Downregulation of NSD3 (WHSC1L1) inhibits cell proliferation and migration via ERK1/2 deactivation and decreasing CAPG expression in colorectal cancer cells.

abstract：Introduction:Odd-skipped related transcription factor 1 (OSR1) is a newly identified tumor suppressor in many tumor types. However, the role and mechanism of OSR1 in colon adenocarcinoma (COAD) remain unknown. Methods:OSR1 expression was detected in COAD tissues and cells. COAD cells with OSR1 overexpression or knockd...

journal_title：OncoTargets and therapy

authors： Zhang F,Jiang Z

更新日期：2020-04-24 00:00:00

abstract：PURPOSE:To investigate the biological effect of gyromagnetic fields (GMFs) on cell proliferation and apoptosis of human prostatic adenocarcinoma cells and explore the underlying mechanisms. METHODS:PC-3 cells were grouped into normal control (NC) and GMF treatment groups. Cell proliferation was analyzed with kit-8 and...

journal_title：OncoTargets and therapy

authors： Lei H,Xu Y,Guan R,Li M,Hui Y,Gao Z,Yang B,Xin Z

更新日期：2015-11-24 00:00:00

abstract：Background:Bromodomain and extra-terminal domain inhibitors like JQ1 have proved to be promising epigenetic agents for the treatment of malignant ovarian carcinoma. However, the resistance of ovarian cancer cells to BET inhibitors has not been elucidated. In this study, we investigated the potential mechanisms underlyi...

journal_title：OncoTargets and therapy

authors： Luan W,Pang Y,Li R,Wei X,Jiao X,Shi J,Yu J,Mao H,Liu P

更新日期：2019-10-03 00:00:00

abstract：Objective:Osteoclastogenesis is a key process in osteolytic bone metastasis (BM). Previous studies indicated that some miRNAs could regulate cancers progression and osteoclastogenesis. Our purpose was to investigate the roles of lung cancer cells-derived circulating miR-21 on osteoclastogenesis and its clinical signifi...

journal_title：OncoTargets and therapy

authors： Zhao Q,Liu C,Xie Y,Tang M,Luo G,Chen X,Tian L,Yu X

更新日期：2020-03-31 00:00:00

abstract：Background:The inflammatory indexes are attracting increasing attention as a prognostic predictor for colorectal cancer (CRC). However, the prognostic value of the preoperative lymphocyte-to-C-reactive protein ratio (LCR) in patients with non-metastatic CRC remains to be established. Methods:A total of 955 patients fr...

journal_title：OncoTargets and therapy

authors： Ou W,Zhou C,Zhu X,Lin L,Xu Q

更新日期：2021-01-12 00:00:00

abstract：Objective:The phenomenon that cancer cells avidly exhibit glycolysis with lactate secretion and decrease in mitochondrial activity under aerobic conditions is known historically as the Warburg effect. Rho GTPase-activating protein 4 (ARHGAP4) is an important negative regulator of the Rho signaling pathway that was asso...

journal_title：OncoTargets and therapy

authors： Shen Y,Chen G,Zhuang L,Xu L,Lin J,Liu L

更新日期：2019-06-28 00:00:00

abstract：:Tbx2 is a cancer-related protein that was found to be overexpressed in several human malignancies. The present study aims to investigate the clinical significance and biological role of Tbx2 in human astrocytoma. We examined its protein expression in 102 cases of astrocytoma tissues using immunohistochemical staining....

journal_title：OncoTargets and therapy

authors： Yi F,Du J,Ni W,Liu W

更新日期：2017-02-20 00:00:00

abstract：BACKGROUND:Associations between Arg399Gln single-nucleotide polymorphism (SNP) in the XRCC1 gene and leukemia susceptibility have been studied extensively, however, the results are inconsistent. The aim of this study was to determine these associations using meta-analytical methods. METHODS:A meta-analysis was perform...

journal_title：OncoTargets and therapy

authors： Wang F,Zhao Q,He HR,Zhai YJ,Lu J,Hu HB,Zhou JS,Yang YH,Li YJ

更新日期：2015-11-06 00:00:00

abstract：BACKGROUND:Pancreatic cancer is one of the most aggressive and intractable malignant tumors, and most deaths from pancreatic cancer are related to metastases. It has been demonstrated in vitro that overexpression of programmed death-ligand 1 (PD-L1) correlates with a lack of phosphatase and tensin homologue (PTEN) expr...

journal_title：OncoTargets and therapy

authors： Zhao L,Li C,Liu F,Zhao Y,Liu J,Hua Y,Liu J,Huang J,Ge C

更新日期：2017-04-12 00:00:00

abstract：BACKGROUND:Nivolumab (BMS-936558/ONO-4538) was the first monoclonal antibody targeting programmed death (PD)-1. So far, a number of clinical trials on nivolumab have showed satisfactory efficacy in treating non-small-cell lung cancer (NSCLC). Herein, we present a meta-analysis evaluating the efficacy and safety of nivo...

