Epigenetic approaches in the treatment of myelodysplastic syndromes: clinical utility of azacitidine.

abstract：Introduction:Immune-based and antibody-drug conjugate therapies have shown promise in the treatment of patients with small cell lung cancer (SCLC). However, better predictive biomarkers are needed for selection of the appropriate SCLC patients for these advanced therapies and also for evaluation of the efficacy of thes...

journal_title：OncoTargets and therapy

authors： Regzedmaa O,Li Y,Li Y,Zhang H,Wang J,Gong H,Yuan Y,Li W,Liu H,Chen J

更新日期：2019-11-21 00:00:00

abstract：Background:A growing body of evidence supports the involvement of long noncoding RNA 00152 (LINC00152) in the progression and metastasis of multiple cancers. However, the exact roles of LINC00152 in the progression of human retinoblastoma (RB) remain unknown. We explored the expression and biological function of human ...

journal_title：OncoTargets and therapy

authors： Li S,Wen D,Che S,Cui Z,Sun Y,Ren H,Hao J

更新日期：2018-06-06 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is a key mediator that plays an important role in angiogenesis, tumor growth, and tumor metastasis. The associations between five polymorphisms of VEGF (rs3025039, rs699947, rs10434, rs1570360, and rs2010963) and renal cell carcinoma (RCC) risk have been extensively ...

journal_title：OncoTargets and therapy

authors： Wang J,Shen C,Fu Y,Yu T,Song J

更新日期：2017-03-21 00:00:00

abstract：:During the past decade, immunotherapy targeting immune checkpoints has become an important component of the treatment paradigm for numerous malignancies, especially PD-1/PD-L1 blockade which was demonstrated to rejuvenate disabled T cells in cancer patients to achieve long-term remissions. However, the clinical outcom...

journal_title：OncoTargets and therapy

authors： Cai J,Wang D,Zhang G,Guo X

更新日期：2019-10-15 00:00:00

abstract：PURPOSE:Telomere shortening occurs in tumor tissues and peripheral blood lymphocytes of many common human malignancies, including lung cancer, but its variation in T-cells has never been investigated. Thus, the aim of this study was to assess telomere length in T-cells and its correlation with the clinical characterist...

journal_title：OncoTargets and therapy

authors： Qian Y,Ding T,Wei L,Cao S,Yang L

更新日期：2016-05-04 00:00:00

abstract：:Basal cell carcinoma (BCC) is a common malignant tumor throughout the world. One of the known risk factors of BCC is intense exposure to ultraviolet radiation. More than 50% of BCCs of the eyelid initially occur on the lower lid. The gold standard of diagnosis of BCC is histopathology. Treatment options for BCC consis...

journal_title：OncoTargets and therapy

authors： Shi Y,Jia R,Fan X

更新日期：2017-05-08 00:00:00

abstract：INTRODUCTION:The prognostic impact of smoking and drinking on esophageal squamous cell carcinoma (ESCC) was scarcely discussed. We investigated the prognostic value of smoking and drinking and their relationships with clinicopathological characteristics in a large cohort of patients with locoregional ESCC. PATIENTS AN...

journal_title：OncoTargets and therapy

authors： Sun P,Chen C,Zhang F,Yang H,Bi XW,An X,Wang FH,Jiang WQ

更新日期：2016-07-13 00:00:00

abstract：Background:This study was designed to research the potential function of lncRNA ANRIL in osteosarcoma (OS). Materials and methods:Quantitative real-time PCR, cell counting kit-8, wound healing assay, Transwell assay, flow cytometric analysis, caspase activity analysis, and Western blot were carried out. Results:ANRIL...

journal_title：OncoTargets and therapy

authors： Guan H,Mei Y,Mi Y,Li C,Sun X,Zhao X,Liu J,Cao W,Li Y,Wang Y

更新日期：2018-08-14 00:00:00

abstract：:The study is designed to explore the correlations of microvascular blood flow of contrast-enhanced ultrasound (CEUS) and hepatocyte growth factor (HGF)/c-Met signaling pathway with clinicopathological features and prognosis of patients with hepatocellular carcinoma (HCC). One hundred and eighteen patients pathological...

journal_title：OncoTargets and therapy

authors： Zhuang PH,Xu L,Gao L,Lu W,Ruan LT,Yang J

更新日期：2017-02-14 00:00:00

abstract：Introduction:Upper tract urothelial carcinoma (UTUC) is a relatively uncommon urologic malignancy for which there has not been significant improvement in survival over the past few decades, highlighting the need for optimal multi-modality management. Methods:A non-systematic review of the latest literature was perform...

