Abstract:
Introduction:The consolidation of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. In this study, a multifunctional platform by WS2 quantum dots (WQDs)-coated doxorubicin (DOX)-loaded periodic mesoporous organosilicas (PMOs-DOX@WQDs) nanoparticles were fabricated for the first time, and which exhibits good potential for synergistic chemo-photothermal therapy. Materials and methods:The structure, light-mediated drug release behavior, photothermal effect, and synergistic therapeutic efficiency of PMOs-DOX@WQDs to HCT-116 colon cancer cells were investigated. The thioether-bridged PMOs exhibit a high DOX loading capacity of 66.7 μg mg-1. The gating of the PMOs not only improve the drug loading capacity but also introduce the dual-stimuli-responsive performance. Furthermore, the as-synthesized PMOs-DOX@WQDs nanoparticles can efficiently generate heat to the hyperthermia temperature with near infrared laser irradiation. Results:It was confirmed that PMOs-DOX@WQDs exhibit remarkable photothermal effect and light-triggered faster release of DOX. More importantly, it was reasonable to attribute the efficient anti-tumor efficiency of PMOs-DOX@WQDs. Conclusion:The in vitro experimental results confirm that the fabricated nanocarrier exhibits a significant synergistic effect, resulting in a higher efficacy to kill cancer cells. Therefore, the WQD-coated PMOs present promising applications in cancer therapy.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Liao W,Zhang L,Zhong Y,Shen Y,Li C,An Ndoi
10.2147/OTT.S160748subject
Has Abstractpub_date
2018-04-05 00:00:00pages
1949-1960issn
1178-6930pii
ott-11-1949journal_volume
11pub_type
杂志文章abstract::Despite improvements in multidisciplinary treatments, survival of pancreatic cancer (PC) patients remains dismal. Studies dealing with early onset pancreatic cancer (EOPC) patients are scarce. In this review, we discuss differences between EOPC and late-onset pancreatic cancer based on findings in original papers and ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S176700
更新日期:2019-05-06 00:00:00
abstract:Background and aims:Gastric cancer (GC) is one of the most common cancers worldwide, and its pathogenesis is related to a complex network of gene interactions. The aims of our study were to find hub genes associated with the progression and prognosis of GC and illustrate the underlying mechanisms. Methods:Weighted gen...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S176511
更新日期:2018-10-02 00:00:00
abstract::Background: Previous studies have reported that the albumin-to-alkaline phosphatase ratio (AAPR), a novel blood biomarker-based index, is associated with clinical outcome in several cancers. However, data relating to lung cancer are rare. This study was performed to clarify the clinical significance of AAPR in patient...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S203321
更新日期:2019-07-02 00:00:00
abstract:OBJECTIVE:To investigate the effects of microRNA-122 (miR-122) on proliferation, migration, and invasion in human hepatocellular carcinoma (HCC) cells by activating epithelial-mesenchymal transition (EMT) pathways. METHODS:miR-122 mimics, miR-122 inhibitors, relevant control oligonucleotides, and Wnt1 were transfected...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S92378
更新日期:2016-04-06 00:00:00
abstract::Hodgkin lymphoma (HL) and anaplastic large-cell lymphoma (ALCL) account for ~10% and 2%-3% of all cases of lymphoid neoplasms, respectively. Up to 30% of patients with HL are refractory or relapse after first-line therapy, and elderly patients with HL represent a subgroup of patients with suboptimal responses to the c...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S141053
更新日期:2018-08-06 00:00:00
abstract:BACKGROUND:Progression-free survival (PFS) and time to progression (TTP) are frequently used to establish the clinical efficacy of anti-cancer drugs. However, the surrogacy of PFS/TTP for overall survival (OS) remains a matter of uncertainty in metastatic breast cancer (mBC). This study assessed the relationship betwee...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S63302
更新日期:2014-06-18 00:00:00
abstract:OBJECTIVE:To assess the need for pulmonary surgery in the treatment of refractory gestational trophoblastic neoplasia with lung metastasis after normalization of serum beta human chorionic gonadotropin (β-hCG) level with salvage chemotherapy. MATERIALS AND METHODS:A review of medical records of patients with refractor...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S56361
更新日期:2014-01-29 00:00:00
