ARHGAP4 mediates the Warburg effect in pancreatic cancer through the mTOR and HIF-1α signaling pathways.

abstract：Background and objective:Transcriptional coactivator with PDZ-binding motif (TAZ) has been found to be associated with tumor progression. Mitochondrial homeostasis regulates cancer cell viability and metastasis. However, the roles of TAZ and mitochondrial homeostasis in liver cancer viability have not been explored. Th...

journal_title：OncoTargets and therapy

authors： Hou Y,Lan C,Kong Y,Zhu C,Peng W,Huang Z,Zhang C

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:To evaluate whether the addition of two biological markers (MYC and BCL-2 protein overexpression) improves the stratification of high-risk patients with diffuse large B-cell lymphoma (DLBCL). METHOD:Seven risk factors were identified at diagnosis, and a maximum of 7 points were assigned to each patient. The pa...

journal_title：OncoTargets and therapy

authors： Wang J,Zhou M,Xu JY,Chen B,Ouyang J

更新日期：2015-09-18 00:00:00

abstract：:Intrahepatic cholangiocarcinomas (IHCCs) are morphologically and biologically similar to pancreatic ductal adenocarcinomas (PDACs), so newly identified PDAC-associated genes or proteins could provide clues for screening novel biomarkers for IHCC. In this study, the expression of three novel PDAC tumor markers (T-box t...

journal_title：OncoTargets and therapy

authors： Zong M,Jia L,Li L

更新日期：2013-01-01 00:00:00

abstract：Background and aims:Studies show that the long non-coding RNA, SBF2-AS1, plays a critical role in cancer progression, but the role of SBF2-AS1 in gastric cancer has not been reported. Therefore, this study aimed to elucidate the mechanism of SBF2-AS1 in gastric cancer (GC). Methods:A meta-analysis, based on the gene e...

journal_title：OncoTargets and therapy

authors： Liang C,Yue C,Liang C,Ge H,Wei Z,Li G,Wu J,Huang H,Guo J

更新日期：2019-10-30 00:00:00

abstract：Purpose:Several studies have proved that single nucleotide polymorphisms (SNPs) of mismatch repair system genes are closely related to the development of colorectal cancer (CRC) by causing microsatellite instability, while effects of the SNPs of MMR system-related genes on the clinical outcomes of cytotoxic chemotherap...

journal_title：OncoTargets and therapy

authors： Wang D,Zhang X,Zhang Y,Wu Y,Guan X,Zhu W,Wang M,Qi C,Shen B

更新日期：2018-11-13 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) have transformed the therapeutic strategy and prognosis of advanced non-small cell lung cancer (NSCLC) patients. Nowadays, ICIs as monotherapy or in combination with chemotherapy are the standard of care treatment in advanced NSCLC, and in stage III, durvalumab (a programmed death l...

journal_title：OncoTargets and therapy

authors： Gullapalli S,Remon J,Hendriks LEL,Lopes G

更新日期：2020-07-14 00:00:00

abstract：Background:Paclitaxel is widely used in the treatment of cancer and has a good effect in the treatment of non-small cell lung cancer. The combination of TMT proteomics and bioinformatics is used to systematically analyze the molecular mechanism of paclitaxel in the treatment of lung adenocarcinoma A549 cell, which is h...

journal_title：OncoTargets and therapy

authors： Zheng W,Xu S

更新日期：2020-10-13 00:00:00

abstract：BACKGROUND:Experimental disruption of the telomere overhang induces a potent DNA damage response and is the target of newly emerging cancer therapeutics. Introduction of T-oligo, an eleven-base oligonucleotide homologous to the 3'-telomeric overhang, mimics telomere disruption and induces DNA damage responses through a...

journal_title：OncoTargets and therapy

authors： Mulnix RE,Pitman RT,Retzer A,Bertram C,Arasi K,Crees Z,Girard J,Uppada SB,Stone AL,Puri N

更新日期：2013-12-18 00:00:00

abstract：:Patients with Lynch Syndrome (LS) are at high risk of developing colorectal cancer at an early age. Germline mutations in DNA mismatch repair genes and microsatellite instability are clear signatures of this autosomal dominant disorder. Here, we report the clinical history of a 38-year-old patient with LS-related meta...

journal_title：OncoTargets and therapy

authors： Salman P,Panay S,Fernández R,Mahave M,Soza-Ried C

更新日期：2018-10-23 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is often diagnosed at late incurable stage and lacks effective treatment strategy. Bufadienolides are cardiotonic steroids isolated from the skin and parotid venom glands of the toad Bufo bufo gargarizans Cantor with novel anticancer activity. However, there is little informat...

