Abstract:
:The mortality of hepatobiliary cancer still stays high around the world, with disappointing treatment status at advanced stage. Genomic analysis has identified the global spectrum of alterations in liver cancer, but the most common mutations are not actionable, meanwhile lacking potent molecular-targeted drugs for specific oncogenic drivers. Multiple-targeted drugs which mainly inhibited tumors' angiogenesis, such as sorafenib and lenvatinib, improved survival time for patients with advanced hepatocellular carcinoma, although the median overall survival remains 1-1.5 years. It is still ambiguous for the precise biomarkers of multiple-targeted drugs utilized in hepatobiliary cancer. Herein, we reported two observational patients who were sequentially treated by various targeted drugs and obtained lasting overall survival time. Both the two patients weekly switched targeted drugs according to the changes of tumor markers. These two cases would get us thinking: what is the underlying mechanism of molecular-targeted drugs in hepatobiliary tumors; and whether a "drugs screening model" during real-time treatment could be achieved through the assistance from sensitive and specific tumor markers.
journal_name
Onco Targets Therjournal_title
OncoTargets and therapyauthors
Lin J,Yang X,Xie Y,Zhao Hdoi
10.2147/OTT.S223568subject
Has Abstractpub_date
2019-11-19 00:00:00pages
9941-9945issn
1178-6930pii
223568journal_volume
12pub_type
abstract:BACKGROUND:Gallbladder carcinoma is a highly malignant tumor and a public health problem in some parts of the world. It is characterized by a poor prognosis and its resistance to radio and chemotherapy. There is an urgent need to develop novel therapeutic alternatives for the treatment of gallbladder carcinoma. The mam...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S46897
更新日期:2013-10-03 00:00:00
abstract:Background/aim:Urothelial bladder cancer arises from the accumulation of multiple epigenetic and genetic changes. We aimed to investigate the specificity and sensitivity of gene-specific promoter methylation of CDH1 and p14ARF genes in the early diagnosis of bladder cancer and compare those with other diagnostic tests ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S158259
更新日期:2018-07-19 00:00:00
abstract:Objective:This study aimed to evaluate the safety and efficacy of intensity-modulated radiotherapy (IMRT) plus nimotuzumab with or without concurrent chemotherapy (CCT) for patients with locally advanced nasopharyngeal carcinoma (LA-NPC). Patients and methods:A total of 50 newly diagnosed patients with LA-NPC treated ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S151554
更新日期:2017-12-08 00:00:00
abstract:Introduction:Dynamin 3 (DNM3) is a large GTPase that possesses mechanochemical properties and has been shown to be involved in malignancies. However, most studies about DNM3 are observational, and knowledge of the precise molecular mechanism of DNM3 remains limited. Materials and methods:We constructed a PCDH-CMV-MCS-...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S176388
更新日期:2018-10-09 00:00:00
abstract::Anterior gradient protein (AGR) 3 is a highly related homologue of pro-oncogenic AGR2 and belongs to the family of protein disulfide isomerases. Although AGR3 was found in breast, ovary, prostate, and liver cancer, it remains of yet poorly defined function in tumorigenesis. This study aimed to determine AGR3 expressio...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S82235
更新日期:2015-06-24 00:00:00
abstract::Glioblastoma is the most aggressive type of brain tumor with a very poor prognosis. Therefore, it is always of great importance to explore and develop new potential treatment for glioblastoma. Quercetin, a flavonoid present in a variety of human foods, has been shown to inhibit various tumor cell proliferation. In thi...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S136821
更新日期:2017-08-11 00:00:00
abstract::The study aimed to investigate the difference of setup errors on different registration in the treatment of nasopharyngeal carcinoma based on weekly cone-beam computed tomography (CBCT). Thirty nasopharyngeal cancer patients scheduled to undergo intensity-modulated radiotherapy (IMRT) were prospectively enrolled in th...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S87159
更新日期:2015-09-14 00:00:00
abstract::Breast cancer is one of the most common malignant cancers among women and a major clinical obstacle. Although studies have reported the abnormal expression of SIRT7 in breast cancer, whether the function of SIRT7 regulates the expression of long noncoding RNAs (lncRNAs) in breast cancer remains unknown. We aimed to de...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S149048