abstract:Purpose:Both obesity and gender are important etiological factors in renal cell carcinoma (RCC) development, suggesting a pivotal role of sex hormone signaling pathway and insulin-like growth factor (IGF) family in RCC carcinogenesis. Here, we aimed to investigate the effect of estrogen on RCC growth and the possible i...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S172149
更新日期:2018-09-17 00:00:00
abstract:Introduction:Multiple myeloma (MM) remains an incurable disease, and patient survival requires a better understanding of this malignancy's molecular aspects. Heparanase (HPSE) is highly expressed in aggressive MM cells and related to tumor growth, metastasis, and bortezomib (BTZ) resistance. Thus, targeting HPSE seems ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S286751
更新日期:2021-01-15 00:00:00
abstract::Activation of the transcription factor, signal transducers and activators of transcription 3 (STAT3), has been linked to the proliferation and migration of a variety of human cancer cells. These actions occur via the upregulation or downregulation of cell survival and tumor suppressor genes, respectively. Importantly,...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S121619
更新日期:2016-12-20 00:00:00
abstract:Background:This study investigated the effect of hyaluronic acid (HA)-CD44st on the invasive ability of human breast cancer MCF-7 cells and the correlation between the expression of CD44st and human epidermal growth factor receptor-2 (HER-2) in postoperative breast cancer patients. Materials and methods:MCF-7 cells tr...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S160531
更新日期:2018-09-10 00:00:00
abstract:INTRODUCTION:The purpose of this study was to evaluate the use of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) to identify the presence of cervical lymph nodes metastases and extracapsular spread with histologic correlations in head and neck squamous cell carcinoma. METH...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S85479
更新日期:2015-08-26 00:00:00
abstract:PURPOSE:Programmed death-ligand 1 (PD-L1) is found to be overexpressed in non-small cell lung cancer. The present study intended to evaluate the status of PD-L1 expression in patients with resection and recurrent lung adenocarcinoma. PATIENTS AND METHODS:Matched resection and recurrent tumor samples were harvested fro...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S127498
更新日期:2017-04-06 00:00:00
abstract:Background:Triple-negative breast cancer has become an intricate part and hotspot in the clinical and experimental research. Connexins, serving as functional proteins in gap junctions, play an important role in tumorigenesis, cell proliferation and metastasis. Methods:We constructed and employed the Connexin 43 (Cx43)...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S229076
更新日期:2020-06-10 00:00:00
abstract:Background:Cordycepin, the main active ingredient of a traditional Chinese herbal remedy - extracted from Cordyceps sinensis - has been demonstrated as a very effective anti-inflammatory and antitumor drug. The present study investigated its antitumor effect on pancreatic cancer, a highly aggressive cancer with extreme...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S164670
更新日期:2018-08-01 00:00:00
abstract:Background:Intra-abdominal desmoplastic small round cell tumor (IADSRCT) is a highly invasive malignant tumor that is rare in clinical practice. Anlotinib is a multitarget receptor tyrosine kinase inhibitor which inhibits vascular endothelial growth factor receptor (VEGFR) 1-3, fibroblast growth factor receptor (FGFR) ...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S190333
更新日期:2018-12-18 00:00:00
abstract::Aberrant methylation of CpG dinucleotides is a commonly observed epigenetic modification in human cancer. Thus, detection of aberrant gene promoter methylation as a tool for diagnosis of tumors or as a prognostic marker has been widely described for many types of cancers, including nonsmall cell lung cancer (NSCLC). E...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S67355
更新日期:2014-10-31 00:00:00
abstract:Background:Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults. Long non-coding RNA taurine-upregulated gene 1 (lncRNA TUG1) has been discovered to participate in multiple cancers including AML. However, the detailed mechanism of TUG1 in AML remains obscure. Materials and methods:AML cell ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S217795
更新日期:2019-11-29 00:00:00
abstract:Purpose:MicroRNA-939 (miR-939) has crucial roles in several types of human cancer. However, the expression profile and precise functions of miR-939 in prostate cancer (PCa) are still unclear. This study aimed to determine miR-939 expression in PCa and explore its roles in PCa tumorigenesis. Methods:miR-939 expression ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S250101