journal_title：OncoTargets and therapy

authors： Huang J,Zhang Y,Sheng J,Zhang H,Fang W,Zhan J,Zhou T,Chen Y,Liu L,Zhang L

更新日期：2016-09-23 00:00:00

abstract：Purpose:Breast cancer (BC) is the most common malignant cancer in women worldwide. Recently, long non-coding RNAs (LncRNAs) have been reported to have essential roles in BC tumorigenesis. Patients and Methods:Tumor and adjacent non-tumor tissue samples were collected from patients with BC (n = 168) for comparison of L...

journal_title：OncoTargets and therapy

authors： Zhang C,Wang J,Zhang J,Qu H,Tang X

更新日期：2020-06-12 00:00:00

abstract：Background:Naloxone is viewed as a specific competitive opioid antagonist acting at the level of opioid receptors (μ, δ, and κ) with blended agonist-adversary or agonist action. The role of naloxone in tumor cell growth has been poorly studied in human cancer cell lines. Materials and methods:In the present study, we ...

journal_title：OncoTargets and therapy

authors： Bimonte S,Barbieri A,Cascella M,Rea D,Palma G,Del Vecchio V,Forte CA,Del Prato F,Arra C,Cuomo A

更新日期：2018-01-03 00:00:00

abstract：Purpose:LINC00680 was reported to be involved in various cancers through multiple mechanisms. Therefore, we intended to investigate its role in the progression of non-small cell lung cancer (NSCLC). Materials and Methods:Firstly, quantitative real-time polymerase chain reaction (qRT-PCR) was used to test LINC00680 in ...

journal_title：OncoTargets and therapy

authors： Wang H,Feng L,Zheng Y,Li W,Liu L,Xie S,Zhou Y,Chen C,Cheng D

更新日期：2020-08-18 00:00:00

abstract：BACKGROUND:Persistent infection with high-risk human papillomavirus (HPV) is a predominant cause of cervical cancer, and HPV58 is the third most common virus detected in the patients with cervical cancer in Asia. E6 and E7 are the viral oncogenes which are constitutively expressed in HPV-associated tumor cells and can ...

journal_title：OncoTargets and therapy

authors： Wang H,Yu J,Li L

更新日期：2015-10-23 00:00:00

abstract：PURPOSE:We validated the use of expression sequence tags (ESTs) as an effective method of screening for DNA segments that could predict urothelial cell carcinoma and for identifying ESTs with such predictive value. PATIENTS AND METHODS:From 2004 to 2009, eleven patients were enrolled in this study: six with high-grade...

journal_title：OncoTargets and therapy

authors： Yang PS,Hsu YC,Lin YH,Hou CP,Chen CL,Chang PL,Juang HH,Tsui KH

更新日期：2014-09-30 00:00:00

abstract：:Basal cell carcinoma (BCC) is a common malignant tumor throughout the world. One of the known risk factors of BCC is intense exposure to ultraviolet radiation. More than 50% of BCCs of the eyelid initially occur on the lower lid. The gold standard of diagnosis of BCC is histopathology. Treatment options for BCC consis...

journal_title：OncoTargets and therapy

authors： Shi Y,Jia R,Fan X

更新日期：2017-05-08 00:00:00

abstract：:Historically, patients with locally advanced or metastatic melanoma have an extremely poor prognosis. In recent years, major breakthroughs in cutaneous melanoma treatment have led to remarkable improvements in patient outcomes. However, there are limited published data on the efficacy of these novel therapies in the t...

journal_title：OncoTargets and therapy

authors： Yu Z,Quiroz E,Shen Y,Jaiyesimi IA

更新日期：2018-12-04 00:00:00

abstract：BACKGROUND:The prognostic value of inflammatory index in esophageal cancer (EC) has not been established. In the present study, therefore, we initially evaluated a novel prognostic system, named the COCC (COmbination of C-reactive protein [CRP] and carcinoembryonic antigen [CEA]), for making a prognosis in patients wit...

journal_title：OncoTargets and therapy

authors： Huang Y,Liu JS,Feng JF

更新日期：2015-04-10 00:00:00

abstract：:Melanoma develops from melanocytes and typically occurs on the skin and mucosa with a high degree of malignancy. Intensive local invasion and distant metastasis of melanoma result in poor patient prognosis, owing to frequent metastases to the lungs, bones, brains, and other parts of the body. In the present study, we ...

journal_title：OncoTargets and therapy

authors： Feng L,Qi DJ,Zhang QF

更新日期：2016-08-10 00:00:00

abstract：:Recently, "ipilimumab," an anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) monoclonal antibody, has been demonstrated to improve overall survival in metastatic melanoma. "CTLA-4" is an immune-checkpoint molecule that downregulates pathways of T-cell activation. Ipilimumab, by targeting CTLA-4, is able to remove the CTL...

journal_title：OncoTargets and therapy

authors： Della Vittoria Scarpati G,Fusciello C,Perri F,Sabbatino F,Ferrone S,Carlomagno C,Pepe S

