Abstract:
:The incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are released from enteroendocrine cells in the intestinal epithelium in response to nutrient ingestion. The actions of GLP-1 and GIP - not only on local gut physiology but also on glucose homeostasis, appetite control and fat metabolism - have made these hormones an attractive area for drug discovery programmes. The potential range of strategies to target the secretion of these hormones therapeutically has been limited by an incomplete understanding of the mechanisms underlying their release. The use of organ and whole-animal perfusion techniques, cell line models and primary L- and K-cells has led to the identification of a variety of pathways involved in the sensing of carbohydrate, fat and protein in the gut lumen. This review focuses on our current understanding of these signalling mechanisms that might underlie nutrient responsiveness of L- and K-cells.
journal_name
Expert Rev Mol Medjournal_title
Expert reviews in molecular medicineauthors
Parker HE,Reimann F,Gribble FMdoi
10.1017/S146239940900132Xsubject
Has Abstractpub_date
2010-01-05 00:00:00pages
e1issn
1462-3994pii
S146239940900132Xjournal_volume
12pub_type
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Expert reviews in molecular medicine
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journal_title:Expert reviews in molecular medicine
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journal_title:Expert reviews in molecular medicine
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journal_title:Expert reviews in molecular medicine
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journal_title:Expert reviews in molecular medicine
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journal_title:Expert reviews in molecular medicine
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journal_title:Expert reviews in molecular medicine
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journal_title:Expert reviews in molecular medicine
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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abstract::Human papillomaviruses (HPVs) are ubiquitous DNA viruses that infect cutaneous and mucosal epithelia. A subset of HPVs infects the female genital tract, to induce cervical lesions that can progress to malignancy in some women. DNA from HPVs can be found in >94% of cervical carcinomas (CaCx) worldwide; this strong asso...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章
doi:10.1017/S1462399498000210
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399403006628
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399406010544
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
doi:10.1017/S1462399403006707
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abstract::The use of mouse models in medical research has greatly contributed to our understanding of the development of type 2 diabetes mellitus and the mechanisms of disease progression in the context of insulin resistance and β-cell dysfunction. Maintenance of glucose homeostasis involves a complex interplay of many genes an...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章,评审
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journal_title:Expert reviews in molecular medicine
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journal_title:Expert reviews in molecular medicine
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journal_title:Expert reviews in molecular medicine
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journal_title:Expert reviews in molecular medicine
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journal_title:Expert reviews in molecular medicine
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abstract::The human brain is a highly complex organ with remarkable energy demands. Although it represents only 2% of the total body weight, it accounts for 20% of all oxygen consumption, reflecting its high rate of metabolic activity. Mitochondria have a crucial role in the supply of energy to the brain. Consequently, their de...
journal_title:Expert reviews in molecular medicine
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abstract::The HEDGEHOG-GLI (HH-GLI) signalling is a key pathway critical in embryonic development, stem cell biology and tissue homeostasis. In recent years, aberrant activation of HH-GLI signalling has been linked to several types of cancer, including those of the skin, brain, lungs, prostate, gastrointestinal tract and blood....
journal_title:Expert reviews in molecular medicine
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abstract::Spinal cord injury is one of the most devastating conditions that affects the central nervous system. It can lead to permanent disability and there are around two million people affected worldwide. After injury, accumulation of myelin debris and formation of an inhibitory glial scar at the site of injury leads to a ph...
journal_title:Expert reviews in molecular medicine
pub_type: 杂志文章
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