journal_title：OncoTargets and therapy

authors： Leow JJ,Liu Z,Tan TW,Lee YM,Yeo EK,Chong YL

更新日期：2020-01-06 00:00:00

abstract：Background:Gastric cancer (GC) is one of the most common malignant tumors and the second most frequent cause of cancer death worldwide. Crocin is a kind of bioactive constituent found in the stigmas of saffron, which has shown various pharmacological activities. Methods:In this study, we investigated the inhibitory ef...

journal_title：OncoTargets and therapy

authors： Luo Y,Yu P,Zhao J,Guo Q,Fan B,Diao Y,Jin Y,Wu J,Zhang C

更新日期：2021-01-07 00:00:00

abstract：BACKGROUND:Bevacizumab plus taxane chemotherapy improves progression-free survival (PFS) versus taxane monotherapy in the first-line treatment of HER2-negative metastatic breast cancer (MBC) and appears promising in the second-line setting. This retrospective analysis evaluated the efficacy and safety of this combinati...

journal_title：OncoTargets and therapy

authors： Redondo A,Martínez V,Zamora P,Castelo B,Pinto A,Cruz P,Higuera O,Mendiola M,Hardisson D,Espinosa E

更新日期：2014-11-27 00:00:00

abstract：:HES1 is the target of Notch signaling which is reported to affect cell differentiation and maintain the cells in G0 phase in various tissues including the hematopoietic tissue. HES1 expression appears to be an independent prognostic factor for survival in a heterogeneous group of acute myeloid leukemia (AML) patients....

journal_title：OncoTargets and therapy

authors： Tian C,Tang Y,Wang T,Yu Y,Wang X,Wang Y,Zhang Y

更新日期：2015-04-22 00:00:00

abstract：Purpose:Circular RNAs (circRNAs) have been found to regulate several human tumors. The present study was to explore the mechanism of hsa_circ_0087862 in regulating non-small cell lung cancer (NSCLC). Methods:Totally 102 NSCLC cases were enrolled. NCI-H1359 and A549 cells were transfected. Cells viability, apoptosis, m...

journal_title：OncoTargets and therapy

authors： Li L,Wan K,Xiong L,Liang S,Tou F,Guo S

更新日期：2020-04-03 00:00:00

abstract：INTRODUCTION:The purpose of this study was to evaluate the use of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) to identify the presence of cervical lymph nodes metastases and extracapsular spread with histologic correlations in head and neck squamous cell carcinoma. METH...

journal_title：OncoTargets and therapy

authors： Dequanter D,Shahla M,Aubert C,Deniz Y,Lothaire P

更新日期：2015-08-26 00:00:00

abstract：:Patients with papillary thyroid cancer (PTC) generally have good prognosis, but inoperable and radioactive iodine-refractory PTC still poses significant clinical challenges due to lack of effective treatment and higher mortality rates. Given the important role of integrins in multiple steps of tumor development, integ...

journal_title：OncoTargets and therapy

authors： Cheng W,Feng F,Ma C,Wang H

更新日期：2016-03-11 00:00:00

abstract：:Increasing evidence has shown that aldehyde dehydrogenase 1A1 (ALDH1A1), a detoxifying enzyme, is responsible for chemoresistance in a variety of tumors. Although the majority of patients with diffuse large B-cell lymphoma (DLBCL) can be cured with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), che...

journal_title：OncoTargets and therapy

authors： Jiang J,Liu Y,Tang Y,Li L,Zeng R,Zeng S,Zhong M

更新日期：2016-08-29 00:00:00

abstract：AIM:The aim of this study was to assess if the expression of Notch 1 receptor is associated with tumor aggressiveness in papillary thyroid carcinomas (PTCs). PATIENTS AND METHODS:By searching the electronic medical record system of Xin Hua Hospital, all cases of PTC patients who underwent thyroidectomy in the hospital...

journal_title：OncoTargets and therapy

authors： Fu H,Ma C,Guan W,Cheng W,Feng F,Wang H

更新日期：2016-03-15 00:00:00

abstract：Purpose:The clinical studies carried out in the last few decades unequivocally introduced activated androgen receptor (AR) as a pathogenic feature of human malignancies which not only endows cancer cells with survival advantage, but also may be exploited for anticancer interventions. Patients and Methods:In this study...

journal_title：OncoTargets and therapy

authors： Soleymani Fard S,Yazdanbod M,Sotoudeh M,Bashash D,Mahmoodzadeh H,Saliminejad K,Mousavi SA,Ghaffari SH,Alimoghaddam K

更新日期：2020-10-02 00:00:00

abstract：:Survivin is a member of the inhibitor-of-apoptosis proteins (IAPs) family; its overexpression has been widely demonstrated to occur in various types of cancer. Overexpression of survivin also correlates with tumor progression and induces anticancer drug resistance. Interestingly, recent studies reveal that survivin ex...

journal_title：OncoTargets and therapy

authors： Cheung CH,Huang CC,Tsai FY,Lee JY,Cheng SM,Chang YC,Huang YC,Chen SH,Chang JY

