Pituitary tumor-transforming gene and its binding factor in endocrine cancer.

Abstract:

:The pituitary tumor-transforming gene (PTTG1) encodes a multifunctional protein (PTTG) that is overexpressed in numerous tumours, including pituitary, thyroid, breast and ovarian carcinomas. PTTG induces cellular transformation in vitro and tumourigenesis in vivo, and several mechanisms by which PTTG contributes to tumourigenesis have been investigated. Also known as the human securin, PTTG is involved in cell cycle regulation, controlling the segregation of sister chromatids during mitosis. This review outlines current information regarding PTTG structure, expression, regulation and function in the pathogenesis of neoplasia. Recent progress concerning the use of PTTG as a prognostic marker or therapeutic target will be considered. In addition, the PTTG binding factor (PBF), identified through its interaction with PTTG, has also been established as a proto-oncogene that is upregulated in several cancers. Current knowledge regarding PBF is outlined and its role both independently and alongside PTTG in endocrine and related cancers is discussed.

journal_name

Expert Rev Mol Med

authors

Smith VE,Franklyn JA,McCabe CJ

doi

10.1017/S1462399410001699

subject

Has Abstract

pub_date

2010-12-03 00:00:00

pages

e38

issn

1462-3994

pii

S1462399410001699

journal_volume

12

pub_type

杂志文章,评审
  • Molecular mechanisms underlying nutrient-stimulated incretin secretion.

    abstract::The incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are released from enteroendocrine cells in the intestinal epithelium in response to nutrient ingestion. The actions of GLP-1 and GIP - not only on local gut physiology but also on glucose homeostasis, appetite ...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S146239940900132X

    authors: Parker HE,Reimann F,Gribble FM

    更新日期:2010-01-05 00:00:00

  • mTOR: more targets of resveratrol?

    abstract::Resveratrol (RSV) is a natural polyphenol produced by plants and is proposed to have multiple beneficial effects on health. In recent years, the interest in this molecule has increased nearly exponentially following the major findings that RSV (I) is chemo-preventive in some cancer models, (II) is cardio-protective an...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/erm.2013.11

    authors: Widlund AL,Baur JA,Vang O

    更新日期:2013-09-23 00:00:00

  • Impact of miRNAs in gastrointestinal cancer diagnosis and prognosis.

    abstract::Since the discovery of noncoding small RNAs such as microRNAs (miRNAs), and their roles as potential tumour suppressors or oncogenes, post-transcriptional and translational control of gene expression have become increasingly important in cancer research. Given that over a third of coding genes, as estimated by computa...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S1462399410001663

    authors: Song B,Ju J

    更新日期:2010-10-14 00:00:00

  • Molecular mechanisms of genomic imprinting and clinical implications for cancer.

    abstract::Genomic imprinting is an epigenetic marking of genes in the parental germline that ensures the stable transmission of monoallelic gene expression patterns in a parent-of-origin-specific manner. Epigenetic marking systems are thus able to regulate gene activity independently of the underlying DNA sequence. Several impr...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S1462399410001717

    authors: Uribe-Lewis S,Woodfine K,Stojic L,Murrell A

    更新日期:2011-01-25 00:00:00

  • Overcoming biological barriers to in vivo efficacy of antisense oligonucleotides.

    abstract::Antisense oligonucleotides as a therapeutic platform have been slow to progress since the approval of the first antisense drug in 1998. Recently, there have been several examples of convincing antisense interventions in animal models and promising clinical trial data. This review considers the factors determining the ...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S1462399409001021

    authors: White PJ,Anastasopoulos F,Pouton CW,Boyd BJ

    更新日期:2009-03-23 00:00:00

  • Adipose-derived stromal cells for osteoarticular repair: trophic function versus stem cell activity.

    abstract::The identification of multipotent adipose-derived stromal cells (ASC) has raised hope that tissue regeneration approaches established with bone-marrow-derived stromal cells (BMSC) can be reproduced with a cell-type that is far more accessible in large quantities. Recent detailed comparisons, however, revealed subtle f...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/erm.2014.9

    authors: Ruetze M,Richter W

    更新日期:2014-05-09 00:00:00

  • Pathogenesis of infantile haemangioma: new molecular and cellular insights.