更新日期:2017-10-24 00:00:00
abstract::The mitogen-activated protein kinase (MAPK) pathway is a critical oncogenic driver signal in a number of malignancies. The discovery of activating mutations in the MAPK pathway has led to the development of MAPK pathway inhibitors. Selumetinib is a potent and selective inhibitor of MEK1 and MEK2, which are essential d...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S51596
更新日期:2014-09-19 00:00:00
abstract::Colorectal cancer continues to be an important public health concern, despite improvements in screening and better systemic chemotherapy. The integration of targeted therapies in the treatment of colon cancer has resulted in significant improvements in efficacy outcomes. Angiogenesis is important for tumor growth and ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:
更新日期:2009-02-18 00:00:00
abstract:Introduction:A disintegrin and metallopeptidase with thrombospondin motifs (ADAMTSs), whose expression is dysregulated in various cancers, is implicated in cancer development. Herein, we aimed to investigate the functional role of ADAMTS8 in breast cancer (BC) and explore the underlying mechanisms. Methods:The protein...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S248085
更新日期:2020-08-21 00:00:00
abstract:Background:The diagnosis rate of early stage esophageal squamous cell carcinoma (ESCC) is low due to the lack of specific tumor markers. Seeking for these markers is beneficial to improve the early diagnosis rate and the prognosis of patients. This study profiles the differentially expressed proteins of early stage ESC...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S171242
更新日期:2018-09-12 00:00:00
abstract::Recent studies have shown that microRNAs play a pivotal role in the pathogenesis of cancer. In our current study, the expression levels of microRNA-211 (miR-211) were measured in human non-small-cell lung cancer (NSCLC) tissues and cell lines. We found that miR-211 expression levels were increased in NSCLC tissues and...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S143084
更新日期:2017-11-28 00:00:00
abstract:Background:Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide. LINC00460, a novel long non-coding RNA (lncRNA), was recently confirmed as an oncogene in various cancers. However, the biological function and underlying mechanism of LINC00460 in HCC is largely obscure. Methods:Fifty pa...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S239258
更新日期:2020-03-06 00:00:00
abstract::Intrahepatic cholangiocarcinomas (IHCCs) are morphologically and biologically similar to pancreatic ductal adenocarcinomas (PDACs), so newly identified PDAC-associated genes or proteins could provide clues for screening novel biomarkers for IHCC. In this study, the expression of three novel PDAC tumor markers (T-box t...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S39646
更新日期:2013-01-01 00:00:00
abstract:Background and aims:Studies show that the long non-coding RNA, SBF2-AS1, plays a critical role in cancer progression, but the role of SBF2-AS1 in gastric cancer has not been reported. Therefore, this study aimed to elucidate the mechanism of SBF2-AS1 in gastric cancer (GC). Methods:A meta-analysis, based on the gene e...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,收录出版
doi:10.2147/OTT.S210697
更新日期:2019-10-30 00:00:00
abstract::Intracranial myeloid sarcoma is a very rare disease with poor prognosis. We report a case of a 28-year-old male patient who was admitted with intense headache, vision disturbance and severe vomiting in June 2017. He had a history of neurosurgical tumor resection operation in April 2017, and the pathological diagnosis ...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S230478
更新日期:2020-01-09 00:00:00
abstract:Purpose:Cutaneous squamous cell carcinoma (cSCC) is the second most common form of skin cancer and its incidence continues to rise yearly. Photodynamic therapy (PDT) is a non-invasive form of cancer therapy, which utilizes the combined action of a photosensitizer, light, and oxygen molecules to selectively cause cellul...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S228792
更新日期:2019-12-31 00:00:00
abstract::Malignant pericardial effusion (MPCE) is a common complication of advanced malignant tumors, and interferes severely with patient prognosis and quality of life. The standard treatment for this complication is intracavitary perfusion of chemotherapeutic drugs, which is limited by unsatisfactory therapeutic effects and ...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S90145
