Abstract:
:Tamoxifen was the first targeted anticancer agent for breast cancer patients and its effects on reduction of breast cancer events and improvement in overall survival are undisputed. Hence, it has long been considered an essential part of patient care. Recent results of several large adjuvant hormonal trials evaluating the use of aromatase inhibitors in comparison with the previous standard of five years of tamoxifen has led to a paradigm shift, ensuring the inclusion of an aromatase inhibitor as part of standard endocrine therapy for most postmenopausal women diagnosed today with estrogen receptor-positive breast cancer. However, one could argue that despite statistically significant improvements in breast cancer events, an overall survival advantage has not been clear. In this review, we discuss recent genomic and molecular data pertaining to estrogen receptor-positive breast cancer and how this knowledge may aid clinicians to prescribe adjuvant hormonal treatment in the future. A combination of gene expression and genetic aberration markers may be most useful in discerning a population that is still appropriate for adjuvant tamoxifen treatment.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Criscitiello C,Fumagalli D,Saini KS,Loi Sdoi
10.2147/OTT.S10155subject
Has Abstractpub_date
2010-12-17 00:00:00pages
1-11issn
1178-6930journal_volume
4pub_type
杂志文章abstract::Forkhead box protein O1 (FOXO1) is a multifunctional transcription factor of the forkhead family. It may function as a tumor suppressor through its ability to regulate cellular events, including cell proliferation, apoptosis, and cell cycle control. As reported, FOXO1 is downregulated in papillary thyroid carcinoma (P...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S95395
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVES:PD-1/PD-L1 and CTLA-4 have been investigated and are thought to play an important role in tumor evasion. This study aimed to investigate expression patterns of immune-related molecules, and their clinical impacts in malignant salivary gland tumors. PATIENTS AND METHODS:We performed immunohistochemical stain...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S134589
更新日期:2017-06-13 00:00:00
abstract::This study tested the potential of circulating RNA-based signals as predictive biomarkers for docetaxel response in patients with metastatic castration-resistant prostate cancer (CRPC). RNA was analyzed in blood from six CRPC patients by whole-transcriptome sequencing (total RNA-sequencing) before and after docetaxel ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S86637
更新日期:2015-07-30 00:00:00
abstract::The aim of this study was to evaluate the efficacy and toxicity of stereotactic body radiation therapy (SBRT) in the treatment of patients with liver metastases. Between August 2006 and July 2011, patients with 1-4 liver metastases were enrolled and treated with SBRT using the CyberKnife(®) system at Tianjin Medical U...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S58409
更新日期:2014-06-12 00:00:00
abstract:Background:The aberrant expression of circular RNAs (circRNAs) has been identified as a novel trait of cancers. However, the role of circRNAs in colorectal cancer (CRC) remains to be elucidated. Methods:Informatic analysis was performed to identify circRNAs in CRC tissues and adjacent tissues. Gain- and loss-of-functi...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S255485
更新日期:2020-06-30 00:00:00
abstract:BACKGROUND:Tumor cells before and after epidermal growth-factor receptor (EGFR) tyrosine-kinase inhibitor (TKI) therapy might display different characteristics. The aim of this study was to evaluate the influence of prior EGFR TKI therapy on the efficacy of subsequent pemetrexed plus platinum (PP) in advanced chemonaïv...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S62639
更新日期:2014-05-23 00:00:00
abstract::In the last decade, the advent of biological targeted therapies has revolutionized the management of several types of cancer, especially in the realm of hematologic malignancies. One of these pathways, and the center of this review, is the phosphatidylinositol-3-kinase (PI3K) pathway. The PI3K pathway seems to play an...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S34641
更新日期:2014-02-21 00:00:00
abstract:Purpose:LINC00680 was reported to be involved in various cancers through multiple mechanisms. Therefore, we intended to investigate its role in the progression of non-small cell lung cancer (NSCLC). Materials and Methods:Firstly, quantitative real-time polymerase chain reaction (qRT-PCR) was used to test LINC00680 in ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S259232
更新日期:2020-08-18 00:00:00
abstract:Background:Esophageal cancer (EC) is one of the aggressive gastrointestinal malignancies. It has been reported that microRNAs (miRNAs) play key roles during the tumorigenesis of EC. To identify novel potential targets for EC, differential expressed miRNAs (DEG) between EC and adjacent normal tissues were analyzed with ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S251508
更新日期:2020-09-24 00:00:00
abstract:Purpose:Colorectal cancer (CRC) is a leading cause of cancer-associated mortality worldwide. Natural antisense transcripts (NATs) are pervasively expressed in human genome and have been confirmed to contribute to cancer progression. In our study, we aimed to investigate the expression and clinical pertinence of serine ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S163883
更新日期:2018-07-10 00:00:00
abstract:Introduction:Cyclophosphamide, which is widely used to treat malignant disease, causes ovarian follicular atresia, which leads to premature ovarian insufficiency. The present study evaluated the protective effect of testosterone in preventing the decline in the ovarian reserve during cyclophosphamide treatment. Method...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S242703
更新日期:2020-04-08 00:00:00
abstract::[This corrects the article DOI: 10.2147/OTT.S262089.]. ...