journal_title：OncoTargets and therapy

authors： Lv J,Lin S,Peng P,Cai C,Deng J,Wang M,Li X,Lin R,Lin Y,Fang A,Li Q

更新日期：2017-02-28 00:00:00

abstract：:Triple-negative breast cancer is associated with a poor prognosis, and effective biomarkers for targeted diagnosis and treatment are lacking. The tumorigenicity of the provirus integration site for Moloney murine leukemia virus 1 (PIM-1) gene has been studied for many years. However, its significance in breast cancer ...

journal_title：OncoTargets and therapy

authors： Chen J,Tang G

更新日期：2019-08-08 00:00:00

abstract：:To date, 10 years after the first demonstration of circulating tumor cells (CTCs), prognostic significance in metastatic breast cancer using the US Food and Drug Administration-cleared system CellSearch(®), the potential utility of CTCs in early clinical development of drugs, their role as a surrogate marker of respon...

journal_title：OncoTargets and therapy

authors： Raimondi C,Gradilone A,Naso G,Cortesi E,Gazzaniga P

更新日期：2014-04-17 00:00:00

abstract：:Giant-cell carcinoma of the lung (GCCL) is a rare histological form of poorly differentiated non-small-cell lung cancer, which is classified as a subtype of pulmonary sarcomatoid carcinomas. In this case report, we describe the case of a 50-year-old Chinese male who presented with a pulmonary nodule in the right upper...

journal_title：OncoTargets and therapy

authors： Li X,Zhang Z,Liu J,Wang D,Wei S,Chen J

更新日期：2018-02-09 00:00:00

abstract：Introduction:Gastric cancer (GC) is one of the most malignancies leading to human mortality due to its development, progress, metastasis and poor prognosis, despite the development of remarkable chemotherapy and surgery. The 5-fluorouracil (5-Fu) is an effective anti-gastric cancer agent. However, a fraction of GC patie...

journal_title：OncoTargets and therapy

authors： Gao S,Song D,Liu Y,Yan H,Chen X

更新日期：2020-07-01 00:00:00

abstract：Purpose:The molecular mechanism of perineural invasion (PNI) in stage II colorectal cancer (CRC) remains not to be defined clearly. This study aims to identify the genomic aberrations related to PNI in stage II CRC. Patients and Methods:Using array-based comparative genomic hybridization (array-CGH), primary tumor tis...

journal_title：OncoTargets and therapy

authors： Su H,Chang C,Hao J,Xu X,Bao M,Luo S,Zhao C,Liu Q,Wang X,Zhou Z,Zhou H

更新日期：2020-11-11 00:00:00

abstract：Background:The non-receptor tyrosine kinase Fyn-related kinase (FRK) has been reported to affect cell proliferation in several cancer types. However, its effect on the proliferation of clear cell renal cell carcinoma (ccRCC) remains largely unknown. Purpose:The objective of this study was to investigate the expression...

journal_title：OncoTargets and therapy

authors： Jing ZF,Bi JB,Li ZL,Liu XK,Li J,Zhu YY,Zhang XT,Zhang Z,Li ZH,Kong CZ

更新日期：2019-04-10 00:00:00

abstract：Purpose:The clinical studies carried out in the last few decades unequivocally introduced activated androgen receptor (AR) as a pathogenic feature of human malignancies which not only endows cancer cells with survival advantage, but also may be exploited for anticancer interventions. Patients and Methods:In this study...

journal_title：OncoTargets and therapy

authors： Soleymani Fard S,Yazdanbod M,Sotoudeh M,Bashash D,Mahmoodzadeh H,Saliminejad K,Mousavi SA,Ghaffari SH,Alimoghaddam K

更新日期：2020-10-02 00:00:00

abstract：Background:Non-small-cell lung cancer (NSCLC) is the major leading cause of cancer-related death around the world. The resistance to chemotherapy limits the effects of clinical treatment. The aim of this study was to identify novel mechanisms involved in NSCLC chemoresistance. Materials and methods:We explored the pub...

journal_title：OncoTargets and therapy

authors： Wang W,Han T,Tong W,Zhao J,Qiu X

更新日期：2018-09-26 00:00:00

abstract：Background:Pancreatic cancer is one of the most lethal malignancies. Accumulating evidence supports for the critical contribution of long noncoding RNAs (lncRNAs) to the cancer development and progression. We tried to identify novel lncRNAs involved in the pancreatic carcinogenesis. Materials and Methods:Two independe...

journal_title：OncoTargets and therapy

authors： Chen G,Xu L,Ye G,Lin J,Meng Z,Shen Y

更新日期：2021-01-05 00:00:00

abstract：:Advances in therapies have led to the approval of six therapeutic agents since 2004, each demonstrating overall survival benefit in randomized studies, and these have significantly improved the outlook for men facing metastatic castration-resistant prostate cancer (CRPC). More recently, efforts have been directed at t...

