Long Non-Coding RNA CASC9 And HIF-1α Form A Positive Feedback Loop To Facilitate Cell Proliferation And Metastasis In Lung Cancer.

abstract：:HES1 is the target of Notch signaling which is reported to affect cell differentiation and maintain the cells in G0 phase in various tissues including the hematopoietic tissue. HES1 expression appears to be an independent prognostic factor for survival in a heterogeneous group of acute myeloid leukemia (AML) patients....

journal_title：OncoTargets and therapy

authors： Tian C,Tang Y,Wang T,Yu Y,Wang X,Wang Y,Zhang Y

更新日期：2015-04-22 00:00:00

abstract：:The association between polymorphic CAG repeats in the androgen receptor gene in women and breast cancer susceptibility has been studied extensively. However, the conclusions regarding this relationship remain conflicting. The purpose of this meta-analysis was to identify whether androgen receptor CAG repeat lengths w...

journal_title：OncoTargets and therapy

authors： Mao Q,Qiu M,Dong G,Xia W,Zhang S,Xu Y,Wang J,Rong Y,Xu L,Jiang F

更新日期：2015-08-13 00:00:00

abstract：:Quercetin is proven to have anticancer effects for many cancers. However, the role of tumor suppressor p53 on quercetin's radiosensitization and regulation of endoplasmic reticulum (ER) stress response in this process remains obscure. Here, quercetin exposure resulted in ER stress, prolonged DNA repair, and the expres...

journal_title：OncoTargets and therapy

authors： Gong C,Yang Z,Zhang L,Wang Y,Gong W,Liu Y

更新日期：2017-12-21 00:00:00

abstract：:Aberrant promoter methylation of RUNX3 has been reported in several tumors including human breast cancer (BC). However, the association between RUNX3 hypermethylation and incidence of BC remains elusive. In this study, a detailed literature search was performed in Medline and Google Scholar for related research public...

journal_title：OncoTargets and therapy

authors： Song XY,Li BY,Zhou EX,Wu FX

更新日期：2016-08-26 00:00:00

abstract：:Neuroendocrine tumors are a rare and heterogeneous group of tumors with a variety of primary origins and variable aggressiveness. Platinum-based chemotherapy has been the cornerstone of treatment for the poorly differentiated tumors. However, well-differentiated neuroendocrine tumors are quite chemoresistant and thera...

journal_title：OncoTargets and therapy

authors： Kotteas EA,Syrigos KN,Saif MW

更新日期：2016-02-09 00:00:00

abstract：Introduction:Previous trials demonstrated that anti-angiogenesis or anti-programmed death protein 1 (PD-1) monotherapy showed unsatisfied effect in advanced hepatocellular carcinoma (HCC). No study existed that focus on the effects of camrelizumab and apatinib ("C+A") combination therapy for HCC patients with the locat...

journal_title：OncoTargets and therapy

authors： Yuan G,Cheng X,Li Q,Zang M,Huang W,Fan W,Wu T,Ruan J,Dai W,Yu W,Chen M,Guo Y,Hu X,Chen J

更新日期：2020-12-09 00:00:00

abstract：Background:Abnormal miR-27a-3p expression has been frequently reported in several types of human cancer and contributes to tumor progression. However, the role and potential molecular mechanism of miR-27a-3p in the progression of pancreatic carcinoma have not been clarified. Materials and methods:The expression of miR...

journal_title：OncoTargets and therapy

authors： Rao X,Wan L,Jie Z,Zhu X,Yin J,Cao H

更新日期：2019-12-19 00:00:00

abstract：:Bladder cancer (BC) is a common urinary system tumor with high aggressiveness, and it results in relatively high mortality due to a lack of precise and suitable biomarkers. In this study, we applied the weighted gene coexpression network analysis method to miRNA expression data from BC patients, and screened for netwo...

journal_title：OncoTargets and therapy

authors： Zhao F,Ge YZ,Zhou LH,Xu LW,Xu Z,Ping WW,Wang M,Zhou CC,Wu R,Jia RP

更新日期：2017-11-22 00:00:00

abstract：:Iliac vein-ureteral fistula is a rare cause of hematuria. The diagnosis of an iliac vein-ureteral fistula can be elusive even with the use of multiple methods. With regards to the treatment, there appears to be a shift in management from primarily open surgical to primarily angiographic management. We present a unique...

journal_title：OncoTargets and therapy

authors： Luo JD,Liu B,Wang P,Zhou F,Xu XL,Li SQ,Cai SL,Wang YM

更新日期：2014-07-23 00:00:00

abstract：OBJECTIVE:To explore the clinical significance of 3-phosphoinositide-dependent protein kinase-1 (PDK1) expression in hepatocellular carcinoma (HCC) and its association with clinicopathologic features and prognosis in HCC patients. MATERIALS AND METHODS:A total of 128 HCC patients who received radical resection were en...