更新日期:2020-05-18 00:00:00
abstract:BACKGROUND:MicroRNA (miR)-126, acting as a tumor suppressor, has been reported to inhibit the invasion of gastric cancer cells in part by targeting v-crk sarcoma virus CT10 oncogene homologue (CRK). The aim of this study was to investigate the clinical significance of miR-126/CRK axis in gastric cancer. METHODS:miR-12...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S87778
更新日期:2016-10-11 00:00:00
abstract::Over the last decades, a better understanding of breast cancer heterogeneity provided tools for a biologically based personalization of anticancer treatments. In particular, the overexpression of the human epidermal growth factor receptor 2 (HER2) by tumor cells provided a specific target in these HER2-positive tumors...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S122397
更新日期:2017-07-10 00:00:00
abstract:OBJECTIVE:SASH1 is a member of the SH3/SAM adapter molecules family and has been identified as a new tumor suppressor and critical protein in signal transduction. An ectopic expression of SASH1 is associated with decreased cell viability of breast cancer. The aim of this study was to explore the association between SAS...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S119244
更新日期:2017-01-10 00:00:00
abstract:Background and Objectives:Non-small cell lung cancer (NSCLC) patients with an epidermal growth factor receptor (EGFR) mutation demonstrate only a median progression-free survival (PFS) of 8 to 10 months and undergo EGFR tyrosine kinase inhibitors (EGFR-TKIs) therapy. For decades, bilirubin has been reported to be assoc...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S266477
更新日期:2020-10-29 00:00:00
abstract::This report describes a patient with intravascular large B-cell lymphoma (IVLBCL) with central nervous system involvement at the time of diagnosis who achieved complete remission for over 5 years in response to therapy. The patient, a 71 year-old woman, was previously healthy with the exception of taking verapamil for...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S72596
更新日期:2014-11-18 00:00:00
abstract:PURPOSE:The expression of an array of signaling molecules, along with the assessment of real-time cell proliferation, has been performed in U87 glioma cell line and in patients' glioblastoma established cell cultures in order to provide a better understanding of cellular and molecular events involved in glioblastoma pa...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S52365
更新日期:2013-11-29 00:00:00
abstract::MicroRNA-126 (miR-126) has been found to promote angiogenesis, but the underlying mechanisms are still unclear. So, we conducted this study to explore the effect of miR-126 expression on angiogenesis in hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). The expression levels of miR-1...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S106513
更新日期:2016-07-19 00:00:00
abstract::Advances in therapies have led to the approval of six therapeutic agents since 2004, each demonstrating overall survival benefit in randomized studies, and these have significantly improved the outlook for men facing metastatic castration-resistant prostate cancer (CRPC). More recently, efforts have been directed at t...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S147168
更新日期:2018-04-12 00:00:00
abstract::Quercetin, a flavone, is multifaceted, having anti-oxidative, anti-inflammatory, and anticancer properties. In the present study, we explored the effects of quercetin on the epithelial-mesenchymal transition (EMT) and invasion of pancreatic cancer cells and the underlying mechanisms. We noted that quercetin exerted pr...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S136840
更新日期:2017-09-25 00:00:00
abstract::ALK rearrangements account for ~5% of non-small-cell lung cancer (NSCLC). Numerous rearrangement partners have been discovered. Here, we describe a 53-year-old nonsmoker with NSCLC, in whom we identified four novel rearrangements. The patient was diagnosed as adenocarcinoma in the right middle lobe of lung, with metas...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S258067
更新日期:2020-08-20 00:00:00
abstract::Purpose: Ornithine decarboxylase 1 (ODC1)-an oncogene involved in the biosynthesis of polyamines-is commonly upregulated and associated with poor prognosis in numerous cancers. However, the role and mechanism of ODC1 in hepatocellular carcinoma (HCC) remains unclear. The aim of the present study was to investigate the...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S198341
更新日期:2019-05-27 00:00:00