Abstract:
:Human papillomaviruses (HPVs) are ubiquitous DNA viruses that infect cutaneous and mucosal epithelia. A subset of HPVs infects the female genital tract, to induce cervical lesions that can progress to malignancy in some women. DNA from HPVs can be found in >94% of cervical carcinomas (CaCx) worldwide; this strong association suggests that it might be possible to develop either prophylaxis or therapies for cervical neoplasia, based on the manipulation of human immune responses against HPVs. This review examines the current research into human immune responses against HPVs in CaCx and the potential impact of this research on human health.
journal_name
Expert Rev Mol Medjournal_title
Expert reviews in molecular medicineauthors
Man Sdoi
10.1017/S1462399498000210keywords:
subject
Has Abstractpub_date
1998-07-03 00:00:00pages
1-19issn
1462-3994pii
S1462399498000210journal_volume
1998pub_type
杂志文章abstract::Polydactyly is one of the most common inherited limb abnormalities, characterised by supernumerary fingers or toes. It results from disturbances in the normal programme of the anterior-posterior axis of the developing limb, with diverse aetiology and variable inter- and intra-familial clinical features. Polydactyly ca...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/erm.2015.18
更新日期:2015-10-30 00:00:00
abstract::Asthma, allergic rhinitis and atopic dermatitis are allergic immune disorders characterised by a predominance of T helper 2 (Th2) cells, the resulting elevation of allergen-specific IgE, and mast-cell- and basophil-associated inflammation. The cytokine environment at the site of the initial antigen stimulation determi...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399404008348
更新日期:2004-10-22 00:00:00
abstract::The human animal type melanoma (ATM) is a rare subtype of melanoma characterised by the proliferation of pigmented dermal epithelioid and spindled melanocytes. However, this variant of melanoma is still lacking a precise nosography definition and classification for the difficulty to be distinguished from other more co...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/erm.2018.4
更新日期:2018-09-12 00:00:00
abstract::Several genetic loci appear to be involved in susceptibility to autoimmune disease. Some loci are disease specific, whereas others appear to exert a general effect on the autoimmune disease process. Despite a large number of studies of many different diseases, consistent associations with multiple autoimmune disorders...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399405009981
更新日期:2005-10-17 00:00:00
abstract::Spinal cord injury is one of the most devastating conditions that affects the central nervous system. It can lead to permanent disability and there are around two million people affected worldwide. After injury, accumulation of myelin debris and formation of an inhibitory glial scar at the site of injury leads to a ph...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章
doi:10.1017/S1462399409001288
更新日期:2009-12-08 00:00:00
abstract::Appropriately functioning adipose tissue is essential for human health, a fact most clearly illustrated by individuals with lipodystrophy, who have impaired adipose development and often suffer severe metabolic disease as a result. Humans with obesity display a similar array of metabolic problems. This reflects failur...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399410001547
更新日期:2010-08-02 00:00:00
abstract::Angptl2 is a multifaceted protein, displaying both physiological and pathological functions, in which scientific and clinical interest is growing exponentially within the past few years. Its physiological functions are not well understood, but angptl2 was first acknowledged for its pro-angiogenic and antiapoptotic cap...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/erm.2014.19
更新日期:2014-11-24 00:00:00
abstract::The human brain is a highly complex organ with remarkable energy demands. Although it represents only 2% of the total body weight, it accounts for 20% of all oxygen consumption, reflecting its high rate of metabolic activity. Mitochondria have a crucial role in the supply of energy to the brain. Consequently, their de...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399410001456
更新日期:2010-04-19 00:00:00
abstract::Experimental and human studies have shown that proteinuria contributes to the progression of renal disease. Overexposure to filtered proteins promotes the expression and release of chemokines by tubular epithelial cells, thus leading to inflammatory cell recruitment and renal impairment. This review focuses on recent ...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/erm.2014.3
更新日期:2014-02-17 00:00:00
abstract::Antiphospholipid (aPL) antibodies (Abs) are associated with thrombosis and pregnancy loss in antiphospholipid syndrome (APS), a disorder initially characterised in patients with systemic lupus erythematosus (SLE) but now known to occur in the absence of other autoimmune disease. There is strong evidence that aPL Abs a...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399407000506
更新日期:2007-11-13 00:00:00
abstract::Common to all forms of chronic kidney disease is the progressive scarring of the tubulo-interstitial space, associated with the acquisition and accumulation of activated myofibroblasts. Many of these myofibroblasts are generated when tubular epithelial cells progressively lose their epithelial characteristics (cell-ce...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399410001481
更新日期:2010-05-27 00:00:00
abstract::Human tumours emerge as the result of multiple genetic and epigenetic aberrations that allow the proto-cancer cell to escape normal social control. Many signal transduction pathways become constitutively active during this process, and one whose importance is increasingly being appreciated involves phosphoinositide 3-...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399405009361
更新日期:2005-06-06 00:00:00
abstract::Engineered tissue derived from ocular surface stem cells (SCs) are a cutting edge biotechnology for repair and restoration of severely damaged eyes as a result of ocular surface dysfunction because of SC failure. Ex-vivo SC expansion techniques have advanced significantly since the first patients were treated in the l...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/erm.2013.5
更新日期:2013-06-25 00:00:00
abstract::The pituitary tumor-transforming gene (PTTG1) encodes a multifunctional protein (PTTG) that is overexpressed in numerous tumours, including pituitary, thyroid, breast and ovarian carcinomas. PTTG induces cellular transformation in vitro and tumourigenesis in vivo, and several mechanisms by which PTTG contributes to tu...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399410001699