journal_title:OncoTargets and therapy
pub_type: 已发布勘误
doi:10.2147/OTT.S292577
更新日期:2020-11-27 00:00:00
abstract::Huaier (Trametes robiniophila Murr), a Chinese traditional herb of medicine, has demonstrated promising curative effects in clinical treatment for various tumors. There are documented experiments showing the biological functions of Huaier with its antineoplastic molecular mechanisms: restraining proliferation and meta...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S281328
更新日期:2020-12-08 00:00:00
abstract:BACKGROUND:Persistent infection with high-risk human papillomavirus (HPV) is a predominant cause of cervical cancer, and HPV58 is the third most common virus detected in the patients with cervical cancer in Asia. E6 and E7 are the viral oncogenes which are constitutively expressed in HPV-associated tumor cells and can ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S84888
更新日期:2015-10-23 00:00:00
abstract:Objective:This study aimed to evaluate the safety and efficacy of intensity-modulated radiotherapy (IMRT) plus nimotuzumab with or without concurrent chemotherapy (CCT) for patients with locally advanced nasopharyngeal carcinoma (LA-NPC). Patients and methods:A total of 50 newly diagnosed patients with LA-NPC treated ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S151554
更新日期:2017-12-08 00:00:00
abstract:BACKGROUND:Forkhead box Q1 (FOXQ1, also known as HFH1), a member of the forkhead transcription factor family, has been demonstrated to be overexpressed in multiple tumors and is thought to be an indicator of poor clinical outcomes. METHODS:A meta-analysis using qualified relevant literature was performed to evaluate t...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S130905
更新日期:2017-03-23 00:00:00
abstract::The clinicopathological and prognostic significance of telomerase reverse transcriptase (TERT) promoter mutations have been widely investigated in thyroid cancer; however, the results are still discrepant. Systematic searches were performed in PubMed, Web of Science, Scopus, Ovid, and the Cochran Library databases for...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S116594
更新日期:2016-11-11 00:00:00
abstract:INTRODUCTION:The purpose of this study was to evaluate the use of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) to identify the presence of cervical lymph nodes metastases and extracapsular spread with histologic correlations in head and neck squamous cell carcinoma. METH...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S85479
更新日期:2015-08-26 00:00:00
abstract::Increasing evidence has shown that aldehyde dehydrogenase 1A1 (ALDH1A1), a detoxifying enzyme, is responsible for chemoresistance in a variety of tumors. Although the majority of patients with diffuse large B-cell lymphoma (DLBCL) can be cured with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), che...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S107957
更新日期:2016-08-29 00:00:00
abstract:Background:Nicotinamide phosphoribosyltransferase (NAMPT) and the transforming growth factor-β (TGF-β) signaling pathway play important roles in colorectal tumorigenesis and progress. However, the underlying regulatory mechanisms between NAMPT and TGF-β signaling in colorectal cancer (CRC) remain poorly understood. Me...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S282367
更新日期:2021-01-08 00:00:00
abstract:Background and aim:Ewing sarcoma (ES) is an aggressive neoplasm predominantly occurring in adolescents and has a poor prognosis when metastasized. In the current study, we were aiming to investigate the function of TRIM3 in autophagy in ES cells. Methods:The expression of TRIM3 in Ewing sarcoma tissues and normal tiss...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S219777
更新日期:2019-12-30 00:00:00
abstract:AIM:This article discusses the current use of volumetric modulated arc therapy (VMAT) techniques in clinical practice and reviews the available data from clinical outcome studies in different clinical settings. An overview of available literature about clinical outcomes with VMAT stereotactic/radiosurgical treatment is...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S113119
更新日期:2017-07-26 00:00:00
abstract:BACKGROUND:The association of cancer stem cells with epithelial-mesenchymal transition (EMT) is receiving attention. We found in our previous study that EMT existed from CD24- phenotype cells to their differentiated cells. It was shown that cyclin D1 functioned in sustaining self-renewal independent of CDK4/CDK6 activa...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S44177
更新日期:2013-06-20 00:00:00
abstract::Background: Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer morbidity and mortality worldwide. In the present study, we identified novel biomarkers associated with the pathogenesis of NSCLC aiming to provide new diagnostic and therapeutic approaches for NSCLC. Methods: The microarray datasets of...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S198621
更新日期:2019-05-13 00:00:00
abstract::Prostate cancer is the leading malignancy and the second most common cause of cancer-related death in men. Despite high cure rates with surgery and/or radiation, 30%-40% of patients eventually develop advanced cancer. Docetaxel is one of the most effective and well established chemotherapeutic agents for prostate canc...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S79105
更新日期:2015-04-10 00:00:00
abstract:Background:Hepatocellular carcinoma is a common malignant cancer and the second most common cause of cancer-related deaths worldwide. Collagen triple helix repeat containing 1 (CTHRC1) has been increasingly reported to be involved in tumorigenesis and/or tumor progression. However, limited data are available regarding ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S219429
更新日期:2019-09-23 00:00:00
abstract::Advanced gastric cancer (AGC) is difficult to treat with poor prognosis. Despite various possible treatments, the median survival time of such patients remains unsatisfactory. Therefore, new therapeutic approaches or combinations need to be further explored. We herein reported a case of a 54-year-old male patient who ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S221436
更新日期:2019-09-19 00:00:00
abstract:Background:Ovarian cancer (OC) is the most common type of gynecological malignant tumors with poor prognosis. The spen paralogue and orthologue C-terminal domain containing 1 (SPOCD1) is a newly identified molecule that has been indicated to discriminate progressive in human solid tumors. However, the role of SPOCD1 in...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S200317
更新日期:2020-01-15 00:00:00
abstract::Myelodysplastic syndromes (MDS) are a varied group of diseases leading to significant morbidity and mortality. Therapy of MDS has been difficult, with supportive cares used to ameliorate symptoms, and hematopoietic stem cell transplantation the only curative option. Agents, such as the cytidine analog azacitidine, exe...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/ott.s5852
更新日期:2010-09-07 00:00:00
abstract::[This corrects the article DOI: 10.2147/OTT.S214060.]. ...
journal_title:OncoTargets and therapy
pub_type: 已发布勘误
doi:10.2147/OTT.S258499
更新日期:2020-05-26 00:00:00