journal_title：OncoTargets and therapy

authors： Wang J,Liu F,Ao P,Li X,Zheng H,Wu D,Zhang N,She J,Yuan J,Wu X

更新日期：2016-09-09 00:00:00

abstract：Introduction:Immune-based and antibody-drug conjugate therapies have shown promise in the treatment of patients with small cell lung cancer (SCLC). However, better predictive biomarkers are needed for selection of the appropriate SCLC patients for these advanced therapies and also for evaluation of the efficacy of thes...

journal_title：OncoTargets and therapy

authors： Regzedmaa O,Li Y,Li Y,Zhang H,Wang J,Gong H,Yuan Y,Li W,Liu H,Chen J

更新日期：2019-11-21 00:00:00

abstract：:Discovered in 2007, anaplastic lymphoma kinase (ALK) gene rearrangements positive (ALK+) lung cancers compose a small subset of non-small cell lung cancer (NSCLC), with rapidly expanded treatments. There are currently several ALK inhibitors, including crizotinib, ceritinib, alectinib, brigatinib, and lorlatinib which ...

journal_title：OncoTargets and therapy

authors： Karachaliou N,Fernandez Bruno M,Bracht JWP,Rosell R

更新日期：2019-06-13 00:00:00

abstract：Introduction:Melanoma is a common skin cancer that is usually associated with poor clinical outcomes. Recently, the immune checkpoint GITR has been identified as a promising target for immunotherapy of melanoma. In this study, we aimed to investigate the post-translational regulation mechanism of GITR in melanoma. Met...

journal_title：OncoTargets and therapy

authors： Guo Y,Yang L,Lei S,Tan W,Long J

更新日期：2019-12-04 00:00:00

abstract：Background:Immunosenescence, the age-related decline of immunity, affects the immune responses of melanoma patients. Through immune responses, immune checkpoint inhibitors (ICIs) exert their antitumor robustness. In different ages of melanoma patients, especially the older patients, the effectiveness of ICIs remains un...

journal_title：OncoTargets and therapy

authors： Li P,Yang X,Feng Y,Wu L,Ma W,Ding G,Wei Y,Sun L

更新日期：2018-10-26 00:00:00

abstract：Purpose:This study aimed to investigate the regulatory roles of estrogen receptor beta (ERβ) on gastric cancer (GC) cells, and reveal the potential mechanisms relating to nuclear factor-kappa B (NF-κB) signaling. Methods:GC cell lines SGC7901 and MKN45 were transfected with pEGFP-C1-ERβ to overexpress ERβ, and treated...

journal_title：OncoTargets and therapy

authors： Zhang Y,Wu Y,Zhou X,Yi B,Wang L

更新日期：2019-11-05 00:00:00

abstract：:Purpose: LncRNA MIR100HG promotes several types of malignancies, while its involvement in other human diseases is unknown. Patients and methods: Our study included 70 patients with LSCC who were diagnosed and treated in the First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and T...

journal_title：OncoTargets and therapy

authors： Huang Y,Zhang C,Zhou Y

更新日期：2019-04-17 00:00:00

abstract：Purpose:The clinical studies carried out in the last few decades unequivocally introduced activated androgen receptor (AR) as a pathogenic feature of human malignancies which not only endows cancer cells with survival advantage, but also may be exploited for anticancer interventions. Patients and Methods:In this study...

journal_title：OncoTargets and therapy

authors： Soleymani Fard S,Yazdanbod M,Sotoudeh M,Bashash D,Mahmoodzadeh H,Saliminejad K,Mousavi SA,Ghaffari SH,Alimoghaddam K

更新日期：2020-10-02 00:00:00

abstract：BACKGROUND:Leucine-rich glioma inactivated 3 (LGI3) is a secreted protein member of LGI family. We previously reported that LGI3 was expressed in brain, adipose tissues and skin, where it played roles as a multifunctional cytokine. We postulated that LGI3 may be involved in cytokine network in cancers. AIM:This study ...

journal_title：OncoTargets and therapy

authors： Kwon NS,Kim DS,Yun HY

更新日期：2017-05-24 00:00:00

abstract：:Activation of the transcription factor, signal transducers and activators of transcription 3 (STAT3), has been linked to the proliferation and migration of a variety of human cancer cells. These actions occur via the upregulation or downregulation of cell survival and tumor suppressor genes, respectively. Importantly,...

journal_title：OncoTargets and therapy

authors： Wang G,Jing Y,Cao L,Gong C,Gong Z,Cao X

更新日期：2016-12-20 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is often diagnosed at late incurable stage and lacks effective treatment strategy. Bufadienolides are cardiotonic steroids isolated from the skin and parotid venom glands of the toad Bufo bufo gargarizans Cantor with novel anticancer activity. However, there is little informat...

journal_title：OncoTargets and therapy

authors： Lv J,Lin S,Peng P,Cai C,Deng J,Wang M,Li X,Lin R,Lin Y,Fang A,Li Q

更新日期：2017-02-28 00:00:00

abstract：Purpose:To evaluate the capability of 18F-fluorodeoxyglucose positron emission tomography/ computed tomography (18F-FDG-PET/CT) to predict the clinical response of metastatic lymph node (mLN) to definitive chemoradiotherapy (dCRT) and guide personalized radiation dose in esophageal squamous cell carcinoma (ESCC) patien...