更新日期:2010-12-03 00:00:00
abstract::Autoimmune diseases of the central nervous system (CNS) involve the migration of abnormal numbers of self-directed leukocytes across the blood-brain barrier that normally separates the CNS from the immune system. The cardinal lesion associated with neuroinflammatory diseases is the perivascular infiltrate, which compr...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399407000397
更新日期:2007-07-19 00:00:00
abstract::Muscular dystrophies are a group of diseases characterised by the primary wasting of skeletal muscle, which compromises patient mobility and in the most severe cases originate a complete paralysis and premature death. Existing evidence implicates calcium dysregulation as an underlying crucial event in the pathophysiol...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/erm.2014.17
更新日期:2014-10-08 00:00:00
abstract::Multiple sclerosis (MS) is an autoimmune disease with an important genetic component. The strongest genetic association is with the major histocompatibility complex (MHC) region. Several MHC alleles predispose to the disease, the most prominent of which are certain alleles in the HLA-DR2 haplotype. Functional and stru...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399405008914
更新日期:2005-02-14 00:00:00
abstract::Resistance to anti-cancer drugs (drug resistance) can be defined in the laboratory by the amount of anti-cancer drug that is required to produce a given level of cell death (drug response). Clinical drug resistance can be defined either as a lack of reduction of the size of a tumour following chemotherapy or as the oc...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章
doi:10.1017/S1462399499001099X
更新日期:1999-10-25 00:00:00
abstract::The protozoan parasite Entamoeba histolytica is the causative agent of amoebic dysentery. It is prevalent in developing countries that cannot prevent its fecal-oral spread and ranks second in worldwide causes of morbidity by parasitic infection. Improvements in sanitation would help curb disease spread. However, a lac...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399405009622
更新日期:2005-07-18 00:00:00
abstract::Transthyretin (TTR) is a transport protein for thyroid hormones and vitamin A and might have an important role in the nervous system. However, TTR can undergo a conformational change and form amyloid fibrils, in both acquired and hereditary forms of systemic amyloidosis. More than 80 TTR mutations have been associated...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399402004647
更新日期:2002-05-14 00:00:00
abstract::Resveratrol (RSV) is a natural polyphenol produced by plants and is proposed to have multiple beneficial effects on health. In recent years, the interest in this molecule has increased nearly exponentially following the major findings that RSV (I) is chemo-preventive in some cancer models, (II) is cardio-protective an...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/erm.2013.11
更新日期:2013-09-23 00:00:00
abstract::Acute kidney injury (AKI) is a serious clinical condition with no effective treatment. Tubular cells are key targets in AKI. Tubular cells and, specifically, proximal tubular cells are extremely rich in mitochondria and mitochondrial changes had long been known to be a feature of AKI. However, only recent advances in ...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/erm.2014.14
更新日期:2014-08-08 00:00:00
abstract::Limb-girdle muscular dystrophy type 2A (LGMD2A) is a form of muscular dystrophy caused by mutations in calpain 3 (CAPN3). Several studies have implicated Ca2+ dysregulation as an underlying event in several muscular dystrophies, including LGMD2A. In this study we used mouse and human myotube cultures, and muscle biops...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章
doi:10.1017/erm.2016.9
更新日期:2016-04-08 00:00:00
abstract::The use of mouse models in medical research has greatly contributed to our understanding of the development of type 2 diabetes mellitus and the mechanisms of disease progression in the context of insulin resistance and β-cell dysfunction. Maintenance of glucose homeostasis involves a complex interplay of many genes an...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399410001729
更新日期:2011-01-06 00:00:00
abstract::The incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are released from enteroendocrine cells in the intestinal epithelium in response to nutrient ingestion. The actions of GLP-1 and GIP - not only on local gut physiology but also on glucose homeostasis, appetite ...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S146239940900132X
更新日期:2010-01-05 00:00:00
abstract::Memory is the process by which organisms are able to record their experiences, and use this information to adapt their responses to the environment. As such, it is vital for survival. In recent years, the development of spatially and temporally selective techniques for the regulation of gene expression has allowed the...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399403006707
更新日期:2003-10-07 00:00:00
abstract::The mammalian target of rapamycin mTOR is a central element in an evolutionary conserved signalling pathway that regulates cell growth, survival and proliferation, orchestrating signals originating from growth factors, nutrients or particular stress stimuli. Two important modulators of mTOR activity are the AKT and ER...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399408000586
更新日期:2008-02-04 00:00:00
abstract::Imaging has become a crucial tool in oncology throughout the course of disease detection and management, and is an integral part of clinical trials. Anatomical and functional imaging led the way, providing valuable information used in the diagnosis of disease, including data regarding the size and location of the tumo...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399410001511
更新日期:2010-07-15 00:00:00
abstract::Atherosclerosis is a pathological process that takes place in the major arteries and is the underlying cause of heart attacks, stroke and peripheral artery disease. The earliest detectable lesions, called fatty streaks, contain macrophage foam cells that are derived from recruited monocytes. More-advanced atherosclero...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章
doi:10.1017/S1462399401003696
更新日期:2001-11-05 00:00:00
abstract::The identification of multipotent adipose-derived stromal cells (ASC) has raised hope that tissue regeneration approaches established with bone-marrow-derived stromal cells (BMSC) can be reproduced with a cell-type that is far more accessible in large quantities. Recent detailed comparisons, however, revealed subtle f...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/erm.2014.9
更新日期:2014-05-09 00:00:00