journal_title：OncoTargets and therapy

authors： Chong JT,Oh WK,Liaw BC

更新日期：2018-04-12 00:00:00

abstract：:The central nervous system (CNS) is regarded as an immune privileged environment; however, changes in the neuroimmunology paradigm have led to an increased interest in systematic immunotherapy in lung cancer therapy. The presence of the lymphatic system in the CNS as well as the physiological and biochemical changes i...

journal_title：OncoTargets and therapy

authors： Wang S,Hu C,Xie F,Liu Y

更新日期：2020-01-23 00:00:00

abstract：:Purpose: NSD3 (WHSC1L1) is a protein lysine methyltransferase that is recurrently amplified (8p11.23) in several cancer types, and its upregulation is involved in tumor cell proliferation, metastasis, and epithelial-mesenchymal transition (EMT). We aimed to evaluate its potential function as an oncogenic force in colo...

journal_title：OncoTargets and therapy

authors： Yi L,Yi L,Liu Q,Li C

更新日期：2019-05-21 00:00:00

abstract：OBJECTIVE:To assess the need for pulmonary surgery in the treatment of refractory gestational trophoblastic neoplasia with lung metastasis after normalization of serum beta human chorionic gonadotropin (β-hCG) level with salvage chemotherapy. MATERIALS AND METHODS:A review of medical records of patients with refractor...

journal_title：OncoTargets and therapy

authors： Feng F,Hu H,Wu L,Ren T,Wan X,Xiang Y

更新日期：2014-01-29 00:00:00

abstract：Aim:To explore the expression and clinical significance of long noncoding RNA (lncRNA) gastric cancer-associated transcript 3 (GACAT3) in human colorectal cancer (CRC). Methods:Expression of GACAT3 in CRC tissues and cell lines was measured using quantitative real-time PCR. CCK-8 and colony formation assays were used ...

journal_title：OncoTargets and therapy

authors： Zhou W,Wang L,Miao Y,Xing R

更新日期：2018-03-19 00:00:00

abstract：Background:Although there have been great advances in mechanisms and therapeutic methods of prostate cancer, the mortality rate of prostate cancer remains high. The castration-resistant prostate cancer (CRPC), which develops from hormone-sensitive prostate cancer, foreshadows a more dismal outcome. Concomitant with the...

journal_title：OncoTargets and therapy

authors： Wang K,Ruan H,Xu T,Liu L,Liu D,Yang H,Zhang X,Chen K

更新日期：2018-05-28 00:00:00

abstract：Purpose:Hepatocellular carcinoma (HCC) has a high incidence in China and exploring effective ways for early diagnosis is an important method to improve the prognosis of patients with HCC. Additional studies reported that. Some kinds of microRNA (miRNA) in plasma will change accordingly during HCC progress, and this cha...

journal_title：OncoTargets and therapy

authors： Wang S,Yang Y,Sun L,Qiao G,Song Y,Liu B

更新日期：2020-03-09 00:00:00

abstract：:Patients with papillary thyroid cancer (PTC) generally have good prognosis, but inoperable and radioactive iodine-refractory PTC still poses significant clinical challenges due to lack of effective treatment and higher mortality rates. Given the important role of integrins in multiple steps of tumor development, integ...

journal_title：OncoTargets and therapy

authors： Cheng W,Feng F,Ma C,Wang H

更新日期：2016-03-11 00:00:00

abstract：Background:Gastric cancer (GC) is an aggressive malignancy with high lethality. Systematic chemotherapy is the main therapeutic strategy for advanced GC patients. The overexpression of Axl is associated with poor prognosis and regulates tumor growth and metastasis in many types of cancer. However, the role of Axl in GC...

journal_title：OncoTargets and therapy

authors： He L,Lei Y,Hou J,Wu J,Lv G

更新日期：2020-06-22 00:00:00

abstract：:The antidiabetic drug metformin has been shown to possess antitumor functions in many types of cancers. Although studies have revealed its beneficial effects on the prognosis of hepatocellular carcinoma (HCC), the detailed molecular mechanism underlying this event remains largely unknown. In this work, we showed that ...

journal_title：OncoTargets and therapy

authors： Sun Y,Tao C,Huang X,He H,Shi H,Zhang Q,Wu H

更新日期：2016-05-12 00:00:00

abstract：:Esophageal carcinoma (EC) is a lethal disease with high morbidity and mortality worldwide, and the incidence has been increasing in recent years. Although the diagnosis and treatment of EC have improved considerably, EC has rapidly progressed in the clinical setting and has a poor prognosis for its metastasis and recu...

journal_title：OncoTargets and therapy

authors： Qian X,Tan C,Wang F,Yang B,Ge Y,Guan Z,Cai J

更新日期：2016-04-19 00:00:00