Pathogenesis of infantile haemangioma: new molecular and cellular insights.

Abstract:

:Infantile haemangioma is the most common tumour of infancy, yet the origin of these lesions remains controversial and the predictable life cycle is poorly understood. Much new information on infantile haemangiomas has emerged over the past decade, but experts continue to debate fundamental features, including cell of origin, nonrandom distribution, and mechanisms regulating the sometimes explosive growth and slow involution. The development of useful laboratory models has been difficult, in turn restricting the development of treatment options available to the clinician. Despite this, new research and creative thinking has spawned several hypotheses on the origin of these tumours and their interesting clinical behaviour, including suggestions of an intrinsic defect in local endothelial cells, a contribution of circulating endothelial progenitors or haemangioblasts, embolisation of shed placental cells and developmental field defects. While no single hypothesis seems to describe all features of infantile haemangioma, continued research seeks to integrate these ideas, create a better understanding of these important tumours and bring new treatments to the clinic.

journal_name

Expert Rev Mol Med

authors

Ritter MR,Butschek RA,Friedlander M,Friedlander SF

doi

10.1017/S146239940700052X

subject

Has Abstract

pub_date

2007-11-29 00:00:00

pages

1-19

issue

32

issn

1462-3994

pii

S146239940700052X

journal_volume

9

pub_type

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