更新日期：2014-02-19 00:00:00

abstract：:Patients with Lynch Syndrome (LS) are at high risk of developing colorectal cancer at an early age. Germline mutations in DNA mismatch repair genes and microsatellite instability are clear signatures of this autosomal dominant disorder. Here, we report the clinical history of a 38-year-old patient with LS-related meta...

journal_title：OncoTargets and therapy

authors： Salman P,Panay S,Fernández R,Mahave M,Soza-Ried C

更新日期：2018-10-23 00:00:00

abstract：Background:Several trials evaluated the role of intensive regimens, made of triplet chemotherapies plus bevacizumab, as first-line treatment for patients with metastatic colorectal cancer (mCRC). We previously reported, in a Phase II prospective study, the efficacy and the tolerability of FIrB/FOx regimen, reporting in...

journal_title：OncoTargets and therapy

authors： Cortellini A,Cannita K,Parisi A,Lanfiuti Baldi P,Venditti O,D'Orazio C,Dal Mas A,Calvisi G,Giordano AV,Vicentini V,Vicentini R,Felicioni L,Marchetti A,Buttitta F,Russo A,Ficorella C

更新日期：2019-03-25 00:00:00

abstract：Purpose:MicroRNA-939 (miR-939) has crucial roles in several types of human cancer. However, the expression profile and precise functions of miR-939 in prostate cancer (PCa) are still unclear. This study aimed to determine miR-939 expression in PCa and explore its roles in PCa tumorigenesis. Methods:miR-939 expression ...

journal_title：OncoTargets and therapy

authors： Situ J,Zhang H,Jin Z,Li K,Mao Y,Huang W

更新日期：2020-05-18 00:00:00

abstract：:Despite improvements in multidisciplinary treatments, survival of pancreatic cancer (PC) patients remains dismal. Studies dealing with early onset pancreatic cancer (EOPC) patients are scarce. In this review, we discuss differences between EOPC and late-onset pancreatic cancer based on findings in original papers and ...

journal_title：OncoTargets and therapy

authors： Primavesi F,Stättner S,Schlick K,Kiesslich T,Mayr C,Klieser E,Urbas R,Neureiter D

更新日期：2019-05-06 00:00:00

abstract：Purpose:Cervical squamous cell carcinoma (CSCC) seriously affects women's health worldwide, and it is of great significance to illuminate the specific role of circRNAs in CSCC. Materials and Methods:Three mRNA datasets, two miRNA datasets and one circRNA dataset of CSCC, downloaded from GEO, were utilized in this stud...

journal_title：OncoTargets and therapy

authors： Wu Q,Liu P,Lao G,Liu Y,Zhang W,Ma C

更新日期：2020-08-25 00:00:00

abstract：BACKGROUND:The purpose of this study was to investigate the prognosis of ipsilateral supraclavicular lymph node metastasis (ISLM) without evidence of distant metastases at diagnosis in Chinese women with breast cancer and to elucidate the clinical value of adjuvant radiotherapy. METHODS:We performed a retrospective an...

journal_title：OncoTargets and therapy

authors： Wu SG,Sun JY,Zhou J,Li FY,Lin Q,Lin HX,He ZY

更新日期：2014-02-15 00:00:00

abstract：:Lung cancer has the highest morbidity and mortality in the world, and non-small cell lung carcinomas (NSCLC) account for 80% of cases of lung cancer. The mechanism of NSCLC is still largely unknown, and finding novel targets is of great importance for the treatment of NSCLC. The current study was designed to evaluate ...

journal_title：OncoTargets and therapy

authors： He M,Xue Y

更新日期：2017-03-02 00:00:00

abstract：Objective:Growing epidemiological evidence supports that coagulation cascades and cancer-associated inflammation are associated with recurrence and survival of epithelial ovarian cancer (EOC). This study aimed to assess the clinical significance of the combination of plasm fibrinogen and neutrophil lymphocyte ratio (F-...

journal_title：OncoTargets and therapy

authors： Yang J,Ma J,Cheng S,Wang Y

更新日期：2020-07-27 00:00:00

abstract：:Targeted radioimmunotherapy in non-Hodgkin's B-cell lymphoma (NHL) offers an efficacious therapy and minimal toxicity compared to conventional chemotherapy. Iodine 131 tositumomab ((131)I-TST) is a murine monoclonal antibody against the CD20 cell surface protein and is directly covalently conjugated to (131)I, a radio...

journal_title：OncoTargets and therapy

authors： Burdick MJ,Macklis RM

更新日期：2009-02-18 00:00:00

abstract：:The association between polymorphic CAG repeats in the androgen receptor gene in women and breast cancer susceptibility has been studied extensively. However, the conclusions regarding this relationship remain conflicting. The purpose of this meta-analysis was to identify whether androgen receptor CAG repeat lengths w...

journal_title：OncoTargets and therapy

authors： Mao Q,Qiu M,Dong G,Xia W,Zhang S,Xu Y,Wang J,Rong Y,Xu L,Jiang F

更新日期：2015-08-13 00:00:00