    abstract::Infantile haemangioma is the most common tumour of infancy, yet the origin of these lesions remains controversial and the predictable life cycle is poorly understood. Much new information on infantile haemangiomas has emerged over the past decade, but experts continue to debate fundamental features, including cell of ...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S146239940700052X

    authors: Ritter MR,Butschek RA,Friedlander M,Friedlander SF

    更新日期:2007-11-29 00:00:00

  • Ebola virus: new insights into disease aetiopathology and possible therapeutic interventions.

    abstract::Ebola virus (EBOV) gained public notoriety in the last decade largely as a consequence of the highly publicized isolation of a new EBOV species in a suburb of Washington, DC, in 1989, together with the dramatic clinical presentation of EBOV infection and high case-fatality rate in Africa (near 90% in some outbreaks), ...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S1462399404008300

    authors: Geisbert TW,Hensley LE

    更新日期:2004-09-21 00:00:00

  • Molecular mechanisms controlling human adipose tissue development: insights from monogenic lipodystrophies.

    abstract::Appropriately functioning adipose tissue is essential for human health, a fact most clearly illustrated by individuals with lipodystrophy, who have impaired adipose development and often suffer severe metabolic disease as a result. Humans with obesity display a similar array of metabolic problems. This reflects failur...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S1462399410001547

    authors: Rochford JJ

    更新日期:2010-08-02 00:00:00

  • Molecular mechanisms of learning and memory.

    abstract::Memory is the process by which organisms are able to record their experiences, and use this information to adapt their responses to the environment. As such, it is vital for survival. In recent years, the development of spatially and temporally selective techniques for the regulation of gene expression has allowed the...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S1462399403006707

    authors: Dunning J,During MJ

    更新日期:2003-10-07 00:00:00

  • Angiopoietin-like-2: a multifaceted protein with physiological and pathophysiological properties.

    abstract::Angptl2 is a multifaceted protein, displaying both physiological and pathological functions, in which scientific and clinical interest is growing exponentially within the past few years. Its physiological functions are not well understood, but angptl2 was first acknowledged for its pro-angiogenic and antiapoptotic cap...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/erm.2014.19

    authors: Thorin-Trescases N,Thorin E

    更新日期:2014-11-24 00:00:00

  • Calpain 3 deficiency affects SERCA expression and function in the skeletal muscle.

    abstract::Limb-girdle muscular dystrophy type 2A (LGMD2A) is a form of muscular dystrophy caused by mutations in calpain 3 (CAPN3). Several studies have implicated Ca2+ dysregulation as an underlying event in several muscular dystrophies, including LGMD2A. In this study we used mouse and human myotube cultures, and muscle biops...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章

    doi:10.1017/erm.2016.9

    authors: Toral-Ojeda I,Aldanondo G,Lasa-Elgarresta J,Lasa-Fernández H,Fernández-Torrón R,López de Munain A,Vallejo-Illarramendi A

    更新日期:2016-04-08 00:00:00

  • Molecular targets for disrupting leukocyte trafficking during multiple sclerosis.

    abstract::Autoimmune diseases of the central nervous system (CNS) involve the migration of abnormal numbers of self-directed leukocytes across the blood-brain barrier that normally separates the CNS from the immune system. The cardinal lesion associated with neuroinflammatory diseases is the perivascular infiltrate, which compr...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S1462399407000397

    authors: McCandless EE,Klein RS

    更新日期:2007-07-19 00:00:00

  • Mitochondria-targeted therapies for acute kidney injury.

    abstract::Acute kidney injury (AKI) is a serious clinical condition with no effective treatment. Tubular cells are key targets in AKI. Tubular cells and, specifically, proximal tubular cells are extremely rich in mitochondria and mitochondrial changes had long been known to be a feature of AKI. However, only recent advances in ...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/erm.2014.14

    authors: Tábara LC,Poveda J,Martin-Cleary C,Selgas R,Ortiz A,Sanchez-Niño MD

    更新日期:2014-08-08 00:00:00

  • Metalloproteinases and their inhibitors in angiogenesis.