journal_title：OncoTargets and therapy

authors： Zhu W,Zhang Y,Kong L,Huang Y,Zheng J,Wang R,Li M,Yu J

更新日期：2018-07-25 00:00:00

abstract：OBJECTIVE:To investigate the effects of microRNA-122 (miR-122) on proliferation, migration, and invasion in human hepatocellular carcinoma (HCC) cells by activating epithelial-mesenchymal transition (EMT) pathways. METHODS:miR-122 mimics, miR-122 inhibitors, relevant control oligonucleotides, and Wnt1 were transfected...

journal_title：OncoTargets and therapy

authors： Wang N,Wang Q,Shen D,Sun X,Cao X,Wu D

更新日期：2016-04-06 00:00:00

abstract：Aim:To explore the expression and clinical significance of long noncoding RNA (lncRNA) gastric cancer-associated transcript 3 (GACAT3) in human colorectal cancer (CRC). Methods:Expression of GACAT3 in CRC tissues and cell lines was measured using quantitative real-time PCR. CCK-8 and colony formation assays were used ...

journal_title：OncoTargets and therapy

authors： Zhou W,Wang L,Miao Y,Xing R

更新日期：2018-03-19 00:00:00

abstract：Background:Pulsed electric field (PEF) has been considered as a cell permeability enhancing agent for cancer treatment. Nevertheless, application of PEF for conventional electrochemo-therapy is usually at high intensity, and contact or even invasive electrodes are typically used, which may cause unwanted side effects. ...

journal_title：OncoTargets and therapy

authors： Lu CH,Lin SH,Hsieh CH,Chen WT,Chao CY

更新日期：2018-08-10 00:00:00

abstract：:Background: Circ-SHPRH is a novel circular RNA which was down-regulated in various cancer tissues. Several recent studies hinted that circ-SHPRH might function as a diagnostic and prognostic biomarker for solid cancers. This meta-analysis was performed to determine the diagnostic and prognostic roles of circ-SHPRH for...

journal_title：OncoTargets and therapy

authors： Li F,Huang Q,Gong Z,Wang H,Chen J

更新日期：2019-05-31 00:00:00

abstract：Introduction:Cyclophosphamide, which is widely used to treat malignant disease, causes ovarian follicular atresia, which leads to premature ovarian insufficiency. The present study evaluated the protective effect of testosterone in preventing the decline in the ovarian reserve during cyclophosphamide treatment. Method...

journal_title：OncoTargets and therapy

authors： Yoo M,Tanaka T,Konishi H,Tanabe A,Taniguchi K,Komura K,Hayashi M,Ohmichi M

更新日期：2020-04-08 00:00:00

abstract：Background:Gastric cancer (GC) is one of the most common malignant tumors and the second most frequent cause of cancer death worldwide. Crocin is a kind of bioactive constituent found in the stigmas of saffron, which has shown various pharmacological activities. Methods:In this study, we investigated the inhibitory ef...

journal_title：OncoTargets and therapy

authors： Luo Y,Yu P,Zhao J,Guo Q,Fan B,Diao Y,Jin Y,Wu J,Zhang C

更新日期：2021-01-07 00:00:00

abstract：Objective:The objective of this study was to investigate the safety of robotic stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma (HCC) patients and its related factors. Methods:A total of 74 HCC patients with Child-Turcotte-Pugh (CTP) Class A were included in a multi-institutional, single-arm Pha...

journal_title：OncoTargets and therapy

authors： Liu X,Song Y,Liang P,Su T,Zhang H,Zhao X,Yuan Z,Wang P

更新日期：2017-11-06 00:00:00

abstract：:Metastases from melanoma have a very poor prognosis for the patient. Single metastatic lesions in the sternum due to melanoma are extremely rare. A rare case of a presternal mass in a 56-year-old patient who had undergone excision for malignant melanoma is presented. Review of the patient's history and surgical resect...

journal_title：OncoTargets and therapy

authors： Gogakos AS,Paliouras D,Asteriou C,Rallis T,Lazopoulos A,Chatzinikolaou F,Zissimopoulos A,Tsavlis D,Tsirgogianni K,Zarogoulidis K,Porpodis K,Tsakiridis K,Pitsiou G,Kioumis I,Karapantzos I,Karapantzou C,Sachpekidis N,Zaro

更新日期：2016-01-18 00:00:00

abstract：OBJECTIVE:This study aims to investigate the potential benefit of combination therapy with magnetic nanoparticles of Fe3O4 (Fe3O4-MNP) and gambogic acid (GA) on SMMC-7721 cells. METHODS:The inhibition of proliferation of SMMC-7721 cells was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assa...

journal_title：OncoTargets and therapy

authors： Tian L,Chen BA,Cheng J,Guo QL

更新日期：2015-08-26 00:00:00