Role of chemokines in proteinuric kidney disorders.

Abstract:

:Experimental and human studies have shown that proteinuria contributes to the progression of renal disease. Overexposure to filtered proteins promotes the expression and release of chemokines by tubular epithelial cells, thus leading to inflammatory cell recruitment and renal impairment. This review focuses on recent progress in cellular and molecular understanding of the role of chemokines in the pathogenesis of proteinuria-induced renal injury, as well as their clinical implications and therapeutic potential.

journal_name

Expert Rev Mol Med

authors

Moreno JA,Moreno S,Rubio-Navarro A,Gómez-Guerrero C,Ortiz A,Egido J

doi

10.1017/erm.2014.3

subject

Has Abstract

pub_date

2014-02-17 00:00:00

pages

e3

issn

1462-3994

pii

S1462399414000039

journal_volume

16

pub_type

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