    abstract::Angiogenesis, the formation of new blood vessels from the pre-existing vasculature, is an integral part of physiological processes such as embryonic development, the female reproductive cycle and wound healing. Angiogenesis is also central to a variety of pathologies including cancer, where it is recognised as being c...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S1462399403006628

    authors: Lafleur MA,Handsley MM,Edwards DR

    更新日期:2003-09-22 00:00:00

  • Gene therapy for severe combined immune deficiency.

    abstract::Infants born with severe combined immune deficiencies are prone to life-threatening infections and, without treatment, do not survive beyond the first year of life. Haematopoietic stem cell transplantation from a fully matched donor offers the possibility of cure. In the absence of a suitable matched donor, haploident...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S1462399404007884

    authors: Qasim W,Gaspar HB,Thrasher AJ

    更新日期:2004-07-02 00:00:00

  • Ex-vivo ocular surface stem cell therapies: current techniques, applications, hurdles and future directions.

    abstract::Engineered tissue derived from ocular surface stem cells (SCs) are a cutting edge biotechnology for repair and restoration of severely damaged eyes as a result of ocular surface dysfunction because of SC failure. Ex-vivo SC expansion techniques have advanced significantly since the first patients were treated in the l...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/erm.2013.5

    authors: Angunawela RI,Mehta JS,Daniels JT

    更新日期:2013-06-25 00:00:00

  • The phosphoinositide 3-kinase pathway and cancer.

    abstract::Human tumours emerge as the result of multiple genetic and epigenetic aberrations that allow the proto-cancer cell to escape normal social control. Many signal transduction pathways become constitutively active during this process, and one whose importance is increasingly being appreciated involves phosphoinositide 3-...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S1462399405009361

    authors: Stokoe D

    更新日期:2005-06-06 00:00:00

  • Hereditary transthyretin amyloidosis: molecular basis and therapeutical strategies.

    abstract::Transthyretin (TTR) is a transport protein for thyroid hormones and vitamin A and might have an important role in the nervous system. However, TTR can undergo a conformational change and form amyloid fibrils, in both acquired and hereditary forms of systemic amyloidosis. More than 80 TTR mutations have been associated...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S1462399402004647

    authors: Saraiva MJ

    更新日期:2002-05-14 00:00:00

  • Costamere proteins and their involvement in myopathic processes.

    abstract::Muscle fibres are very specialised cells with a complex structure that requires a high level of organisation of the constituent proteins. For muscle contraction to function properly, there is a need for not only sarcomeres, the contractile structures of the muscle fibre, but also costameres. These are supramolecular s...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/erm.2015.9

    authors: Jaka O,Casas-Fraile L,López de Munain A,Sáenz A

    更新日期:2015-06-19 00:00:00

  • MHC-based vaccination approaches: progress and perspectives.

    abstract::The major histocompatibility complex (MHC) harbours genes whose primary function in regulating immune responsiveness to infection is to present foreign antigens to cytotoxic T lymphocytes (CTLs) and T helper cells. In the case of infection by human immunodeficiency virus (HIV), defining the optimal HIV epitopes that a...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S1462399403005957

    authors: Mehra NK,Kaur G

    更新日期:2003-02-24 00:00:00

  • Animal-type melanoma: dog or wolf? A review of the literature and a case report.

    abstract::The human animal type melanoma (ATM) is a rare subtype of melanoma characterised by the proliferation of pigmented dermal epithelioid and spindled melanocytes. However, this variant of melanoma is still lacking a precise nosography definition and classification for the difficulty to be distinguished from other more co...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/erm.2018.4

    authors: Stucci LS,Palmirotta R,Lovero D,Silvestris E,Cafforio P,Felici C,Todisco A,Nacchiero E,Pezzuto F,Tucci M,Silvestris F

    更新日期:2018-09-12 00:00:00

  • DNA-damage response pathways triggered by viral replication.