更新日期:2015-10-01 00:00:00
abstract:Background:Bladder cancer (BC) is one of the most prevalent malignancies of the genitourinary system, yet the underlying mechanism of BC progression still remains unclear. Growth arrest and DNA damage-inducible 45 alpha (GADD45a) is a repressive gene implicated in cell cycle regulation, as well as in human cancers deve...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S222223
更新日期:2019-09-16 00:00:00
abstract::Purpose: Lung adenocarcinoma (LUAD) is a main subtype of lung cancer, which is the leading cause of cancer-related deaths. The five-year survival rates of lung cancer patients are still comparatively low. Therefore, potential therapeutic targets are urgently needed to improve the survival of lung cancer patients. In t...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S190934
更新日期:2019-04-17 00:00:00
abstract:BACKGROUNDS:Sitting time and physical activity are associated with cancer risk; however, their roles in the development of esophageal squamous cell carcinoma (ESCC) are inconclusive. This study aimed to investigate the effects of total sitting time, occupational activity time (OAT), and recreational activity time (RAT)...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S147711
更新日期:2017-09-27 00:00:00
abstract::Bladder cancer (BC) is a common urinary system tumor with high aggressiveness, and it results in relatively high mortality due to a lack of precise and suitable biomarkers. In this study, we applied the weighted gene coexpression network analysis method to miRNA expression data from BC patients, and screened for netwo...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S146479
更新日期:2017-11-22 00:00:00
abstract:Purpose:Sorafenib has revolutionized treatment of hepatocellular carcinoma (HCC), but its efficacy is limited by drug resistance. Autophagy is the process by which cellular components are transported to lysosomes for degradation, which promotes energy production and production of macromolecular precursors. Studies have...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S247655
更新日期:2020-04-28 00:00:00
abstract:Background:Erdheim-Chester Disease (ECD) is a clonal non-Langerhans histiocytosis, classified as a macrophage-dendritic cell neoplasm in the 2016 WHO classification. The exact cell of origin of ECD is unknown, although some limited evidence suggests that it arises from myeloid progenitors. Case Presentation:A 43-year-...
journal_title:OncoTargets and therapy
pub_type:
doi:10.2147/OTT.S276497
更新日期:2020-11-16 00:00:00
abstract::[This corrects the article DOI: 10.2147/OTT.S227758.]. ...
journal_title:OncoTargets and therapy
pub_type: 已发布勘误
doi:10.2147/OTT.S242712
更新日期:2020-01-29 00:00:00
abstract:BACKGROUND AND PURPOSE:Vandetanib is a promising anticancer targeted agent for treating advanced carcinomas, such as non-small-cell lung cancer, small-cell lung cancer, breast cancer, malignant glioma, hepatocellular cancer, and unresectable, locally advanced, or metastatic medullary thyroid cancer. However, diarrhea i...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S96830
更新日期:2016-06-20 00:00:00
abstract:Background and aim:Standard chemotherapy has limited clinical efficacy in patients with esophageal cancer and there is a significant and unmet clinical need for effective treatment options for these patients. The aim of this study was to compare the clinical efficacy of the novel, targeted drug apatinib combined with d...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S191736
更新日期:2019-04-08 00:00:00
abstract::Despite improvements in multidisciplinary treatments, survival of pancreatic cancer (PC) patients remains dismal. Studies dealing with early onset pancreatic cancer (EOPC) patients are scarce. In this review, we discuss differences between EOPC and late-onset pancreatic cancer based on findings in original papers and ...
journal_title:OncoTargets and therapy
pub_type: 杂志文章,评审
doi:10.2147/OTT.S176700
更新日期:2019-05-06 00:00:00
abstract:OBJECTIVE:This study aims to investigate the potential benefit of combination therapy with magnetic nanoparticles of Fe3O4 (Fe3O4-MNP) and gambogic acid (GA) on SMMC-7721 cells. METHODS:The inhibition of proliferation of SMMC-7721 cells was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assa...
journal_title:OncoTargets and therapy
pub_type: 杂志文章
doi:10.2147/OTT.S86494
更新日期:2015-08-26 00:00:00