更新日期：2013-10-16 00:00:00

abstract：:The incidence rate of breast cancers in People's Republic of China has increased in the last decade, and many cases are responsive to hormone therapies. The third-generation aromatase inhibitor letrozole inhibits estrogen production, and is more efficacious than the estrogen receptor inhibitor tamoxifen. In recent yea...

journal_title：OncoTargets and therapy

authors： He DX,Ma X

更新日期：2016-03-01 00:00:00

abstract：Background:Neuroblastoma, mainly affecting children, is a lethal malignancy arising from the developing sympathetic nervous system. The genetic etiology of neuroblastoma remains mostly obscure. High mobility group AT-hook 2 (HMGA2), an oncogenic gene, is up-regulated in many tumors. Single nucleotide polymorphisms (SNP...

journal_title：OncoTargets and therapy

authors： Liu J,Hua RX,Cheng Y,Zhu J,Zhang J,Cheng J,Zhou H,Xia H,Bian J,He J

更新日期：2020-01-15 00:00:00

abstract：:In the absence of a driver mutation, chemotherapy is the standard treatment option as first- and second-line therapy for advanced non-small-cell lung cancer (NSCLC). Though a large number of patients are suitable for post second-line therapies, the quality and quantity of the available drugs in this setting is poor. A...

journal_title：OncoTargets and therapy

authors： Fang SC,Zhang HT,Zhang YM,Xie WP

更新日期：2017-01-18 00:00:00

abstract：:Preclinical studies have demonstrated that Apatinib, major targeting vascular endothelial growth factor receptor-2 (VEGFR-2), could inhibit the proliferation of anaplastic thyroid carcinoma (ATC) cells in vitro and in vivo. The efficacy and safety in ATC patients, however, remains unknown. Here, we report the case of ...

journal_title：OncoTargets and therapy

authors： Cheng L,Jiao Q,Jin Y,Fu H,Zhang H,Chen L

更新日期：2019-12-02 00:00:00

abstract：Background:Although there have been great advances in mechanisms and therapeutic methods of prostate cancer, the mortality rate of prostate cancer remains high. The castration-resistant prostate cancer (CRPC), which develops from hormone-sensitive prostate cancer, foreshadows a more dismal outcome. Concomitant with the...

journal_title：OncoTargets and therapy

authors： Wang K,Ruan H,Xu T,Liu L,Liu D,Yang H,Zhang X,Chen K

更新日期：2018-05-28 00:00:00

abstract：:Oncolytic viruses (OVs) have the ability to selectively replicate in and lyse cancer cells. Angiogenesis is an essential requirement for tumor growth. Like OVs, the therapeutic effect of many angiogenesis inhibitors has been limited, leading to the development of more effective approaches to combine antiangiogenic the...

journal_title：OncoTargets and therapy

authors： Tysome JR,Lemoine NR,Wang Y

更新日期：2013-07-31 00:00:00

abstract：Aim:Colorectal cancer (CRC) is the fourth most frequently diagnosed cancer worldwide. Despite the decrease in mortality of CRC patients, further investigation of the molecular pathogenesis of CRC could unveil new therapeutic targets and offer better prognosis predictions, which might direct attention to epigenetic regu...

journal_title：OncoTargets and therapy

authors： Liu X,Hou X,Zhou Y,Li Q,Kong F,Yan S,Lei S,Xiong L,He J

更新日期：2019-11-26 00:00:00

abstract：Background:Leukemia related protein 16 (LRP16), one of the genes belonging to the macro domain family, has been found up-regulated in various tumors including testicles, ovaries and mucosa of colon and is associated with poor clinical outcomes. Purpose:The objective of this study was to investigate expression pattern ...

journal_title：OncoTargets and therapy

authors： Mo Z,Hu M,Yu F,Shao L,Fan K,Jiao S

更新日期：2018-03-05 00:00:00

abstract：Background:The neutrophil-lymphocyte ratio (NLR), a biomarker for systematic inflammation, has been recently identified as a prognostic factor for various types of both solid and hematologic malignancies. Our study presented here was the first meta-analysis assessing the prognostic role of NLR in multiple myeloma (MM)....

journal_title：OncoTargets and therapy

authors： Mu S,Ai L,Fan F,Sun C,Hu Y

更新日期：2018-01-23 00:00:00

abstract：:p125 is one of four subunits of human DNA polymerases - DNA Pol δ as well as one of p53 target protein encoded by POLD1. However, the function and significance of p125 and the role that p53 plays in regulating p125 expression are not fully understood in breast cancer. Tissue sections of human breast cancer obtained fr...

journal_title：OncoTargets and therapy

authors： Zhang L,Yang W,Zhu X,Wei C

更新日期：2016-03-10 00:00:00