumors and presents dual roles in bladder cancer (BC). Therefore, the definite role of miR-200c in BC needs to be investigated fu...

journal_title：OncoTargets and therapy

authors： Cheng Y,Zhang X,Li P,Yang C,Tang J,Deng X,Yang X,Tao J,Lu Q,Li P

更新日期：2016-08-16 00:00:00

abstract：BACKGROUND:The prognostic and predictive significance of the high-level microsatellite instability (MSI-H) phenotype in various malignancies is unclear. We describe the characteristics, clinical course, and outcomes of patients with MSI-H malignancies treated in a real-life hospital setting. PATIENTS AND METHODS:A ret...

journal_title：OncoTargets and therapy

authors： Halpern N,Goldberg Y,Kadouri L,Duvdevani M,Hamburger T,Peretz T,Hubert A

更新日期：2017-03-29 00:00:00