    abstract::Many viruses, with distinct replication strategies, activate DNA-damage response pathways, including the lentivirus human immunodeficiency virus (HIV) and the DNA viruses Epstein-Barr virus (EBV), herpes simplex virus 1, adenovirus and SV40. DNA-damage response pathways involving DNA-dependent protein kinase, ataxia-t...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S1462399406010544

    authors: Sinclair A,Yarranton S,Schelcher C

    更新日期:2006-03-03 00:00:00

  • Extrinsic and intrinsic factors controlling axonal regeneration after spinal cord injury.

    abstract::Spinal cord injury is one of the most devastating conditions that affects the central nervous system. It can lead to permanent disability and there are around two million people affected worldwide. After injury, accumulation of myelin debris and formation of an inhibitory glial scar at the site of injury leads to a ph...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章

    doi:10.1017/S1462399409001288

    authors: Afshari FT,Kappagantula S,Fawcett JW

    更新日期:2009-12-08 00:00:00

  • Multiple sclerosis: MHC associations and therapeutic implications.

    abstract::Multiple sclerosis (MS) is an autoimmune disease with an important genetic component. The strongest genetic association is with the major histocompatibility complex (MHC) region. Several MHC alleles predispose to the disease, the most prominent of which are certain alleles in the HLA-DR2 haplotype. Functional and stru...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S1462399405008914

    authors: Holmes S,Friese MA,Siebold C,Jones EY,Bell J,Fugger L

    更新日期:2005-02-14 00:00:00

  • Role of chemokines in proteinuric kidney disorders.

    abstract::Experimental and human studies have shown that proteinuria contributes to the progression of renal disease. Overexposure to filtered proteins promotes the expression and release of chemokines by tubular epithelial cells, thus leading to inflammatory cell recruitment and renal impairment. This review focuses on recent ...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/erm.2014.3

    authors: Moreno JA,Moreno S,Rubio-Navarro A,Gómez-Guerrero C,Ortiz A,Egido J

    更新日期:2014-02-17 00:00:00

  • New targeted therapies for treatment of thrombosis in antiphospholipid syndrome.

    abstract::Antiphospholipid (aPL) antibodies (Abs) are associated with thrombosis and pregnancy loss in antiphospholipid syndrome (APS), a disorder initially characterised in patients with systemic lupus erythematosus (SLE) but now known to occur in the absence of other autoimmune disease. There is strong evidence that aPL Abs a...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S1462399407000506

    authors: Pierangeli SS,Vega-Ostertag ME,González EB

    更新日期:2007-11-13 00:00:00

  • Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy.

    abstract::The HEDGEHOG-GLI (HH-GLI) signalling is a key pathway critical in embryonic development, stem cell biology and tissue homeostasis. In recent years, aberrant activation of HH-GLI signalling has been linked to several types of cancer, including those of the skin, brain, lungs, prostate, gastrointestinal tract and blood....

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/erm.2015.3

    authors: Pandolfi S,Stecca B

    更新日期:2015-02-09 00:00:00

  • Molecular mechanisms of endothelial hyperpermeability: implications in inflammation.

    abstract::Endothelial hyperpermeability is a significant problem in vascular inflammation associated with trauma, ischaemia-reperfusion injury, sepsis, adult respiratory distress syndrome, diabetes, thrombosis and cancer. An important mechanism underlying this process is increased paracellular leakage of plasma fluid and protei...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S1462399409001112

    authors: Kumar P,Shen Q,Pivetti CD,Lee ES,Wu MH,Yuan SY

    更新日期:2009-06-30 00:00:00

  • HLA , CTLA-4 and PTPN22 : the shared genetic master-key to autoimmunity?

    abstract::Several genetic loci appear to be involved in susceptibility to autoimmune disease. Some loci are disease specific, whereas others appear to exert a general effect on the autoimmune disease process. Despite a large number of studies of many different diseases, consistent associations with multiple autoimmune disorders...

    journal_title:Expert reviews in molecular medicine

    pub_type: 杂志文章,评审

    doi:10.1017/S1462399405009981

    authors: Brand O,Gough S,Heward J

    更新日期:2005-10-17 00:00:00